{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:14:53Z","timestamp":1764080093312,"version":"3.41.2"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Digit. Health"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The increasing prevalence of dementia in aging populations necessitates effective and accessible cognitive screening tools. This study aimed to evaluate the feasibility and reliability of a newly developed mobile app for detecting and screening mild cognitive impairment (MCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The mobile app, developed by LifeQuest Co., Ltd. (Minato-ku, Tokyo), is an original tool inspired by the Japanese version of the Montreal Cognitive Assessment (MoCA-J). A prospective observational study was conducted with 20 participants, including healthy individuals, MCI patients, and those with mild to moderate-severe dementia. Participants completed both the mobile app and the MoCA-J in a randomized order within a two-week period, with a minimum one-day interval between tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusion<\/jats:title><jats:p>The intraclass correlation coefficient (ICC) between the mobile app and the MoCA-J was 0.956 (95% CI: 0.89-0.983), demonstrating a very high level of correlation. All participants successfully completed the mobile app assessment, highlighting its feasibility across various cognitive levels. Although minor technical issues and usability challenges were identified, the results support the mobile app as a reliable and user-friendly alternative for cognitive screening. Further studies with larger sample sizes are necessary to validate these findings and refine the app for broader clinical use.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fdgth.2025.1535900","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T13:32:26Z","timestamp":1738935146000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prospective observational study to evaluate the feasibility of the mobile app for mild cognitive impairment detection and screening"],"prefix":"10.3389","volume":"7","author":[{"given":"Reo","family":"Hamaguchi","sequence":"first","affiliation":[]},{"given":"Seiji","family":"Hongo","sequence":"additional","affiliation":[]},{"given":"Naoto","family":"Doi","sequence":"additional","affiliation":[]},{"given":"Hisamitsu","family":"Ide","sequence":"additional","affiliation":[]},{"given":"Ryozo","family":"Saito","sequence":"additional","affiliation":[]},{"given":"Junji","family":"Kishimoto","sequence":"additional","affiliation":[]},{"given":"Nobuhiro","family":"Handa","sequence":"additional","affiliation":[]},{"given":"Shigeo","family":"Horie","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"444","DOI":"10.2188\/jea.JE20180150","article-title":"Japanese Legacy cohort studies: the Hisayama study","volume":"28","author":"Ninomiya","year":"2018","journal-title":"J Epidemiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"key":"B4","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s40120-024-00604-x","article-title":"Donanemab in Japanese patients with early Alzheimer\u2019s disease: subpopulation analysis of the TRAILBLAZER-ALZ 2 randomized trial","volume":"13","author":"Sato","year":"2024","journal-title":"Neurol Ther"},{"key":"B5","doi-asserted-by":"publisher","first-page":"324","DOI":"10.2174\/156720509788929237","article-title":"Early diagnosis of Alzheimer\u2019s disease: is MCI too late?","volume":"6","author":"Petersen","year":"2009","journal-title":"Curr Alzheimer Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1159\/000272424","article-title":"Incidence of mild cognitive impairment: a systematic review","volume":"29","author":"Luck","year":"2010","journal-title":"Dement Geriatr Cogn Disord"},{"key":"B7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jalz.2011.01.002","article-title":"Mild cognitive impairment: disparity of incidence and prevalence estimates","volume":"8","author":"Ward","year":"2012","journal-title":"Alzheimers Dement"},{"key":"B8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1017\/S1041610204000092","article-title":"Is MCI really just early dementia? 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