{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:30:57Z","timestamp":1778211057273,"version":"3.51.4"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Digit. Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We compared gait measures that best differentiated individuals with spinocerebellar ataxia (SCA) from age-matched healthy controls (HC) during a supervised gait test in the clinic vs. a week of unsupervised gait during daily life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty-six individuals with SCA types 1, 2, 3, and 6, and 13 (HC) wore three Opal inertial sensors (on both feet and lower back) during a 2-minute walk in the clinic and for seven days in daily life. Seventeen gait measures were analyzed to investigate the group differences using Mann\u2013Whitney <jats:italic>U<\/jats:italic>-tests and area under the curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten gait measures were significantly worse in SCA than HC for the clinic test (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.003), but only 3 were worse in daily life (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.003). Only a few gait measures consistently discriminated groups in both environments. Specifically, variability in Swing Time and Double Support Time had AUCs of 0.99 (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.0001) and 0.96 (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.0001) in the clinic, and 0.84 (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.0003) and 0.80 (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.002) in daily life, respectively. Clinical gait measures showed stronger correlations with clinical outcomes (ie, SARA and FARS-ADL; <jats:sans-serif>r<\/jats:sans-serif>\u2009=\u2009<jats:sans-serif>0.50\u20130.77<\/jats:sans-serif>) than between daily life gait measures (<jats:sans-serif>r<\/jats:sans-serif>\u2009=\u2009<jats:sans-serif>0.31\u20130.49<\/jats:sans-serif>). Gait activity in daily life was not statistically significant between the SCA and HC groups (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u2009<jats:sans-serif>0.06<\/jats:sans-serif>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Digital gait measures discriminate SCA in both environments. In-clinic measures are more sensitive, while daily life measures provide ecological validity, highlighting a trade-off and offering complementary insights.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fdgth.2025.1590150","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T05:39:02Z","timestamp":1756877942000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinic vs. daily life gait characteristics in patients with spinocerebellar ataxia"],"prefix":"10.3389","volume":"7","author":[{"given":"Vrutangkumar 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