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There is a need to develop novel methods for statistical inference in this context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, motivated by the analysis of fNIRS hyperscanning data, which measure the activity of multiple brains simultaneously, we propose a two-step network estimation: Tabu search local method and global maximization in the selected subgroup [partial conditional directed acyclic graph (DAG) + multiregression dynamic model]. We illustrate this approach in a dataset of two individuals who are playing the violin together.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study contributes new tools to the social neuroscience field, which may provide new perspectives about intersubject interactions. Our proposed approach estimates the best probabilistic network representation, in addition to providing access to the time-varying parameters, which may be helpful in understanding the brain-to-brain association of these two players.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The illustration of the violin duo highlights the time-evolving changes in the brain activation of an individual influencing the other one through a data-driven analysis. We confirmed that one player was leading the other given the ROI causal relation toward the other player.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fncom.2023.1132160","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T15:13:39Z","timestamp":1690470819000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Hyperscanning fNIRS data analysis using multiregression dynamic models: an illustration in a violin duo"],"prefix":"10.3389","volume":"17","author":[{"given":"Diego Carvalho","family":"do Nascimento","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Roberto","family":"Santos da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson","family":"Ara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Ricardo","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilia","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.neubiorev.2012.07.006","article-title":"Social neuroscience and hyperscanning techniques: past, present and future","volume":"44","author":"Babiloni","year":"2014","journal-title":"Neurosci. 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