{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:21:33Z","timestamp":1770747693373,"version":"3.49.0"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Comput. Neurosci."],"abstract":"<jats:p>Understanding the neural mechanisms underlying the transitions between different states of consciousness is a fundamental challenge in neuroscience. Thus, we investigate the underlying drivers of changes during the resting-state dynamics of the human brain, as captured by functional magnetic resonance imaging (fMRI) across varying levels of consciousness (awake, light sedation, deep sedation, and recovery). We deploy a model-based approach relying on linear time-invariant (LTI) dynamical systems under unknown inputs (UI). Our findings reveal distinct changes in the spectral profile of brain dynamics\u2014particularly regarding the stability and frequency of the system's oscillatory modes during transitions between consciousness states. These models further enable us to identify external drivers influencing large-scale brain activity during naturalistic auditory stimulation. Our findings suggest that these identified inputs delineate how stimulus-induced co-activity propagation differs across consciousness states. Notably, our approach showcases the effectiveness of LTI models under UI in capturing large-scale brain dynamic changes and drivers in complex paradigms, such as naturalistic stimulation, which are not conducive to conventional general linear model analysis. Importantly, our findings shed light on how brain-wide dynamics and drivers evolve as the brain transitions toward conscious states, holding promise for developing more accurate biomarkers of consciousness recovery in disorders of consciousness.<\/jats:p>","DOI":"10.3389\/fncom.2026.1731868","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:56:59Z","timestamp":1770706619000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Shifts in brain dynamics and drivers of consciousness state transitions"],"prefix":"10.3389","volume":"20","author":[{"given":"Joseph","family":"Bodenheimer","sequence":"first","affiliation":[{"name":"Department of Psychology, The University of Kansas","place":["Lawrence, KS, United States"]}]},{"given":"Paul","family":"Bogdan","sequence":"additional","affiliation":[{"name":"Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California","place":["Los Angeles, CA, United States"]}]},{"given":"S\u00e9rgio","family":"Pequito","sequence":"additional","affiliation":[{"name":"Institute for Systems and Robotics, Instituto Superior T\u00e9cnico, Universidade de Lisboa","place":["Lisbon, Portugal"]}]},{"given":"Arian","family":"Ashourvan","sequence":"additional","affiliation":[{"name":"Department of Psychology, The University of Kansas","place":["Lawrence, KS, United States"]}]}],"member":"1965","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fncir.2014.00020","article-title":"Dynamical criticality during induction of anesthesia in human ecog recordings","volume":"8","author":"Alonso","year":"2014","journal-title":"Front. 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