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The connectivity model was calculated by machine-learning-based neural representation and effective functional connectivity using psychophysiological interaction and dynamic causal modeling analyses. The model indicated the network difference wherein the inferior parietal lobule receives extrinsic information from the rostral lingual gyrus through the superior parietal lobule and transmits intrinsic information to the Handknob, whereas extrinsic information is transmitted to the Handknob directly from the rostral lingual gyrus. A behavioral experiment provided further evidence on the difference between motor coordinate frames showing onset timing delay of muscle activity of intrinsic coordinate-directed wrist movement compared to extrinsic one. These results suggest that, if the movement is externally directed, intrinsic coordinate system information is bypassed to reach the primary motor area.<\/jats:p>","DOI":"10.3389\/fninf.2023.1199862","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T12:26:01Z","timestamp":1688991961000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential processing of intrinsic vs. extrinsic coordinates in wrist movement: connectivity and chronometry perspectives"],"prefix":"10.3389","volume":"17","author":[{"given":"Laura Alejandra","family":"Martinez-Tejada","sequence":"first","affiliation":[]},{"given":"Yuji","family":"Imakura","sequence":"additional","affiliation":[]},{"given":"Ying-Tung","family":"Cho","sequence":"additional","affiliation":[]},{"given":"Ludovico","family":"Minati","sequence":"additional","affiliation":[]},{"given":"Natsue","family":"Yoshimura","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"year":"2009","article-title":"SLR Toolbox Web Page.","key":"B1"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.cortex.2008.10.005","article-title":"Is the human primary motor cortex activated by muscular or direction-dependent features of observed movements?","volume":"45","author":"Alaerts","year":"2009","journal-title":"Cortex"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1093\/cercor\/bhq007","article-title":"Cortical connections of parietal field PEc in the macaque: Linking vision and somatic sensation for the control of limb action.","volume":"20","author":"Bakola","year":"2010","journal-title":"Cereb. 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