{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T16:24:19Z","timestamp":1781367859391,"version":"3.54.1"},"reference-count":142,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Artif. Intell."],"abstract":"<jats:p>This review provides a thorough and organized overview of machine learning (ML) applications in predicting heart disease, covering technological advancements, challenges, and future prospects. As cardiovascular diseases (CVDs) are the leading cause of global mortality, there is an urgent demand for early and precise diagnostic tools. ML models hold considerable potential by utilizing large-scale healthcare data to enhance predictive diagnostics. To systematically investigate this field, the literature is organized into five thematic categories such as \u201cHeart Disease Detection and Diagnostics,\u201d \u201cMachine Learning Models and Algorithms for Healthcare,\u201d \u201cFeature Engineering and Optimization Techniques,\u201d \u201cEmerging Technologies in Healthcare,\u201d and \u201cApplications of AI Across Diseases and Conditions.\u201d The review incorporates performance benchmarking of various ML models, highlighting that hybrid deep learning (DL) frameworks, e.g., convolutional neural network-long short-term memory (CNN-LSTM) consistently outperform traditional models in terms of sensitivity, specificity, and area under the curve (AUC). Several real-world case studies are presented to demonstrate the successful deployment of ML models in clinical and wearable settings. This review showcases the progression of ML approaches from traditional classifiers to hybrid DL structures and federated learning (FL) frameworks. It also discusses ethical issues, dataset limitations, and model transparency. The conclusions provide important insights for the development of artificial intelligence (AI) powered, clinically applicable heart disease prediction systems.<\/jats:p>","DOI":"10.3389\/frai.2025.1583459","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:11:21Z","timestamp":1747116681000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["A comprehensive review of machine learning for heart disease prediction: challenges, trends, ethical considerations, and future directions"],"prefix":"10.3389","volume":"8","author":[{"given":"Raman","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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