{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:31:06Z","timestamp":1779931866255,"version":"3.53.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Robot. AI"],"abstract":"<jats:p>Advancements in the research on so-called \u201csynthetic (artificial) cells\u201d have been mainly characterized by an important acceleration in all sorts of experimental approaches, providing a growing amount of knowledge and techniques that will shape future successful developments. Synthetic cell technology, indeed, shows potential in driving a revolution in science and technology. On the other hand, theoretical and epistemological investigations related to what synthetic cells \u201care,\u201d how they behave, and what their role is in generating knowledge have not received sufficient attention. Open questions about these less explored subjects range from the analysis of the organizational theories applied to synthetic cells to the study of the \u201crelevance\u201d of synthetic cells as scientific tools to investigate life and cognition; and from the recognition and the cultural reappraisal of cybernetic inheritance in synthetic biology to the need for developing concepts on synthetic cells and to the exploration, in a novel perspective, of information theories, complexity, and artificial intelligence applied in this novel field. In these contributions, we will briefly sketch some crucial aspects related to the aforementioned issues, based on our ongoing studies. An important take-home message will result: together with their impactful experimental results and potential applications, synthetic cells can play a major role in the exploration of theoretical questions as well.<\/jats:p>","DOI":"10.3389\/frobt.2023.1143196","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T07:14:49Z","timestamp":1679555689000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthetic cell research: Is technical progress leaving theoretical and epistemological investigations one step behind?"],"prefix":"10.3389","volume":"10","author":[{"given":"Pasquale","family":"Stano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Damiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1039\/C7CS00117G","article-title":"Systems chemistry","volume":"46","author":"Ashkenasy","year":"2017","journal-title":"Chem. 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