{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T20:51:19Z","timestamp":1764363079007,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Robot. AI"],"abstract":"<jats:p><jats:bold>Objectives:<\/jats:bold> We recently introduced a frameless, navigated, robot-driven laser tool for depth electrode implantation as an alternative to frame-based procedures. This method has only been used in cadaver and non-recovery studies. This is the first study to test the robot-driven laser tool in an <jats:italic>in vivo<\/jats:italic> recovery animal study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A preoperative computed tomography (CT) scan was conducted to plan trajectories in sheep specimens. Burr hole craniotomies were performed using a frameless, navigated, robot-driven laser tool. Depth electrodes were implanted after cut-through detection was confirmed. The electrodes were cut at the skin level postoperatively. Postoperative imaging was performed to verify accuracy. Histopathological analysis was performed on the bone, dura, and cortex samples.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Fourteen depth electrodes were implanted in two sheep specimens. Anesthetic protocols did not show any intraoperative irregularities. One sheep was euthanized on the same day of the procedure while the other sheep remained alive for 1 week without neurological deficits. Postoperative MRI and CT showed no intracerebral bleeding, infarction, or unintended damage. The average bone thickness was 6.2 mm (range 4.1\u20138.0 mm). The angulation of the planned trajectories varied from 65.5\u00b0 to 87.4\u00b0. The deviation of the entry point performed by the frameless laser beam ranged from 0.27 mm to 2.24 mm. The histopathological analysis did not reveal any damage associated with the laser beam.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The novel robot-driven laser craniotomy tool showed promising results in this first <jats:italic>in vivo<\/jats:italic> recovery study. These findings indicate that laser craniotomies can be performed safely and that cut-through detection is reliable.<\/jats:p>","DOI":"10.3389\/frobt.2024.1355409","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T04:10:18Z","timestamp":1718165418000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A navigated, robot-driven laser craniotomy tool for frameless depth electrode implantation. 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