{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:46:42Z","timestamp":1780634802858,"version":"3.54.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Robot. AI"],"abstract":"<jats:p>The Expanded Endoscopic Endonasal Approach, one of the best examples of endoscopic neurosurgery, allows access to the skull base through the natural orifice of the nostril. Current standard instruments lack articulation limiting operative access and surgeon dexterity, and thus, could benefit from robotic articulation. In this study, a handheld robotic system with a series of detachable end-effectors for this approach is presented. This system is comprised of interchangeable articulated 2\/3 degrees-of-freedom 3 <jats:italic>mm<\/jats:italic> instruments that expand the operative workspace and enhance the surgeon\u2019s dexterity, an ergonomically designed handheld controller with a rotating joystick-body that can be placed at the position most comfortable for the user, and the accompanying control box. The robotic instruments were experimentally evaluated for their workspace, structural integrity, and force-delivery capabilities. The entire system was then tested in a pre-clinical context during a phantom feasibility test, followed up by a cadaveric pilot study by a cohort of surgeons of varied clinical experience. Results from this series of experiments suggested enhanced dexterity and adequate robustness that could be associated with feasibility in a clinical context, as well as improvement over current neurosurgical instruments.<\/jats:p>","DOI":"10.3389\/frobt.2024.1400017","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T19:32:23Z","timestamp":1718134343000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Handheld robotic device for endoscopic neurosurgery: system integration and pre-clinical evaluation"],"prefix":"10.3389","volume":"11","author":[{"given":"Emmanouil","family":"Dimitrakakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Newall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyal Z.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani J.","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danail","family":"Stoyanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1109\/ICRA.2019.8793798","article-title":"Compliant four degree-of-freedom manipulator with locally deformable elastic elements for minimally invasive surgery","volume-title":"2019 international conference on robotics and automation (ICRA)","author":"Arata","year":"2019"},{"key":"B2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1080\/01691864.2022.2138721","article-title":"3.5 mm compliant robotic surgical forceps with 4 dof: design and performance evaluation","volume":"37","author":"Bandara","year":"2022","journal-title":"Adv. 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