{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:05:13Z","timestamp":1791378313152,"version":"4.3.2"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Br. J. Biomed. Sci."],"abstract":"<jats:p>Non-malignant disorders of granulocytes and monocytes include a range of conditions characterized by either quantitative issues (such as cytopenias or cytophilias) or qualitative defects in innate immune cells. These disorders encompass neutropenias, monocytopenias, eosinophilic syndromes, and defects in granulocyte maturation. They can result from genetic mutations (including ELANE, HAX1, GATA2, and CSF3R), autoimmune dysregulation, or idiopathic mechanisms. The clinical manifestations of these disorders vary and can include recurrent infections, inflammatory complications, and organ damage. These issues arise from disrupted granulopoiesis, abnormal apoptosis, or dysfunctional chemotaxis. Recent innovations underscore how molecular diagnostics inform both mutation detection and risk stratification in congenital neutropenias. Take ELANE-associated severe congenital neutropenia: such variants not only establish the disorder but also highlight the subsequent hazard of myelodysplastic progression. In contrast, GATA2 deficiency generates isolated monocytopenia, correlating with a broadened window for opportunistic pathogens. Frontline practice now advocates for prompt, integrative assessment using next-generation sequencing alongside quantitative flow cytometry, thereby parsing mild benign states from early clonal hematopoiesis. Management hurdles persist, especially in patients with refractory neutropenia and the calibrated use of immunosuppression in autoimmune etiologies. The COVID-19 pandemic incidentally reiterated the extent of infectious susceptibility within this cohort, prompting the refinement of absolute, personalized prophylactic strategies. This review synthesizes the molecular mechanisms, genetic basis, and therapeutic innovations in non-malignant granulocyte\/monocyte disorders, offering a roadmap for personalized management. By bridging mechanistic insights with clinical practice, it addresses unmet needs in diagnostics, risk prediction, and novel biologics, ultimately improving outcomes for these underrecognized yet impactful conditions.<\/jats:p>","DOI":"10.3389\/bjbs.2025.15072","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T05:10:06Z","timestamp":1760073006000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-Malignant Granulocyte and Monocyte Disorders: An Update"],"prefix":"10.3389","volume":"82","author":[{"given":"Sorfina Binti","family":"Ahmad Hilmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Kumar","family":"Chellappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Philip","family":"Kunnath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1189\/jlb.0211094","article-title":"The Historical Milestones in the Understanding of Leukocyte Biology Initiated by Elie Metchnikoff","volume":"90","author":"Cavaillon","year":"2011","journal-title":"J Leukoc Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1161\/CIRCULATIONAHA.119.043833","article-title":"Neutrophil-Derived S100A8\/A9 Amplify Granulopoiesis After Myocardial Infarction","volume":"141","author":"Sreejit","year":"2020","journal-title":"Circulation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"107424","DOI":"10.1016\/j.pharmthera.2019.107424","article-title":"Role of Neutrophils in Ischemic Heart Failure","volume":"205","author":"Kain","year":"2020","journal-title":"Pharmacol Ther"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1444558","DOI":"10.3389\/fimmu.2024.1444558","article-title":"Unveiling Signaling Pathways Inducing MHC Class II Expression in Neutrophils","volume":"15","author":"Forrer","year":"2024","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1182\/hematology.2021000284","article-title":"Diagnosis and Therapeutic decision-making for the Neutropenic Patient","volume":"2021","author":"Connelly","year":"2021","journal-title":"Hematology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5772\/intechopen.1007382","article-title":"Congenital Neutropenia Associated","volume":"26","author":"Malbora","year":"2025","journal-title":"Stem Cell Transplant"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1080\/10428194.2025.2453093","article-title":"Comprehensive Analysis of Clinical, Pathological, and Molecular Features in Chronic Myelomonocytic Leukemia: Frequent ASXL1 and NRAS Mutations and Higher Mutation Burden in Myeloproliferative CMML Compared to Myelodysplastic CMML","volume":"17","author":"Jeong","year":"2025","journal-title":"Leuk & Lymphoma"},{"key":"B8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/17474086.2021.1860004","article-title":"Chronic Myelomonocytic leukemia-a Review","volume":"14","author":"Thomopoulos","year":"2021","journal-title":"Expert Rev Hematol"},{"key":"B9","volume-title":"Histology, Monocytes. 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