{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:37:10Z","timestamp":1790858230635,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R00NS130463"],"award-info":[{"award-number":["R00NS130463"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001595","name":"Dystonia Medical Research Foundation","doi-asserted-by":"publisher","award":["DMRF-BCAD-2024-4"],"award-info":[{"award-number":["DMRF-BCAD-2024-4"]}],"id":[{"id":"10.13039\/100001595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Dystonia"],"abstract":"<jats:p>\n                    Vocal impairments are a debilitating but understudied feature of several dystonias, including generalized and early-onset genetic forms. Despite growing recognition that cerebellar dysfunction contributes to dystonic pathophysiology, the circuit mechanisms underlying vocal-motor abnormalities remain poorly understood, and effective treatments remain limited, in part due to the lack of a preclinical model that captures specific vocal features. Our experiment evaluates ultrasonic vocalizations (USVs) in\n                    <jats:italic>Ptf1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>Cre\/+<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>;Vglut2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    mice, a cerebellum-specific generalized dystonia model, to assess cerebellar contributions to phonation and explore translational relevance for vocal features. At postnatal day 9, dystonic mice demonstrated statistically significant reductions in total USV count, relative count of complex calls, and key spectral parameters\u2014especially frequency modulation and power\u2014mirroring general phonatory abnormalities seen in dystonia. Cluster analyses further revealed impaired vocal burst initiation, suggesting disrupted cerebellar coordination of temporal vocal-motor output. These findings support the model\u2019s construct and face validity for studying cerebellar mechanisms of vocal impairment. By identifying quantifiable acoustic disruptions, our study establishes a foundational platform for future circuit-targeted investigations of vocal-motor dysfunction in dystonia.\n                  <\/jats:p>","DOI":"10.3389\/dyst.2026.15530","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:10:16Z","timestamp":1774591816000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing vocal changes through spectral analyses of vocalizations in a cerebellar-specific dystonia mouse model"],"prefix":"10.3389","volume":"5","author":[{"given":"Austin L.","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"Fralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine","place":["Roanoke, VA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan 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Heijden","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine","place":["Roanoke, VA, United States"]},{"name":"Graduate Program in Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University","place":["Blacksburg, VA, United States"]},{"name":"Center for Neurobiology Research, Fralin Biomedical Research Institute","place":["Roanoke, VA, United States"]},{"name":"School of Neuroscience, Virginia Polytechnic Institute and State University","place":["Blacksburg, VA, United States"]},{"name":"Department of Pediatrics, Virginia Tech Carilion School of Medicine","place":["Roanoke, VA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e70000","DOI":"10.1002\/hbm.70000","article-title":"Structural and functional brain alterations 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