{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:09:33Z","timestamp":1772111373610,"version":"3.50.1"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ebm-journal.org"],"crossmark-restriction":true},"short-container-title":["Exp. Biol. Med."],"abstract":"<jats:p>Tinnitus is a disturbing condition defined as the occurrence of acoustic hallucinations with no actual sound. Although the mechanisms underlying tinnitus have been explored extensively, the pathophysiology of the disease is not completely understood. Moreover, genes and potential treatment targets related to auditory hallucinations remain unknown. In this study, we examined transcriptional-profile changes in the medial geniculate body after noise-induced tinnitus in rats by performing RNA sequencing and validated differentially expressed genes via quantitative polymerase chain reaction analysis. The rat model of tinnitus was established by analyzing startle behavior based on gap-pre-pulse inhibition of acoustic startles. We identified 87 differently expressed genes, of which 40 were upregulated and 47 were downregulated. Pathway-enrichment analysis revealed that the differentially enriched genes in the tinnitus group were associated with pathway terms, such as coronavirus disease COVID-19, neuroactive ligand-receptor interaction. Protein\u2013protein-interaction networks were established, and two hub genes (Rpl7a and AC136661.1) were identified among the selected genes. Further studies focusing on targeting and modulating these genes are required for developing potential treatments for noise-induced tinnitus in patients.<\/jats:p>","DOI":"10.3389\/ebm.2024.10057","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T17:36:07Z","timestamp":1710783367000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptional-profile changes in the medial geniculate body after noise-induced tinnitus"],"prefix":"10.3389","volume":"249","author":[{"given":"Peng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmiao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanwen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuke","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Dong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.amjmed.2010.02.015","article-title":"Prevalence and characteristics of tinnitus among US adults","volume":"123","author":"Shargorodsky","year":"2010","journal-title":"Am J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1185\/03007995.2011.595781","article-title":"A review of tinnitus symptoms beyond 'ringing in the ears': a call to action","volume":"27","author":"Langguth","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"B3","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/s1474-4422(13)70160-1","article-title":"Tinnitus: causes and clinical management","volume":"12","author":"Langguth","year":"2013","journal-title":"Lancet Neurol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1056\/nejmcp1506631","article-title":"Tinnitus","volume":"378","author":"Bauer","year":"2018","journal-title":"New Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/9780470720677.ch12","article-title":"Tinnitus: surgical treatment","volume":"85","author":"House","year":"1981","journal-title":"Ciba Found Symp"},{"key":"B6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bandl.2013.03.003","article-title":"The organization and physiology of the auditory thalamus and its role in processing acoustic features important for speech perception","volume":"126","author":"Bartlett","year":"2013","journal-title":"Brain Lang"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1152\/physrev.00029.2020","article-title":"What's the buzz? 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