{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:52:24Z","timestamp":1781596344136,"version":"3.54.5"},"reference-count":175,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ebm-journal.org"],"crossmark-restriction":true},"short-container-title":["Exp. Biol. Med."],"abstract":"<jats:p>Peripheral nerve injury (PNI) presents a significant clinical challenge, frequently leading to long-term neuromuscular dysfunction, muscle atrophy, fibrosis, and chronic pain. Traditional repair strategies, including microsurgical reconnection and neurotrophic support, often yield limited functional recovery, especially in cases of delayed or incomplete reinnervation. In this context, skeletal muscle reprogramming\u2014defined as the intentional modulation of cellular fate, function, or metabolic state in muscle-resident cells\u2014has emerged as a promising strategy to enhance regenerative outcomes. This process involves transcriptional, epigenetic, and metabolic interventions targeting myogenic progenitors, fibro-adipogenic progenitors (FAPs), satellite cells (MuSCs), and the broader muscle microenvironment. Recent studies demonstrate that reprogramming strategies can mitigate denervation-induced muscle atrophy, delay fibrotic remodeling, promote neuromuscular junction (NMJ) reconstruction, and even stimulate endogenous nerve regrowth via retrograde signaling. Mechanistic insights have uncovered pivotal roles for signaling pathways such as Wnt\/\u03b2-catenin, TGF-\u03b2, Notch, and HDAC-regulated chromatin dynamics. Furthermore, innovations in small molecule cocktails, CRISPR-based transcriptional reactivation, and metabolic rewiring have expanded the therapeutic toolkit for muscle preservation and regeneration. This review comprehensively examines the molecular mechanisms, therapeutic roles, and translational challenges of skeletal muscle reprogramming in the context of PNI. We explore how muscle-targeted interventions can address complications of denervation, improve the efficacy of nerve repair, and offer a synergistic axis of regeneration when integrated with nerve-centric strategies. Finally, we identify key knowledge gaps and outline future research directions required to translate reprogramming-based therapies into clinical practice.<\/jats:p>","DOI":"10.3389\/ebm.2026.10835","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T06:10:14Z","timestamp":1772431814000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Skeletal muscle reprogramming in peripheral nerve injury: mechanisms, therapeutic roles, and complication management"],"prefix":"10.3389","volume":"251","author":[{"given":"Fuqiang","family":"Long","sequence":"first","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoru","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anxin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zairong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"The 2011 Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2013.04.002","article-title":"Nerve physiology: mechanisms of injury and recovery","volume":"29","author":"Rm","year":"2013","journal-title":"Hand Clinics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"698256","DOI":"10.1155\/2014\/698256","article-title":"Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies","volume":"2014","author":"Grinsell","year":"2014","journal-title":"Biomed Res Int"},{"key":"B3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/diagnostics11010030","article-title":"Nerve ultrasound in traumatic and iatrogenic peripheral nerve injury","volume":"11","author":"Wijntjes","year":"2020","journal-title":"Diagnostics"},{"key":"B4","doi-asserted-by":"publisher","first-page":"810919","DOI":"10.3389\/fnmol.2021.810919","article-title":"Denervation-related neuromuscular junction changes: from degeneration to regeneration","volume":"14","author":"Huang","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2976185","DOI":"10.1155\/2022\/2976185","article-title":"Constructing tissue-engineered dressing membranes with adipose-derived stem cells and acellular dermal matrix for diabetic wound healing: a comparative study of Hypoxia- or normoxia-culture modes","volume":"2022","author":"Zhou","year":"2022","journal-title":"Stem Cells Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1177\/17531934231216646","article-title":"Muscle preservation in proximal nerve injuries: a current update","volume":"49","author":"Lysak","year":"2024","journal-title":"Jhand Surg Eur"},{"key":"B7","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1523\/JNEUROSCI.4489-07.2008","article-title":"Retrograde signaling onto ret during motor nerve terminal maturation","volume":"28","author":"Baudet","year":"2008","journal-title":"JNeurosci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"210110","DOI":"10.1098\/rsob.210110","article-title":"Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases","volume":"11","author":"Molina","year":"2021","journal-title":"Mol Med Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2024.13374","article-title":"Denervation-induced NRG3 aggravates muscle heterotopic ossification via the ErbB4\/PI3K\/Akt signaling pathway","volume":"31","author":"Ma","year":"2025","journal-title":"Mol Medicine Reports"},{"key":"B10","doi-asserted-by":"publisher","first-page":"9218","DOI":"10.1038\/s41467-024-53276-4","article-title":"Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury","volume":"15","author":"Mehrotra","year":"2024","journal-title":"Nat Commun"},{"key":"B11","doi-asserted-by":"publisher","first-page":"RP97662","DOI":"10.7554\/eLife.97662","article-title":"Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis","volume":"13","author":"Yoo","year":"2024","journal-title":"Elife"},{"key":"B12","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/stem.3316","article-title":"Satellite cell activation and retention of muscle regenerative potential after long-term denervation","volume":"39","author":"Wong","year":"2021","journal-title":"Stem Cells"},{"key":"B13","doi-asserted-by":"publisher","first-page":"862478","DOI":"10.3389\/fsurg.2022.862478","article-title":"Incorporating blood flow in nerve injury and regeneration assessment","volume":"9","author":"Yeoh","year":"2022","journal-title":"Front Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"133572","DOI":"10.52965\/001c.133572","article-title":"Regenerative medicine: a new horizon in peripheral nerve injury and repair","volume":"17","author":"Widodo","year":"2025","journal-title":"Orthop Rev (Pavia)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.3390\/jpm12101673","article-title":"An epidemiological and etiological analysis of 5026 peripheral nerve lesions from a European level I trauma center","volume":"12","author":"Aman","year":"2022","journal-title":"JPM"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/foc.2004.16.5.2","article-title":"Pathophysiology of peripheral nerve injury: a brief review","volume":"16","author":"Burnett","year":"2004","journal-title":"FOC"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1113\/JP270874","article-title":"The repair schwann cell and its function in regenerating nerves","volume":"594","author":"Jessen","year":"2016","journal-title":"The J ofPhysiology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"918","DOI":"10.3390\/ijms23020918","article-title":"Peripheral nerve injury treatments and advances: one health perspective","volume":"23","author":"Lopes","year":"2022","journal-title":"IJMS"},{"key":"B19","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/ejn.13005","article-title":"Strategies to promote peripheral nerve regeneration: electrical stimulation and\/or exercise","volume":"43","author":"Gordon","year":"2016","journal-title":"Eur J Ofneuroscience"},{"key":"B20","doi-asserted-by":"publisher","first-page":"10416","DOI":"10.4081\/ejtm.2022.10416","article-title":"Exercise-mediated reinnervation of skeletal muscle in elderly people: an update","volume":"32","author":"Coletti","year":"2022","journal-title":"Eur J Transl Myol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e0160839","DOI":"10.1371\/journal.pone.0160839","article-title":"Denervation-Induced activation of the ubiquitin-proteasome system reduces skeletal muscle quantity not quality","volume":"11","author":"Baumann","year":"2016","journal-title":"PLoS ONE"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1113\/JP282173","article-title":"Time\u2010dependent changes in autophagy, mitophagy and lysosomes in skeletal muscle during denervation\u2010induced disuse","volume":"600","author":"Triolo","year":"2022","journal-title":"The J of Physiology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metab"},{"key":"B24","doi-asserted-by":"publisher","first-page":"ra18","DOI":"10.1126\/scisignal.2004809","article-title":"mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation ofFoxO and E3 ubiquitin ligases","volume":"7","author":"Tang","year":"2014","journal-title":"Sci Signal"},{"key":"B25","doi-asserted-by":"publisher","first-page":"8900","DOI":"10.18632\/aging.204365","article-title":"Denervation induces mitochondrial decline and exacerbates lysosome dysfunction in middle-aged mice","volume":"14","author":"Triolo","year":"2022","journal-title":"Aging"},{"key":"B26","doi-asserted-by":"publisher","first-page":"6484","DOI":"10.1111\/febs.16080","article-title":"Signaling pathways regulating the fate of fibro\/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease","volume":"289","author":"Giuliani","year":"2022","journal-title":"The FEBS J"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3654","DOI":"10.1242\/jcs.086629","article-title":"Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle","volume":"124","author":"Uezumi","year":"2011","journal-title":"J Cell Sci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3233\/JND-160183","article-title":"Matrix metalloproteinases and tissue inhibitor of metalloproteinases in inflammation and fibrosis of skeletal muscles","volume":"3","author":"Alameddine","year":"2016","journal-title":"J Neuromuscul Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nm.3869","article-title":"Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis offibro\/adipogenic progenitors","volume":"21","author":"Lemos","year":"2015","journal-title":"Nat Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e28090","DOI":"10.1371\/journal.pone.0028090","article-title":"Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle","volume":"6","author":"Chai","year":"2011","journal-title":"PLoS ONE"},{"key":"B31","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/j.1460-9568.2010.07096.x","article-title":"Differential muscle\u2010driven synaptic remodeling in the neuromuscular junction after denervation","volume":"31","author":"Yampolsky","year":"2010","journal-title":"Eur J Ofneuroscience"},{"key":"B32","doi-asserted-by":"publisher","first-page":"9770","DOI":"10.1523\/JNEUROSCI.0174-16.2016","article-title":"Schwann cells in neuromuscular junction formation and maintenance","volume":"36","author":"Barik","year":"2016","journal-title":"JNeurosci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"731","DOI":"10.4103\/1673-5374.266925","article-title":"Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair","volume":"15","author":"Enomoto","year":"2020","journal-title":"Neural Regen Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic pain: from mechanisms to treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol Rev"},{"key":"B35","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1097\/j.pain.0000000000003115","article-title":"Spontaneous activity in peripheral sensory nerves: a systematic review","volume":"165","author":"Choi","year":"2024","journal-title":"Pain"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1172\/JCI134439","article-title":"Neuroimmune modulation of pain and regenerative pain medicine","volume":"130","author":"Buchheit","year":"2020","journal-title":"J Clin Invest"},{"key":"B37","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/s41467-023-36265-x","article-title":"Transcriptional reprogramming of skeletal muscle stem cells by the niche environment","volume":"14","author":"Lazure","year":"2023","journal-title":"Nat Commun"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4014","DOI":"10.1111\/febs.12383","article-title":"Epigenetic control of skeletal muscle regeneration","volume":"280","author":"Giordani","year":"2013","journal-title":"The FEBS J"},{"key":"B39","doi-asserted-by":"publisher","first-page":"eabo1360","DOI":"10.1126\/sciadv.abo1360","article-title":"Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging","volume":"9","author":"Zhao","year":"2023","journal-title":"Sci Adv"},{"key":"B40","doi-asserted-by":"publisher","first-page":"eabe5671","DOI":"10.1126\/sciadv.abe5671","article-title":"Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo","volume":"7","author":"Shahini","year":"2021","journal-title":"Sci Adv"},{"key":"B41","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.stem.2018.12.014","article-title":"Aging disrupts muscle stem cell function by impairing matricellular WISP1 secretion from fibro-adipogenic progenitors","volume":"24","author":"Lukjanenko","year":"2019","journal-title":"Cell Stem Cell"},{"key":"B42","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/nm.4126","article-title":"Loss offibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice","volume":"22","author":"Lukjanenko","year":"2016","journal-title":"Nat Med"},{"key":"B43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.tem.2015.03.006","article-title":"Muscle stem cell aging: regulation and rejuvenation","volume":"26","author":"Sousa-Victor","year":"2015","journal-title":"Trends in Endocrinol and Metab"},{"key":"B44","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1152\/physrev.00007.2015","article-title":"Absence of dystrophin disrupts skeletal muscle signaling: roles of Ca2+, reactive oxygen species, and nitric oxide in the development of muscular dystrophy","volume":"96","author":"Allen","year":"2016","journal-title":"Physiol Rev"},{"key":"B45","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s00109-008-0308-4","article-title":"NF-\u03baB signaling in skeletal muscle: prospects for intervention in muscle diseases","volume":"86","author":"Mourkioti","year":"2008","journal-title":"J Mol Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.stemcr.2016.09.009","article-title":"Transcriptional and chromatin dynamics of muscle regeneration after severe trauma","volume":"7","author":"Aguilar","year":"2016","journal-title":"Stem Cell Rep"},{"key":"B47","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1016\/j.bioactmat.2021.04.017","article-title":"Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization","volume":"6","author":"Ye","year":"2021","journal-title":"Bioactive Mater"},{"key":"B48","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.biomaterials.2018.11.037","article-title":"Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells","volume":"193","author":"Bansal","year":"2019","journal-title":"Biomaterials"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1089\/ars.2017.7420","article-title":"The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration","volume":"30","author":"De Santa","year":"2019","journal-title":"Antioxid and Redox Signaling"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1093\/hmg\/ddw167","article-title":"Sustained AMPK activation improves muscle function in a mitochondrial myopathy mouse model by promoting muscle fiber regeneration","volume":"25","author":"Peralta","year":"2016","journal-title":"Hum Mol Genet"},{"key":"B51","doi-asserted-by":"publisher","first-page":"13380","DOI":"10.3390\/ijms232113380","article-title":"Skeletal muscle regeneration in cardiotoxin-induced muscle injury models","volume":"23","author":"Wang","year":"2022","journal-title":"IJMS"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e12996","DOI":"10.1111\/acel.12996","article-title":"Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells","volume":"18","author":"Zhou","year":"2019","journal-title":"Aging Cell"},{"key":"B53","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.cbpa.2019.04.025","article-title":"Chemically induced cell fate reprogramming and the acquisition of plasticity in somatic cells","volume":"51","author":"Zhao","year":"2019","journal-title":"Curr Opin Chem Biol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.stemcr.2018.01.027","article-title":"Loss of MyoD and Myf5 in skeletal muscle stem cells results in altered myogenic programming and failed regeneration","volume":"10","author":"Yamamoto","year":"2018","journal-title":"Stem Cell Rep"},{"key":"B55","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fphys.2016.00041","article-title":"YAP-mediated mechanotransduction in skeletal muscle","volume":"7","author":"Fischer","year":"2016","journal-title":"Front Physiol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"eabj4928","DOI":"10.1126\/sciadv.abj4928","article-title":"Integrative molecular roadmap for direct conversion of fibroblasts into myocytes and myogenic progenitor cells","volume":"8","author":"Kim","year":"2022","journal-title":"Sci Adv"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e3000467","DOI":"10.1371\/journal.pbio.3000467","article-title":"Dynamic enhancers control skeletal muscle identity and reprogramming","volume":"17","author":"Ramachandran","year":"2019","journal-title":"Plos Biol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.stemcr.2014.09.013","article-title":"A CRISPR\/Cas9-Based system for reprogramming cell lineage specification","volume":"3","author":"Chakraborty","year":"2014","journal-title":"Stem Cell Rep"},{"key":"B59","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/s12276-020-0383-3","article-title":"Small-molecule-mediated reprogramming: a silver lining for regenerative medicine","volume":"52","author":"Kim","year":"2020","journal-title":"Exp Mol Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s40883-019-00146-x","article-title":"Hydrogels for skeletal muscle regeneration","volume":"7","author":"Fischer","year":"2021","journal-title":"Regen Eng Transl Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jconrel.2021.11.027","article-title":"A spatiotemporal release platform based on pH\/ROS stimuli-responsive hydrogel in wound repairing","volume":"341","author":"Wu","year":"2022","journal-title":"J Controlled Release"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1901714","DOI":"10.1002\/adhm.201901714","article-title":"Stimuli\u2010responsive delivery of growth factors for tissue engineering","volume":"9","author":"Qu","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"B63","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.devcel.2010.02.014","article-title":"Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming","volume":"18","author":"Cao","year":"2010","journal-title":"Developmental Cell"},{"key":"B64","doi-asserted-by":"publisher","first-page":"10064","DOI":"10.4081\/ejtm.2022.10064","article-title":"Involvement of muscle satellite cell dysfunction in neuromuscular disorders: expanding the portfolio of satellite cell-opathies","volume":"32","author":"Ganassi","year":"2022","journal-title":"Eur J Transl Myol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1002\/stem.3343","article-title":"Suppressing hippo signaling in the stem cell niche promotes skeletal muscle regeneration","volume":"39","author":"Liu","year":"2021","journal-title":"Stem Cells"},{"key":"B66","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3390\/biology11030446","article-title":"Transcription regulation ofTceal7 by the triple complex of Mef2c, Creb1 and myod","volume":"11","author":"Xiong","year":"2022","journal-title":"Biology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-024-01976-0","article-title":"Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p","volume":"9","author":"Chen","year":"2024","journal-title":"Sig Transduct Target Ther"},{"key":"B68","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3390\/ijms25010512","article-title":"Regulation of satellite cells functions during skeletal muscle regeneration: a critical step in physiological and pathological conditions","volume":"25","author":"Careccia","year":"2023","journal-title":"IJMS"},{"key":"B69","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fcell.2016.00058","article-title":"Gene expression profiling of muscle stem cells identifies novel regulators of postnatal myogenesis","volume":"4","author":"Alonso-Martin","year":"2016","journal-title":"Front Cell Dev Biol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nature13255","article-title":"mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert","volume":"510","author":"Rodgers","year":"2014","journal-title":"Nature"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e00045","DOI":"10.1042\/AN20100019","article-title":"Mitochondria and neuroplasticity","volume":"2","author":"Cheng","year":"2010","journal-title":"ASNNeuro"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1126\/science.aaf2693","article-title":"NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice","volume":"352","author":"Zhang","year":"2016","journal-title":"Science"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceb.2014.09.004","article-title":"AMPK: positive and negative regulation, and its role in whole-body energy homeostasis","volume":"33","author":"Hardie","year":"2015","journal-title":"Curr Opin Cell Biol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"B75","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1089\/ars.2016.6782","article-title":"Redox control of skeletal muscle regeneration","volume":"27","author":"Le Moal","year":"2017","journal-title":"Antioxid and Redox Signaling"},{"key":"B76","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/2044-5040-1-21","article-title":"Aberrant repair and fibrosis development in skeletal muscle","volume":"1","author":"Mann","year":"2011","journal-title":"Skeletal Muscle"},{"key":"B77","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nm1536","article-title":"Angiotensin II type 1 receptor blockade attenuates TGF-\u03b2\u2013induced failure of muscle regeneration in multiple myopathic states","volume":"13","author":"Cohn","year":"2007","journal-title":"Nat Med"},{"key":"B78","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1242\/jcs.026534","article-title":"Canonical wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration","volume":"121","author":"Otto","year":"2008","journal-title":"J ofCell Sci"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-213X-14-2","article-title":"Distinct contextual roles for notch signalling in skeletal muscle stem cells","volume":"14","author":"Mourikis","year":"2014","journal-title":"BMC Dev Biol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.4049\/jimmunol.1103180","article-title":"IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration","volume":"189","author":"Deng","year":"2012","journal-title":"J Immunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s12031-015-0648-9","article-title":"Ectopic muscle expression of neurotrophic factors improves recovery after nerve injury","volume":"58","author":"Glat","year":"2016","journal-title":"J Mol Neurosci"},{"key":"B82","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13395-024-00336-4","article-title":"Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes","volume":"14","author":"Das","year":"2024","journal-title":"Skeletal Muscle"},{"key":"B83","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3390\/ijms18030491","article-title":"Role of Netrin-1 signaling in nerve regeneration","volume":"18","author":"Dun","year":"2017","journal-title":"IJMS"},{"key":"B84","doi-asserted-by":"publisher","first-page":"e13691","DOI":"10.1002\/jcsm.13691","article-title":"Targeting drug delivery system to skeletal muscles: a comprehensive review of different approaches","volume":"16","author":"Li","year":"2025","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B85","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/nbt.2623","article-title":"High-frequency off-target mutagenesis induced by CRISPR-cas nucleases in human cells","volume":"31","author":"Fu","year":"2013","journal-title":"Nat Biotechnol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.3390\/ijms21051830","article-title":"Stem cell aging in skeletal muscle regeneration and disease","volume":"21","author":"Yamakawa","year":"2020","journal-title":"IJMS"},{"key":"B87","volume-title":"Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration","author":"Sambasivan","year":"2025"},{"key":"B88","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1152\/physrev.00043.2011","article-title":"Satellite cells and the muscle stem cell niche","volume":"93","author":"Yin","year":"2013","journal-title":"Physiol Rev"},{"key":"B89","doi-asserted-by":"publisher","first-page":"6670","DOI":"10.1038\/ncomms7670","article-title":"Regulation of autophagy and the ubiquitin\u2013proteasome system by the FoxO transcriptional network during muscle atrophy","volume":"6","author":"Milan","year":"2015","journal-title":"Nat Commun"},{"key":"B90","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.cmet.2020.09.012","article-title":"Exposure to static magnetic and electric fields treats type 2 diabetes","volume":"32","author":"Carter","year":"2020","journal-title":"Cell Metab"},{"key":"B91","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/jcsm.12017","article-title":"Febuxostat improves outcome in a rat model of cancer cachexia","volume":"6","author":"Konishi","year":"2015","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1016\/j.celrep.2019.07.027","article-title":"p63 and SOX2 dictate glucose reliance and metabolic vulnerabilities in squamous cell carcinomas","volume":"28","author":"Hsieh","year":"2019","journal-title":"Cell Rep"},{"key":"B93","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13395-021-00265-6","article-title":"Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic Progenitors\u2014time for new definitions","volume":"11","author":"Contreras","year":"2021","journal-title":"Skeletal Muscle"},{"key":"B94","doi-asserted-by":"publisher","first-page":"673404","DOI":"10.3389\/fphys.2021.673404","article-title":"Evolving roles of muscle-resident Fibro- adipogenic progenitors in health, regeneration, neuromuscular disorders, and aging","volume":"12","author":"Theret","year":"2021","journal-title":"Front Physiol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"e00949","DOI":"10.1128\/mBio.00949-20","article-title":"Molecular insight into TdfH-Mediated zinc piracy from human calprotectin by Neisseria gonorrhoeae","volume":"11","author":"Kammerman","year":"2020","journal-title":"mBio"},{"key":"B96","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1038\/s41418-020-0551-y","article-title":"Adipogenesis of skeletal muscle fibro\/adipogenic progenitors is affected by the WNT5a\/GSK3\/\u03b2-catenin axis","volume":"27","author":"Reggio","year":"2020","journal-title":"Cell Death Differ."},{"key":"B97","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3390\/bioengineering11070697","article-title":"Adipose tissue derivatives in peripheral nerve regeneration after transection: a systematic review","volume":"11","author":"Ara\u00fajo","year":"2024","journal-title":"Bioengineering"},{"key":"B98","doi-asserted-by":"publisher","first-page":"8058","DOI":"10.3390\/ijms22158058","article-title":"The neuromuscular junction: roles in aging and neuromuscular disease","volume":"22","author":"Iyer","year":"2021","journal-title":"Int J ofMolecular Sci"},{"key":"B99","doi-asserted-by":"publisher","first-page":"11695","DOI":"10.1038\/s41598-021-91203-5","article-title":"Bioengineered model of the human motor unit with physiologically functional neuromuscular junctions","volume":"11","author":"Rimington","year":"2021","journal-title":"Sci Rep"},{"key":"B100","doi-asserted-by":"publisher","first-page":"772","DOI":"10.17305\/bb.2022.8641","article-title":"The role ofRapsyn in neuromuscular junction and congenital myasthenic syndrome","volume":"23","author":"Liao","year":"2023","journal-title":"Biomol Biomed"},{"key":"B101","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3389\/fmolb.2019.00156","article-title":"Dissecting the extracellular complexity of neuromuscular junction organizers","volume":"6","author":"Guarino","year":"2020","journal-title":"Front Mol Biosci"},{"key":"B102","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1007\/s00018-012-1209-9","article-title":"Structural mechanisms of the agrin\u2013LRP4\u2013MuSK signaling pathway in neuromuscular junction differentiation","volume":"70","author":"Zong","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"B103","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1002\/mus.27360","article-title":"Creating stem cell\u2010derived neuromuscular junctions in vitro","volume":"64","author":"Luttrell","year":"2021","journal-title":"Muscle and Nerve"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1476370","DOI":"10.3389\/fbioe.2024.1476370","article-title":"Accelerated innervation of biofabricated skeletal muscle implants containing a neurotrophic factor delivery system","volume":"12","author":"Mashanov","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.stemcr.2023.05.005","article-title":"Aging disrupts gene expression timing during muscle regeneration","volume":"18","author":"Kurland","year":"2023","journal-title":"Stem Cell Rep"},{"key":"B106","doi-asserted-by":"publisher","first-page":"e10841","DOI":"10.7554\/eLife.10841","article-title":"Synergistic integration of netrin and ephrin axon guidance signals by spinal motor neurons","volume":"4","author":"Poliak","year":"2025","journal-title":"eLife"},{"key":"B107","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.3390\/ijms22052455","article-title":"Secreted signaling molecules at the neuromuscular junction in physiology and pathology","volume":"22","author":"Ohkawara","year":"2021","journal-title":"IJMS"},{"key":"B108","doi-asserted-by":"publisher","first-page":"13172","DOI":"10.1038\/s41598-024-62115-x","article-title":"Changes in protein fluxes in skeletal muscle during sequential stages of muscle regeneration after acute injury in male mice","volume":"14","author":"Bizieff","year":"2024","journal-title":"Sci Rep"},{"key":"B109","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s11658-022-00367-z","article-title":"SESN2 prevents the slow-to-fastmyofiber shift in denervated atrophy via AMPK\/PGC-1\u03b1 pathway","volume":"27","author":"Yang","year":"2022","journal-title":"Cell Mol BiolLett"},{"key":"B110","doi-asserted-by":"publisher","first-page":"22808000241310684","DOI":"10.1177\/22808000241310684","article-title":"Advancements in biomaterials and scaffold design for tendon repair and regeneration","volume":"23","author":"Alhaskawi","year":"2025","journal-title":"J ofApplied Biomater and Funct Mater"},{"key":"B111","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41536-022-00233-8","article-title":"Clinically relevant small-molecule promotes nerve repair and visual function recovery","volume":"7","author":"Au","year":"2022","journal-title":"Npj Regen Med"},{"key":"B112","doi-asserted-by":"publisher","first-page":"20417314251316918","DOI":"10.1177\/20417314251316918","article-title":"Advances in tissue engineering of peripheral nerve and tissue innervation \u2013 a systematic review","volume":"16","author":"Sueters","year":"2025","journal-title":"J Tissue Eng"},{"key":"B113","doi-asserted-by":"publisher","first-page":"e70060","DOI":"10.1002\/jnr.70060","article-title":"Peripheral nerve repair: historical perspectives, current advances, and future directions in natural and synthetic neural conduits","volume":"103","author":"Tabatabai","year":"2025","journal-title":"J Ofneuroscience Res"},{"key":"B114","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/mus.26760","article-title":"Stem\u2010cell\u2013based therapies to enhance peripheral nerve regeneration","volume":"61","author":"Kubiak","year":"2020","journal-title":"Muscle and Nerve"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41401-019-0338-1","article-title":"Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration","volume":"41","author":"Li","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"B116","doi-asserted-by":"publisher","first-page":"651e","DOI":"10.1097\/PRS.0000000000007235","article-title":"Targeted muscle reinnervation as a solution for nerve pain","volume":"146","author":"Lanier","year":"2020","journal-title":"Plast and Reconstr Surg"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1038\/s41598-023-27981-x","article-title":"Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury","volume":"13","author":"Huynh","year":"2023","journal-title":"Sci Rep"},{"key":"B118","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3390\/cells14070529","article-title":"Induced pluripotent stem cell-derived exosomes promote peripheral nerve regeneration in a rat sciatic nerve crush injury model: a safety and efficacy study","volume":"14","author":"Aldali","year":"2025","journal-title":"Cells"},{"key":"B119","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3390\/polym12030620","article-title":"Polymer- and hybrid-based biomaterials for interstitial, connective, vascular, nerve, visceral and musculoskeletal tissue engineering","volume":"12","author":"Abalymov","year":"2020","journal-title":"Polymers"},{"key":"B120","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4103\/ATN.ATN-D-24-00002","article-title":"Electromagnetic-responsive targeted delivery scaffold technology has better potential to repair injured peripheral nerves: a narrative review","volume":"1","author":"Chen","year":"2024","journal-title":"Adv Technology Neurosci"},{"key":"B121","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s12951-023-02044-5","article-title":"Emerging non-viral vectors for gene delivery","volume":"21","author":"Wang","year":"2023","journal-title":"J Nanobiotechnol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.1039\/D1NR06939J","article-title":"Overcoming barriers in non-viral gene delivery for neurological applications","volume":"14","author":"Tasset","year":"2022","journal-title":"Nanoscale"},{"key":"B123","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1186\/s12951-024-02580-8","article-title":"Advanced gene nanocarriers\/scaffolds in nonviral-mediated delivery system for tissue regeneration and repair","volume":"22","author":"Zhang","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"B124","doi-asserted-by":"publisher","first-page":"101756","DOI":"10.1016\/j.xcrm.2024.101756","article-title":"Gene therapy for chronic pain management","volume":"5","author":"Li","year":"2024","journal-title":"Cell Rep Med"},{"key":"B125","doi-asserted-by":"publisher","first-page":"rbaf050","DOI":"10.1093\/rb\/rbaf050","article-title":"Advancements in skeletal muscle tissue engineering: strategies for repair and regeneration of skeletal muscle beyond Self-repair","volume":"12","author":"Qi","year":"2025","journal-title":"Regenerative Biomater"},{"key":"B126","unstructured":"Data integration from multi-omics approaches reveal inflammation dynamics upon muscle tissue injury and regeneration\n          \n          \n            \n              Giannakis\n              N\n            \n          \n          \n          2020"},{"key":"B127","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12915-023-01519-z","article-title":"Integrative single-cell RNA-seq and ATAC-seq analysis of myogenic differentiation in pig","volume":"21","author":"Cai","year":"2023","journal-title":"BMC Biol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3390\/ijms17020226","article-title":"Chemically induced reprogramming of somatic cells to pluripotent stem cells and neural cells","volume":"17","author":"Biswas","year":"2016","journal-title":"IJMS"},{"key":"B129","doi-asserted-by":"publisher","first-page":"S248","DOI":"10.1016\/S1525-0016(16)33434-7","article-title":"Directing skeletal myogenic progenitor cell lineage specification with CRISPR\/Cas9 transcriptional activators","volume":"24","author":"Kwon","year":"2016","journal-title":"Mol Ther"},{"key":"B130","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/s41434-021-00250-0","article-title":"AAV9-mediated schwann cell-targeted gene therapy rescues a model ofdemyelinating neuropathy","volume":"28","author":"Kagiava","year":"2021","journal-title":"Gene Ther"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.3390\/ijms25031863","article-title":"Human-induced pluripotent stem cells in plastic and reconstructive surgery","volume":"25","author":"Hadzimustafic","year":"2024","journal-title":"IJMS"},{"key":"B132","doi-asserted-by":"publisher","first-page":"8034","DOI":"10.1016\/j.biomaterials.2012.07.056","article-title":"A systematic review of animal models used to study nerve regeneration in tissue-engineered scaffolds","volume":"33","author":"Angius","year":"2012","journal-title":"Biomaterials"},{"key":"B133","doi-asserted-by":"publisher","first-page":"6367","DOI":"10.1097\/JS9.0000000000001609","article-title":"Recent advances in stem cell therapy: efficacy, ethics, safety concerns, and future directions focusing on neurodegenerative disorders \u2013 a review","volume":"110","author":"Khandia","year":"2024","journal-title":"Int J Surg"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1365870","DOI":"10.3389\/fbioe.2024.1365870","article-title":"Genetically stable kill-switch using \u201cdemon and angel\u201d expression construct of essential genes","volume":"12","author":"Kato","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"e21308","DOI":"10.1096\/fj.202001812RR","article-title":"Targeted overexpression of PPAR\u03b3 in skeletal muscle by random insertion and CRISPR\/Cas9 transgenic pig cloning enhances oxidative fiber formation and intramuscular fat deposition","volume":"35","author":"Gu","year":"2021","journal-title":"FASEBj"},{"key":"B136","doi-asserted-by":"publisher","first-page":"6581","DOI":"10.1038\/s41467-023-42313-3","article-title":"Reprogramming of cis-regulatory networks during skeletal muscle atrophy in Male mice","volume":"14","author":"Lin","year":"2023","journal-title":"Nat Commun"},{"key":"B137","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.3390\/toxins7114519","article-title":"Current status and future directions of botulinum neurotoxins for targeting pain processing","volume":"7","author":"Pellett","year":"2015","journal-title":"Toxins"},{"key":"B138","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/nar\/gkad1124","article-title":"The YAP1\/TAZ-TEAD transcriptional network regulates gene expression at neuromuscular junctions in skeletal muscle fibers","volume":"52","author":"Gessler","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1016\/j.stem.2023.09.007","article-title":"Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation","volume":"30","author":"Jing","year":"2023","journal-title":"Cell Stem Cell"},{"key":"B140","article-title":"A porcine model of peripheral nerve injury enabling","author":"Burrell","year":"2025","journal-title":"Neurosurgery"},{"key":"B141","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1089\/wound.2024.0079","article-title":"Biomaterial-based regenerative strategies for volumetric muscle loss: challenges and solutions","volume":"14","author":"Cai","year":"2025","journal-title":"Adv Wound Care"},{"key":"B142","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41536-020-0094-3","article-title":"Towards stem cell therapies for skeletal muscle repair","volume":"5","author":"Judson","year":"2020","journal-title":"Npj Regen Med"},{"key":"B143","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1002\/jcsm.12416","article-title":"Cell therapy to improve regeneration of skeletal muscle injuries","volume":"10","author":"Qazi","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B144","doi-asserted-by":"publisher","first-page":"6093601","DOI":"10.1155\/2016\/6093601","article-title":"Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies","volume":"2016","author":"Consalvi","year":"2016","journal-title":"Stem Cells Int"},{"key":"B145","doi-asserted-by":"publisher","first-page":"723","DOI":"10.14670\/HH-18-458","article-title":"Limitations and challenges of direct cell reprogramming in vitro and in vivo","volume":"37","author":"Zhang","year":"2022","journal-title":"Histol Histopathol"},{"key":"B146","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3390\/ijms27010419","article-title":"Phase-specific evaluation of sciatic nerve regeneration in preclinical studies: a review of functional assessment, emerging therapies, and translational value","volume":"27","author":"Viezuin\u0103","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B147","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1089\/hgtb.2015.082","article-title":"Preexisting neutralizing antibodies to Adeno- associated virus capsids in large animals other than monkeys may confound in vivo gene therapy studies","volume":"26","author":"Calcedo","year":"2015","journal-title":"Hum Gene Ther Methods"},{"key":"B148","doi-asserted-by":"publisher","first-page":"e19214","DOI":"10.7554\/eLife.19214","article-title":"Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma","volume":"6","author":"Tenente","year":"2017","journal-title":"eLife"},{"key":"B149","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/mt.2015.234","article-title":"Serial activation of the inducible caspase 9 safety switch after human stem cell transplantation","volume":"24","author":"Zhou","year":"2016","journal-title":"Mol Ther"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1627149","DOI":"10.3389\/fcell.2025.1627149","article-title":"Clinical translation of human iPSC technologies: advances, safety concerns, and future directions","volume":"13","author":"Dhaiban","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"7489","DOI":"10.3390\/ijms23147489","article-title":"Skeletal muscle denervation: past, present and future","volume":"23","author":"Kostrominova","year":"2022","journal-title":"IJMS"},{"key":"B152","doi-asserted-by":"publisher","first-page":"e3150","DOI":"10.1002\/jgm.3150","article-title":"Gene transfer to skeletal muscle using hydrodynamic limb vein injection: current applications, hurdles and possible optimizations","volume":"22","author":"Le Guen","year":"2020","journal-title":"The J ofGene Med"},{"key":"B153","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3390\/bioengineering9050190","article-title":"Applications of ultrasound-mediated gene delivery in regenerative medicine","volume":"9","author":"Krut","year":"2022","journal-title":"Bioengineering"},{"key":"B154","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/mt.2012.13","article-title":"Clinical development of advanced therapy medicinal products in Europe: evidence that regulators must be proactive","volume":"20","author":"Maciulaitis","year":"2012","journal-title":"Mol Ther"},{"key":"B155","doi-asserted-by":"publisher","first-page":"szaf069","DOI":"10.1093\/stcltm\/szaf069","article-title":"Molecular time machines unleashed: small-molecule-driven reprogramming to reverse the senescence","volume":"15","author":"Tang","year":"2026","journal-title":"Stem Cells Transl Med"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.jcyt.2017.07.005","article-title":"Decentralized manufacturing of cell and gene therapies: overcoming challenges and identifying opportunities","volume":"19","author":"Harrison","year":"2017","journal-title":"Cytotherapy"},{"key":"B157","doi-asserted-by":"publisher","first-page":"4744","DOI":"10.1038\/s41467-021-24776-4","article-title":"Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions","volume":"12","author":"Pereira","year":"2021","journal-title":"Nat Commun"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1270364","DOI":"10.3389\/fbioe.2023.1270364","article-title":"pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery","volume":"11","author":"Vegad","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/s41467-020-14930-9","article-title":"Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function","volume":"11","author":"Kim","year":"2020","journal-title":"Nat Commun"},{"key":"B160","doi-asserted-by":"publisher","first-page":"RP87081","DOI":"10.7554\/eLife.87081","article-title":"Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors","volume":"12","author":"Mavrommatis","year":"2023","journal-title":"eLife"},{"key":"B161","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/978-1-61737-982-6_21","article-title":"Whole body skeletal muscle transduction in neonatal dogs with AAV-9","volume":"709","author":"Yue","year":"2011","journal-title":"Methods Mol Biol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s42978-022-00191-z","article-title":"Long-lasting stretching induces muscle hypertrophy: a meta-analysis of animal studies","volume":"5","author":"Warneke","year":"2023","journal-title":"J Ofsci IN SPORT and EXERCISE"},{"key":"B163","doi-asserted-by":"publisher","first-page":"e2303395","DOI":"10.1002\/advs.202303395","article-title":"Cyclic stretch promotes cellular reprogramming process through cytoskeletal-nuclear mechano-coupling and epigenetic modification","volume":"10","author":"Park","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"B164","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/s41580-021-00335-z","article-title":"Direct cell reprogramming: approaches, mechanisms and progress","volume":"22","author":"Wang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.3390\/jcm12041555","article-title":"Molecular basis of surgical coaptation techniques in peripheral nerve injuries","volume":"12","author":"Pereira","year":"2023","journal-title":"JCM"},{"key":"B166","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.3390\/ijms24043866","article-title":"Neurotrophic factors as regenerative therapy for neurodegenerative diseases: current status, challenges and future perspectives","volume":"24","author":"El Ouaamari","year":"2023","journal-title":"IJMS"},{"key":"B167","doi-asserted-by":"publisher","first-page":"9170","DOI":"10.3390\/ijms24119170","article-title":"Bridging gaps in peripheral nerves: from current strategies to future perspectives in conduit design","volume":"24","author":"Stocco","year":"2023","journal-title":"IJMS"},{"key":"B168","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13395-020-00259-w","article-title":"Epigenetic regulation of satellite cell fate during skeletal muscle regeneration","volume":"11","author":"Massenet","year":"2021","journal-title":"Skeletal Muscle"},{"key":"B169","doi-asserted-by":"publisher","first-page":"6099","DOI":"10.7150\/thno.36790","article-title":"CRISPR-Based activation of endogenous neurotrophic genes in adipose stem cell sheets to stimulate peripheral nerve regeneration","volume":"9","author":"Hsu","year":"2019","journal-title":"Theranostics"},{"key":"B170","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00418-024-02343-4","article-title":"Co-culture of postnatal mouse spinal cord and skeletal muscle explants as an experimental model of neuromuscular interactions","volume":"163","author":"Mikhailova","year":"2025","journal-title":"Histochem Cell Biol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3390\/pharmaceutics13020278","article-title":"Nanomedicine for gene delivery and drug repurposing in the treatment of muscular dystrophies","volume":"13","author":"Andreana","year":"2021","journal-title":"Pharmaceutics"},{"key":"B172","doi-asserted-by":"publisher","first-page":"105769","DOI":"10.1016\/j.yrtph.2024.105769","article-title":"Global regulatory considerations and practices for tumorigenicity evaluation of cell-based therapy","volume":"156","author":"Dou","year":"2025","journal-title":"Regul Toxicol Pharmacol"},{"key":"B173","doi-asserted-by":"publisher","first-page":"344","DOI":"10.2174\/1570159X19666210407155543","article-title":"Vitro, in vivo and Ex Vivo models for peripheral nerve injury and regeneration","volume":"20","author":"Li","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/hum.2022.090","article-title":"Regulatory consideration for the nonclinical safety assessment of gene therapies","volume":"33","author":"Moffit","year":"2022","journal-title":"Hum Gene Ther"},{"key":"B175","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jcyt.2024.02.021","article-title":"Good manufacturing Practice\u2013 compliant human induced pluripotent stem cells: from bench to putative clinical products","volume":"26","author":"Novoa","year":"2024","journal-title":"Cytotherapy"}],"container-title":["Experimental Biology and Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ebm-journal.org\/articles\/10.3389\/ebm.2026.10835\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T06:10:19Z","timestamp":1772431819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ebm-journal.org\/articles\/10.3389\/ebm.2026.10835\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":175,"alternative-id":["10.3389\/ebm.2026.10835"],"URL":"https:\/\/doi.org\/10.3389\/ebm.2026.10835","relation":{},"ISSN":["1535-3699"],"issn-type":[{"value":"1535-3699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"article-number":"10835"}}