{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:12:34Z","timestamp":1792235554789,"version":"4.4.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Allergy"],"abstract":"<jats:p>\n                    Penicillin allergy is the most commonly reported drug allergy, while perioperative anaphylaxis is overall rare. This review covers the epidemiology of both penicillin allergy and perioperative anaphylaxis both separately and taken together. Considerations regarding anaphylaxis to penicillin during pregnancy are also discussed, since penicillin is the drug of choice for Group B\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    prophylaxis. The minimal cross reactivity between penicillins and cephalosporins is addressed, since the vast majority of patients with a penicillin allergy label can receive perioperative cephalosporins. The management of the patient who has experienced perioperative anaphylaxis, including the importance of allergy referral is covered. Approaches to pre-operative penicillin allergy evaluations and opportunities for education are highlighted.\n                  <\/jats:p>","DOI":"10.3389\/falgy.2022.903161","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:50:26Z","timestamp":1654735826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Penicillin Allergy and Perioperative Anaphylaxis"],"prefix":"10.3389","volume":"3","author":[{"given":"Allison","family":"Ramsey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1001\/jama.2018.19283","article-title":"Evaluation and management of penicillin allergy: a review","volume":"321","author":"Shenoy","year":"2019","journal-title":"JAMA."},{"key":"B2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.iac.2021.09.002","article-title":"Perioperative anaphylaxis","volume":"42","author":"Pitlick","year":"2022","journal-title":"Immunol Allergy Clin North Am."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1016\/j.bja.2019.01.027","article-title":"Comparative epidemiology of suspected perioperative hypersensitivity reactions","volume":"123","author":"Mertes","year":"2019","journal-title":"Br J Anaesth."},{"key":"B4","unstructured":"Ambulatory Surgery Data From Hospitals and Ambulatory Surgery Centers: United States, 2010 Centers for Disease Control\n            Hall MJSA\n            ZhangJ\n            LiuX\n          2017"},{"key":"B5","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.jaci.2013.09.021","article-title":"Health care use and serious infection prevalence associated with penicillin \u201callergy\u201d in hospitalized patients: a cohort study","volume":"133","author":"Macy","year":"2014","journal-title":"J Allergy Clin Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s11606-019-04991-y","article-title":"Recorded penicillin allergy and risk of mortality: a population-based matched cohort study","volume":"34","author":"Blumenthal","year":"2019","journal-title":"J Gen Intern Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.jaip.2017.02.012","article-title":"The effect of penicillin allergy testing on future health care utilization: a matched cohort study","volume":"5","author":"Macy","year":"2017","journal-title":"J Allergy Clin Immunol Pract."},{"key":"B8","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/cid\/cix794","article-title":"The impact of a reported penicillin allergy on surgical site infection risk","volume":"66","author":"Blumenthal","year":"2018","journal-title":"Clin Infect Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.anai.2015.07.019","article-title":"Anaphylaxis\u2013a practice parameter update 2015","volume":"115","author":"Lieberman","year":"2015","journal-title":"Ann Allergy Asthma Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.bja.2021.06.036","article-title":"Incidence and risk factors for near-fatal and fatal outcomes after perioperative and periprocedural anaphylaxis in the USA, 2005-2014","volume":"127","author":"Gonzalez-Estrada","year":"2021","journal-title":"Br J Anaesth."},{"key":"B11","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.anai.2020.10.001","article-title":"Incidence of and risk factors for perioperative or periprocedural anaphylaxis in the United States from 2005 to 2014","volume":"126","author":"Gonzalez-Estrada","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.jaip.2014.12.016","article-title":"Incidence of suspected perioperative anaphylaxis: a multicenter snapshot study","volume":"3","author":"Savic","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B13","first-page":"350","article-title":"Study of hypersensitivity reactions and anaphylaxis during anesthesia in Spain","volume":"18","author":"Lobera","year":"2008","journal-title":"J Investig Allergol Clin Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1093\/bja\/87.4.549","article-title":"Anaphylaxis during anaesthesia. 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