{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:56:54Z","timestamp":1785823014700,"version":"3.56.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Allergy"],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The association between autoimmune diseases and chronic rhinosinusitis in observational studies remains unclear. This study aimed to explore the genetic correlation between chronic rhinosinusitis and autoimmune diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed Mendelian randomization (MR) analysis and linkage disequilibrium score regression (LDSC) to investigate causal relationships and genetic correlations between autoimmune phenotypes and chronic rhinosinusitis. Additionally, transcriptome-wide association (TWAS) analysis was conducted to identify the shared genes between the two conditions to demonstrate their relationship. The CRS GWAS (genome-wide association study) data and other autoimmune diseases were retrieved from ieuOpenGWAS (<jats:ext-link>https:\/\/gwas.mrcieu.ac.uk\/<\/jats:ext-link>), the FinnGen alliance (<jats:ext-link>https:\/\/r8.finngen.fi\/<\/jats:ext-link>), the UK Biobank (<jats:ext-link>https:\/\/www.ukbiobank.ac.uk\/<\/jats:ext-link>), and the EBI database (<jats:ext-link>https:\/\/www.ebi.ac.uk\/<\/jats:ext-link>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Utilizing a bivariate two-sample Mendelian randomization approach, our findings suggest a significant association of chronic rhinosinusitis with various autoimmune diseases, including allergic rhinitis (<jats:italic>p<\/jats:italic>\u2009=\u20099.55E-10, Odds Ratio [OR]\u2009=\u20092,711.019, 95% confidence interval [CI]\u2009=\u2009261.83391\u201328,069.8), asthma (<jats:italic>p<\/jats:italic>\u2009=\u20091.81E-23, OR\u2009=\u200933.99643, 95%CI\u2009=\u200917.52439\u201365.95137), rheumatoid arthritis (<jats:italic>p<\/jats:italic>\u2009=\u20099.55E-10, OR\u2009=\u20091.115526, 95%CI\u2009=\u20091.0799484\u20131.1522758), hypothyroidism (<jats:italic>p<\/jats:italic>\u2009=\u20092.08828E-2, OR\u2009=\u20094.849254, 95%CI\u2009=\u20091.7154455\u201313.707962), and type 1 diabetes (<jats:italic>p<\/jats:italic>\u2009=\u20092.08828E-2, OR\u2009=\u200901.04849, 95%CI\u2009=\u20091.0162932\u20131.0817062). LDSC analysis revealed a genetic correlation between the positive autoimmune phenotypes mentioned above and chronic rhinosinusitis: AR (rg\u2009=\u20090.344724754, <jats:italic>p<\/jats:italic>\u2009=\u20093.94E-8), asthma (rg\u2009=\u20090.43703672, <jats:italic>p<\/jats:italic>\u2009=\u20091.86E-10), rheumatoid arthritis (rg\u2009=\u20090.27834931, <jats:italic>p<\/jats:italic>\u2009=\u20093.5376E-2), and hypothyroidism (rg\u2009=\u2009\u22120.213201473, <jats:italic>p<\/jats:italic>\u2009=\u20093.83093E-4). Utilizing the Transcriptome-Wide Association Studies (TWAS) approach, we identified several genes commonly associated with both chronic rhinosinusitis and autoimmune diseases. Genes such as TSLP\/WDR36 (Chromosome 5, top SNP: rs1837253), ORMDL3 (Chromosome 13, top SNP: rs11557467), and IL1RL1\/IL18R1 (Chromosome 2, top SNP: rs12905) exhibited a higher degree of consistency in their shared involvement across atopic dermatitis (AT), allergic rhinitis (AR), and chronic rhinosinusitis (CRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current evidence suggests a genetic correlation between chronic rhinosinusitis and autoimmune diseases like allergic rhinitis, asthma, rheumatoid arthritis, hypothyroidism, and type 1 diabetes. Further research is required to elucidate the mechanisms underlying these associations.<\/jats:p><\/jats:sec>","DOI":"10.3389\/falgy.2024.1387774","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T05:10:34Z","timestamp":1727154634000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Genetic correlation between chronic sinusitis and autoimmune diseases"],"prefix":"10.3389","volume":"5","author":[{"given":"Enze","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. 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