{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:56:57Z","timestamp":1792796217578,"version":"4.5.0"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Allergy"],"abstract":"<jats:p>Food allergy, a group of adverse immune responses to normally innocuous food protein antigens, is an increasingly prevalent public health issue. The most common form is IgE-mediated food allergy in which food antigen-induced crosslinking of the high-affinity IgE-receptor, Fc\u03b5RI, on the surface of mast cells triggers the release of inflammatory mediators that contribute to a wide range of clinical manifestations, including systemic anaphylaxis. Mast cells also play a critical function in adaptive immunity to foods, acting as adjuvants for food-antigen driven Th2 cell responses. While the diagnosis and treatment of food allergy has improved in recent years, no curative treatments are currently available. However, there is emerging evidence to suggest that both allergen-specific IgA and IgG antibodies can counter the activating effects of IgE antibodies on mast cells. Most notably, both antigen-specific IgA and IgG antibodies are induced in the course of oral immunotherapy. In this review, we highlight the role of mast cells in food allergy, both as inducers of immediate hypersensitivity reactions and as adjuvants for type 2 adaptive immune responses. Furthermore, we summarize current understanding of the immunomodulatory effects of antigen-specific IgA and IgG antibodies on IgE-induced mast cell activation and effector function. A more comprehensive understanding of the regulatory role of IgA and IgG in food allergy may provide insights into physiologic regulation of immune responses to ingested antigens and could seed novel strategies to treat allergic disease.<\/jats:p>","DOI":"10.3389\/falgy.2024.1389669","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:32:45Z","timestamp":1718199165000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Allergen-specific IgA and IgG antibodies as inhibitors of mast cell function in food allergy"],"prefix":"10.3389","volume":"5","author":[{"given":"Kameryn N.","family":"Furiness","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen S.","family":"El Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans C.","family":"Oettgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Kanagaratham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e185630","DOI":"10.1001\/jamanetworkopen.2018.5630","article-title":"Prevalence and severity of food allergies among US adults","volume":"2","author":"Gupta","year":"2019","journal-title":"JAMA Netw Open"},{"key":"B2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/nrgastro.2016.187","article-title":"Food allergy and the gut","volume":"14","author":"Nowak-Wegrzyn","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0065-2776(08)00403-3","article-title":"New insights on mast cell activation via the high affinity receptor for IgE","volume":"98","author":"Rivera","year":"2008","journal-title":"Adv Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.ajpath.2015.07.025","article-title":"The mast cell-IgE paradox: from homeostasis to anaphylaxis","volume":"186","author":"Galli","year":"2016","journal-title":"Am J Pathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nri1782","article-title":"Integrated signalling pathways for mast-cell activation","volume":"6","author":"Gilfillan","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","article-title":"Mast cells","volume":"77","author":"Metcalfe","year":"1997","journal-title":"Physiol Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.jaci.2006.04.015","article-title":"Molecular regulation of mast cell activation","volume":"117","author":"Rivera","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jaci.2017.06.003","article-title":"The pathophysiology of anaphylaxis","volume":"140","author":"Reber","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"603050","DOI":"10.3389\/fimmu.2020.603050","article-title":"Ige and IgG antibodies as regulators of mast cell and basophil functions in food allergy","volume":"11","author":"Kanagaratham","year":"2020","journal-title":"Front Immunol"},{"key":"B10","first-page":"711","article-title":"Mast cells as regulators of adaptive immune responses in food allergy","volume":"93","author":"El Ansari","year":"2020","journal-title":"Yale J Biol Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"CD010638","DOI":"10.1002\/14651858.CD010638.pub3","article-title":"Oral and sublingual immunotherapy for egg allergy","volume":"4","author":"Romantsik","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"B12","doi-asserted-by":"publisher","first-page":"CD009542","DOI":"10.1002\/14651858.CD009542.pub2","article-title":"Oral immunotherapy for milk allergy","volume":"11","author":"Yeung","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.jaci.2008.09.030","article-title":"A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow\u2019s milk allergy","volume":"122","author":"Skripak","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/mi.2012.5","article-title":"Changes in antigen-specific T-cell number and function during oral desensitization in cow\u2019s milk allergy enabled with omalizumab","volume":"5","author":"Bedoret","year":"2012","journal-title":"Mucosal Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jaci.2009.05.022","article-title":"Clinical efficacy and immune regulation with peanut oral immunotherapy","volume":"124","author":"Jones","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jaci.2012.10.048","article-title":"Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens","volume":"131","author":"Vickery","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1016\/j.jaip.2022.07.030","article-title":"Peanut-specific IgG4 and IgA in saliva are modulated by peanut oral immunotherapy","volume":"10","author":"Smeekens","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B18","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.anai.2010.09.030","article-title":"Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance","volume":"105","author":"Vickery","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/pai.12535","article-title":"Differential response in allergen-specific IgE, IgGs, and IgA levels for predicting outcome of oral immunotherapy","volume":"27","author":"Sugimoto","year":"2016","journal-title":"Pediatr Allergy Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1111\/all.12895","article-title":"Component-resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness","volume":"71","author":"Wright","year":"2016","journal-title":"Allergy"},{"key":"B21","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000485891","article-title":"Low-dose oral immunotherapy using low-egg-allergen cookies for severe egg-allergic children reduces allergy severity and affects allergen-specific antibodies in serum","volume":"175","author":"Maeta","year":"2018","journal-title":"Int Arch Allergy Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.jaci.2010.03.025","article-title":"Early recovery from cow\u2019s milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow\u2019s milk epitopes","volume":"125","author":"Savilahti","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.jaci.2014.05.042","article-title":"Oral immunotherapy induces IgG antibodies that act through FcgammaRIIb to suppress IgE-mediated hypersensitivity","volume":"134","author":"Burton","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jaci.2017.03.045","article-title":"Allergen-specific IgG antibody signaling through FcgammaRIIb promotes food tolerance","volume":"141","author":"Burton","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030329","article-title":"Mucosal mast cells as key effector cells in food allergies","volume":"11","author":"Nakano","year":"2022","journal-title":"Cells"},{"key":"B26","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/mi.2009.136","article-title":"Advances in mast cell biology: new understanding of heterogeneity and function","volume":"3","author":"Moon","year":"2010","journal-title":"Mucosal Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"S73","DOI":"10.1016\/j.jaci.2009.11.017","article-title":"IgE, mast cells, basophils, and eosinophils","volume":"125","author":"Stone","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"4933","DOI":"10.1016\/j.febslet.2010.08.006","article-title":"Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants","volume":"584","author":"Siraganian","year":"2010","journal-title":"FEBS Lett"},{"key":"B29","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1600-065X.2008.00742.x","article-title":"The tyrosine kinase network regulating mast cell activation","volume":"228","author":"Gilfillan","year":"2009","journal-title":"Immunol Rev"},{"key":"B30","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1615\/CritRevImmunol.v29.i2.40","article-title":"Regulation of Ca2+ signaling with particular focus on mast cells","volume":"29","author":"Ma","year":"2009","journal-title":"Crit Rev Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/355353a0","article-title":"Depletion of intracellular calcium stores activates a calcium current in mast cells","volume":"355","author":"Hoth","year":"1992","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jaci.2022.10.003","article-title":"Mast cells in food allergy: inducing immediate reactions and shaping long-term immunity","volume":"151","author":"Oettgen","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"5455","DOI":"10.4049\/jimmunol.162.9.5455","article-title":"IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release","volume":"162","author":"Yamaguchi","year":"1999","journal-title":"J Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/mi.2012.112","article-title":"Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy","volume":"6","author":"Burton","year":"2013","journal-title":"Mucosal Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/cea.13075","article-title":"IgE promotes type 2 innate lymphoid cells in murine food allergy","volume":"48","author":"Burton","year":"2018","journal-title":"Clin Exp Allergy"},{"key":"B36","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.immuni.2014.05.017","article-title":"Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells","volume":"41","author":"Burton","year":"2014","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3389\/fimmu.2014.00520","article-title":"IgG subclasses and allotypes: from structure to effector functions","volume":"5","author":"Vidarsson","year":"2014","journal-title":"Front Immunol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/antib8020030","article-title":"The ligands for human IgG and their effector functions","volume":"8","author":"de Taeye","year":"2019","journal-title":"Antibodies (Basel)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1365-2222.2009.03207.x","article-title":"Immunoglobulin G4: an odd antibody","volume":"39","author":"Aalberse","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1002\/pmic.201500367","article-title":"Isotype-specific glycosylation analysis of mouse IgG by LC-MS","volume":"16","author":"Maresch","year":"2016","journal-title":"Proteomics"},{"key":"B41","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/icb.2016.65","article-title":"IgG subclass co-expression brings harmony to the quartet model of murine IgG function","volume":"94","author":"Collins","year":"2016","journal-title":"Immunol Cell Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.3389\/fimmu.2018.01244","article-title":"Tissue-specific expression of the low-affinity IgG receptor, FcgammaRIIb, on human mast cells","volume":"9","author":"Burton","year":"2018","journal-title":"Front Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nri2762","article-title":"FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications","volume":"10","author":"Smith","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1111\/j.1365-2222.2007.02749.x","article-title":"Maintenance of tolerance to cow\u2019s milk in atopic individuals is characterized by high levels of specific immunoglobulin G4","volume":"37","author":"Ruiter","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jaci.2015.01.012","article-title":"IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens","volume":"135","author":"Santos","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"100747","DOI":"10.1016\/j.waojou.2023.100747","article-title":"Oral immunotherapy for food allergy: translation from studies to clinical practice?","volume":"16","author":"Pouessel","year":"2023","journal-title":"World Allergy Organ J"},{"key":"B47","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.jaci.2019.09.005","article-title":"Peanut oral immunotherapy induces blocking antibodies but does not change the functional characteristics of peanut-specific IgE","volume":"145","author":"Santos","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"100410","DOI":"10.1016\/j.xcrm.2021.100410","article-title":"High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy","volume":"2","author":"Chen","year":"2021","journal-title":"Cell Rep Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/j.jaci.2021.10.018","article-title":"Food allergy across the globe","volume":"148","author":"Sampath","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev-immunol-030409-101314","article-title":"Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis","volume":"28","author":"Fagarasan","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41467-019-13992-8","article-title":"IgA subclasses have different effector functions associated with distinct glycosylation profiles","volume":"11","author":"Steffen","year":"2020","journal-title":"Nat Commun"},{"key":"B52","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1042\/bj2710285","article-title":"The structure and function of human IgA","volume":"271","author":"Kerr","year":"1990","journal-title":"Biochem J"},{"key":"B53","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s11882-023-01105-x","article-title":"The role of IgA in the manifestation and prevention of allergic immune responses","volume":"23","author":"Scheurer","year":"2023","journal-title":"Curr Allergy Asthma Rep"},{"key":"B54","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/mi.2011.41","article-title":"Secretory IgA\u2019s complex roles in immunity and mucosal homeostasis in the gut","volume":"4","author":"Mantis","year":"2011","journal-title":"Mucosal Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/intimm\/dxl142","article-title":"Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora","volume":"19","author":"Sait","year":"2007","journal-title":"Int Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"eade2335","DOI":"10.1126\/sciimmunol.ade2335","article-title":"IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation","volume":"8","author":"Conrey","year":"2023","journal-title":"Sci Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s12026-012-8307-5","article-title":"Regulation of frontline antibody responses by innate immune signals","volume":"54","author":"Chorny","year":"2012","journal-title":"Immunol Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.immuni.2015.08.024","article-title":"Independence day for IgA","volume":"43","author":"Macpherson","year":"2015","journal-title":"Immunity"},{"key":"B59","doi-asserted-by":"publisher","first-page":"16103","DOI":"10.1038\/nmicrobiol.2016.103","article-title":"High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice","volume":"1","author":"Okai","year":"2016","journal-title":"Nat Microbiol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/nri3322","article-title":"New concepts in the generation and functions of IgA","volume":"12","author":"Pabst","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2014.08.006","article-title":"Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease","volume":"158","author":"Palm","year":"2014","journal-title":"Cell"},{"key":"B62","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/s41577-021-00506-1","article-title":"Diversity and dynamism of IgA-microbiota interactions","volume":"21","author":"Huus","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181635","article-title":"Human IgA binds a diverse array of commensal bacteria","volume":"217","author":"Sterlin","year":"2020","journal-title":"J Exp Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s10875-009-9357-x","article-title":"Selective IgA deficiency","volume":"30","author":"Yel","year":"2010","journal-title":"J Clin Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173809","article-title":"The epidemiology and clinical presentations of atopic diseases in selective IgA deficiency","volume":"10","author":"Morawska","year":"2021","journal-title":"J Clin Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3906\/sag-1605-50","article-title":"Allergic and autoimmune disorders in families with selective IgA deficiency","volume":"47","author":"Erkocoglu","year":"2017","journal-title":"Turk J Med Sci"},{"key":"B67","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.gendis.2019.10.014","article-title":"Selective immunoglobulin A deficiency (SIgAD) primarily leads to recurrent infections and autoimmune diseases: a retrospective study of Chinese patients in the past 40 years","volume":"7","author":"Wang","year":"2020","journal-title":"Genes Dis"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1046\/j.1365-2222.2002.01470.x","article-title":"Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age","volume":"32","author":"Bottcher","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"B69","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/j.1399-3038.2010.01106.x","article-title":"High salivary secretory IgA antibody levels are associated with less late-onset wheezing in IgE-sensitized infants","volume":"22","author":"Sandin","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1365-2222.2005.02141.x","article-title":"Allergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre-school children: a follow-up community-based study","volume":"35","author":"Ludviksson","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"B71","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1203\/PDR.0b013e318232169e","article-title":"Slow salivary secretory IgA maturation may relate to low microbial pressure and allergic symptoms in sensitized children","volume":"70","author":"Fageras","year":"2011","journal-title":"Pediatr Res"},{"key":"B72","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1399-3038.2009.00907.x","article-title":"High intestinal IgA associates with reduced risk of IgE-associated allergic diseases","volume":"21","author":"Kukkonen","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12016-018-8680-5","article-title":"Mechanisms of oral tolerance","volume":"55","author":"Tordesillas","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e1800369","DOI":"10.1002\/mnfr.201800369","article-title":"Dietary supplementation with nondigestible oligosaccharides reduces allergic symptoms and supports low dose oral immunotherapy in a peanut allergy mouse model","volume":"62","author":"Wagenaar","year":"2018","journal-title":"Mol Nutr Food Res"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.08.006","article-title":"Mucosal IgA immune complex induces immunomodulatory responses in allergic airway and intestinal T(H)2 disease","author":"Elesela","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00741-19","article-title":"Dysregulation of intestinal microbiota elicited by food allergy induces IgA-mediated oral dysbiosis","volume":"88","author":"Matsui","year":"2019","journal-title":"Infect Immun"},{"key":"B77","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.chom.2007.09.013","article-title":"IgA response to symbiotic bacteria as a mediator of gut homeostasis","volume":"2","author":"Peterson","year":"2007","journal-title":"Cell Host Microbe"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/s41591-019-0461-z","article-title":"Microbiota therapy acts via a regulatory T cell MyD88\/RORgammat pathway to suppress food allergy","volume":"25","author":"Abdel-Gadir","year":"2019","journal-title":"Nat Med"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aay2754","article-title":"Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization","volume":"5","author":"Zhang","year":"2020","journal-title":"Sci Immunol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"eabq0599","DOI":"10.1126\/scitranslmed.abq0599","article-title":"Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens","volume":"14","author":"Liu","year":"2022","journal-title":"Sci Transl Med"},{"key":"B81","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jaci.2004.03.040","article-title":"Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy","volume":"114","author":"Frossard","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1172\/JCI117701","article-title":"Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors","volume":"95","author":"Daeron","year":"1995","journal-title":"J Clin Invest"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.03.027","article-title":"IgG:Fc\u03b3RIIb signals block effector programs of IgE:Fc\u03b5RI-activated mast cells but spare survival pathways","author":"Kanagaratham","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1084\/jem.189.10.1573","article-title":"Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG","volume":"189","author":"Ujike","year":"1999","journal-title":"J Exp Med"},{"key":"B85","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1172\/JCI25575","article-title":"IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking","volume":"116","author":"Strait","year":"2006","journal-title":"J Clin Invest"},{"key":"B86","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1126\/science.1237910","article-title":"Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals","volume":"342","author":"Shan","year":"2013","journal-title":"Science"},{"key":"B87","doi-asserted-by":"publisher","first-page":"4412","DOI":"10.4049\/jimmunol.1301324","article-title":"Important role for FcgammaRIIB on B lymphocytes for mucosal antigen-induced tolerance and Foxp3+\u2009regulatory T cells","volume":"191","author":"Sun","year":"2013","journal-title":"J Immunol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jaci.2011.01.034","article-title":"Ingested allergens must be absorbed systemically to induce systemic anaphylaxis","volume":"127","author":"Strait","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"881655","DOI":"10.3389\/fimmu.2022.881655","article-title":"Allergen-specific IgA antibodies block IgE-mediated activation of mast cells and basophils","volume":"13","author":"El Ansari","year":"2022","journal-title":"Front Immunol"}],"container-title":["Frontiers in Allergy"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/falgy.2024.1389669\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:32:50Z","timestamp":1718199170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/falgy.2024.1389669\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":89,"alternative-id":["10.3389\/falgy.2024.1389669"],"URL":"https:\/\/doi.org\/10.3389\/falgy.2024.1389669","relation":{},"ISSN":["2673-6101"],"issn-type":[{"value":"2673-6101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,11]]},"article-number":"1389669"}}