{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:51:12Z","timestamp":1782449472734,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Allergy"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sinonasal inverted papilloma (SNIP) is a benign but locally aggressive tumor. Although recurrence typically presents as a solid mass on imaging, atypical manifestations may pose diagnostic difficulties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 56-year-old man with previous SNIP resection presented with progressive left orbital pain. Computed tomography (CT) and magnetic resonance imaging (MRI) showed an expansile cystic lesion in the left frontal and ethmoid sinuses, initially interpreted as a mucocele. Intraoperatively, a papillomatous lesion was identified at the frontal sinus ostium. Pathology confirmed SNIP with focal mild cytologic atypia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SNIP recurrence can be masked by a secondary mucocele, leading to negative preoperative tests. Our experience suggests that in high-risk patients, thin-section MRI (\u22641\u20132\u2005mm) may improves detection, and surgical exploration with cyst wall biopsy should be performed when clinical suspicion remains high.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/falgy.2026.1877618","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:34:46Z","timestamp":1782448486000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Occult recurrence of sinonasal inverted papilloma masked by a mucocele: a case report"],"prefix":"10.3389","volume":"7","author":[{"given":"Ronghua","family":"Wu","sequence":"first","affiliation":[{"name":"Allergy Center, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangmiao","family":"Li","sequence":"additional","affiliation":[{"name":"Allergy Center, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Liang","sequence":"additional","affiliation":[{"name":"Allergy Center, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Translational Medicine Laboratory, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Tang","sequence":"additional","affiliation":[{"name":"Allergy Center, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zou","sequence":"additional","affiliation":[{"name":"Allergy Center, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Translational Medicine Laboratory, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[{"name":"Allergy Center, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Translational Medicine Laboratory, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Allergy Center, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Translational Medicine Laboratory, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Guangxi Talent Highland of Promoting the Construction of National Regional Medical Center","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Allergy Center, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Translational Medicine Laboratory, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University","place":["Nanning, China"]},{"name":"Guangxi Talent Highland of Promoting the Construction of National Regional Medical Center","place":["Nanning, Guangxi, China"]},{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou Key Laboratory of Otorhinolaryngology, Otorhinolaryngology Institute of Sun Yat-sen University","place":["Guangzhou, China"]},{"name":"Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.anorl.2016.03.006","article-title":"Sinonasal inverted papilloma: from diagnosis to treatment","volume":"133","author":"Lisan","year":"2016","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1017\/S002221510700624X","article-title":"Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy","volume":"121","author":"Mirza","year":"2007","journal-title":"J Laryngol Otol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1002\/alr.22342","article-title":"Inverted papilloma with multifocal attachment is associated with increased recurrence","volume":"9","author":"Tong","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1001\/jamaoto.2017.1686","article-title":"Association of krouse classification for sinonasal inverted papilloma with recurrence: a systematic review and meta-analysis","volume":"143","author":"Lisan","year":"2017","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/lary.23876","article-title":"Smoking and malignancy in sinonasal inverted papilloma","volume":"123","author":"Hong","year":"2013","journal-title":"Laryngoscope"},{"key":"B6","doi-asserted-by":"publisher","first-page":"19299","DOI":"10.1038\/s41598-024-70134-x","article-title":"Utilizing radiomics for differential diagnosis of inverted papilloma and chronic rhinosinusitis with polyps based on unenhanced CT scans","volume":"14","author":"He","year":"2024","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1007\/s00405-017-4571-2","article-title":"Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review","volume":"274","author":"Re","year":"2017","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/lary.22495","article-title":"Inverted papilloma of the nasal cavity and paranasal sinuses: a Korean multicenter study","volume":"122","author":"Kim","year":"2012","journal-title":"Laryngoscope"},{"key":"B9","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1067\/j.cpradiol.2015.10.004","article-title":"Imaging features of sinonasal inverted papilloma: a pictorial review","volume":"45","author":"Chawla","year":"2016","journal-title":"Curr Probl Diagn Radiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.anl.2021.02.011","article-title":"High CT values relative to the brainstem differentiate inverted papillomas from nasal polyps","volume":"48","author":"Sano","year":"2021","journal-title":"Auris Nasus Larynx"},{"key":"B11","doi-asserted-by":"publisher","first-page":"419","DOI":"10.2214\/ajr.162.2.8310938","article-title":"Inverted papilloma of the nasal vault and paranasal sinuses: spectrum of CT findings","volume":"162","author":"Woodruff","year":"1994","journal-title":"AJR Am J Roentgenol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/s12105-021-01289-6","article-title":"Sine qua non: sinonasal inverted papilloma","volume":"15","author":"Jewett","year":"2021","journal-title":"Head Neck Pathol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/alr.23262","article-title":"International consensus statement on allergy and rhinology: sinonasal tumors","volume":"14","author":"Kuan","year":"2024","journal-title":"Int Forum Allergy Rhinol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1002\/alr.21836","article-title":"Prediction of the originating site of sinonasal inverted papilloma by preoperative magnetic resonance imaging and computed tomography","volume":"6","author":"Fang","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1148\/radiol.2020200723","article-title":"Thin-slice pituitary MRI with deep learning-based reconstruction: diagnostic performance in a postoperative setting","volume":"298","author":"Kim","year":"2021","journal-title":"Radiology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1626584","DOI":"10.3389\/fonc.2025.1626584","article-title":"Chinese expert consensus on imaging examination and diagnosis of nasal cavity and paranasal sinus tumors","volume":"15","author":"Zhang","year":"2025","journal-title":"Front Oncol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/s0730-725x(98)00210-0","article-title":"Partial volume effects in MRI studies of multiple sclerosis","volume":"17","author":"Firbank","year":"1999","journal-title":"Magn Reson Imaging"},{"key":"B18","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1002\/lary.27582","article-title":"Imaging predictors for malignant transformation of inverted papilloma","volume":"129","author":"Yan","year":"2019","journal-title":"Laryngoscope"},{"key":"B19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s40463-017-0246-7","article-title":"Surgical management of inverted papilloma; a single-center analysis of 247 patients with long follow-up","volume":"46","author":"Bugter","year":"2017","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"B20","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2500\/ajra.2009.23.3296","article-title":"Treatment results of sinonasal inverted papilloma: an 18-year study","volume":"23","author":"Sham","year":"2009","journal-title":"Am J Rhinol Allergy"},{"key":"B21","doi-asserted-by":"publisher","first-page":"405","DOI":"10.4103\/0973-029X.174644","article-title":"Sinonasal inverted papilloma: a case report and mini review of histopathological features","volume":"19","author":"Khandekar","year":"2015","journal-title":"J Oral Maxillofac Pathol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.3390\/cancers14092195","article-title":"Sinonasal inverted papilloma and squamous cell carcinoma: contemporary management and patient outcomes","volume":"14","author":"Eide","year":"2022","journal-title":"Cancers (Basel"},{"key":"B23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.2500\/ajr.2007.21.2984","article-title":"Site of attachment of inverted papilloma predicted by CT findings of osteitis","volume":"21","author":"Yousuf","year":"2007","journal-title":"Am J Rhinol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.4193\/Rhin08.229","article-title":"Predicting the site of attachment of sinonasal inverted papilloma","volume":"47","author":"Bhalla","year":"2009","journal-title":"Rhinology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.anl.2021.04.008","article-title":"Clinical characteristics of sinonasal inverted papilloma associated with recurrence and malignant transformation","volume":"48","author":"He","year":"2021","journal-title":"Auris Nasus Larynx"},{"key":"B26","doi-asserted-by":"publisher","first-page":"599","DOI":"10.47162\/RJME.65.4.06","article-title":"Sinonasal inverted papilloma from diagnosis to treatment - a narrative review","volume":"65","author":"Tusaliu","year":"2024","journal-title":"Rom J Morphol Embryol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.21873\/invivo.14144","article-title":"Patterns of recurrence and malignant transformation in sinonasal papilloma: implications for long-term follow-up","volume":"39","author":"Kimura","year":"2025","journal-title":"In Vivo"},{"key":"B28","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/hed.26523","article-title":"Need for long-term follow-up in sinonasal inverted papilloma: a single-institution experience","volume":"43","author":"Binz","year":"2021","journal-title":"Head Neck"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1002\/lary.70263","article-title":"Sinonasal inverted papilloma and clinical significance of dysplasia: a multi-institutional study","volume":"136","author":"Kim","year":"2026","journal-title":"Laryngoscope"},{"key":"B30","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1017\/S0022215109990703","article-title":"An unusual presentation of inverted papilloma: case report and literature review","volume":"124","author":"Visvanathan","year":"2010","journal-title":"J Laryngol Otol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e136","DOI":"10.1097\/IOP.0000000000001465","article-title":"Surgical management of a recurrent orbit-eroding mucocele associated with frontal-ethmoidal Sinus inverted papilloma","volume":"35","author":"Desjarlais","year":"2019","journal-title":"Ophthalmic Plast Reconstr Surg"}],"container-title":["Frontiers in Allergy"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/falgy.2026.1877618\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:34:54Z","timestamp":1782448494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/falgy.2026.1877618\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":31,"alternative-id":["10.3389\/falgy.2026.1877618"],"URL":"https:\/\/doi.org\/10.3389\/falgy.2026.1877618","relation":{},"ISSN":["2673-6101"],"issn-type":[{"value":"2673-6101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"article-number":"1877618"}}