{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:19:38Z","timestamp":1787552378358,"version":"build-2736575974"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-114-104"],"award-info":[{"award-number":["DMR-114-104"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioinform."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood lipids are heritable risk factors for cardiovascular disease (CVD), a leading cause of mortality worldwide. However, the genetic architecture of lipid traits and the performance of polygenic risk scores (PRSs) remain underexplored in East Asian (EAS) populations, including Taiwanese Han individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted genome-wide association studies and PRS analyses for five lipid traits: total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and the ratio of low-density lipoprotein cholesterol to total cholesterol. Lipid profile data were obtained from the China Medical University Hospital cohort. PRSs were evaluated on the basis of their correlations with measured lipid levels. To evaluate trans-ancestry PRS transferability, localized models were systematically compared against models derived from discovery-stage GWAS meta-analyses incorporating five ancestry groups from the Global Lipids Genetics Consortium. The performance of the PRS models in predicting lipid-related diseases was evaluated through receiver operating characteristic curve analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The population-specific PRS models explained 11%\u201340% of the variance in lipid levels within the target cohort. Models leveraging global multiancestry GWAS meta-analysis weights revealed limited predictive performance (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.04\u20130.19), whereas analyses incorporating EAS-specific data yielded higher correlations (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.13\u20130.30), although these correlations did not exceed those derived from the hospital-based cohort alone. When combined with age and sex, the PRS models demonstrated strong predictive performance for coronary artery disease, atherosclerosis, and ischemic stroke, with area under the curve values of 0.910, 0.926, and 0.854, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Population-specific PRS models derived from a Taiwanese population outperformed meta-analysis-derived frameworks in predicting lipid levels and demonstrated substantial potential for predicting CVD risk, indicating the importance of ancestry-matched genetic studies in precision medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbinf.2026.1823599","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T05:31:38Z","timestamp":1787549498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of population-specific polygenic risk scores for blood lipids: insights from Taiwanese cohorts and multiancestry meta-analysis"],"prefix":"10.3389","volume":"6","author":[{"given":"Yu-Chia","family":"Chen","sequence":"first","affiliation":[{"name":"Million-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital","place":["Taichung, Taiwan"]},{"name":"Master Program for Digital Health Innovation, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Million-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital","place":["Taichung, Taiwan"]},{"name":"Master Program for Digital Health Innovation, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chou","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai-Sing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-De","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital","place":["Taichung, Taiwan"]},{"name":"School of Post Baccalaureate Chinese Medicine, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ling","family":"Liao","sequence":"additional","affiliation":[{"name":"Center for Personalized Medicine, China Medical University Hospital","place":["Taichung, Taiwan"]},{"name":"Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital","place":["Taichung, Taiwan"]},{"name":"School of Chinese Medicine, College of Chinese Medicine, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuu-Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital","place":["Taichung, Taiwan"]},{"name":"School of Chinese Medicine, College of Chinese Medicine, China Medical University","place":["Taichung, Taiwan"]},{"name":"Departments of Medical Genetics, China Medical University Hospital","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"224","DOI":"10.24875\/ric.18002575","article-title":"Familial combined hyperlipidemia: current knowledge, perspectives, and controversies","volume":"70","author":"Bello-Chavolla","year":"2018","journal-title":"Rev. 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