{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:25:19Z","timestamp":1787034319030,"version":"build-2736575974"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioinform."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Diabetes retinopathy (DR) is a progressive microvascular complication of diabetes mellitus characterized by oxidative stress, inflammation, and neurovascular dysfunction. Current therapies provide limited efficacy, highlighting the need for multi-targeted, natural therapeutic alternatives.\n                      <jats:italic>Syzygium samarangense<\/jats:italic>\n                      (SS) is a phytochemical-rich medicinal plant with potential anti-Diabetes properties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      A data-driven systems pharmacology approach was employed to explore the anti-DR potential of\n                      <jats:italic>S. samarangense<\/jats:italic>\n                      phytochemicals. Twenty-nine active compounds were screened for drug-likeness using Lipinski\u2019s Rule of Five. Overlapping targets between SS and DR were identified, yielding 403 shared targets. Network pharmacology analysis highlighted ten core proteins, including SRC, ALB, GAPDH, and TNF. Gene Ontology (GO) and KEGG pathway enrichment analyses identified key pathways such as AGE-RAGE and HIF-1 signaling. Molecular docking was performed to evaluate ligand\u2013target interactions, followed by 500 ns molecular dynamics (MD) simulations and MM-GBSA binding free energy analysis for validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Discussion<\/jats:title>\n                    <jats:p>\n                      Docking studies identified Pinocembrin (SS5) and Stercurensin (SS4) as top-ranked ligands, with strong binding affinities toward SRC and ALB, respectively. MD simulations demonstrated superior structural stability for the SS5\u2013SRC complex, whereas SS4\u2013ALB exhibited moderate stability. MM-GBSA calculations further confirmed favorable binding energies, supporting their drug-like behavior. These multi-target interactions suggest that\n                      <jats:italic>S. samarangense<\/jats:italic>\n                      phytochemicals can modulate key DR-associated pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>S. samarangense<\/jats:italic>\n                      exhibits promising multi-target activity against Diabetes retinopathy. Pinocembrin (SS5) and Stercurensin (SS4) emerge as potential lead compounds for further experimental validation and drug development.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fbinf.2026.1884743","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:37:20Z","timestamp":1787031440000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative network pharmacology and molecular modeling approaches reveal the therapeutic potential of Syzygium samarangense phytocompounds against diabetes retinopathy"],"prefix":"10.3389","volume":"6","author":[{"given":"Arun","family":"Kandhan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology","place":["Chengalpattu, Tamil Nadu, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijo","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus","place":["Kochi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundarrajan","family":"Thirugnanasambandam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology","place":["Chengalpattu, Tamil Nadu, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1570385","DOI":"10.3389\/fphar.2025.1570385","article-title":"Pharmacological potential of natural chalcones: a recent studies and future perspective","volume":"16","author":"Adhikari","year":"2025","journal-title":"Front. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.51329\/mehdiophthal1438","article-title":"Common causes of visual impairment in the elderly, medical hypothesis discovery and innovation","volume":"10","author":"Al-Namaeh","year":"2022","journal-title":"Ophthalmology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"33770","DOI":"10.1039\/D3RA05672D","article-title":"Exploring cyclin-dependent kinase inhibitors: a comprehensive study in search of CDK-6 inhibitors using a pharmacophore modelling and dynamics approach","volume":"13","author":"Chagaleti","year":"2023","journal-title":"RSC Adv."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1359949","DOI":"10.3389\/fmicb.2024.1359949","article-title":"Postbiotics: emerging therapeutic approach in diabetes retinopathy","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s10930-020-09953-6","article-title":"Structure-based identification of potential drugs against FmtA of staphylococcus aureus: virtual screening, molecular dynamics, MM-GBSA, and QM\/MM","volume":"40","author":"Dalal","year":"2021","journal-title":"Protein J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"788","DOI":"10.3390\/biomedicines12040788","article-title":"Dual anti-inflammatory and anticancer activity of novel 1,5-Diaryl pyrazole derivatives: molecular modeling, synthesis, in vitro activity, and dynamics study","volume":"12","author":"Deivasigamani","year":"2024","journal-title":"Biomedicines"},{"key":"B10","doi-asserted-by":"publisher","first-page":"6654976","DOI":"10.1155\/bmri\/6654976","article-title":"The role of diet and oral supplementation for the management of diabetes retinopathy and diabetes macular edema: a narrative review","volume":"2025","author":"D\u2019Angelo","year":"2025","journal-title":"Biomed. Res. Int."},{"key":"B11","doi-asserted-by":"publisher","first-page":"114032","DOI":"10.1016\/j.biopha.2022.114032","article-title":"Current advances on the therapeutic potential of pinocembrin: an updated review","volume":"157","author":"Elbatreek","year":"2023","journal-title":"Biomed. & Pharmacother."},{"key":"B12","doi-asserted-by":"publisher","first-page":"8725","DOI":"10.1080\/07391102.2021.1916597","article-title":"In-silico screening and identification of potential inhibitors against 2Cys peroxiredoxin of candidatus Liberibacter asiaticus","volume":"40","author":"Gupta","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"B13","doi-asserted-by":"publisher","first-page":"103518","DOI":"10.1016\/j.fbio.2023.103518","article-title":"Fermented Syzygium samarangense leaves mitigate oxidative stress-triggered hepatotoxicity through Nrf2 activation and epigenetic regulation","volume":"57","author":"Huang","year":"2024","journal-title":"Food Biosci."},{"key":"B14","first-page":"1213","article-title":"Src tyrosine kinase regulates the stem cell factor-induced breakdown of the blood-retinal barrier","volume":"22","author":"Im","year":"2016","journal-title":"Mol. Vis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1021\/acsabm.4c01212","article-title":"Glycyrrhizic acid-loaded poloxamer and HPMC-based in situ forming gel of acacia honey for improved wound dressing: formulation optimization and characterization for wound treatment","volume":"8","author":"Jha","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"B16","first-page":"1418","article-title":"TNF-Alpha mediated apoptosis plays an important role in the development of early diabetes retinopathy and long-term histopathological alterations","volume":"15","author":"Joussen","year":"2009","journal-title":"Mol. Vis."},{"key":"B17","first-page":"1418","article-title":"TNF-alpha mediated apoptosis plays an important role in the development of early diabetes retinopathy and long-term histopathological alterations","volume":"15","author":"Joussen","year":"2009","journal-title":"Mol. Vis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","article-title":"KEGG: biological systems database as a model of the real world","volume":"53","author":"Kanehisa","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"D1516","DOI":"10.1093\/nar\/gkae1059","article-title":"PubChem 2025 update","volume":"53","author":"Kim","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3928\/01913913-20241121-03","article-title":"The relationship of serum diabetes antibodies with the development of early diabetes retinopathy findings in children with type 1 diabetes mellitus","volume":"62","author":"Korkmaz","year":"2025","journal-title":"J. Pediatr. Ophthalmol. Strabismus"},{"key":"B22","doi-asserted-by":"publisher","first-page":"102425","DOI":"10.1016\/j.coph.2023.102425","article-title":"Integrating network pharmacology: the next-generation approach in ocular drug discovery","volume":"74","author":"Lazzara","year":"2024","journal-title":"Curr. Opin. Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"113237","DOI":"10.1016\/j.intimp.2024.113237","article-title":"The natural flavonoid pinocembrin shows antithrombotic activity and suppresses septic thrombosis","volume":"142","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3390\/jcm12030733","article-title":"Identification of S100A9 as a potential inflammation-related biomarker for radiation-induced lung injury","volume":"12","author":"Liu","year":"2023","journal-title":"J. Clin. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.sajb.2024.08.043","article-title":"Diabetes wound healing potentials of phenylethanoid glycosides from Clerodendrum glandulosum lindl.: connecting the dots by integrating network pharmacology, molecular docking, and molecular dynamics simulation","volume":"173","author":"Majie","year":"2024","journal-title":"South Afr. J. Bot."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e03450","DOI":"10.1002\/cbdv.202503450","article-title":"Exploring molecular mechanism of thymoquinone via cMet and PDGFR for accelerated hemostasis: an approach through in silico, in vitro, and in vivo studies","volume":"23","author":"Majie","year":"2026","journal-title":"Chem. Biodivers."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e106490","DOI":"10.1371\/journal.pone.0106490","article-title":"Albumin antioxidant response to stress in diabetes nephropathy progression","volume":"9","author":"Medina-Navarro","year":"2014","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"100769","DOI":"10.1016\/j.chphi.2024.100769","article-title":"Rational design of some 1,3,4 trisubstituted pyrazole-thiazole derivatives to serve as MtInhA inhibitors using QSAR, ADMET, molecular docking, MM-GBSA, and molecular dynamics simulations approach","volume":"9","author":"Mhetre","year":"2024","journal-title":"Chem. Phys. Impact"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1210\/clinem\/dgab362","article-title":"The role of HIF1\u03b1-PFKFB3 pathway in diabetes retinopathy","volume":"106","author":"Min","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.1038\/s41598-018-22631-z","article-title":"IMPPAT: a curated database of Indian medicinal plants, phytochemistry and therapeutics","volume":"8","author":"Mohanraj","year":"2018","journal-title":"Sci. Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"140385","DOI":"10.1016\/j.molstruc.2024.140385","article-title":"Exploring the cyclization of thiosemicarbazone to 1,3,4-thiadiazole: synthesis, characterization and in-silico study","volume":"1322","author":"Mukhrish","year":"2025","journal-title":"J. Mol. Struct."},{"key":"B33","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.procbio.2024.04.012","article-title":"Furan-based chalcone protects \u03b2-cell damage and improves glucose uptake in alloxan-induced zebrafish diabetes model via influencing peroxisome proliferator-activated receptor agonists (PPAR-\u03b3) signaling","volume":"142","author":"Nayak","year":"2024","journal-title":"Process Biochem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s13059-019-1758-4","article-title":"Cytoscape automation: empowering workflow-based network analysis","volume":"20","author":"Otasek","year":"2019","journal-title":"Genome Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"108073","DOI":"10.1016\/j.compbiolchem.2024.108073","article-title":"Identification of novel CA IX inhibitor: pharmacophore modeling, docking, DFT, and dynamic simulation","volume":"110","author":"Packiapalavesam","year":"2024","journal-title":"Comput. Biol. Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"D845","DOI":"10.1093\/nar\/gkz1021","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Pi\u00f1ero","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"152113","DOI":"10.1016\/j.bbrc.2025.152113","article-title":"Integrating network pharmacology, experimental validation and molecular dynamics simulation to investigate the underlying mechanism of apigenin against diabetes wound","volume":"775","author":"Pu","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"103822","DOI":"10.1016\/j.arabjc.2022.103822","article-title":"Syzygium samarangense leaf extract exhibits distinct antiDiabetes activities: evidences from in silico and in vivo studies","volume":"15","author":"Rashied","year":"2022","journal-title":"Arabian J. Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1001\/jamaophthalmol.2016.2213","article-title":"Association between diabetes-related eye complications and symptoms of anxiety and depression","volume":"134","author":"Rees","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"B40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-981-16-5812-9_2","article-title":"The GeneCards suite","volume-title":"Practical Guide to Life Science Databases","author":"Safran","year":"2021"},{"key":"B41","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3390\/biology13090732","article-title":"Forecasting the pharmacological mechanisms of Plumbago zeylanica and Solanum xanthocarpum in diabetes retinopathy treatment: a network pharmacology, molecular docking, and molecular dynamics simulation study","volume":"13","author":"Sahu","year":"2024","journal-title":"Biol. (Basel)."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1039\/D3RA08618F","article-title":"Ligand based pharmacophore modelling and integrated computational approaches in the quest for small molecule inhibitors against hCA IX","volume":"14","author":"Saravanan","year":"2024","journal-title":"RSC Adv."},{"key":"B43","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1109\/TCBBIO.2024.3521790","article-title":"Ligand-based pharmacophore modeling and quantum computational approaches for the development of hCA XII inhibitor","volume":"22","author":"Saravanan","year":"2025","journal-title":"IEEE Trans. Comput. Biol. Bioinforma."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1172\/JCI33361","article-title":"Retinal vascular permeability suppression by topical application of a novel VEGFR2\/Src kinase inhibitor in mice and rabbits","volume":"118","author":"Scheppke","year":"2008","journal-title":"J. Clin. Investigation"},{"key":"B45","doi-asserted-by":"publisher","first-page":"106143","DOI":"10.1016\/j.bioorg.2022.106143","article-title":"Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2","volume":"129","author":"Shaker","year":"2022","journal-title":"Bioorg. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.cyto.2018.05.033","article-title":"Pinocembrin protects endothelial cells from oxidized LDL-induced injury","volume":"111","author":"Su","year":"2018","journal-title":"Cytokine"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2024.143017","article-title":"Identification of bioactive compounds and ADMET profile of stem bark of Syzygium samarangense and their potential as antibreast cancer and antiinflammatory","author":"Sururi","year":"2024","journal-title":"J. Appl. Pharm. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global prevalence of diabetes retinopathy and projection of burden through 2045","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/mol.116.105031","article-title":"Novel small molecule JP-153 targets the Src-FAK-Paxillin signaling complex to inhibit VEGF-induced retinal angiogenesis","volume":"91","author":"Toutounchian","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e22546","DOI":"10.1016\/j.heliyon.2023.e22546","article-title":"Chalcones: the flavonoid derivatives synthesis, characterization, their antioxidant and in vitro\/in vivo antiDiabetes potentials","volume":"9","author":"Uddin","year":"2023","journal-title":"Heliyon"},{"key":"B54","doi-asserted-by":"publisher","first-page":"13885","DOI":"10.1038\/s41598-022-18297-3","article-title":"Pinocembrin suppresses oxidized low-density lipoprotein-triggered NLRP3 inflammasome\/GSDMD-mediated endothelial cell pyroptosis through an Nrf2-dependent signaling pathway","volume":"12","author":"Wang","year":"2022","journal-title":"Sci. Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3390\/antiox14010055","article-title":"Antioxidant properties of Albumin and diseases related to obstetrics and gynecology","volume":"14","author":"Watanabe","year":"2025","journal-title":"Antioxidants"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.3390\/nu16111715","article-title":"Nutraceuticals for diabetes retinopathy: recent advances and novel delivery systems","volume":"16","author":"Ye","year":"2024","journal-title":"Nutrients"},{"key":"B57","doi-asserted-by":"publisher","first-page":"7382","DOI":"10.1038\/s41598-021-86914-8","article-title":"Network pharmacology and molecular docking study on the active ingredients of qidengmingmu capsule for the treatment of diabetes retinopathy","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"bbad518","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Brief. Bioinform."},{"key":"B59","doi-asserted-by":"publisher","first-page":"6687606","DOI":"10.1155\/abb\/6687606","article-title":"Network pharmacology study on the mechanisms of Panax notoginseng in the treatment of diabetes retinopathy and cataract","volume":"2025","author":"Zhang","year":"2025","journal-title":"Appl. Bionics Biomech."},{"key":"B60","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s11892-011-0198-7","article-title":"AGEs, RAGE, and diabetes retinopathy","volume":"11","author":"Zong","year":"2011","journal-title":"Curr. Diab. Rep."}],"container-title":["Frontiers in Bioinformatics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbinf.2026.1884743\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:37:21Z","timestamp":1787031441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbinf.2026.1884743\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":60,"alternative-id":["10.3389\/fbinf.2026.1884743"],"URL":"https:\/\/doi.org\/10.3389\/fbinf.2026.1884743","relation":{},"ISSN":["2673-7647"],"issn-type":[{"value":"2673-7647","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]},"article-number":"1884743"}}