{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:42:37Z","timestamp":1790426557322,"version":"4.1.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["306757"],"award-info":[{"award-number":["306757"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003185","name":"Fraunhofer-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"DOI":"10.3389\/fbioe.2018.00126","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T02:38:13Z","timestamp":1537324693000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["An Efficient Modelling-Simulation-Analysis Workflow to Investigate Stump-Socket Interaction Using Patient-Specific, Three-Dimensional, Continuum-Mechanical, Finite Element Residual Limb Models"],"prefix":"10.3389","volume":"6","author":[{"given":"Ellankavi","family":"Ramasamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan","family":"Avci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Dorow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook-Yee","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Gizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Steidle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Schick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"R\u00f6hrle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","article-title":"Diffusion tensor imaging of the brain","volume":"4","author":"Alexander","year":"2007","journal-title":"Neurotherapeutics"},{"key":"B2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/11866565_15","article-title":"Rician noise removal in diffusion tensor mri","volume-title":"Medical Image Computing and Computer-Assisted Intervention\u2013MICCAI 2006","author":"Basu","year":"2006"},{"key":"B3","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/jmri.20805","article-title":"Image-based musculoskeletal modeling: applications, advances, and future opportunities","volume":"25","author":"Blemker","year":"2007","journal-title":"J. Magn. Reson. Imaging"},{"key":"B4","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1682\/JRRD.2011.08.0143","article-title":"Perception of socket alignment perturbations in amputees with transtibial prostheses","volume":"49","author":"Boone","year":"2012","journal-title":"J. Rehabil. Res. Dev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3389\/fphys.2018.00816","article-title":"Enabling detailed, biophysics-based skeletal muscle models on hpc systems","volume":"9","author":"Bradley","year":"2018","journal-title":"Front. Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.jmbbm.2017.07.014","article-title":"Viscoelastic parameter identification of human brain tissue","volume":"74","author":"Budday","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s11517-017-1758-z","article-title":"A finite element model to assess transtibial prosthetic sockets with elastomeric liners","volume":"56","author":"Cagle","year":"2018","journal-title":"Med. Biol. Eng. Comput."},{"key":"B8","volume-title":"Nonlinear Finite Element Analysis of Solids and Structures","author":"Crisfield","year":"1997"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.medengphy.2017.02.008","article-title":"Finite element analysis of the amputated lower limb: a systematic review and recommendations","volume":"43","author":"Dickinson","year":"2017","journal-title":"Med. Eng. Phys."},{"key":"B10","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1113\/expphysiol.2005.031047","article-title":"Integrating modelling and experiments to assess dynamic musculoskeletal function in humans","volume":"91","author":"Fernandez","year":"2006","journal-title":"Exp. Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1148\/radiol.14140702","article-title":"Muscle changes detected with diffusion-tensor imaging after long-distance running","volume":"274","author":"Froeling","year":"2014","journal-title":"Radiology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1016\/j.jbiomech.2008.03.039","article-title":"Strain-time cell-death threshold for skeletal muscle in a tissue-engineered model system for deep tissue injury","volume":"41","author":"Gefen","year":"2008","journal-title":"J. Biomech."},{"key":"B13","first-page":"885","article-title":"High resolution diffusion tensor mri of rabbit tendons and ligaments at 11.7 t","volume-title":"Proceedings of the International Society for Magnetic Resonance in Medicine (ISMRM)","author":"Gupta","year":"2010"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1005773","DOI":"10.1371\/journal.pcbi.1005773","article-title":"A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation","volume":"13","author":"Heidlauf","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3389\/fphys.2014.00498","article-title":"A multiscale chemo-electro-mechanical skeletal muscle model to analyze muscle contraction and force generation for different muscle fiber arrangements","volume":"5","author":"Heidlauf","year":"2014","journal-title":"Front. Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1002\/nbm.1791","article-title":"Considerations in high resolution skeletal muscle dti using single-shot epi with stimulated echo preparation and sense","volume":"25","author":"Karampinos","year":"2012","journal-title":"NMR Biomed."},{"key":"B17","first-page":"299","article-title":"Mechanical properties of prosthetic limbs: adapting to the patient","volume":"38","author":"Klute","year":"2001","journal-title":"J. Rehabil. Res. Dev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1177\/0309364614545421","article-title":"Dynamic alignment of transtibial prostheses through visualization of socket reaction moments","volume":"39","author":"Kobayashi","year":"2015","journal-title":"Prosthet. Orthot. Int."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.1007\/s10439-011-0389-z","article-title":"Finite element analysis of donning procedure of a prosthetic transfemoral socket","volume":"39","author":"Lacroix","year":"2011","journal-title":"Ann. Biomed. Eng."},{"key":"B20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.4467\/2353737XCT.18.048.8343","article-title":"The determination of mechanical properties of prosthetic liners through experimental and constitutive modelling approaches","volume":"3","author":"\u0141agan","year":"2018","journal-title":"Czas. Techn."},{"key":"B21","first-page":"155","article-title":"Issues of importance reported by persons with lower limb amputations and prostheses","volume":"36","author":"Legro","year":"1999","journal-title":"J. Rehabil. Res. Dev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e73021","DOI":"10.1371\/journal.pone.0073021","article-title":"Diffusion Weighted Image Denoising Using Overcomplete Local PCA","volume":"8","author":"Manj\u00f3n","year":"2013","journal-title":"PLoS ONE"},{"key":"B23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s10439-015-1433-1","article-title":"Computational modeling for enhancing soft tissue image guided surgery: an application in neurosurgery","volume":"44","author":"Miga","year":"2016","journal-title":"Ann. Biomed. Eng."},{"key":"B24","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.neuron.2006.08.012","article-title":"Principles of diffusion tensor imaging and its applications to basic neuroscience research","volume":"51","author":"Mori","year":"2006","journal-title":"Neuron"},{"key":"B25","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10439-014-1202-6","article-title":"Pressure induced deep tissue injury explained","volume":"43","author":"Oomens","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e13012","DOI":"10.14814\/phy2.13012","article-title":"A novel diffusion-tensor mri approach for skeletal muscle fascicle length measurements","volume":"4","author":"Oudeman","year":"2016","journal-title":"Physiol. Rep."},{"key":"B27","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1743-0003-3-5","article-title":"Muscle-driven forward dynamic simulations for the study of normal and pathological gait","volume":"3","author":"Piazza","year":"2006","journal-title":"J. Neuroeng. Rehabil."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1016\/j.jbiomech.2008.03.035","article-title":"Internal mechanical conditions in the soft tissues of a residual limb of a trans-tibial amputee","volume":"41","author":"Portnoy","year":"2008","journal-title":"J. Biomech."},{"key":"B29","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3389\/fphys.2012.00358","article-title":"A physiologically based, multi-scale model of skeletal muscle structure and function","volume":"3","author":"R\u00f6hrle","year":"2012","journal-title":"Front. Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s10237-016-0850-x","article-title":"A two-muscle, continuum-mechanical forward simulation of the upper limb","volume":"16","author":"R\u00f6hrle","year":"2017","journal-title":"Biomechan. Model. Mechanobiol."},{"key":"B31","doi-asserted-by":"crossref","DOI":"10.1007\/11790273_7","article-title":"Image based musculoskeletal modeling allows personalized biomechanical analysis of gait","volume-title":"International Symposium on Biomedical Simulation","author":"Scheys","year":"2006"},{"key":"B32","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.jmbbm.2016.02.020","article-title":"Multi-material 3-d viscoelastic model of a transtibial residuum from in-vivo indentation and mri data","volume":"59","author":"Sengeh","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"B33","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.clinbiomech.2015.11.018","article-title":"Persons with unilateral transfemoral amputation experience larger spinal loads during level-ground walking compared to able-bodied individuals","volume":"32","author":"Shojaei","year":"2016","journal-title":"Clin. Biomechan."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cnm.2965","article-title":"Gradient-based optimization with b-splines on sparse grids for solving forward-dynamics simulations of three-dimensional, continuum-mechanical musculoskeletal system models","volume":"34","author":"Valentin","year":"2018","journal-title":"Int. J. Num. Methods Biomed. Eng."},{"key":"B35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1080\/03093640500238857","article-title":"Usability of gait analysis in the alignment of trans-tibial prostheses: a clinical study","volume":"29","author":"Van Velzen","year":"2005","journal-title":"Prosthet. Orthot. Int."},{"key":"B36","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1109\/86.506406","article-title":"Automated hexahedral mesh generation from biomedical image data: applications in limb prosthetics","volume":"4","author":"Zachariah","year":"1996","journal-title":"IEEE Trans. Rehabil. Eng"},{"key":"B37","first-page":"1270","article-title":"Finite element analysis of the contact interface between trans-femoral stump and prosthetic socket","volume-title":"Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS","author":"Zhang","year":"2013"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2018.00126\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T02:38:17Z","timestamp":1537324697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2018.00126\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":37,"alternative-id":["10.3389\/fbioe.2018.00126"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2018.00126","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]},"article-number":"126"}}