{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T03:19:13Z","timestamp":1772680753620,"version":"3.50.1"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571015"],"award-info":[{"award-number":["81571015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"DOI":"10.3389\/fbioe.2020.00119","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T14:01:59Z","timestamp":1582293719000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["The Injectable Woven Bone-Like Hydrogel to Perform Alveolar Ridge Preservation With Adapted Remodeling Performance After Tooth Extraction"],"prefix":"10.3389","volume":"8","author":[{"given":"Tao","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunmao","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1016\/j.biomaterials.2005.12.008","article-title":"Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD.","volume":"27","author":"Balasundaram","year":"2006","journal-title":"Biomaterials"},{"key":"B2","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jcis.2011.09.072","article-title":"Hydroxyapatite-coated carboxymethyl chitosan scaffolds for promoting osteoblast and stem cell differentiation.","volume":"366","author":"Budiraharjo","year":"2012","journal-title":"J. Colloid Interface Sci."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12167","article-title":"Clinical relevance of dimensional bone and soft tissue alterations post-extraction in esthetic sites.","volume":"73","author":"Chappuis","year":"2017","journal-title":"Periodontology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/biom9090450","article-title":"Newly designed human-like collagen to maximize sensitive release of BMP-2 for remarkable repairing of bone defects.","volume":"9","author":"Chen","year":"2019","journal-title":"Biomolecules"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1039\/c8bm00524a","article-title":"An injectable and physical levan-based hydrogel as a dermal filler for soft tissue augmentation.","volume":"6","author":"Choi","year":"2018","journal-title":"Biomater. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3362","DOI":"10.1016\/j.actbio.2010.02.017","article-title":"Amorphous calcium phosphates: synthesis, properties and uses in biomaterials.","volume":"6","author":"Combes","year":"2010","journal-title":"Acta Biomater."},{"key":"B7","doi-asserted-by":"publisher","first-page":"119617","DOI":"10.1016\/j.biomaterials.2019.119617","article-title":"Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation.","volume":"230","author":"Cui","year":"2020","journal-title":"Biomaterials"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.progpolymsci.2019.01.002","article-title":"Electrospun polymer biomaterials.","volume":"90","author":"Ding","year":"2019","journal-title":"Prog. Poly. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/clr.12108","article-title":"Ridge dimensional changes following single-tooth extraction in the aesthetic zone.","volume":"25","author":"Farmer","year":"2014","journal-title":"Clin. Oral Implants Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jconrel.2019.03.020","article-title":"Electrospun polymer micro\/nanofibers as pharmaceutical repositories for healthcare.","volume":"302","author":"Feng","year":"2019","journal-title":"J. Control. Release"},{"key":"B11","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10237-016-0808-z","article-title":"Elastic properties of woven bone: effect of mineral content and collagen fibrils orientation.","volume":"16","author":"Garcia-Rodriguez","year":"2017","journal-title":"Biomech. Model. Mechanobiol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080886","article-title":"Mesenchymal stem cells for regenerative medicine.","volume":"8","author":"Han","year":"2019","journal-title":"Cells"},{"key":"B13","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.jconrel.2012.05.038","article-title":"Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide.","volume":"161","author":"Hsiao","year":"2012","journal-title":"J. Control. Release"},{"key":"B14","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1186\/1423-0127-16-65","article-title":"Preparation and properties of nano-hydroxyapatite\/chitosan\/carboxymethyl cellulose composite scaffold.","volume":"74","author":"Jiang","year":"2008","journal-title":"Carbohydr. Polym."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00184","article-title":"Ultra-low-cost 3D bioprinting: modification and application of an off-the-shelf desktop 3D-printer for biofabrication.","volume":"7","author":"Kahl","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41415-019-0647-2","article-title":"Alveolar ridge preservation: why, when and how.","volume":"227","author":"Kalsi","year":"2019","journal-title":"Br. Dent. J."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2015.00081","article-title":"3D Printing of octacalcium phosphate bone substitutes.","volume":"3","author":"Komlev","year":"2015","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201804730","article-title":"Multiphasic collagen scaffolds for engineered tissue interfaces.","volume":"28","author":"Lausch","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"B19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s10561-009-9161-0","article-title":"Mineral status and mechanical properties of cancellous bone exposed to hydrogen peroxide for various time periods.","volume":"12","author":"Li","year":"2011","journal-title":"Cell and Tissue Bank."},{"key":"B20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1021\/bm201070g","article-title":"Biomimetic mineralization of woven bone-like nanocomposites: role of collagen cross-links.","volume":"13","author":"Li","year":"2011","journal-title":"Biomacromolecules"},{"key":"B21","doi-asserted-by":"publisher","first-page":"6307","DOI":"10.1039\/C7TB01209H","article-title":"Manipulation of cell adhesion and dynamics using RGD functionalized polymers.","volume":"5","author":"Li","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802306","article-title":"Combining in silico design and biomimetic assembly: a new approach for developing high-performance dynamic responsive bio-nanomaterials.","volume":"30","author":"Ling","year":"2018","journal-title":"Adv. Mater."},{"key":"B23","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.carbpol.2014.03.065","article-title":"A novel thermo-sensitive hydrogel based on thiolated chitosan\/hydroxyapatite\/beta-glycerophosphate.","volume":"110","author":"Liu","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"B24","doi-asserted-by":"publisher","first-page":"8740","DOI":"10.1002\/adma.201602628","article-title":"Hierarchically staggered nanostructure of mineralized collagen as a bone-grafting scaffold.","volume":"28","author":"Liu","year":"","journal-title":"Adv. Mater."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1002\/smll.201600626","article-title":"Hierarchical structures of bone and bioinspired bone tissue engineering.","volume":"12","author":"Liu","year":"","journal-title":"Small"},{"key":"B26","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.biomaterials.2016.10.039","article-title":"Bone regeneration induced by a 3D architectured hydrogel in a rat critical-size calvarial defect.","volume":"113","author":"Lohmann","year":"2017","journal-title":"Biomaterials"},{"key":"B27","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1111\/clr.12911","article-title":"Hard and soft tissue changes following alveolar ridge preservation: a systematic review.","volume":"28","author":"MacBeth","year":"2017","journal-title":"Clin. Oral Implants Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/nmat4789","article-title":"Collagen intrafibrillar mineralization as a result of the balance between osmotic equilibrium and electroneutrality.","volume":"16","author":"Niu","year":"2017","journal-title":"Nat. Mater."},{"key":"B29","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1042\/cs20170047","article-title":"Human DPSCs fabricate vascularized woven bone tissue: a new tool in bone tissue engineering.","volume":"131","author":"Paino","year":"2017","journal-title":"Clin. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1089\/scd.2019.0184","article-title":"Thermosensitive hydrogel delivery of human periodontal stem cells overexpressing platelet-derived growth factor-bb enhances alveolar bone defect repair.","volume":"28","author":"Pan","year":"2019","journal-title":"Stem cells and Dev."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119278","article-title":"Expanded skeletal stem and progenitor cells promote and participate in induced bone regeneration at subcritical BMP-2 dose.","volume":"217","author":"Papageorgiou","year":"2019","journal-title":"Biomaterials"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1021\/acsbiomaterials.8b00512","article-title":"Effects of molecular weight and concentration of poly(acrylic acid) on biomimetic mineralization of collagen.","volume":"4","author":"Qi","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B33","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.1016\/j.actbio.2014.05.024","article-title":"Bone hierarchical structure in three dimensions.","volume":"10","author":"Reznikov","year":"2014","journal-title":"Acta Biomater."},{"key":"B34","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0142-9612(98)00107-100","article-title":"Alginate hydrogels as synthetic extracellular matrix materials.","volume":"20","author":"Rowley","year":"1999","journal-title":"Biomaterials"},{"key":"B35","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.semcdb.2008.07.004","article-title":"Bone remodeling during fracture repair: the cellular picture.","volume":"19","author":"Schindeler","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"B36","first-page":"313","article-title":"Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study.","volume":"23","author":"Schropp","year":"2003","journal-title":"Int. J. Periodontics Restorative Dent."},{"key":"B37","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.bone.2019.06.003","article-title":"Extracellular matrix composition during bone regeneration in the human dental alveolar socket.","volume":"127","author":"Shah","year":"2019","journal-title":"Bone"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1016\/j.jeurceramsoc.2016.01.005","article-title":"Bio-inspired assembling\/mineralization process as a flexible approach to develop new smart scaffolds for the regeneration of complex anatomical regions.","volume":"36","author":"Sprio","year":"2016","journal-title":"J. Eur. Ceram. Soc."},{"key":"B39","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/s8756-3282(02)00945-6","article-title":"Organization of apatite crystals in human woven bone.","volume":"32","author":"Su","year":"2003","journal-title":"Bone"},{"key":"B40","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.biomaterials.2015.09.044","article-title":"Hydroxyapatite-calcium sulfate-hyaluronic acid composite encapsulated with collagenase as bone substitute for alveolar bone regeneration.","volume":"74","author":"Subramaniam","year":"2016","journal-title":"Biomaterials"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1016\/s0142-9612(01)00390-8","article-title":"Continuous synthesis of amorphous carbonated apatites.","volume":"23","author":"Tadic","year":"2002","journal-title":"Biomaterials"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.actbio.2008.11.025","article-title":"Biomimetic chitosan\u2013nanohydroxyapatite composite scaffolds for bone tissue engineering.","volume":"5","author":"Thein-Han","year":"2009","journal-title":"Acta Biomater."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00186","article-title":"Micro-nano bioactive glass particles incorporated porous scaffold for promoting osteogenesis and angiogenesis in vitro.","volume":"7","author":"Tian","year":"2019","journal-title":"Front. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1021\/bm900154b","article-title":"Alginate\/hydroxyapatite biocomposite for bone ingrowth: a trabecular structure with high and isotropic connectivity.","volume":"10","author":"Turco","year":"2009","journal-title":"Biomacromolecules"},{"key":"B45","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.actbio.2009.07.038","article-title":"Characterization of calcium phosphate cements modified by addition of amorphous calcium phosphate.","volume":"6","author":"Van den Vreken","year":"2010","journal-title":"Acta Biomater."},{"key":"B46","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.ijbiomac.2014.07.008","article-title":"Alginate composites for bone tissue engineering: a review.","volume":"72","author":"Venkatesan","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/polym10090949","article-title":"A hyaluronic acid based injectable hydrogel formed via photo-crosslinking reaction and thermal-induced diels-alder reaction for cartilage tissue engineering.","volume":"10","author":"Wang","year":"2018","journal-title":"Polymers"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1002\/term.2670","article-title":"Using biomimetically mineralized collagen membranes with different surface stiffness to guide regeneration of bone defects.","volume":"12","author":"Wang","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nmat4089","article-title":"Bioinspired structural materials.","volume":"14","author":"Wegst","year":"2015","journal-title":"Nat. Mater."},{"key":"B50","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1902\/jop.2017.160771","article-title":"Standardized rat model testing effects of inflammation and grafting on extraction healing.","volume":"88","author":"Willett","year":"2017","journal-title":"J. Periodontol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.matbio.2016.02.004","article-title":"Biomimetic organization of collagen matrices to template bone-like microstructures.","author":"Wingender","year":"2016","journal-title":"Matrix Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"12582","DOI":"10.1166\/jnn.2016.12982","article-title":"Effect of carboxymethyl chitosan and aging time on synthesis and storage of amorphous calcium phosphate.","volume":"16","author":"Yang","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1039\/c4bm00291a","article-title":"Bone tissue regeneration: the role of scaffold geometry.","volume":"3","author":"Zadpoor","year":"2015","journal-title":"Biomater. Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jcrysgro.2006.03.006","article-title":"Recombinant human-like collagen directed growth of hydroxyapatite nanocrystals.","volume":"291","author":"Zhai","year":"2006","journal-title":"J. Cryst. Growth"},{"key":"B55","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.actbio.2018.11.039","article-title":"Three-dimensional (3D) printed scaffold and material selection for bone repair.","volume":"84","author":"Zhang","year":"2019","journal-title":"Acta Biomater."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201902834","article-title":"Multifunctional fibers to shape future biomedical devices.","volume":"29","author":"Zhang","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201903279","article-title":"Polymer fiber scaffolds for bone and cartilage tissue engineering.","volume":"29","author":"Zhang","year":"","journal-title":"Adv. Funct. Mater."},{"key":"B58","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.actbio.2018.06.028","article-title":"Templated dentin formation by dental pulp stem cells on banded collagen bundles nucleated on electrospun poly (4-vinyl pyridine) fibers in vitro.","volume":"76","author":"Zhang","year":"2018","journal-title":"Acta Biomater."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/5\/6\/065005","article-title":"Microfibrous beta-TCP\/collagen scaffolds mimic woven bone in structure and composition.","volume":"5","author":"Zhang","year":"2010","journal-title":"Biomed. Mater."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1021\/cm030080g","article-title":"Hierarchical self-assembly of nano-fibrils in mineralized collagen.","volume":"15","author":"Zhang","year":"2003","journal-title":"Chem. Mater."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1186\/1752-153x-5-40","article-title":"Amorphous calcium phosphate and its application in dentistry.","volume":"5","author":"Zhao","year":"2011","journal-title":"Chem. Cent. J."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12460","article-title":"Topographical cues of direct metal laser sintering titanium surfaces facilitate osteogenic differentiation of bone marrow mesenchymal stem cells through epigenetic regulation.","volume":"51","author":"Zheng","year":"2018","journal-title":"Cell Prolif."},{"key":"B63","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1097\/ID.0000000000000573","article-title":"Radiographic and histological evaluation of the healing of extraction sockets filled with bovine-derived xenograft: an experimental study in rats.","volume":"26","author":"Zhou","year":"2017","journal-title":"Implant Dent."},{"key":"B64","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1021\/acsbiomaterials.8b01371","article-title":"Osteoinductive agents-incorporated three-dimensional biphasic polymer scaffold for synergistic bone regeneration.","volume":"5","author":"Zhu","year":"2019","journal-title":"Acs Biomater. Sci. Eng."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2020.00119\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T14:02:01Z","timestamp":1582293721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2020.00119\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":64,"alternative-id":["10.3389\/fbioe.2020.00119"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2020.00119","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,21]]},"article-number":"119"}}