{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:35:39Z","timestamp":1762868139606,"version":"3.41.2"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"DOI":"10.3389\/fbioe.2020.00423","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T05:09:16Z","timestamp":1588914556000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Intelligent Bimetallic Nanoagents as Reactive Oxygen Species Initiator System for Effective Combination Phototherapy"],"prefix":"10.3389","volume":"8","author":[{"given":"Hongfeng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunbing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuangjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/nrc2540","article-title":"Hypoxia and metabolism series-timeline the impact of O2 availability on human cancer.","volume":"8","author":"Bertout","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"B3","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/s1470-2045(04)01529-23","article-title":"The present and future role of photodynamic therapy in cancer treatment.","volume":"5","author":"Brown","year":"2004","journal-title":"Lancet Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.seppur.2009.03.035","article-title":"Phenol degradation using 20, 300 and 520 kHz ultrasonic reactors with hydrogen peroxide, ozone and zero valent metals.","volume":"67","author":"Chand","year":"2009","journal-title":"Sep. Purif. Technol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1021\/ja511420n","article-title":"H2O2-Activatable and O-2-evolving nanoparticles for highly efficient and selective photodynamic therapy against hypoxic tumor cells.","volume":"137","author":"Chen","year":"","journal-title":"J. Am. Chem. Soc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/adma.201404308","article-title":"An imagable and photothermal \u201cAbraxane-Like\u201d nanodrug for combination cancer therapy to treat subcutaneous and metastatic breast tumors.","volume":"27","author":"Chen","year":"","journal-title":"Adv. Mater."},{"key":"B7","doi-asserted-by":"publisher","first-page":"5223","DOI":"10.1021\/acsnano.5b00640","article-title":"Drug-Induced self-assembly of modified albumins as nano-theranostics for tumor-targeted combination therapy.","volume":"9","author":"Chen","year":"","journal-title":"ACS Nano"},{"key":"B8","doi-asserted-by":"publisher","first-page":"9355","DOI":"10.1016\/j.biomaterials.2014.07.062","article-title":"An albumin-based theranostic nano-agent for dual-modal imaging guided photothermal therapy to inhibit lymphatic metastasis of cancer post surgery.","volume":"35","author":"Chen","year":"","journal-title":"Biomaterials"},{"key":"B9","doi-asserted-by":"publisher","first-page":"8206","DOI":"10.1016\/j.biomaterials.2014.06.013","article-title":"Near-infrared dye bound albumin with separated imaging and therapy wavelength channels for imaging-guided photothermal therapy.","volume":"35","author":"Chen","year":"","journal-title":"Biomaterials"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201908365","article-title":"Amorphous Fe-based nanoagents for self-enhanced chemodynamic therapy by re-establishing tumor acidosis.","volume":"30","author":"Chen","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.cclet.2018.08.007","article-title":"Synthesis, functionalization, and nanomedical applications of functional magnetic nanoparticles.","volume":"29","author":"Chen","year":"2018","journal-title":"Chin. Chem. Lett."},{"key":"B12","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nrc1071","article-title":"Photodynamic therapy for cancer.","volume":"3","author":"Dolmans","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"B13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1093\/jnci\/55.1.115","article-title":"Photoradiation therapy cure of animal tumors with hematoporphyrin and light.","volume":"55","author":"Dougherty","year":"1975","journal-title":"J. Natl. Cancer Inst."},{"key":"B14","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jconrel.2011.07.031","article-title":"Albumin-based nanoparticles as potential controlled release drug delivery systems.","volume":"157","author":"Elzoghby","year":"2012","journal-title":"J. Control Release"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1021\/acsnano.5b00393","article-title":"Physicochemical and immunological assessment of engineered pure protein particles with different redox states.","volume":"9","author":"Gause","year":"2015","journal-title":"ACS Nano"},{"key":"B16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.biomaterials.2016.03.037","article-title":"Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer.","volume":"93","author":"Hu","year":"2016","journal-title":"Biomaterials"},{"key":"B17","doi-asserted-by":"publisher","first-page":"5860","DOI":"10.1002\/smll.201501923","article-title":"Nanocomposite-Based photodynamic therapy strategies for deep tumor treatment.","volume":"11","author":"Hu","year":"2015","journal-title":"Small"},{"key":"B18","doi-asserted-by":"publisher","first-page":"15418","DOI":"10.1021\/acs.analchem.9b02871","article-title":"NIR light-responsive hollow porous gold nanospheres for controllable pressure-based sensing and photothermal therapy of cancer cells.","volume":"91","author":"Hu","year":"2019","journal-title":"Anal. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"10489","DOI":"10.1021\/acsnano.6b06450","article-title":"Combining two-photon-activated fluorescence resonance energy transfer and near-infrared photothermal effect of unimolecular micelles for enhanced photodynamic therapy.","volume":"10","author":"Huang","year":"2016","journal-title":"ACS Nano"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1021\/ja5122809","article-title":"Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting.","volume":"137","author":"Jung","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"B21","doi-asserted-by":"publisher","first-page":"19278","DOI":"10.1021\/ja2073824","article-title":"Hydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugs.","volume":"133","author":"Kuang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"B22","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1021\/cr300213b","article-title":"Nanomaterials for theranostics: recent advances and future challenges.","volume":"115","author":"Lim","year":"2015","journal-title":"Chem. Rev."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201908865","article-title":"Biodegradable nanoscale coordination polymers for targeted tumor combination therapy with oxidative stress amplification.","volume":"30","author":"Liu","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"B24","doi-asserted-by":"publisher","first-page":"12503","DOI":"10.1002\/anie.201606795","article-title":"Mimicking primitive photobacteria: sustainable hydrogen evolution based on peptide-porphyrin co-assemblies with a self-mineralized reaction center.","volume":"55","author":"Liu","year":"2016","journal-title":"Angewandte Chem Int. Ed."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1002\/bit.26566","article-title":"Combination drug delivery via multilamellar vesicles enables targeting of tumor cells and tumor vasculature.","volume":"115","author":"Liu","year":"2018","journal-title":"Biotechnol. Bioeng."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1158\/0008-5472.can-10-4261","article-title":"Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.","volume":"71","author":"Lou","year":"2011","journal-title":"Cancer Res."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901100","article-title":"A cell membrane-targeting self-delivery chimeric peptide for enhanced photodynamic therapy and in situ therapeutic feedback.","volume":"9","author":"Ma","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"B28","doi-asserted-by":"publisher","first-page":"4332","DOI":"10.7150\/thno.26768","article-title":"Aptamer-functionalized nanoscale metal-organic frameworks for targeted photodynamic therapy.","volume":"8","author":"Meng","year":"2018","journal-title":"Theranostics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"7584","DOI":"10.1021\/nn302024t","article-title":"Protein capsules assembled via isobutyramide grafts: sequential growth, biofunctionalization, and cellular uptake.","volume":"6","author":"Mertz","year":"","journal-title":"ACS Nano"},{"key":"B30","doi-asserted-by":"publisher","first-page":"21434","DOI":"10.1039\/c2jm33737a","article-title":"Ultrathin, bioresponsive and drug-functionalized protein capsules.","volume":"22","author":"Mertz","year":"","journal-title":"J. Mater. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1021\/es102401d","article-title":"Oxidation of Sulfoxides and Arsenic(III) in corrosion of nanoscale zero valent iron by oxygen: evidence against ferryl ions (Fe(IV)) as active intermediates in fenton reaction.","volume":"45","author":"Pang","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1021\/nn405773r","article-title":"Multifunctional Albumin-MnO2 nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response.","volume":"8","author":"Prasad","year":"2014","journal-title":"ACS Nano"},{"key":"B33","doi-asserted-by":"publisher","first-page":"285","DOI":"10.2174\/1568009619666181206114904","article-title":"Mesoporous silica nanoparticles as a prospective and promising approach for drug delivery and biomedical applications.","volume":"19","author":"Pu","year":"2019","journal-title":"Curr. Cancer Drug. Targets"},{"key":"B34","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bios.2019.05.014","article-title":"Progress in biosensor based on DNA-templated copper nanoparticles.","volume":"137","author":"Qing","year":"","journal-title":"Biosens. Bioelectron."},{"key":"B35","doi-asserted-by":"publisher","first-page":"11574","DOI":"10.1002\/anie.201812449","article-title":"In situ amplification-based imaging of RNA in living cells.","volume":"58","author":"Qing","year":"","journal-title":"Angewandte Chem Int. Ed."},{"key":"B36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.molonc.2008.03.006","article-title":"Molecular aspects of tumour hypoxia.","volume":"2","author":"Rademakers","year":"2008","journal-title":"Mol. Oncol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"6825","DOI":"10.1021\/ja2010175","article-title":"Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy.","volume":"133","author":"Robinson","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"B38","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy.","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"B39","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.tips.2012.01.005","article-title":"Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.","volume":"33","author":"Semenza","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1002\/adma.201504617","article-title":"Perfluorocarbon-Loaded Hollow Bi2Se3 nanoparticles for timely supply of oxygen under near-infrared light to enhance the radiotherapy of cancer.","volume":"28","author":"Song","year":"2016","journal-title":"Adv. Mater."},{"key":"B41","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.ajps.2019.04.005","article-title":"Cancer nanotechnology: enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy.","volume":"14","author":"Sun","year":"2019","journal-title":"Asian J. Pharm. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1007\/s12274-014-0498-498","article-title":"Bimetallic Pd-Ni core-shell nanoparticles as effective catalysts for the Suzuki reaction.","volume":"7","author":"Xiang","year":"2014","journal-title":"Nano Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1039\/b917195a","article-title":"Human serum albumin coated iron oxide nanoparticles for efficient cell labeling.","volume":"46","author":"Xie","year":"2010","journal-title":"Chem. Commun."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3980","DOI":"10.1016\/j.biomaterials.2012.02.016","article-title":"Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy.","volume":"33","author":"Yoon","year":"2012","journal-title":"Biomaterials"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201801008","article-title":"Dye-Anchored MnO nanoparticles targeting tumor and inducing enhanced phototherapy effect via mitochondria-mediated pathway.","volume":"14","author":"Zhou","year":"2018","journal-title":"Small"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2020.00423\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T05:09:17Z","timestamp":1588914557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2020.00423\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,8]]},"references-count":45,"alternative-id":["10.3389\/fbioe.2020.00423"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2020.00423","relation":{},"ISSN":["2296-4185"],"issn-type":[{"type":"electronic","value":"2296-4185"}],"subject":[],"published":{"date-parts":[[2020,5,8]]},"article-number":"423"}}