{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:07:50Z","timestamp":1791893270513,"version":"4.3.4"},"reference-count":151,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"DOI":"10.3389\/fbioe.2020.00827","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T08:33:26Z","timestamp":1596011606000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":77,"title":["Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications"],"prefix":"10.3389","volume":"8","author":[{"given":"Luis Abelardo","family":"Villarruel Mendoza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Antonela","family":"Scilletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Gonzalo","family":"Bellino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Federico","family":"Desimone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Nicolas","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1749-6632.2009.04083.x","article-title":"Optimizing microneedle arrays to increase skin permeability for transdermal drug delivery.","volume":"1161","author":"Al-Qallaf","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4660","DOI":"10.1039\/c4tb00327f","article-title":"Antibiotic-loaded silica nanoparticle\u2013collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention.","volume":"2","author":"Alvarez","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"B3","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/elan.201400643","article-title":"Electrochemical actuators: controlled drug release strategies for use in micro devices.","volume":"27","author":"Anderson","year":"2015","journal-title":"Electroanalysis"},{"key":"B4","doi-asserted-by":"crossref","DOI":"10.3390\/s19061301","article-title":"A novel PZT pump with built-in compliant structures.","volume":"19","author":"Bao","year":"2019","journal-title":"Sensors"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.addr.2004.03.002","article-title":"BioMEMS: state-of-the-art in detection, opportunities and prospects.","volume":"56","author":"Bashir","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2019.100321","article-title":"Clinical study of safety and immunogenicity of pentavalent DTP-HB-Hib vaccine administered by disposable-syringe jet injector in India.","volume":"14","author":"Bavdekar","year":"2019","journal-title":"Contemp. Clin. Trials Commun."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1063\/1.4940038","article-title":"Continuous-wave laser generated jets for needle free applications.","volume":"10","author":"Berrospe-Rodriguez","year":"2016","journal-title":"Biomicrofluidics"},{"key":"B8","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jconrel.2014.05.004","article-title":"Organ-on-a-chip platforms for studying drug delivery systems.","volume":"190","author":"Bhise","year":"2014","journal-title":"J. Control. Release"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2015.00177","article-title":"Uniform surface modification of 3D bioglass\u00a7-based scaffolds with mesoporous silica particles (MCM-41) for enhancing drug delivery capability.","volume":"3","author":"Boccardi","year":"2015","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1089\/152091501300209598","article-title":"Delivery of insulin by jet injection: recent observations.","volume":"3","author":"Bremseth","year":"2001","journal-title":"Diabetes Technol. Ther."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/j.addr.2009.09.002","article-title":"Micro- and nanotechnologies for intelligent and responsive biomaterial-based medical systems.","volume":"61","author":"Caldorera-Moore","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1088\/0960-1317\/24\/11\/117001","article-title":"Modular reservoir concept for MEMS-based transdermal drug delivery systems.","volume":"24","author":"Cantwell","year":"2014","journal-title":"J. Micromech. Microeng."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201807369","article-title":"Microneedle-array patch fabricated with enzyme-free polymeric components capable of on-demand insulin delivery.","volume":"29","author":"Chen","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101547","article-title":"Optimal scaling analysis of polymeric microneedle length and its effect on transdermal insulin delivery.","volume":"56","author":"Chen","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00137","article-title":"Microneedles as a delivery system for gene therapy.","volume":"7","author":"Chen","year":"2016","journal-title":"Front. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jconrel.2018.08.042","article-title":"Preparation, properties and challenges of the microneedles-based insulin delivery system.","volume":"288","author":"Chen","year":"2018","journal-title":"J. Control. Release"},{"key":"B17","doi-asserted-by":"publisher","first-page":"15541","DOI":"10.1039\/d0ra01382j","article-title":"A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery.","volume":"10","author":"Chen","year":"2020","journal-title":"RSC Adv."},{"key":"B18","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s10544-009-9303-y","article-title":"A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release.","volume":"11","author":"Chung","year":"2009","journal-title":"Biomedical Microdev."},{"key":"B19","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/adhm.201400772","article-title":"MEMS: enabled drug delivery systems.","volume":"4","author":"Cobo","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"B20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.sna.2016.01.001","article-title":"A wireless implantable micropump for chronic drug infusion against cancer.","volume":"239","author":"Cobo","year":"2016","journal-title":"Sens. Actuat. A Phys."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00166","article-title":"Collagen-based tissue engineering strategies for vascular medicine.","volume":"7","author":"Copes","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.addr.2012.04.010","article-title":"Nanoparticles in drug delivery: past, present and future.","volume":"65","author":"Couvreur","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.addr.2014.12.004","article-title":"Polymer-based nanocarriers for vaginal drug delivery.","volume":"92","author":"das Neves","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1039\/c9bm01029g","article-title":"Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites.","volume":"8","author":"Debons","year":"2020","journal-title":"Biomater. Sci."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00489","article-title":"Application of the nano-drug delivery system in treatment of cardiovascular diseases.","volume":"7","author":"Deng","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.1016\/j.actbio.2010.05.014","article-title":"Silica\u2013collagen bionanocomposites as three-dimensional scaffolds for fibroblast immobilization.","volume":"6","author":"Desimone","year":"2010","journal-title":"Acta Biomater."},{"key":"B27","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s41551-019-0369-4","article-title":"Slowly dissolving intradermal microneedles.","volume":"3","author":"Donnelly","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"B28","doi-asserted-by":"publisher","first-page":"47771","DOI":"10.1021\/acsami.9b17826","article-title":"Biphasic hydrogels integrating mineralized and anisotropic features for interfacial tissue engineering.","volume":"11","author":"Echave","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003276","article-title":"First-in-human testing of a wirelessly controlled drug delivery microchip.","volume":"4","author":"Farra","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"B30","doi-asserted-by":"crossref","DOI":"10.3390\/mi10040259","article-title":"3-D design and simulation of a piezoelectric micropump.","volume":"10","author":"Farshchi Yazdi","year":"2019","journal-title":"Micromachines"},{"key":"B31","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jconrel.2019.01.032","article-title":"A nanoliter resolution implantable micropump for murine inner ear drug delivery.","volume":"298","author":"Forouzandeh","year":"2019","journal-title":"J. Control. Release"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116042","article-title":"Extracellular matrix-mimetic composite hydrogels of cross-linked hyaluronan and fibrillar collagen with tunable properties and ultrastructure.","volume":"236","author":"Frayssinet","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"B33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10404-020-02334-6","article-title":"Acoustic bubble-based bidirectional micropump.","volume":"24","author":"Gao","year":"2020","journal-title":"Microfluid. Nanofluid."},{"key":"B34","doi-asserted-by":"crossref","DOI":"10.1002\/9780470846087","author":"Gardner","year":"2001","journal-title":"Microsensors, MEMS and Smart Devices."},{"key":"B35","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1088\/0960-1317\/17\/5\/015","article-title":"A novel two-stage backpressure-independent micropump: modeling and characterization.","volume":"17","author":"Geipel","year":"2007","journal-title":"J. Micromech. Microeng."},{"key":"B36","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10544-011-9625-4","article-title":"An implantable MEMS micropump system for drug delivery in small animals.","volume":"14","author":"Gensler","year":"2012","journal-title":"Biomed. Microdev."},{"key":"B37","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jconrel.2013.03.037","article-title":"A new potential nano-oncological therapy based on polyamino acid nanocapsules.","volume":"169","author":"Gonzalo","year":"2013","journal-title":"J. Control. Release"},{"key":"B38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1109\/JPROC.2003.820534","article-title":"A BioMEMS review: MEMS technology for physiologically integrated devices.","volume":"92","author":"Grayson","year":"2004","journal-title":"Proc. IEEE"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1063\/1.5037328","article-title":"Vibrational modes prediction for water-air bubbles trapped in circular microcavities.","volume":"30","author":"Gritsenko","year":"2018","journal-title":"Phys. Fluids"},{"key":"B40","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.copbio.2013.03.011","article-title":"Biomimetic conducting polymer-based tissue scaffolds.","volume":"24","author":"Hardy","year":"2013","journal-title":"Curr. Opin. Biotechnol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5717","DOI":"10.1002\/adma.201505417","article-title":"Responsive biomaterials: advances in materials based on shape-memory polymers.","volume":"28","author":"Hardy","year":"2016","journal-title":"Adv. Mater."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.xphs.2017.11.013","article-title":"Dissolving microneedles loaded with etonogestrel microcrystal particles for intradermal sustained delivery.","volume":"107","author":"He","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"10272","DOI":"10.1021\/acsnano.8b05373","article-title":"Synthetic charge-invertible polymer for rapid and complete implantation of layer-by-layer microneedle drug films for enhanced transdermal vaccination.","volume":"12","author":"He","year":"2018","journal-title":"ACS Nano"},{"key":"B44","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1146\/annurev.fluid.30.1.579","article-title":"Micro-electro-mechanical-systems (MEMS) and fluid flows.","volume":"30","author":"Ho","year":"1998","journal-title":"Annu. Rev. Fluid Mech."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00134","article-title":"Polymeric approaches to reduce tissue responses against devices applied for islet-cell encapsulation.","volume":"7","author":"Hu","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B46","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1109\/TIE.2011.2160135","article-title":"A controlled-release drug delivery system on a chip using electrolysis.","volume":"59","author":"Huang","year":"2012","journal-title":"IEEE Trans. Ind. Electron."},{"key":"B47","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ijpharm.2018.02.031","article-title":"Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding.","volume":"541","author":"Hutton","year":"2018","journal-title":"Int. J. Pharm."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00069","article-title":"Targeted drug delivery via the use of ECM-mimetic materials.","volume":"8","author":"Hwang","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B49","first-page":"1","year":"2002","journal-title":"IEEE Standard for Safety Levels With Respect to Human Exposure to Electromagnetic Fields, 0-3 kHz."},{"key":"B50","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jconrel.2014.04.052","article-title":"Current advances in the fabrication of microneedles for transdermal delivery.","volume":"185","author":"Indermun","year":"2014","journal-title":"J. Control. Release"},{"key":"B51","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1109\/TMTT.2016.2615623","article-title":"Wireless power delivery to flexible subcutaneous implants using capacitive coupling.","volume":"65","author":"Jegadeesan","year":"2017","journal-title":"IEEE Trans. Microwave Theory Tech."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00077","article-title":"Multifunctional polymeric micelles for delivery of drugs and siRNA.","volume":"5","author":"Jhaveri","year":"2014","journal-title":"Front. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/mi7060099","article-title":"Towards an implantable, low flow micropump that uses no power in the blocked-flow state.","volume":"7","author":"Johnson","year":"2016","journal-title":"Micromachines"},{"key":"B54","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3010564","article-title":"An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors.","volume":"7","author":"Jonas","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08739-4","article-title":"HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge.","volume":"10","author":"Jones","year":"2019","journal-title":"Nat. Commun."},{"key":"B56","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1109\/WiSPNET.2017.8299745","article-title":"A review on micropumps for drug delivery system","author":"Joshitha","year":"2017","journal-title":"Proceedings of the Wireless Communications, Signal Processing and Networking (WiSPNET), 2017 International Conference on: IEEE"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1088\/0964-1726\/10\/6\/301","article-title":"Microelectromechanical systems (MEMS): fabrication, design and applications.","volume":"10","author":"Judy","year":"2001","journal-title":"Smart Mater. Struct."},{"key":"B58","author":"Kaajakari","year":"2009","journal-title":"Practical MEMS: Design of Microsystems, Accelerometers, Gyroscopes, RF MEMS, optical MEMS, and Microfluidic Systems."},{"key":"B59","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1109\/RDCAPE.2017.8358254","article-title":"Implantable Bio-MEMS applications: a review","author":"Kalra","year":"2017","journal-title":"Proceedings of the 2017 Recent Developments in Control, Automation & Power Engineering (RDCAPE)"},{"key":"B60","first-page":"1","article-title":"Design of efficient MEMS based actuator for drug delivery applications","author":"Khare","year":"2014","journal-title":"Proceedings of the Convergence of Technology (I2CT), 2014 International Conference for: IEEE"},{"key":"B61","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jconrel.2013.05.026","article-title":"Droplet-born air blowing: novel dissolving microneedle fabrication.","volume":"170","author":"Kim","year":"2013","journal-title":"J. Control. Release"},{"key":"B62","doi-asserted-by":"publisher","first-page":"9702","DOI":"10.1021\/acsnano.8b04146","article-title":"Enhanced cancer vaccination by in situ nanomicelle-generating dissolving microneedles.","volume":"12","author":"Kim","year":"2018","journal-title":"ACS Nano"},{"key":"B63","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jconrel.2018.08.024","article-title":"Mesoporous silica nanoparticles as cutting-edge theranostics: advancement from merely a carrier to tailor-made smart delivery platform.","volume":"287","author":"Kumar","year":"2018","journal-title":"J. Control. Release"},{"key":"B64","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cbpa.2018.03.015","article-title":"Emergence of two near-infrared windows for in vivo and intraoperative SERS.","volume":"45","author":"Lane","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"key":"B65","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.addr.2017.11.003","article-title":"MEMS devices for drug delivery.","volume":"128","author":"Lee","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B66","doi-asserted-by":"publisher","first-page":"7309","DOI":"10.1016\/j.biomaterials.2012.06.065","article-title":"Drawing lithography for microneedles: a review of fundamentals and biomedical applications.","volume":"33","author":"Lee","year":"2012","journal-title":"Biomaterials"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202000086","article-title":"A patch of detachable hybrid microneedle depot for localized delivery of mesenchymal stem cells in regeneration therapy.","volume":"30","author":"Lee","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"B68","doi-asserted-by":"publisher","first-page":"11664","DOI":"10.1073\/pnas.1906931116","article-title":"Implantable multireservoir device with stimulus-responsive membrane for on-demand and pulsatile delivery of growth hormone.","volume":"116","author":"Lee","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B69","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/s41551-018-0337-4","article-title":"Rapidly separable microneedle patch for the sustained release of a contraceptive.","volume":"3","author":"Li","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"B70","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jconrel.2005.04.009","article-title":"In vivo delivery of BCNU from a MEMS device to a tumor model.","volume":"106","author":"Li","year":"2005","journal-title":"J. Control. Release"},{"key":"B71","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.jconrel.2004.08.018","article-title":"In vivo release from a drug delivery MEMS device.","volume":"100","author":"Li","year":"2004","journal-title":"J. Control. Release"},{"key":"B72","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.snb.2019.02.050","article-title":"Acoustofluidic micromixer on lab-on-a-foil devices.","volume":"287","author":"Lin","year":"","journal-title":"Sens. Actuat. B Chem."},{"key":"B73","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1039\/c9lc00484j","article-title":"Acoustofluidic stick-and-play micropump built on foil for single-cell trapping.","volume":"19","author":"Lin","year":"","journal-title":"Lab Chip"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1021\/acsbiomaterials.8b00159","article-title":"Fabrication of dissolving microneedles with thermal-responsive coating for nir-triggered transdermal delivery of metformin on diabetic rats.","volume":"4","author":"Liu","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-014-9917-6","article-title":"An in-vivo evaluation of a MEMS drug delivery device using Kunming mice model.","volume":"17","author":"Liu","year":"2015","journal-title":"Biomedical Microdev."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2019.106991","article-title":"3D-printed polymer composites with acoustically assembled multidimensional filler networks for accelerated heat dissipation.","volume":"174","author":"Lu","year":"2019","journal-title":"Composites Part B Eng."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801054","article-title":"Biodegradable gelatin methacryloyl microneedles for transdermal drug delivery.","volume":"8","author":"Luo","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"B78","author":"Lyshevski","year":"2002","journal-title":"MEMS and NEMS: Systems, Devices, and Structures."},{"key":"B79","doi-asserted-by":"crossref","DOI":"10.1201\/9781482274004","author":"Madou","year":"2002","journal-title":"Fundamentals of Microfabrication: The Science of Miniaturization."},{"key":"B80","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/156720181101140212165729","article-title":"A survey on the applications of implantable micropump systems in drug delivery.","volume":"11","author":"Mahnama","year":"2014","journal-title":"Curr. Drug Deliv."},{"key":"B81","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jconrel.2005.09.035","article-title":"Electrothermally activated microchips for implantable drug delivery and biosensing.","volume":"109","author":"Maloney","year":"2005","journal-title":"J. Control. Release"},{"key":"B82","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1023\/B:PHAM.0000029282.44140.2e","article-title":"Transdermal delivery of insulin using microneedles in vivo.","volume":"21","author":"Martanto","year":"2004","journal-title":"Pharm. Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1039\/c6tb00281a","article-title":"Silica core\u2013shell particles for the dual delivery of gentamicin and rifamycin antibiotics.","volume":"4","author":"Mebert","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"B84","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.fct.2017.05.054","article-title":"Nanoengineered silica: properties, applications and toxicity.","volume":"109","author":"Mebert","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"B85","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.addr.2012.08.006","article-title":"MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications.","volume":"64","author":"Meng","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B86","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nm0402-415","article-title":"Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery.","volume":"8","author":"Mikszta","year":"2002","journal-title":"Nat. Med."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41378-018-0039-9","article-title":"Glassy carbon microneedles\u2014new transdermal drug delivery device derived from a scalable C-MEMS process.","volume":"4","author":"Mishra","year":"2018","journal-title":"Microsyst. Nanoeng."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00395","article-title":"Technology advancements in blood coagulation measurements for point-of-care diagnostic testing.","volume":"7","author":"Mohammadi Aria","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.mechatronics.2019.04.009","article-title":"Recent trends in mechanical micropumps and their applications: a review.","volume":"60","author":"Mohith","year":"2019","journal-title":"Mechatronics"},{"key":"B90","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00170-016-9698-6","article-title":"Solid silicon microneedles for drug delivery applications.","volume":"93","author":"Narayanan","year":"2017","journal-title":"Int. J. Adv. Manuf. Technol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.copbio.2003.10.007","article-title":"Drug delivery in biotechnology: present and future.","volume":"14","author":"Orive","year":"2003","journal-title":"Curr. Opin. Biotechnol."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901023","article-title":"A new Era for cyborg science is emerging: the promise of cyborganic beings.","volume":"9","author":"Orive","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"B93","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ejps.2018.05.009","article-title":"Dissolving polymeric microneedle arrays for enhanced site-specific acyclovir delivery.","volume":"121","author":"Pamornpathomkul","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19463-2","article-title":"Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles.","volume":"8","author":"Pan","year":"2018","journal-title":"Sci. Rep."},{"key":"B95","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jconrel.2015.11.022","article-title":"Hydrogel-based biosensors and sensing devices for drug delivery.","volume":"240","author":"Peppas","year":"2016","journal-title":"J. Control. Release"},{"key":"B96","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1039\/c1lc20438f","article-title":"A magnetically controlled MEMS device for drug delivery: design, fabrication, and testing.","volume":"11","author":"Pirmoradi","year":"","journal-title":"Lab Chip"},{"key":"B97","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1039\/c1lc20134d","article-title":"On-demand controlled release of docetaxel from a battery-less MEMS drug delivery device.","volume":"11","author":"Pirmoradi","year":"","journal-title":"Lab Chip"},{"key":"B98","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1149\/07201.0045ecst","article-title":"Fabrication of biocompatible hollow microneedles using the C-MEMS process for transdermal drug delivery.","volume":"72","author":"Pramanick","year":"2016","journal-title":"ECS Trans."},{"key":"B99","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.addr.2003.10.023","article-title":"Microneedles for transdermal drug delivery.","volume":"56","author":"Prausnitz","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B100","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nbt1199","article-title":"Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device.","volume":"24","author":"Prescott","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"B101","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s11095-008-9544-0","article-title":"Long-term stability and in vitro release of hPTH (1\u201334) from a multi-reservoir array.","volume":"25","author":"Proos","year":"2008","journal-title":"Pharm. Res."},{"key":"B102","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/j.proeng.2014.12.443","article-title":"Design of mems based microneedle for drug delivery system.","volume":"97","author":"Rajeswari","year":"2014","journal-title":"Proc. Eng."},{"key":"B103","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1007\/s12206-015-0738-1","article-title":"Analytical approach for optimization design of MEMS based microneedles in drug delivery system.","volume":"29","author":"Rajeswari","year":"2015","journal-title":"J. Mech. Sci. Technol."},{"key":"B104","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.addr.2007.08.024","article-title":"3D lithographically fabricated nanoliter containers for drug delivery.","volume":"59","author":"Randall","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1007\/s00542-018-3807-4","article-title":"Design and analysis of MEMS based piezoelectric micro pump integrated with micro needle.","author":"Rao","year":"2018","journal-title":"Microsyst. Technol."},{"key":"B106","author":"Rebeiz","year":"2004","journal-title":"RF MEMS: Theory, Design, and Technology."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118503","article-title":"In-vitro studies of jet injections.","volume":"568","author":"Rohilla","year":"2019","journal-title":"Int. J. Pharm."},{"key":"B108","doi-asserted-by":"crossref","DOI":"10.1201\/9781315117584","author":"Rosen","year":"2017","journal-title":"Drug Delivery: An Integrated Clinical and Engineering Approach."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/j.snb.2017.08.165","article-title":"Electro-drawn polymer microneedle arrays with controlled shape and dimension.","volume":"255","author":"Ruggiero","year":"2018","journal-title":"Sens. Actuat. B Chem."},{"key":"B110","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/16898","article-title":"A controlled-release microchip.","volume":"397","author":"Santini","year":"1999","journal-title":"Nature"},{"key":"B111","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s00542-017-3563-x","article-title":"Design and flow analysis of MEMS based piezo-electric micro pump.","volume":"24","author":"Sateesh","year":"2018","journal-title":"Microsyst. Technol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.colsurfb.2019.02.056","article-title":"Transforming an inert nanopolymer into broad-spectrum bactericidal by superstructure tuning.","volume":"178","author":"Scilletta","year":"2019","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"B113","doi-asserted-by":"publisher","first-page":"9690","DOI":"10.1039\/c3nr02787b","article-title":"Hyaluronan degrading silica nanoparticles for skin cancer therapy.","volume":"5","author":"Scodeller","year":"2013","journal-title":"Nanoscale"},{"key":"B114","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1359-0286(02)00032-3","article-title":"BioMEMS for drug delivery.","volume":"6","author":"Shawgo","year":"2002","journal-title":"Curr. Opin. Solid State Mater. Sci."},{"key":"B115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10544-012-9685-0","article-title":"A MEMS electrochemical bellows actuator for fluid metering applications.","volume":"15","author":"Sheybani","year":"","journal-title":"Biomed. Microdev."},{"key":"B116","first-page":"489","article-title":"15 - Drug delivery using wireless MEMS","author":"Sheybani","year":"","journal-title":"Handbook of Mems for Wireless and Mobile Applications"},{"key":"B117","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jconrel.2019.10.022","article-title":"Polymeric microneedles for controlled transdermal drug delivery.","volume":"315","author":"Singh","year":"2019","journal-title":"J. Control. Release"},{"key":"B118","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0924-4247(90)85039-7","article-title":"Piezoelectric micropump with three valves working peristaltically.","volume":"21","author":"Smits","year":"1990","journal-title":"Sens. Actuat. A Phys."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201605668","article-title":"A self-powered implantable drug-delivery system using biokinetic energy.","volume":"29","author":"Song","year":"2017","journal-title":"Adv. Mater."},{"key":"B120","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/adhm.201200356","article-title":"An electrochemically actuated MEMS device for individualized drug delivery: an in vitro study.","volume":"2","author":"Song","year":"2013","journal-title":"Adv. Healthc. Mater."},{"key":"B121","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s11095-006-9906-4","article-title":"Application of micro-and nano-electromechanical devices to drug delivery.","volume":"23","author":"Staples","year":"2006","journal-title":"Pharm. Res."},{"key":"B122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10717544.2014.903579","article-title":"Implantable microchip: the futuristic controlled drug delivery system.","volume":"23","author":"Sutradhar","year":"2016","journal-title":"Drug Deliv."},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00015","article-title":"Heat: a highly efficient skin enhancer for transdermal drug delivery.","volume":"6","author":"Szunerits","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00164","article-title":"3D and 4D printing of polymers for tissue engineering applications.","volume":"7","author":"Tamay","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/adma.201404071","article-title":"Self-powered water splitting using flowing kinetic energy.","volume":"27","author":"Tang","year":"2015","journal-title":"Adv. Mater."},{"key":"B126","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jconrel.2017.10.021","article-title":"Dihydroergotamine mesylate-loaded dissolving microneedle patch made of polyvinylpyrrolidone for management of acute migraine therapy.","volume":"268","author":"Tas","year":"2017","journal-title":"J. Control. Release"},{"key":"B127","first-page":"1","article-title":"A review of various actuation methods in micropumps for drug delivery appliactions","author":"Tetteh","year":"2014","journal-title":"Proceedings of the 2014 11th International Conference on Electronics, Computer and Computation (ICECCO)"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00324","article-title":"Nano-enhanced drug delivery and therapeutic ultrasound for cancer treatment and beyond.","volume":"7","author":"Tharkar","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B129","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1109\/INEC.2013.6465982","article-title":"A sustainable approach to individualized disease treatment: the Engineering of a multiple use MEMS drug delivery device","author":"Tng","year":"2013","journal-title":"Proceedings of the 2013 IEEE 5th International Nanoelectronics Conference (INEC)"},{"key":"B130","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1007\/s12206-019-0728-9","article-title":"Numerical analysis and simulation of an impulse driven piezoelectric needle-free jet injector.","volume":"33","author":"Trimzi","year":"2019","journal-title":"J. Mech. Sci. Technol."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/741\/1\/012167","article-title":"A simple electrochemical micropump: design and fabrication.","volume":"741","author":"Uvarov","year":"","journal-title":"J. Phys. Conf. Ser."},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/757\/1\/012008","article-title":"A micropump driven by electrochemically produced short-lived bubbles.","volume":"757","author":"Uvarov","year":"","journal-title":"J. Phys. Conf. Ser."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6439\/aa8914","article-title":"Exploding microbubbles driving a simple electrochemical micropump.","volume":"27","author":"Uvarov","year":"2017","journal-title":"J. Micromech. Microeng."},{"key":"B134","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1533\/9780857096289.3.331","article-title":"11 - Microelectromechanical systems (MEMS) for in vivo applications","author":"Vasudev","year":"2013","journal-title":"Implantable Sensor Systems for Medical Applications"},{"key":"B135","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1002\/adfm.201303679","article-title":"Electro-drawn drug-loaded biodegradable polymer microneedles as a viable route to hypodermic injection.","volume":"24","author":"Vecchione","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fmech.2015.00015","article-title":"Grand challenge in N\/MEMS.","volume":"1","author":"Villanueva","year":"2016","journal-title":"Front. Mech. Eng."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1016\/S0142-9612(02)00565-3","article-title":"Biocompatibility and biofouling of MEMS drug delivery devices.","volume":"24","author":"Voskerician","year":"2003","journal-title":"Biomaterials"},{"key":"B138","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/86684","article-title":"A clearer vision for in vivo imaging.","volume":"19","author":"Weissleder","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"B139","year":"2007","journal-title":"Extremely Low Frequency Fields. Environmental Health Criteria Monograph No.238."},{"key":"B140","doi-asserted-by":"publisher","first-page":"7097","DOI":"10.1021\/acs.analchem.9b00069","article-title":"A digital acoustofluidic pump powered by localized fluid-substrate interactions.","volume":"91","author":"Wu","year":"2019","journal-title":"Anal. Chem."},{"key":"B141","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/17425247.2019.1649251","article-title":"Efficacy and safety of a needle-free injector in Chinese patients with type 2 diabetes mellitus treated with basal insulin: a multicentre, prospective, randomised, crossover study.","volume":"16","author":"Xing","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2017.e00395","article-title":"Feasibility of conducting intradermal vaccination campaign with inactivated poliovirus vaccine using Tropis intradermal needle free injection system, Karachi, Pakistan.","volume":"3","author":"Yousafzai","year":"2017","journal-title":"Heliyon"},{"key":"B143","doi-asserted-by":"crossref","first-page":"98087","DOI":"10.1039\/C5RA23172H","article-title":"A cylindrical magnetically-actuated drug delivery device proposed for minimally invasive treatment of prostate cancer.","volume":"5","author":"Zachkani","year":"2015","journal-title":"RSC Adv."},{"key":"B144","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1007\/s12206-019-1051-1","article-title":"An experimental study of a spring-loaded needle-free injector: influence of the ejection volume and injector orifice diameter.","volume":"33","author":"Zeng","year":"2019","journal-title":"J. Mech. Sci. Technol."},{"key":"B145","author":"Zhang","year":"2016","journal-title":"Advanced Mechatronics and MEMS Devices II."},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201703606","article-title":"Microfabricated drug delivery devices: design, fabrication, and applications.","volume":"27","author":"Zhang","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"B147","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1039\/c1lc20236g","article-title":"Lensless imaging for simultaneous microfluidic sperm monitoring and sorting.","volume":"11","author":"Zhang","year":"2011","journal-title":"Lab Chip"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-018-0262-z","article-title":"Finite element analysis of hollow out-of-plane HfO2 microneedles for transdermal drug delivery applications.","volume":"20","author":"Zhang","year":"","journal-title":"Biomed. Microdev."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201704181","article-title":"Bioresponsive microneedles with a sheath structure for H2O2 and pH cascade-triggered insulin delivery.","volume":"14","author":"Zhang","year":"","journal-title":"Small"},{"key":"B150","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-18293-8","author":"Zhou","year":"2012","journal-title":"Microsystems and Nanotechnology."},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201905910","article-title":"Gelatin methacryloyl microneedle patches for minimally invasive extraction of skin interstitial fluid.","volume":"16","author":"Zhu","year":"2020","journal-title":"Small"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2020.00827\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T03:23:40Z","timestamp":1616815420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2020.00827\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,29]]},"references-count":151,"alternative-id":["10.3389\/fbioe.2020.00827"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2020.00827","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,29]]},"article-number":"827"}}