{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:27:15Z","timestamp":1790753235380,"version":"4.1.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"DOI":"10.3389\/fbioe.2020.591467","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T11:06:21Z","timestamp":1602068781000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Building Osteogenic Microenvironments With Strontium-Substituted Calcium Phosphate Ceramics"],"prefix":"10.3389","volume":"8","author":[{"given":"Ben","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-017-0726-8","article-title":"Low-dose strontium stimulates osteogenesis but high-dose doses cause apoptosis in human adipose-derived stem cells via regulation of the ERK1\/2 signaling pathway.","volume":"8","author":"Aimaiti","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1002\/jbmr.354","article-title":"Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model.","volume":"26","author":"Alexander","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1039\/c9tb02710f","article-title":"Substituted hydroxyapatite coatings of bone implants.","volume":"8","author":"Arcos","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1016\/j.biomaterials.2012.01.020","article-title":"A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells.","volume":"33","author":"Barradas","year":"2012","journal-title":"Biomaterials"},{"key":"B5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.biomaterials.2017.10.033","article-title":"CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair.","volume":"196","author":"Batoon","year":"2019","journal-title":"Biomaterials"},{"key":"B6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bone.2007.08.043","article-title":"Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro.","volume":"42","author":"Bonnelye","year":"2008","journal-title":"Bone"},{"key":"B7","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.tibtech.2013.06.005","article-title":"Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics.","volume":"31","author":"Bose","year":"2013","journal-title":"Trends Biotechnol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.actbio.2011.11.017","article-title":"Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review.","volume":"8","author":"Bose","year":"2012","journal-title":"Acta Biomater."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/ma9120985","article-title":"Strontium-substituted bioceramics particles: a new way to modulate MCP-1 and Gro-\u03b1 production by human primary osteoblastic cells.","volume":"9","author":"Braux","year":"2016","journal-title":"Materials"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1016\/j.actbio.2012.04.045","article-title":"Effect of strontium-substituted biphasic calcium phosphate on inflammatory mediators production by human monocytes.","volume":"8","author":"Buache","year":"2012","journal-title":"Acta Biomater."},{"key":"B11","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.apsusc.2008.06.154","article-title":"Interaction of endothelial cells with biodegradable strontium-doped calcium polyphosphate for bone tissue engineering.","volume":"255","author":"Chen","year":"2008","journal-title":"Appl. Surface Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.mattod.2015.11.004","article-title":"Osteoimmunomodulation for the development of advanced bone biomaterials.","volume":"19","author":"Chen","year":"2016","journal-title":"Mater. Today"},{"key":"B13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-0-08-100881-2.00002-6","article-title":"2 - types of ceramics: material class","author":"Drouet","year":"2017","journal-title":"Advances in Ceramic Biomaterials"},{"key":"B14","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ceca.2003.10.014","article-title":"Ca2+ as an extracellular signal in bone.","volume":"35","author":"Dvorak","year":"2004","journal-title":"Cell Calcium"},{"key":"B15","doi-asserted-by":"publisher","first-page":"5140","DOI":"10.1073\/pnas.0306141101","article-title":"Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones.","volume":"101","author":"Dvorak","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B16","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1302\/2058-5241.3.170056","article-title":"Bioceramics and bone healing.","volume":"3","author":"Ginebra","year":"2018","journal-title":"EFORT Open Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1039\/c3ra44323j","article-title":"Effects of strontium-doped calcium polyphosphate on angiogenic growth factors expression of co-culturing system in vitro and of host cell in vivo.","volume":"4","author":"Gu","year":"2014","journal-title":"RSC Adv."},{"key":"B18","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.msec.2012.08.040","article-title":"Acceleration of segmental bone regeneration in a rabbit model by strontium-doped calcium polyphosphate scaffold through stimulating VEGF and bFGF secretion from osteoblasts.","volume":"33","author":"Gu","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.7150\/ijbs.16499","article-title":"Dose-dependent effects of strontium ranelate on ovariectomy rat bone marrow mesenchymal stem cells and human umbilical vein endothelial cells.","volume":"12","author":"Guo","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1126\/science.1067404","article-title":"Third-generation biomedical materials.","volume":"295","author":"Hench","year":"2002","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1126\/science.6093253","article-title":"Surface-active biomaterials.","volume":"226","author":"Hench","year":"1984","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/jbm.820221406","article-title":"Physicochemical characterization of deposits associated with HA ceramics implanted in nonosseous sites.","volume":"22","author":"Heughebaert","year":"1988","journal-title":"J. Biomed. Mater. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1021\/acsbiomaterials.0c00443","article-title":"Biomimetic gelatin methacrylate\/nano fish bone hybrid hydrogel for bone regeneration via osteoimmunomodulation.","volume":"6","author":"Huang","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B24","year":"2010","journal-title":"Strontium and Strontium Compounds."},{"key":"B25","doi-asserted-by":"crossref","DOI":"10.1186\/s40824-018-0149-3","article-title":"Bioactive calcium phosphate materials and applications in bone regeneration.","volume":"23","author":"Jeong","year":"2019","journal-title":"Biomater. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1039\/c8tb02738b","article-title":"Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications.","volume":"7","author":"Jim\u00e9nez","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"B27","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00018-010-0527-z","article-title":"The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals.","volume":"68","author":"Khoshniat","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.dental.2016.02.002","article-title":"Development, characterization and comparison of two strontium doped nano hydroxyapatite molecules for enamel repair\/regeneration.","volume":"32","author":"Krishnan","year":"2016","journal-title":"Dental Mater."},{"key":"B29","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/dgd.12588","article-title":"Strontium ions promote in vitro human bone marrow stromal cell proliferation and differentiation in calcium-lacking media.","volume":"61","author":"Kruppke","year":"","journal-title":"Dev., Growth Diff."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109933","article-title":"Biomaterial based treatment of osteoclastic\/osteoblastic cell imbalance \u2013 Gelatin-modified calcium\/strontium phosphates.","volume":"104","author":"Kruppke","year":"","journal-title":"Mater. Sci. Eng. C"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/jbm.a.35298","article-title":"Strontium exerts dual effects on calcium phosphate cement: accelerating the degradation and enhancing the osteoconductivity both in vitro and in vivo.","volume":"103","author":"Kuang","year":"2015","journal-title":"J. Biomed. Mater. Res. A"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/27\/8\/085101","article-title":"Modulating macrophage polarization with divalent cations in nanostructured titanium implant surfaces.","volume":"27","author":"Lee","year":"2016","journal-title":"Nanotechnology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.bbrc.2012.01.088","article-title":"Effects of strontium on proliferation and differentiation of rat bone marrow mesenchymal stem cells.","volume":"418","author":"Li","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"9006","DOI":"10.1016\/j.biomaterials.2010.07.112","article-title":"The effect of strontium-substituted hydroxyapatite coating on implant fixation in ovariectomized rats.","volume":"31","author":"Li","year":"2010","journal-title":"Biomaterials"},{"key":"B35","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cej.2013.02.037","article-title":"Strontium substituted hydroxyapatite porous microspheres: surfactant-free hydrothermal synthesis, enhanced biological response and sustained drug release.","volume":"222","author":"Lin","year":"2013","journal-title":"Chem. Eng. J."},{"key":"B36","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s10856-011-4247-1","article-title":"In vitro study in stimulating the secretion of angiogenic growth factors of strontium-doped calcium polyphosphate for bone tissue engineering.","volume":"22","author":"Liu","year":"2011","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bone.2016.02.020","article-title":"Inflammation, fracture and bone repair.","volume":"86","author":"Loi","year":"2016","journal-title":"Bone"},{"key":"B38","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s11706-020-0508-6","article-title":"Injectable hydrogel wound dressing based on strontium ion cross-linked starch.","volume":"14","author":"Mao","year":"2020","journal-title":"Front. Mater. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1016\/j.ceramint.2015.11.001","article-title":"Antibiotic-loaded Sr-doped porous calcium phosphate granules as multifunctional bone grafts.","volume":"42","author":"Marques","year":"2016","journal-title":"Ceram. Int."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2020.100273","article-title":"A review of the latest insights into the mechanism of action of strontium in bone.","volume":"12","author":"Marx","year":"2020","journal-title":"Bone Rep."},{"key":"B41","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMoa022436","article-title":"The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis.","volume":"350","author":"Meunier","year":"2004","journal-title":"New Engl. J. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1302\/2046-3758.66.bjr-2016-0311.r1","article-title":"In vivo and clinical application of strontium-enriched biomaterials for bone regeneration.","volume":"6","author":"Neves","year":"2017","journal-title":"Bone Joint Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000204105","article-title":"Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras\/MAPK signaling pathway.","volume":"23","author":"Peng","year":"2009","journal-title":"Cell. Physiol. Biochem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1007\/s00467-012-2175-z","article-title":"Phosphate homeostasis and its role in bone health.","volume":"27","author":"Penido","year":"2012","journal-title":"Pediatr. Nephrol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.msec.2018.09.054","article-title":"Strontium functionalized scaffold for bone tissue engineering.","volume":"94","author":"Prabha","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s00198-011-1847-z","article-title":"Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis.","volume":"23","author":"Reginster","year":"2012","journal-title":"Osteoporosis Int."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1039\/b804140g","article-title":"Structural characterization of sol\u2013gel derived Sr-substituted calcium phosphates with anti-osteoporotic and anti-inflammatory properties.","volume":"18","author":"Renaudin","year":"2008","journal-title":"J. Mater. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.aanat.2011.09.008","article-title":"Strontium promotes cell proliferation and suppresses IL-6 expression in human PDL cells.","volume":"194","author":"R\u00f6mer","year":"2012","journal-title":"Ann. Anat. Anatomischer Anzeiger"},{"key":"B49","doi-asserted-by":"crossref","DOI":"10.1186\/s13036-018-0133-4","article-title":"Tissue engineering strategies for the induction of angiogenesis using biomaterials.","volume":"12","author":"Saberianpour","year":"2018","journal-title":"J. Biol. Eng."},{"key":"B50","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.pharmthera.2012.07.009","article-title":"Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis.","volume":"136","author":"Saidak","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"B51","doi-asserted-by":"publisher","first-page":"9547","DOI":"10.1016\/j.actbio.2013.07.027","article-title":"A novel strontium(II)-modified calcium phosphate bone cement stimulates human-bone-marrow-derived mesenchymal stem cell proliferation and osteogenic differentiation in vitro.","volume":"9","author":"Schumacher","year":"2013","journal-title":"Acta Biomater."},{"key":"B52","first-page":"25","article-title":"Osteoblast differentiation and bone formation gene expression in strontium-inducing bone marrow mesenchymal stem cell.","volume":"53","author":"Sila-Asna","year":"2007","journal-title":"Kobe J. Med. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1001\/archsurg.1963.01310160115023","article-title":"Ceramic-plastic material as a bone substitute.","volume":"87","author":"Smith","year":"1963","journal-title":"Arch. Surg."},{"key":"B54","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s12011-007-9024-0","article-title":"In Situ effect of strontium toothpaste on artificially decalcified human enamel.","volume":"116","author":"Surdacka","year":"2007","journal-title":"Biol. Trace Elem. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0885328218765847","article-title":"Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats.","volume":"33","author":"Tao","year":"2018","journal-title":"J. Biomater. Appl."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1007\/s11517-016-1494-9","article-title":"A comparative study of strontium-substituted hydroxyapatite coating on implant\u2019s osseointegration for osteopenic rats.","volume":"54","author":"Tao","year":"","journal-title":"Med. Biol. Eng. Comput."},{"key":"B57","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.msec.2016.01.034","article-title":"A comparative study of zinc, magnesium, strontium-incorporated hydroxyapatite-coated titanium implants for osseointegration of osteopenic rats.","volume":"62","author":"Tao","year":"","journal-title":"Mater. Sci. Eng. C"},{"key":"B58","doi-asserted-by":"publisher","first-page":"8589","DOI":"10.1016\/j.biomaterials.2013.07.036","article-title":"Bone formation induced by strontium modified calcium phosphate cement in critical-size metaphyseal fracture defects in ovariectomized rats.","volume":"34","author":"Thormann","year":"2013","journal-title":"Biomaterials"},{"key":"B59","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.1007\/s00586-015-3870-9","article-title":"Complications and cancer rates in spine fusion with recombinant human bone morphogenetic protein-2 (rhBMP-2).","volume":"25","author":"Vavken","year":"2016","journal-title":"Eur. Spine J."},{"key":"B60","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-44620-6","article-title":"Bone mineral: new insights into its chemical composition.","volume":"9","author":"Von Euw","year":"2019","journal-title":"Sci. Rep."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2020.153924","article-title":"Novel CoCrWNi alloys with Cu addition: microstructure, mechanical properties, corrosion properties and biocompatibility.","volume":"824","author":"Wang","year":"2020","journal-title":"J. Alloys Compounds"},{"key":"B62","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.bioactmat.2017.05.007","article-title":"Bone grafts and biomaterials substitutes for bone defect repair: a review.","volume":"2","author":"Wang","year":"2017","journal-title":"Bioactive Mater."},{"key":"B63","doi-asserted-by":"publisher","first-page":"6999","DOI":"10.1016\/j.ceramint.2013.12.027","article-title":"Stimulations of strontium-doped calcium polyphosphate for bone tissue engineering to protein secretion and mRNA expression of the angiogenic growth factors from endothelial cells in vitro.","volume":"40","author":"Wang","year":"2014","journal-title":"Ceram. Int."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1007\/s00198-014-2791-5","article-title":"Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures.","volume":"25","author":"Wornham","year":"2014","journal-title":"Osteoporosis Int."},{"key":"B65","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.msec.2014.08.020","article-title":"Enhanced healing of rabbit segmental radius defects with surface-coated calcium phosphate cement\/bone morphogenetic protein-2 scaffolds.","volume":"44","author":"Wu","year":"2014","journal-title":"Mater. Sci. Eng. C"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1039\/c8tb00306h","article-title":"Microenvironment construction of strontium\u2013calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium.","volume":"6","author":"Xie","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.apt.2018.01.008","article-title":"Controlled hydrothermal synthesis of strontium-substituted hydroxyapatite nanorods and their application as a drug carrier for proteins.","volume":"29","author":"Xu","year":"2018","journal-title":"Adv. Powder Technol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1021\/acsbiomaterials.8b00459","article-title":"Controlled release of BMP-2 from a heparin-conjugated strontium-substituted nanohydroxyapatite\/silk fibroin scaffold for bone regeneration.","volume":"4","author":"Yan","year":"2018","journal-title":"ACS Biomat. Sci. Eng."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1080\/09205063.2019.1646628","article-title":"Enhanced osteogenesis and angiogenesis by PCL\/chitosan\/Sr-doped calcium phosphate electrospun nanocomposite membrane for guided bone regeneration.","volume":"30","author":"Ye","year":"2019","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"B70","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.biomaterials.2018.06.004","article-title":"Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes.","volume":"178","author":"Zhao","year":"2018","journal-title":"Biomaterials"},{"key":"B71","doi-asserted-by":"publisher","first-page":"5554","DOI":"10.1016\/j.jeurceramsoc.2018.07.056","article-title":"Nanostructural insights into the dissolution behavior of Sr-doped hydroxyapatite.","volume":"38","author":"Zhu","year":"2018","journal-title":"J. Eur. Ceram. Soc."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2020.591467\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T11:06:26Z","timestamp":1602068786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fbioe.2020.591467\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,7]]},"references-count":71,"alternative-id":["10.3389\/fbioe.2020.591467"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2020.591467","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,7]]},"article-number":"591467"}}