{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:35:38Z","timestamp":1779352538043,"version":"3.51.4"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971013"],"award-info":[{"award-number":["81971013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870915"],"award-info":[{"award-number":["81870915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571109"],"award-info":[{"award-number":["81571109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"DOI":"10.3389\/fbioe.2020.599058","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T04:51:23Z","timestamp":1605761483000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Mesenchymal-Stem-Cell\u2013Derived Extracellular Vesicles Mitigate Trained Immunity in the Brain"],"prefix":"10.3389","volume":"8","author":[{"given":"Yiwei","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sida","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.it.2009.07.009","article-title":"Endotoxin tolerance: new mechanisms, molecules and clinical significance.","volume":"30","author":"Biswas","year":"2009","journal-title":"Trends Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1161\/strokeaha.117.018292","article-title":"Exosome therapy for stroke.","volume":"49","author":"Chen","year":"2018","journal-title":"Stroke"},{"key":"B3","doi-asserted-by":"crossref","first-page":"162.e14","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western diet triggers NLRP3-dependent innate immune reprogramming.","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection.","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1002\/eji.201545497","article-title":"Innate immune memory: implications for host responses to damage-associated molecular patterns.","volume":"46","author":"Cri\u015fan","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.kint.2016.12.023","article-title":"Mesenchymal stem cell\u2013derived extracellular vesicles attenuate kidney inflammation.","volume":"92","author":"Eirin","year":"2017","journal-title":"Kidney Int."},{"key":"B7","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.addr.2012.08.008","article-title":"Exosomes for targeted siRNA delivery across biological barriers.","volume":"65","author":"El Andaloussi","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01746","article-title":"hUCMSCs Mitigate LPS-induced trained immunity in ischemic stroke.","volume":"11","author":"Feng","year":"2020","journal-title":"Front. Immunol."},{"key":"B9","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/564089","article-title":"Mesenchymal stem cell therapy modulates the inflammatory response in experimental traumatic brain injury.","volume":"2011","author":"Galindo","year":"2011","journal-title":"Neurol. Res. Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-4939-3584-0_7","article-title":"Paracrine mechanisms of mesenchymal stem cells in tissue repair.","volume":"1416","author":"Gnecchi","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.apsb.2016.02.001","article-title":"Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges.","volume":"6","author":"Ha","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"B12","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1177\/0963689718816990","article-title":"Potential of exosomes for the treatment of stroke.","volume":"28","author":"Hong","year":"2018","journal-title":"Cell Transplant."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1681\/asn.2007010044","article-title":"Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes.","volume":"18","author":"Kunter","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"B14","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-016-0763-8","article-title":"Balancing the immune response in the brain: IL-10 and its regulation.","volume":"13","author":"Lobo-Silva","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"B15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41409-019-0616-z","article-title":"Mesenchymal stem cell-derived exosomes for clinical use.","volume":"54","author":"Mendt","year":"2019","journal-title":"Bone Marrow Transplant."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease.","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/ni.3178","article-title":"Innate immune memory: a paradigm shift in understanding host defense.","volume":"16","author":"Netea","year":"2015","journal-title":"Nat. Immunol."},{"key":"B18","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-019-1352-4","article-title":"Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10.","volume":"10","author":"Park","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"B19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease.","volume":"10","author":"Perry","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/stem.2575","article-title":"Concise review: MSC-derived exosomes for cell-free therapy.","volume":"35","author":"Phinney","year":"2017","journal-title":"Stem Cells"},{"key":"B21","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"B22","doi-asserted-by":"publisher","first-page":"16513","DOI":"10.1074\/jbc.274.23.16513","article-title":"Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action.","volume":"274","author":"Riley","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-015-0029-4","article-title":"Studies of lipopolysaccharide effects on the induction of \u03b1-synuclein pathology by exogenous fibrils in transgenic mice.","volume":"10","author":"Rutherford","year":"2015","journal-title":"Mol. Neurodegen."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-38","article-title":"Induction of CNS \u03b1-synuclein pathology by fibrillar and non-amyloidogenic recombinant \u03b1-synuclein.","volume":"1","author":"Sacino","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.","volume":"345","author":"Saeed","year":"2014","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1161\/hypertensionaha.115.05333","article-title":"Microglia participate in neurogenic regulation of hypertension.","volume":"66","author":"Shen","year":"2015","journal-title":"Hypertension"},{"key":"B27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.semcdb.2019.03.003","article-title":"Mesenchymal stem cell therapies in brain disease.","volume":"95","author":"Sherman","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1615\/CritRevImmunol.v21.i5.20","article-title":"Interleukin-10 in the brain.","volume":"21","author":"Strle","year":"2001","journal-title":"Crit. Rev. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.apsb.2018.08.006","article-title":"Efficient lung cancer-targeted drug delivery via a nanoparticle\/MSC system.","volume":"9","author":"Wang","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"B30","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41586-018-0023-4","article-title":"Innate immune memory in the brain shapes neurological disease hallmarks.","volume":"556","author":"Wendeln","year":"2018","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.4155\/tde.11.83","article-title":"Exosomes and the blood\u2013brain barrier: implications for neurological diseases.","volume":"2","author":"Wood","year":"2011","journal-title":"Ther. Deliv."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00055","article-title":"MSCs-derived exosomes and neuroinflammation, neurogenesis and therapy of traumatic brain injury.","volume":"11","author":"Yang","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.1186\/s40364-019-0159-x","article-title":"Exosomes from mesenchymal stem\/stromal cells: a new therapeutic paradigm.","volume":"7","author":"Yin","year":"2019","journal-title":"Biomarker Res."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00811","article-title":"Multicellular crosstalk between exosomes and the neurovascular unit after cerebral ischemia. therapeutic implications.","volume":"12","author":"Zagrean","year":"2018","journal-title":"Front. Neurosci."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2020.599058\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T04:51:27Z","timestamp":1605761487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2020.599058\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":34,"alternative-id":["10.3389\/fbioe.2020.599058"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2020.599058","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,19]]},"article-number":"599058"}}