{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:43:50Z","timestamp":1792172630795,"version":"4.4.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The etiology of Anterior Cruciate Ligament (ACL) injury in women football results from the interaction of several extrinsic and intrinsic risk factors. Extrinsic factors change dynamically, also due to fatigue. However, existing biomechanical findings concerning the impact of fatigue on the risk of ACL injuries remains inconsistent. We hypothesized that fatigue induced by acute workload in short and intense game periods, might in either of two ways: by pushing lower limbs mechanics toward a pattern close to injury mechanism, or alternatively by inducing opposed protective compensatory adjustments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this study, we aimed at assessing the extent to which fatigue impact on joints kinematics and kinetics while performing repeated changes of direction (CoDs) in the light of the ACL risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an observational, cross-sectional associative study. Twenty female players (age: 20\u201331 years, 1st\u20132nd Italian division) performed a continuous shuttle run test (5-m) involving repeated 180\u00b0-CoDs until exhaustion. During the whole test, 3D kinematics and ground reaction forces were used to compute lower limb joints angles and internal moments. Measures of exercise internal load were: peak post-exercise blood lactate concentration, heart rate (HR) and perceived exertion. Continuous linear correlations between kinematics\/kinetics waveforms (during the ground contact phase of the pivoting limb) and the number of consecutive CoD were computed during the exercise using a Statistical Parametric Mapping (SPM) approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The test lasted 153 \u00b1 72 s, with a rate of 14 \u00b1 2 CoDs\/min. Participants reached 95% of maximum HR and a peak lactate concentration of 11.2 \u00b1 2.8 mmol\/L. Exercise duration was inversely related to lactate concentration (<jats:italic>r<\/jats:italic> = \u22120.517, <jats:italic>p<\/jats:italic> &amp;lt; 0.01), while neither%HR<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub> nor [La<jats:sup>\u2013<\/jats:sup>]<jats:sub><jats:italic>b<\/jats:italic><\/jats:sub> nor RPE were correlated with test duration before exhaustion (<jats:italic>p<\/jats:italic> &amp;gt; 0.05). Alterations in lower limb kinematics were found in 100%, and in lower limb kinetics in 85% of the players. The most common kinematic pattern was a concurrent progressive reduction in hip and knee flexion angle at initial contact (10 players); 5 of them also showed a significantly more adducted hip. Knee extension moment decreased in 8, knee valgus moment increased in 5 players. A subset of participants showed a drift of pivoting limb kinematics that matches the known ACL injury mechanism; other players displayed less definite or even opposed behaviors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Players exhibited different strategies to cope with repeated CoDs, ranging from protective to potentially dangerous behaviors. While the latter was not a univocal effect, it reinforces the importance of individual biomechanical assessment when coping with fatigue.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fbioe.2021.666841","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T07:04:44Z","timestamp":1625468684000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Fatigue Induced by Repeated Changes of Direction in \u00c9lite Female Football (Soccer) Players: Impact on Lower Limb Biomechanics and Implications for ACL Injury Prevention"],"prefix":"10.3389","volume":"9","author":[{"given":"Matteo","family":"Zago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Bertozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Salaorni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Tarabini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Galvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiarella","family":"Sforza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Galli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00167-009-0813-1","article-title":"Prevention of non-contact anterior cruciate ligament injuries in soccer players. Part 1: mechanisms of injury and underlying risk factors.","volume":"17","author":"Alentorn-Geli","year":"2009","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"B2","article-title":"Lactate production contributes to development of fatigue during intense exercise in humans.","volume":"181","author":"Bangsbo","year":"2019","journal-title":"Ugeskr. Laeger"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1177\/0363546517693846","article-title":"Effect of fatigue protocols on lower limb neuromuscular function and implications for anterior cruciate ligament injury prevention training: a systematic review.","volume":"45","author":"Barber-Westin","year":"2017","journal-title":"Am. J. Sports Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s40279-019-01052-6","article-title":"Revised approach to the role of fatigue in anterior cruciate ligament injury prevention: a systematic review with meta-analyses.","volume":"49","author":"Benjaminse","year":"2019","journal-title":"Sports Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1249\/01.mss.0000043608.79537.ab","article-title":"Muscle activation strategies at the knee.","volume":"35","author":"Besier","year":"2003","journal-title":"Med. Sci. Sports Exerc."},{"key":"B6","first-page":"63","article-title":"Physical demands of different positions in FA premier league soccer.","volume":"6","author":"Bloomfield","year":"2007","journal-title":"J. Sports Sci. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1007\/s40279-019-01134-5","article-title":"Is fatigue a risk factor for anterior cruciate ligament rupture?","volume":"49","author":"Bourne","year":"2019","journal-title":"Sports Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1177\/0363546512459476.Return","article-title":"Return to play and future ACL injury risk following ACL reconstruction in soccer athletes from the MOON group.","volume":"40","author":"Brophy","year":"2013","journal-title":"Am. J. Sports Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1109\/10.649988","article-title":"Surface-marker cluster design criteria for 3-d bone movement reconstruction.","volume":"44","author":"Cappozzo","year":"1997","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1519\/jsc.0000000000002366","article-title":"Energy cost of continuous shuttle running: comparison of 4 measurement methods.","volume":"32","author":"Ciprandi","year":"2018","journal-title":"J. Strength Cond. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.clinbiomech.2016.04.004","article-title":"The effects of fatigue and anticipation on the mechanics of the knee during cutting in female athletes.","volume":"35","author":"Collins","year":"2016","journal-title":"J. Clin. Biomech."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1007\/s00167-013-2673-y","article-title":"Knee kinematics is altered post-fatigue while performing a crossover task.","volume":"22","author":"Cortes","year":"2014","journal-title":"Knee Surg. Sports Traumatol. Arhrosc."},{"key":"B13","doi-asserted-by":"publisher","first-page":"306","DOI":"10.4085\/1062-6050-48.2.03","article-title":"Changes in lower extremity biomechanics due to a short-term fatigue protocol.","volume":"48","author":"Cortes","year":"2013","journal-title":"J. Athl. Train."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.jsams.2017.05.011","article-title":"Identification and risk estimation of movement strategies during cutting maneuvers.","volume":"20","author":"David","year":"2017","journal-title":"J. Sci. Med. Sport"},{"key":"B15","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.humov.2018.10.005","article-title":"Understanding cutting maneuvers \u2013 the mechanical consequence of preparatory strategies and foot strike pattern.","volume":"62","author":"David","year":"2018","journal-title":"Hum. Mov. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.jsams.2015.07.016","article-title":"Effects of maturation on combined female muscle strength and ACL structural factors.","volume":"19","author":"Davidson","year":"2016","journal-title":"J. Sci. Med. Sport"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1136\/bjsports-2019-101247","article-title":"Systematic video analysis of ACL injuries in professional male football (soccer) players: situational patterns and injury mechanisms study on 134 consecutive cases.","volume":"54","author":"Della Villa","year":"2020","journal-title":"Br. J. Sports Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1519\/jsc.0000000000001535","article-title":"Mechanical determinants of faster change of direction speed performance in male athletes.","volume":"31","author":"Dos\u2019Santos","year":"2017","journal-title":"J. Strength Cond. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1519\/JSC.0000000000003439","article-title":"Biomechanical determinants of the modified and traditional 505 change of direction speed test.","volume":"34","author":"Dos\u2019Santos","year":"2020","journal-title":"J. Strength Cond. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1113\/jphysiol.2007.139477","article-title":"Muscle fatigue: what, why and how it influences muscle function.","volume":"586","author":"Enoka","year":"2008","journal-title":"J. Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1177\/0363546505275011","article-title":"Injuries in female soccer players: a prospective study in the German national league.","volume":"33","author":"Faude","year":"2005","journal-title":"Am. J. Sports Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s40279-014-0168-8","article-title":"What is normal? Female lower limb kinematic profiles during athletic tasks used to examine anterior cruciate ligament injury risk: a systematic review.","volume":"44","author":"Fox","year":"2014","journal-title":"Sports Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/17461390802579129","article-title":"The influence of soccer-specific activity on the kinematics of an agility sprint.","volume":"9","author":"Greig","year":"2009","journal-title":"Eur. J. Sport Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1002\/jor.23414","article-title":"Mechanisms, prediction, and prevention of ACL injuries: cut risk with three sharpened and validated tools.","volume":"34","author":"Hewett","year":"2016","journal-title":"J. Orthop. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1080\/00913847.2015.1092856","article-title":"Common injuries and ailments of the female athlete; pathophysiology, treatment and prevention.","volume":"43","author":"Hilibrand","year":"2015","journal-title":"Phys. Sportsmed."},{"key":"B26","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1123\/jab.2018-0392","article-title":"Statistical parametric mapping as a measure of differences between limbs: applications to clinical populations.","volume":"35","author":"Hughes-Oliver","year":"2019","journal-title":"J. Appl. Biomech."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/sports5020042","article-title":"The role of eccentric strength in 180\u00b0 turns in female soccer players.","volume":"5","author":"Jones","year":"2017","journal-title":"Sports"},{"key":"B28","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jelekin.2016.05.006","article-title":"Braking characteristics during cutting and pivoting in female soccer players.","volume":"30","author":"Jones","year":"","journal-title":"J. Electromyogr. Kinesiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.clinbiomech.2015.09.012","article-title":"Technique determinants of knee abduction moments during pivoting in female soccer players.","volume":"31","author":"Jones","year":"","journal-title":"Clin. Biomech."},{"key":"B30","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1177\/0363546517732750","article-title":"Hip and ankle kinematics in noncontact anterior cruciate ligament injury situations: video analysis using model-based image matching.","volume":"46","author":"Koga","year":"2018","journal-title":"Am. J. Sports Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1249\/01.MSS.0000058441.94520.32","article-title":"The Yo-Yo intermittent recovery test: physiological response, reliability, and validity.","volume":"35","author":"Krustrup","year":"2003","journal-title":"Med. Sci. Sports Exerc."},{"key":"B32","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/sms.12860","article-title":"A comparison of injuries in elite male and female football players: a five-season prospective study.","volume":"28","author":"Larruskain","year":"2018","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B33","doi-asserted-by":"publisher","first-page":"291","DOI":"10.5114\/biolsport.2018.77829","article-title":"Physiological responses, fatigue and perception of female soccer players in small-sided games with different pitch size and sport surfaces.","volume":"35","author":"L\u00f3pez-Fern\u00e1ndez","year":"2018","journal-title":"Biol. Sport"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1177\/03635465211008169","article-title":"Systematic video analysis of ACL injuries in professional women soccer players.","volume":"49","author":"Lucarno","year":"2021","journal-title":"Am. J. Sports Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jsams.2011.05.001","article-title":"Knee and hip sagittal and transverse plane changes after two fatigue protocols.","volume":"14","author":"Lucci","year":"2011","journal-title":"J. Sci. Med. Sport"},{"key":"B36","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.gaitpost.2013.08.025","article-title":"Validation of a protocol for the estimation of three-dimensional body center of mass kinematics in sport.","volume":"39","author":"Mapelli","year":"2014","journal-title":"Gait Posture"},{"key":"B37","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.clinbiomech.2004.06.006","article-title":"Sagittal plane biomechanics cannot injure the ACL during sidestep cutting.","volume":"19","author":"McLean","year":"2004","journal-title":"Clin. Biomech."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1249\/MSS.0b013e31819ca07b","article-title":"Fatigue-induced acl injury risk stems from a degradation in central control.","volume":"41","author":"McLean","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"B39","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/JSM.0b013e3180592a48","article-title":"A dynamic model of etiology in sport injury: the recursive nature of risk and causation.","volume":"17","author":"Meeuwisse","year":"2007","journal-title":"Clin. J. Sport Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.knee.2018.10.017","article-title":"The combined impact of a perceptual \u2013 cognitive task and neuromuscular fatigue on knee biomechanics during landing.","volume":"26","author":"Mejane","year":"2019","journal-title":"Knee"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1177\/0363546519834544","article-title":"Visual-spatial memory deficits are related to increased knee valgus angle during a sport-specific sidestep cut.","volume":"47","author":"Monfort","year":"2019","journal-title":"Am. J. Sports Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1136\/bjsports-2016-096274","article-title":"\u201cwhat\u2019s my risk of sustaining an ACL injury while playing sports?\u201d A systematic review with meta-analysis.","volume":"53","author":"Montalvo","year":"2019","journal-title":"Br. J. Sports Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1177\/0363546513518741","article-title":"Risk factors for lower extremity injuries in elite female soccer players.","volume":"42","author":"Nilstad","year":"2014","journal-title":"Am. J. Sports Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1016\/j.jbiomech.2013.07.031","article-title":"Vector field statistical analysis of kinematic and force trajectories.","volume":"46","author":"Pataky","year":"2013","journal-title":"J. Biomech."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1136\/bjsports-2016-097395","article-title":"From microscopic to macroscopic sports injuries. applying the complex dynamic systems approach to sports medicine: a narrative review.","volume":"53","author":"Pol","year":"2019","journal-title":"Br. J. Sports Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ptsp.2016.06.004","article-title":"Mapping current research trends on neuromuscular risk factors of non-contact ACL injury.","volume":"22","author":"Rafeeuddin","year":"2016","journal-title":"Phys. Ther. Sport"},{"key":"B47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1600-0838.2010.01069.x","article-title":"Activity profile and physiological response to football training for untrained males and females, elderly and youngsters: influence of the number of players.","volume":"20","author":"Randers","year":"2010","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B48","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1136\/bjsm.2008.048934","article-title":"Non-contact ACL injuries in female athletes: an International Olympic Committee current concepts statement.","volume":"42","author":"Renstrom","year":"2008","journal-title":"Br. J. Sports Med."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229194","article-title":"Area per player in small-sided games to replicate the external load and estimated physiological match demands in elite soccer players.","volume":"15","author":"Riboli","year":"2020","journal-title":"PLoS One"},{"key":"B50","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.clinbiomech.2008.03.065","article-title":"Fatigue-related changes in stance legmechanics during sidestep cutting maneuvers.","volume":"23","author":"Sanna","year":"2008","journal-title":"Clin. Biomech."},{"key":"B51","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.jsams.2017.07.007","article-title":"Prolonged running increases knee moments in sidestepping and cutting manoeuvres in sport.","volume":"21","author":"Savage","year":"2018","journal-title":"J. Sci. Med. Sport"},{"key":"B52","first-page":"349","article-title":"Anterior cruciate ligament injuries: anatomy.","volume":"22","author":"Siegel","year":"2012","journal-title":"Physiol. Biomech. Manage."},{"key":"B53","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1249\/MSS.0000000000002143","article-title":"Are anterior cruciate ligament-reconstructed athletes more vulnerable to fatigue than uninjured athletes?","volume":"52","author":"Smeets","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"key":"B54","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/sms.13571","article-title":"By failing to prepare, you are preparing your anterior cruciate ligament to fail.","volume":"30","author":"Staynor","year":"2020","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B55","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/j.1440-1681.2006.04363.x","article-title":"Evidence for a supraspinal contribution to human muscle fatigue.","volume":"33","author":"Taylor","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/j.1748-1716.1978.tb06235.x","article-title":"Muscle fatigue and its relation to lactate accumulation and LDH activity in man.","volume":"103","author":"Tesch","year":"1978","journal-title":"Acta Physiol. Scand."},{"key":"B57","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/j.1600-0838.2009.01076.x","article-title":"Isolated hip and ankle fatigue are unlikely risk factors for anterior cruciate ligament injury.","volume":"21","author":"Thomas","year":"2011","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000004022","article-title":"Between-limb differences during 180\u00b0 turns in female soccer players: application of statistical parametric mapping.","author":"Thomas","year":"2021","journal-title":"J. Strength Cond. Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s40279-019-01235-1","article-title":"Does acute fatigue negatively affect intrinsic risk factors of the lower extremity injury risk profile? A systematic and critical review.","volume":"50","author":"Verschueren","year":"2020","journal-title":"Sports Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1007\/s40279-015-0353-4","article-title":"Biomechanics associated with patellofemoral pain and ACL injuries in sports.","volume":"45","author":"Weiss","year":"2015","journal-title":"Sports Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1002\/jor.23441","article-title":"New perspectives on ACL injury: on the role of repetitive sub-maximal knee loading in causing ACL fatigue failure.","volume":"34","author":"Wojtys","year":"2016","journal-title":"J. Orthop. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1080\/17461391.2019.1578416","article-title":"Kinematic effects of repeated turns while running.","volume":"19","author":"Zago","year":"2019","journal-title":"Eur. J. Sport Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jbiomech.2018.05.028","article-title":"Kinematic algorithm to determine the energy cost of running with changes of direction.","volume":"76","author":"Zago","year":"2018","journal-title":"J. Biomech."},{"key":"B64","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/j.1600-0838.2010.01052.x","article-title":"Acute fatigue impairs neuromuscular activity of anterior cruciate ligament-agonist muscles in female team handball players.","volume":"21","author":"Zebis","year":"2011","journal-title":"Scand. J. Med. Sci. Sports"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2021.666841\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T07:04:47Z","timestamp":1625468687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2021.666841\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,5]]},"references-count":64,"alternative-id":["10.3389\/fbioe.2021.666841"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2021.666841","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,5]]},"article-number":"666841"}}