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Biotechnol."],"abstract":"<jats:p>Finite element (FE) head models have become powerful tools in many fields within neuroscience, especially for studying the biomechanics of traumatic brain injury (TBI). Subject-specific head models accounting for geometric variations among subjects are needed for more reliable predictions. However, the generation of such models suitable for studying TBIs remains a significant challenge and has been a bottleneck hindering personalized simulations. This study presents a personalization framework for generating subject-specific models across the lifespan and for pathological brains with significant anatomical changes by morphing a baseline model. The framework consists of hierarchical multiple feature and multimodality imaging registrations, mesh morphing, and mesh grouping, which is shown to be efficient with a heterogeneous dataset including a newborn, 1-year-old (1Y), 2Y, adult, 92Y, and a hydrocephalus brain. The generated models of the six subjects show competitive personalization accuracy, demonstrating the capacity of the framework for generating subject-specific models with significant anatomical differences. The family of the generated head models allows studying age-dependent and groupwise brain injury mechanisms. The framework for efficient generation of subject-specific FE head models helps to facilitate personalized simulations in many fields of neuroscience.<\/jats:p>","DOI":"10.3389\/fbioe.2021.706566","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T23:31:33Z","timestamp":1634599893000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Subject-Specific Head Model Generation by Mesh Morphing: A Personalization Framework and Its Applications"],"prefix":"10.3389","volume":"9","author":[{"given":"Xiaogai","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3171\/jns.2004.100.1.0111","article-title":"Tensile Strength of Cranial Pia Mater: Preliminary Results","volume":"100","author":"Aimedieu","year":"2004","journal-title":"J. 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