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Despite rare thrombotic events have been documented in astronauts, some<jats:italic>in vivo<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>studies demonstrate that microgravity affects platelet\u2019s number and function, thus increasing the risk of hemorrhages and contributing to retard wound healing. Here we provide an overview about events linking platelets to the impairment of wound healing in space, also considering, besides weightlessness, exposure to radiation and psychological stress. In the end we discuss the possibility of utilizing platelet rich plasma as a tool to treat skin injuries eventually occurring during space missions.<\/jats:p>","DOI":"10.3389\/fbioe.2021.716184","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T04:51:06Z","timestamp":1635137466000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":78,"title":["Platelets in Wound Healing: What Happens in Space?"],"prefix":"10.3389","volume":"9","author":[{"given":"Laura","family":"Locatelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Colciago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Castiglioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette A.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1023\/a:1007097511914","article-title":"Expression of PDGF-Beta Receptor, EGF Receptor, and Receptor Adaptor Protein Shc in Rat Osteoblasts during Spaceflight","volume":"202","author":"Akiyama","year":"1999","journal-title":"Mol. 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