{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:22:22Z","timestamp":1781929342934,"version":"3.54.5"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Keratectasia after corneal refractive surgery is a rare but serious postoperative complication, and reports on accelerated transepithelial corneal crosslinking (ATE-CXL)-based treatment of patients with post-laser-assisted <jats:italic>in situ<\/jats:italic> keratomileusis (LASIK) ectasia are limited. Therefore, this study evaluated the long-term efficacy and safety of ATE-CXL for progressive post-LASIK ectasia.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This prospective observational study was conducted at the Eye and ENT Hospital, Fudan University, Shanghai, China, and 25 eyes from 25 patients with post-LASIK ectasia undergoing ATE-CXL were examined. Clinical examinations were conducted preoperatively and postoperatively to assess parameters such as manifest refraction, corrected distance visual acuity (CDVA), endothelial cell density; keratometry, corneal thickness, posterior elevation and topometric indices were measured using Pentacam; sectoral pachymetry and epithelial thickness were evaluated using optical coherence tomography. A paired t-test, Wilcoxon rank-sum test, Kruskal-Wallis test, and repeated measures analysis of variance were used for statistical analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Participants were examined for an average of 46\u00a0months. No severe complications occurred during or after ATE-CXL. CDVA improved from 0.25 \u00b1 0.31 preoperatively to 0.15 \u00b1 0.17 postoperatively (<jats:italic>p<\/jats:italic> = 0.011). Maximum keratometry decreased from 55.20 \u00b1 8.33 D to 54.40 \u00b1 7.98 D, with no statistical significance (<jats:italic>p<\/jats:italic> = 0.074), and the central corneal thickness increased from 414.92 \u00b1 40.96\u00a0\u03bcm to 420.28 \u00b1 44.78\u00a0\u03bcm (<jats:italic>p<\/jats:italic> = 0.047) at the final follow-up. Posterior elevation, pachymetry, and epithelial thickness remained stable (<jats:italic>p<\/jats:italic> &amp;gt; 0.05) throughout the follow-up. No significant differences were noted in topometric indices, except the central keratoconus index, which decreased significantly (<jats:italic>p<\/jats:italic> &amp;lt; 0.001) at the final follow-up.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Improvements in CDVA and stabilization in corneal keratometry and posterior elevation after ATE-CXL were noted at the 46-months follow-up, demonstrating that ATE-CXL is a safe and effective treatment for progressive post-LASIK ectasia.<\/jats:p>","DOI":"10.3389\/fbioe.2021.809262","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T08:17:11Z","timestamp":1640161031000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-Term Follow-Up of Accelerated Transepithelial Corneal Crosslinking for Post-LASIK Ectasia: A Pilot Prospective Observational Study"],"prefix":"10.3389","volume":"9","author":[{"given":"Mi","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingtao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1136\/bjophthalmol-2016-309775","article-title":"Accelerated Transepithelial Corneal Cross-Linking for Progressive Keratoconus: a Prospective Study of 12 Months","volume":"101","author":"Aixinjueluo","year":"2017","journal-title":"Br. 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