{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:36:03Z","timestamp":1789475763586,"version":"build-2803163510"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> To investigate the differences in corneal biomechanical parameter stress\u2013strain index (SSI) among different degrees of myopic eyes in Chinese individuals and to analyze the relevant factors of the SSI.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This study analyzed the right eyes of 240 participants (240 eyes) aged 18\u201334\u00a0years. The participants were divided into low-, moderate-, high-, and ultra-high myopia groups according to their spherical equivalent (SE), with 60 eyes included in each group. Spherical, cylinder, and SE were measured <jats:italic>via<\/jats:italic> automatically integrated optometry. Intraocular pressure (IOP) was measured using a non-contact tonometer. AL was measured using an IOLMaster device. Corneal curvature and central corneal thickness (CCT) were measured using a Pentacam. SSI and biomechanical corrected IOP (bIOP) were measured <jats:italic>via<\/jats:italic> corneal visualization Scheimpflug technology (Corvis ST). The statistical analyses included one-sample Kolmogorov\u2013Smirnov tests and normal distribution histogram methods, Levene variance homogeneity tests, Pearson\u2019s correlation analyses, multiple linear stepwise regression analyses, one-way ANOVA, and LSD <jats:italic>t<\/jats:italic>-tests.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The mean (\u00b1SD) age of the 240 participants was (24.97 \u00b1 4.16) years. The SSI was positively correlated with spherical, cylinder, SE, CCT, IOP, and bIOP and negatively correlated with K1 and AL (<jats:italic>r<\/jats:italic> = 0.475, 0.371, 0.497, 0.169, 0.291, 0.144, \u22120.154, and \u22120.464, respectively; all <jats:italic>p<\/jats:italic> &amp;lt; 0.05), but were not correlated with age, K2, or Km (all <jats:italic>p<\/jats:italic> &amp;gt; 0.05). Multiple linear regression analysis performed with SSI as the dependent variable, and spherical, cylinder, K1, CCT, and IOP as independent variables produced the following regression equation: SSI = 0.989 + 0.017 spherical + 0.042 cylinder +0.018 IOP (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.402, <jats:italic>F<\/jats:italic> = 31.518, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). The SSI values in the low-, moderate-, high-, and ultra-high myopia groups were 0.945 \u00b1 0.135, 0.940 \u00b1 0.128, 0.874 \u00b1 0.110, and 0.771 \u00b1 0.104, respectively. The values decreased sequentially, and the differences between pairs were statistically significant (all <jats:italic>p<\/jats:italic> &amp;lt; 0.05), except for that between the low- and moderate-myopia groups (<jats:italic>p<\/jats:italic> &amp;gt; 0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> SSI decreased with increasing myopia and astigmatism in the Chinese participants. The SSI was significantly lower in high and ultra-high myopia, especially ultra-high myopia. These findings indicate that increased corneal elasticity may be related to the pathogenesis of high and ultra-high myopia.<\/jats:p>","DOI":"10.3389\/fbioe.2022.1018653","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T06:31:10Z","timestamp":1667802670000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of myopia and astigmatism deepening on the corneal biomechanical parameter stress-strain index in individuals of Chinese ethnicity"],"prefix":"10.3389","volume":"10","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjiu","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.ophtha.2017.03.055","article-title":"Comparison of corneal biomechanical properties between Indian and Chinese adults","volume":"124","author":"Chua","year":"2017","journal-title":"Ophthalmology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fbioe.2019.00105","article-title":"Determination of corneal biomechanical behavior in-vivo for healthy eyes using CorVis ST tonometry: Stress-strain index","volume":"7","author":"Eliasy","year":"2019","journal-title":"Front. 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