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Bioeng. Biotechnol."],"abstract":"<jats:p>Chemodynamic therapy (CDT) is an emerging and promising therapeutic strategy that suppresses tumor growth by catalytically converting intracellular hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) into highly-reactive hydroxyl radicals (\u2022OH). However, the inherent substrate of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> is relatively insufficient to achieve desirable CDT efficacy. Therefore, searching for integrated therapeutic methods with synergistic therapeutic modality is especially vital to augment therapeutic outcomes. Herein, we reported nanodot- Cu<jats:sub>x<\/jats:sub>Mn<jats:sub>y<\/jats:sub>S<jats:sub>z<\/jats:sub> @BSA@ICG (denoted as CMS@B@I) and bovine serum albumin (BSA)-based biomineralization Cu<jats:sub>x<\/jats:sub>Mn<jats:sub>y<\/jats:sub>S<jats:sub>z<\/jats:sub> (CMS) loaded with photodynamic agent-indocyanine green (ICG). CMS@B@I converts endogenous hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) into highly active hydroxyl radical (\u2022OH) via Fenton reaction, and effectively produces reactive oxygen species (ROS) after being exposed to 808\u00a0nm laser irradiation, attributable to the excellent photodynamic agent-ICG. This results in eliciting a ROS storm. Additionally, CMS@B@I exhibits a superior photothermal effect under NIR-II 1064\u00a0nm laser irradiation to enhance tumor CDT efficacy. The NIR-II fluorescence imaging agent of ICG and the excellent photothermal effect of CMS@B@I are highly beneficial to NIR-II fluorescence and infrared thermal imaging, respectively, resulting in tracing the fate of CMS@B@I. This study attempts to design a bimodal imaging-guided and photothermal-enhanced CDT nanoagent for augmenting tumor catalytic therapy.<\/jats:p>","DOI":"10.3389\/fbioe.2022.1052014","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T07:08:35Z","timestamp":1667200115000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Biomineralized hybrid nanodots for tumor therapy via NIR-II fluorescence and photothermal imaging"],"prefix":"10.3389","volume":"10","author":[{"given":"Xuegang","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penghui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangnan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dezhi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e2106996","DOI":"10.1002\/adma.202106996","article-title":"Fe3 O4\/Ag\/Bi2 MoO6 photoactivatable nanozyme for self-replenishing and sustainable cascaded nanocatalytic cancer therapy","volume":"33","author":"Cao","year":"2021","journal-title":"Adv. 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