{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:55:08Z","timestamp":1792738508019,"version":"4.5.0"},"reference-count":233,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Intervertebral disc (IVD) degeneration (IDD) is the most universal pathogenesis of low back pain (LBP), a prevalent and costly medical problem across the world. Persistent low back pain can seriously affect a patient\u2019s quality of life and even lead to disability. Furthermore, the corresponding medical expenses create a serious economic burden to both individuals and society. Intervertebral disc degeneration is commonly thought to be related to age, injury, obesity, genetic susceptibility, and other risk factors. Nonetheless, its specific pathological process has not been completely elucidated; the current mainstream view considers that this condition arises from the interaction of multiple mechanisms. With the development of medical concepts and technology, clinicians and scientists tend to intervene in the early or middle stages of intervertebral disc degeneration to avoid further aggravation. However, with the aid of modern delivery systems, it is now possible to intervene in the process of intervertebral disc at the cellular and molecular levels. This review aims to provide an overview of the main mechanisms associated with intervertebral disc degeneration and the delivery systems that can help us to improve the efficacy of intervertebral disc degeneration treatment.<\/jats:p>","DOI":"10.3389\/fbioe.2022.1058251","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T06:18:06Z","timestamp":1668406686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration"],"prefix":"10.3389","volume":"10","author":[{"given":"Zongtai","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/00007632-199602150-00006","article-title":"Sustained loading generates stress concentrations in lumbar intervertebral discs","volume":"21","author":"Adams","year":"1996","journal-title":"Spine (Phila Pa 1976)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1097\/01.brs.0000231761.73859.2c","article-title":"What is intervertebral disc degeneration, and what causes it?","volume":"31","author":"Adams","year":"2006","journal-title":"Spine (Phila Pa 1976)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1089\/ten.tea.2018.0170","article-title":"Injectable chitosan hydrogels with enhanced mechanical properties for nucleus pulposus regeneration","volume":"25","author":"Alinejad","year":"2019","journal-title":"Tissue Eng. 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