{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:09:45Z","timestamp":1788800985087,"version":"build-2803163510"},"reference-count":157,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Temporomandibular joint osteoarthritis (TMJOA) is a debilitating degenerative disease with high incidence, deteriorating quality of patient life. Currently, due to ambiguous etiology, the traditional clinical strategies of TMJOA emphasize on symptomatic treatments such as pain relief and inflammation alleviation, which are unable to halt or reverse the destruction of cartilage or subchondral bone. A number of studies have suggested the potential application prospect of mesenchymal stem cells (MSCs)-based therapy in TMJOA and other cartilage injury. Worthy of note, exosomes are increasingly being considered the principal efficacious agent of MSC secretions for TMJOA management. The extensive study of exosomes (derived from MSCs, synoviocytes, chondrocytes or adipose tissue et al.) on arthritis recently, has indicated exosomes and their specific miRNA components to be potential therapeutic agents for TMJOA. In this review, we aim to systematically summarize therapeutic properties and underlying mechanisms of MSCs and exosomes from different sources in TMJOA, also analyze and discuss the approaches to optimization, challenges, and prospects of exosome-based therapeutic strategy.<\/jats:p>","DOI":"10.3389\/fbioe.2022.1074536","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T04:33:26Z","timestamp":1669350806000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy"],"prefix":"10.3389","volume":"10","author":[{"given":"Wenxiu","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yange","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maotuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueman","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"20130287","DOI":"10.1098\/rsif.2013.0287","article-title":"Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc","volume":"10","author":"Ahtiainen","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"B2","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s10495-010-0458-z","article-title":"Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model","volume":"15","author":"Almonte-Becerril","year":"2010","journal-title":"Apoptosis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1016\/j.jacc.2009.08.092","article-title":"Mesenchymal stem cells provide better results than hematopoietic precursors for the treatment of myocardial infarction","volume":"55","author":"Armi\u00f1\u00e1n","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41419-020-02945-5","article-title":"LncRNA MM2P-induced, exosome-mediated transfer of Sox9 from monocyte-derived cells modulates primary chondrocytes","volume":"11","author":"Bai","year":"2020","journal-title":"Cell Death Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/s0301-472x(01)00769-x","article-title":"Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo","volume":"30","author":"Bartholomew","year":"2002","journal-title":"Exp. Hematol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.jcyt.2021.07.011","article-title":"Amniotic fluid-derived extracellular vesicles: characterization and therapeutic efficacy in an experimental model of bronchopulmonary dysplasia","volume":"23","author":"Bellio","year":"2021","journal-title":"Cytother."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e12127","DOI":"10.1002\/jev2.12127","article-title":"Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses","volume":"10","author":"Budden","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.matbio.2021.07.002","article-title":"Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid","volume":"102","author":"Chandrasekaran","year":"2021","journal-title":"Matrix Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1161\/01.RES.0000257774.55970.f4","article-title":"High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells","volume":"100","author":"Chavakis","year":"2007","journal-title":"Circulation Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"eabb6683","DOI":"10.1126\/scitranslmed.abb6683","article-title":"Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration","volume":"12","author":"Chen","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ijom.2012.05.030","article-title":"Effect of in vitro chondrogenic differentiation of autologous mesenchymal stem cells on cartilage and subchondral cancellous bone repair in osteoarthritis of temporomandibular joint","volume":"42","author":"Chen","year":"2013","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.7150\/thno.31017","article-title":"Desktop-stereolithography 3D printing of a radially oriented extracellular matrix\/mesenchymal stem cell exosome bioink for osteochondral defect regeneration","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/549762","article-title":"Mesenchymal stem cells and platelet gel improve bone deposition within CAD-CAM custom-made ceramic HA scaffolds for condyle substitution","volume":"2013","author":"Ciocca","year":"2013","journal-title":"BioMed Res. Int."},{"key":"B13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.bcp.2011.11.024","article-title":"Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1\u03b2 in osteoarthritic osteoblasts","volume":"83","author":"Cl\u00e9rigues","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"16214","DOI":"10.1038\/s41598-017-15376-8","article-title":"Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis","volume":"7","author":"Cosenza","year":"2017","journal-title":"Sci. Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/1873-3468.12024","article-title":"Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression","volume":"590","author":"Cui","year":"2016","journal-title":"FEBS Lett."},{"key":"B16","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1136\/gutjnl-2011-301393","article-title":"Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1\/HER3 signalling","volume":"62","author":"De Boeck","year":"2013","journal-title":"Gut"},{"key":"B17","doi-asserted-by":"publisher","first-page":"7405","DOI":"10.3390\/ijms22147405","article-title":"Mechanisms of action and efficacy of hyaluronic acid, corticosteroids and platelet-rich plasma in the treatment of temporomandibular joint osteoarthritis-A systematic review","volume":"22","author":"Derwich","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e2007174","DOI":"10.1002\/smll.202007174","article-title":"A holistic review of the state-of-the-art microfluidics for exosome separation: An overview of the current status, existing obstacles, and future outlook","volume":"17","author":"Ding","year":"2021","journal-title":"Small (Weinheim Der Bergstrasse, Ger."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1073\/pnas.0409781102","article-title":"The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles","volume":"102","author":"Distler","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)","volume":"27","author":"Dohan Ehrenfest","year":"2009","journal-title":"Trends Biotechnol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/4814987","article-title":"Characterization of the proinflammatory profile of synovial fluid-derived exosomes of patients with osteoarthritis","volume":"2017","author":"Domenis","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"B22","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nrrheum.2015.52","article-title":"Osteoarthritis: SIRT6 prevents chondrocyte senescence and DNA damage","volume":"11","author":"Duarte","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.actbio.2021.10.026","article-title":"Bone marrow mesenchymal stem cells offer an immune-privileged niche to Cutibacterium acnes in case of implant-associated osteomyelitis","volume":"137","author":"Dubus","year":"2022","journal-title":"Acta Biomater."},{"key":"B24","doi-asserted-by":"publisher","first-page":"13073","DOI":"10.1038\/ncomms13073","article-title":"Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury","volume":"7","author":"Embree","year":"2016","journal-title":"Nat. Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e103009","DOI":"10.15252\/embj.2019103009","article-title":"Glutamine deprivation alters the origin and function of cancer cell exosomes","volume":"39","author":"Fan","year":"2020","journal-title":"EMBO J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3390\/bioengineering9030099","article-title":"Exosomes in the pathogenesis, progression, and treatment of osteoarthritis","volume":"9","author":"Fan","year":"2022","journal-title":"Bioeng. (Basel, Switz."},{"key":"B27","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/joor.13129","article-title":"HMGB1 contributes to osteoarthritis of temporomandibular joint by inducing synovial angiogenesis","volume":"48","author":"Feng","year":"2021","journal-title":"J. Oral Rehabil."},{"key":"B28","first-page":"217","article-title":"Marrow microenvironment transfer by heterotopic transplantation of freshly isolated and cultured cells in porous sponges","volume":"10","author":"Friedenstein","year":"1982","journal-title":"Exp. Hematol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1476-4598-13-20","article-title":"Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival","volume":"13","author":"Funes","year":"2014","journal-title":"Mol. Cancer"},{"key":"B154","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1161\/CIRCRESAHA.117.311215","article-title":"Extracellular vesicles and the application of system biology and computational modeling in cardiac repair","volume":"123","author":"Garikipati","year":"2018","journal-title":"Circ. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.bbrc.2015.09.135","article-title":"Identification and proteomic analysis of osteoblast-derived exosomes","volume":"467","author":"Ge","year":"2015","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.bbrc.2015.09.166","article-title":"Human fibrocyte-derived exosomes accelerate wound healing in genetically diabetic mice","volume":"467","author":"Geiger","year":"2015","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B157","doi-asserted-by":"publisher","first-page":"pe37","DOI":"10.1126\/stke.2942005pe37","article-title":"Adult bone marrow stem\/progenitor cells (MSCs) are preconditioned by microenvironmental \u201cniches\u201d in culture: A two-stage hypothesis for regulation of MSC fate","volume":"2005","author":"Gregory","year":"2005","journal-title":"Sci. STKE."},{"key":"B32","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","article-title":"Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis","volume":"11","author":"He","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"B33","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1089\/ten.TEB.2017.0429","article-title":"Scaffold-based temporomandibular joint tissue regeneration in experimental animal models: A systematic ReviewAn abstract of this article was presented as a poster, at the bergen stem cell consortium (BSCC), annual meeting, bergen, Norway, september 3\u20134, 2017","volume":"24","author":"Helgeland","year":"2018","journal-title":"Tissue Eng. Part B Rev."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1177\/0022034511401405","article-title":"Host-pathogen interactions in progressive chronic periodontitis","volume":"90","author":"Hern\u00e1ndez","year":"2011","journal-title":"J. Dent. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13148-021-01008-6","article-title":"BRD4 inhibition alleviates mechanical stress-induced TMJ OA-like pathological changes and attenuates TREM1-mediated inflammatory response","volume":"13","author":"Huang","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00167-018-5186-x","article-title":"More tendon degeneration in patients with shoulder osteoarthritis","volume":"27","author":"Ibrahim","year":"2019","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"B37","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1080\/03008207.2016.1240790","article-title":"Autophagy in osteoarthritis","volume":"58","author":"Jeon","year":"2017","journal-title":"Connect. Tissue Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1016\/j.bioactmat.2021.01.031","article-title":"Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration","volume":"6","author":"Jiang","year":"2021","journal-title":"Bioact. Mater."},{"key":"B39","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.bone.2010.09.010","article-title":"Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats","volume":"48","author":"Jiao","year":"2011","journal-title":"Bone"},{"key":"B40","doi-asserted-by":"publisher","first-page":"105946","DOI":"10.1016\/j.intimp.2019.105946","article-title":"Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2","volume":"78","author":"Jin","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.3349\/ymj.2013.54.5.1293","article-title":"Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy","volume":"54","author":"Jung","year":"2013","journal-title":"Yonsei Med. J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.3389\/fimmu.2020.01051","article-title":"Interleukin 35-producing exosomes suppress neuroinflammation and autoimmune uveitis","volume":"11","author":"Kang","year":"2020","journal-title":"Front. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.yjmcc.2011.02.003","article-title":"Identification of targeting peptides for ischemic myocardium by in vivo phage display","volume":"50","author":"Kanki","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"R163","DOI":"10.1186\/ar4679","article-title":"Exosomes from IL-1\u03b2 stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes","volume":"16","author":"Kato","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"B45","doi-asserted-by":"publisher","first-page":"13854","DOI":"10.1038\/s41598-019-50435-2","article-title":"Therapeutic effect of mesenchymal stem cells derived from human umbilical cord in rabbit temporomandibular joint model of osteoarthritis","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.biomaterials.2015.09.040","article-title":"Therapeutic effects of neuropeptide substance P coupled with self-assembled peptide nanofibers on the progression of osteoarthritis in a rat model","volume":"74","author":"Kim","year":"2016","journal-title":"Biomaterials"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e2000082","DOI":"10.1002\/biot.202000082","article-title":"Mesenchymal stem cell-derived exosomes for effective cartilage tissue repair and treatment of osteoarthritis","volume":"15","author":"Kim","year":"2020","journal-title":"Biotechnol. J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.stem.2009.01.015","article-title":"Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis","volume":"4","author":"Koelling","year":"2009","journal-title":"Cell Stem Cell"},{"key":"B49","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.knee.2012.04.001","article-title":"Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis","volume":"19","author":"Koh","year":"2012","journal-title":"Knee"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1038\/s41598-017-01905-y","article-title":"Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis","volume":"7","author":"Kolhe","year":"2017","journal-title":"Sci. Rep."},{"key":"B51","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/s41590-020-0741-2","article-title":"The mesenchymal context in inflammation, immunity and cancer","volume":"21","author":"Koliaraki","year":"2020","journal-title":"Nat. Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.lfs.2011.09.005","article-title":"Pluripotency of mesenchymal cells derived from synovial fluid in patients with temporomandibular joint disorder","volume":"89","author":"Koyama","year":"2011","journal-title":"Life Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1634\/stemcells.2005-0008","article-title":"Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells","volume":"24","author":"Krampera","year":"2006","journal-title":"Stem Cells Dayt. Ohio)"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1177\/0022034511415275","article-title":"Effect of mechanical loading on electrical conductivity in porcine TMJ discs","volume":"90","author":"Kuo","year":"2011","journal-title":"J. Dent. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e47559","DOI":"10.1371\/journal.pone.0047559","article-title":"Safe ty of cell therapy with mesenchymal stromal cells (safecell): A systematic review and meta-analysis of clinical trials","volume":"7","author":"Lalu","year":"2012","journal-title":"PLoS ONE"},{"key":"B56","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1177\/00220345211059079","article-title":"Inhibiting hh signaling in Gli1+ osteogenic progenitors alleviates TMJOA","volume":"101","author":"Lei","year":"2022","journal-title":"J. Dent. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.omtn.2019.11.034","article-title":"The MSC-derived exosomal lncRNA H19 promotes wound healing in diabetic foot ulcers by upregulating PTEN via MicroRNA-152-3p","volume":"19","author":"Li","year":"2020","journal-title":"Mol. Ther. - Nucleic Acids"},{"key":"B58","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.jconrel.2022.08.002","article-title":"Overcoming the blood-brain barrier: Exosomes as theranostic nanocarriers for precision neuroimaging","volume":"349","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"key":"B59","doi-asserted-by":"publisher","first-page":"10872","DOI":"10.1038\/ncomms10872","article-title":"Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1002\/hep.25722","article-title":"Immediate intraportal transplantation of human bone marrow mesenchymal stem cells prevents death from fulminant hepatic failure in pigs","volume":"56","author":"Li","year":"2012","journal-title":"Hepatology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12943-019-0948-8","article-title":"Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis","volume":"18","author":"Li","year":"","journal-title":"Mol. Cancer"},{"key":"B62","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3389\/fphar.2019.00015","article-title":"Potential novel prediction of TMJ-OA: MiR-140-5p regulates inflammation through smad\/TGF-\u03b2 signaling","volume":"10","author":"Li","year":"","journal-title":"Front. Pharmacol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"eabf3002","DOI":"10.1126\/science.abf3002","article-title":"Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring","volume":"373","author":"Lim","year":"2021","journal-title":"Sci. (New York, N.Y.)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13075-022-02738-5","article-title":"Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis","volume":"24","author":"Liu","year":"","journal-title":"Arthritis Res. Ther."},{"key":"B65","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/joor.13261","article-title":"Effect of platelet-rich plasma injection combined with individualised comprehensive physical therapy on temporomandibular joint osteoarthritis: A prospective cohort study","volume":"49","author":"Liu","year":"","journal-title":"J. Oral Rehabil."},{"key":"B66","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3892\/ijmm.2016.2832","article-title":"IL-1\u03b2 impedes the chondrogenic differentiation of synovial fluid mesenchymal stem cells in the human temporomandibular joint","volume":"39","author":"Liu","year":"","journal-title":"Int. J. Mol. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/jor.24525","article-title":"Extracellular vesicles released from articular chondrocytes play a major role in cell-cell communication","volume":"38","author":"Liu","year":"2020","journal-title":"J. Orthop. Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1186\/s13018-019-1529-7","article-title":"Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt\/\u03b2-catenin signaling pathway","volume":"14","author":"Liu","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"4430","DOI":"10.1039\/c7nr00352h","article-title":"Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration","volume":"9","author":"Liu","year":"","journal-title":"Nanoscale"},{"key":"B70","doi-asserted-by":"publisher","first-page":"25465","DOI":"10.3402\/jev.v3.25465","article-title":"Effect of storage on physical and functional properties of extracellular vesicles derived from neutrophilic granulocytes","volume":"3","author":"L\u0151rincz","year":"2014","journal-title":"J. Extracell. Vesicles"},{"key":"B71","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nrrheum.2011.109","article-title":"Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA","volume":"7","author":"Lotz","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1177\/0022034515604621","article-title":"RANTES and SDF-1 are keys in cell-based therapy of TMJ osteoarthritis","volume":"94","author":"Lu","year":"2015","journal-title":"J. Dent. Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13287-019-1341-7","article-title":"Exosomes of stem cells from human exfoliated deciduous teeth as an anti-inflammatory agent in temporomandibular joint chondrocytes via miR-100-5p\/mTOR","volume":"10","author":"Luo","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/3290372","article-title":"MicroRNA-132, delivered by mesenchymal stem cell-derived exosomes, promote angiogenesis in myocardial infarction","volume":"2018","author":"Ma","year":"2018","journal-title":"Stem Cells Int."},{"key":"B75","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jconrel.2017.06.031","article-title":"Microneedles enhance topical delivery of 15-deoxy-\u0394 12, 14 -prostaglandin J 2 and reduce nociception in temporomandibular joint of rats","volume":"265","author":"Macedo","year":"2017","journal-title":"J. Control. Release"},{"key":"B76","first-page":"1323","article-title":"A pilot study of tumor necrosis factor inhibition in erosive\/inflammatory osteoarthritis of the hands","volume":"34","author":"Magnano","year":"2007","journal-title":"J. Rheumatol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.jcyt.2014.12.004","article-title":"Safety and biodistribution study of bone marrow-derived mesenchymal stromal cells and mononuclear cells and the impact of the administration route in an intact porcine model","volume":"17","author":"M\u00e4kel\u00e4","year":"2015","journal-title":"Cytotherapy"},{"key":"B78","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s13287-018-1004-0","article-title":"Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A","volume":"9","author":"Mao","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.joca.2022.05.006","article-title":"Stem cell-based therapies for temporomandibular joint osteoarthritis and regeneration of cartilage\/osteochondral defects: A systematic review of preclinical experiments","volume":"30","author":"Matheus","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"B80","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1161\/CIRCRESAHA.118.312420","article-title":"Exosomal microRNA-21-5p mediates mesenchymal stem cell paracrine effects on human cardiac tissue contractility","volume":"122","author":"Mayourian","year":"2018","journal-title":"Circ. Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/joor.12649","article-title":"Th1\/Th17\/Th22 immune response and their association with joint pain, imagenological bone loss, rankl expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report","volume":"45","author":"Monasterio","year":"2018","journal-title":"J. Oral Rehabil."},{"key":"B153","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.cmet.2019.07.011","article-title":"Extracellular miRNAs: From biomarkers to mediators of physiology and disease","volume":"30","author":"Mori","year":"2019","journal-title":"Cell Metab."},{"key":"B82","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/s41419-019-1739-2","article-title":"The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1\u03b2 production of macrophages and aggravated synovitis in osteoarthritis","volume":"10","author":"Ni","year":"2019","journal-title":"Cell Death Dis."},{"key":"B83","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1002\/bit.27982","article-title":"Evaluating potential of tissue-engineered cryogels and chondrocyte derived exosomes in articular cartilage repair","volume":"119","author":"Nikhil","year":"2022","journal-title":"Biotechnol. Bioeng."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/j.joca.2021.08.005","article-title":"Effects of mechanical stress and deficiency of dihydrotestosterone or 17\u03b2-estradiol on Temporomandibular Joint Osteoarthritis in mice","volume":"29","author":"Ootake","year":"2021","journal-title":"Osteoarthr. Cartil."},{"key":"B85","doi-asserted-by":"publisher","first-page":"584050","DOI":"10.3389\/fbioe.2020.584050","article-title":"Characterization and chondroprotective effects of extracellular vesicles from plasma- and serum-based autologous blood-derived products for osteoarthritis therapy","volume":"8","author":"Otahal","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s10753-020-01310-0","article-title":"Yohimbine ameliorates temporomandibular joint chondrocyte inflammation with suppression of NF-\u03baB pathway","volume":"44","author":"Ou","year":"2021","journal-title":"Inflammation"},{"key":"B87","doi-asserted-by":"publisher","first-page":"6328","DOI":"10.1073\/pnas.0914843107","article-title":"Functional delivery of viral miRNAs via exosomes","volume":"107","author":"Pegtel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B88","doi-asserted-by":"publisher","first-page":"4336","DOI":"10.1093\/eurheartj\/ehab249","article-title":"STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: A link between innate immunity and chronic inflammation caused by lifestyle-related diseases","volume":"42","author":"Pham","year":"2021","journal-title":"Eur. Heart J."},{"key":"B89","doi-asserted-by":"publisher","first-page":"836","DOI":"10.7150\/ijbs.14809","article-title":"Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells repair critical-sized bone defects through enhanced angiogenesis and osteogenesis in osteoporotic rats","volume":"12","author":"Qi","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1136\/annrheumdis-2016-210426","article-title":"CCL2\/CCR2, but not CCL5\/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis","volume":"76","author":"Raghu","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"B91","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/sj.leu.2404132","article-title":"Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: Evidence for horizontal transfer of mRNA and protein delivery","volume":"20","author":"Ratajczak","year":"2006","journal-title":"Leukemia"},{"key":"B92","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.joca.2015.10.017","article-title":"Insulin decreases autophagy and leads to cartilage degradation","volume":"24","author":"Ribeiro","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.joca.2010.07.008","article-title":"Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI","volume":"18","author":"Roemer","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"B155","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jconrel.2017.07.001","article-title":"Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases","volume":"262","author":"Rufino-Ramos","year":"2017","journal-title":"J. Control. Release"},{"key":"B94","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.joca.2005.07.012","article-title":"Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes","volume":"13","author":"Sanchez","year":"2005","journal-title":"Osteoarthr. Cartil."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.3390\/ijms23052861","article-title":"Isolation of platelet-derived exosomes from human platelet-rich plasma: Biochemical and morphological characterization","volume":"23","author":"Saumell-Esnaola","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41574-019-0230-6","article-title":"The endocrine function of adipose tissues in health and cardiometabolic disease","volume":"15","author":"Scheja","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1242\/dev.112714","article-title":"Enthesis fibrocartilage cells originate from a population of Hedgehog-responsive cells modulated by the loading environment","volume":"142","author":"Schwartz","year":"2015","journal-title":"Development"},{"key":"B98","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1056\/NEJMra0802472","article-title":"Temporomandibular disorders","volume":"359","author":"Scrivani","year":"2008","journal-title":"N. Engl. J. Med. Overseas. Ed."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.joms.2021.01.038","article-title":"Temporomandibular joint arthrocentesis and microfragmented adipose tissue injection for the treatment of internal derangement and osteoarthritis: A randomized clinical trial","volume":"79","author":"Sembronio","year":"2021","journal-title":"J. Oral Maxillofac. Surg."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1002\/jor.20402","article-title":"Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering","volume":"25","author":"Siddappa","year":"2007","journal-title":"J. Orthop. Res."},{"key":"B101","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1182\/blood-2005-07-2793","article-title":"Interferon-gamma-stimulated marrow stromal cells: A new type of nonhematopoietic antigen-presenting cell","volume":"107","author":"Stagg","year":"2006","journal-title":"Blood"},{"key":"B102","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.joca.2014.03.011","article-title":"Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress","volume":"22","author":"Su","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1002\/stem.68","article-title":"Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans","volume":"27","author":"Sun","year":"2009","journal-title":"Stem Cells"},{"key":"B104","doi-asserted-by":"publisher","first-page":"16015","DOI":"10.1038\/celldisc.2016.15","article-title":"Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity","volume":"2","author":"Sun","year":"2016","journal-title":"Cell Discov."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1007\/s10753-020-01227-8","article-title":"The fibroblast-like synoviocyte derived exosomal long non-coding RNA H19 alleviates osteoarthritis progression through the miR-106b-5p\/TIMP2 Axis","volume":"43","author":"Tan","year":"2020","journal-title":"Inflammation"},{"key":"B106","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1177\/154405910808700406","article-title":"Degenerative disorders of the temporomandibular joint: Etiology, diagnosis, and treatment","volume":"87","author":"Tanaka","year":"2008","journal-title":"J. Dent. Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"8185","DOI":"10.2147\/IJN.S336062","article-title":"Comparison of curative effect of human umbilical cord-derived mesenchymal stem cells and their small extracellular vesicles in treating osteoarthritis","volume":"16","author":"Tang","year":"","journal-title":"Int. J. Nanomedicine"},{"key":"B108","doi-asserted-by":"publisher","first-page":"151796","DOI":"10.1016\/j.acthis.2021.151796","article-title":"Bone marrow mesenchymal stem cell-derived exosomes inhibit chondrocyte apoptosis and the expression of MMPs by regulating Drp1-mediated mitophagy","volume":"123","author":"Tang","year":"","journal-title":"Acta Histochem."},{"key":"B109","doi-asserted-by":"publisher","first-page":"180","DOI":"10.7150\/thno.17133","article-title":"Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"key":"B110","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1146\/annurev.immunol.20.100301.064753","article-title":"RANK-L and RANK: T cells, bone loss, and mammalian evolution","volume":"20","author":"Theill","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"B111","first-page":"1347","article-title":"Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: A randomized double blind controlled 3 month clinical trial","volume":"28","author":"Thie","year":"2001","journal-title":"J. Rheumatol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/7197598","article-title":"Extracellular vesicles from adipose-derived mesenchymal stem cells downregulate senescence features in osteoarthritic osteoblasts","volume":"2017","author":"Tofi\u00f1o-Vian","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B113","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.knee.2010.03.001","article-title":"Treatment of osteoarthritis with infrapatellar fat pad derived mesenchymal stem cells in Rabbit","volume":"18","author":"Toghraie","year":"2011","journal-title":"Knee"},{"key":"B114","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/sj.bdj.4802982","article-title":"Osteoarthrosis of the mandibular condyle","volume":"134","author":"Toller","year":"1973","journal-title":"Br. Dent. J."},{"key":"B115","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.joca.2012.06.003","article-title":"Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture","volume":"20","author":"van Buul","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"B117","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/s41419-022-05089-w","article-title":"Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression","volume":"13","author":"Varela-Eir\u00edn","year":"2022","journal-title":"Cell Death Dis."},{"key":"B118","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s13287-020-01594-x","article-title":"Intra-articular delivery of extracellular vesicles secreted by chondrogenic progenitor cells from MRL\/MpJ superhealer mice enhances articular cartilage repair in a mouse injury model","volume":"11","author":"Wang","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"B119","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00441-020-03319-1","article-title":"TGF-\u03b21-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6","volume":"384","author":"Wang","year":"2021","journal-title":"Cell Tissue Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"e008737","DOI":"10.1161\/JAHA.118.008737","article-title":"Engineered exosomes with ischemic myocardium-targeting peptide for targeted therapy in myocardial infarction","volume":"7","author":"Wang","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"B121","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/iub.2414","article-title":"ATF4-modified serum exosomes derived from osteoarthritic mice inhibit osteoarthritis by inducing autophagy","volume":"73","author":"Wang","year":"","journal-title":"IUBMB Life"},{"key":"B122","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s10565-020-09559-9","article-title":"Exosomes derived from miR-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes","volume":"37","author":"Wang","year":"","journal-title":"Cell Biol. Toxicol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"e10088","DOI":"10.1371\/journal.pone.0010088","article-title":"A new mesenchymal stem cell (MSC) paradigm: Polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype","volume":"5","author":"Waterman","year":"2010","journal-title":"PloS One"},{"key":"B124","doi-asserted-by":"publisher","first-page":"5099","DOI":"10.1021\/acsnano.0c01860","article-title":"Visceral adipose tissue derived exosomes exacerbate colitis severity via pro-inflammatory MiRNAs in high fat diet fed mice","volume":"14","author":"Wei","year":"2020","journal-title":"ACS Nano"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1177\/0022034517717485","article-title":"Glycosylation of DMP1 is essential for chondrogenesis of condylar cartilage","volume":"96","author":"Weng","year":"2017","journal-title":"J. Dent. Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"e46425","DOI":"10.1371\/journal.pone.0046425","article-title":"In vivo tumorigenesis was observed after injection of in vitro expanded neural crest stem cells isolated from adult bone marrow","volume":"7","author":"Wislet-Gendebien","year":"2012","journal-title":"PloS One"},{"key":"B127","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.biomaterials.2019.03.022","article-title":"miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis","volume":"206","author":"Wu","year":"2019","journal-title":"Biomaterials"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1089\/ten.TEA.2010.0517","article-title":"Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation","volume":"17","author":"Wu","year":"2011","journal-title":"Tissue Eng. Part A"},{"key":"B129","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/cells10020251","article-title":"Osteoarthritic subchondral bone release exosomes that promote cartilage degeneration","volume":"10","author":"Wu","year":"2021","journal-title":"Cells"},{"key":"B130","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41368-022-00187-z","article-title":"Exosomes rewire the cartilage microenvironment in osteoarthritis: From intercellular communication to therapeutic strategies","volume":"14","author":"Wu","year":"2022","journal-title":"Int. J. Oral Sci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1038\/cr.2017.62","article-title":"Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity","volume":"27","author":"Xu","year":"2017","journal-title":"Cell Res."},{"key":"B132","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1002\/art.11233","article-title":"Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho)","volume":"48","author":"Xu","year":"2003","journal-title":"Arthritis Rheum."},{"key":"B133","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10616-018-0264-y","article-title":"Tenocyte-derived exosomes induce the tenogenic differentiation of mesenchymal stem cells through TGF-\u03b2","volume":"71","author":"Xu","year":"2019","journal-title":"Cytotechnology"},{"key":"B134","doi-asserted-by":"publisher","first-page":"120539","DOI":"10.1016\/j.biomaterials.2020.120539","article-title":"Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration","volume":"269","author":"Xu","year":"2021","journal-title":"Biomaterials"},{"key":"B135","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1055\/s-0040-1709170","article-title":"Efficacy of platelet-rich plasma for low back pain: A systematic review and meta-analysis","volume":"81","author":"Xuan","year":"2020","journal-title":"J. Neurol. Surg. A. Cent. Eur. Neurosurg."},{"key":"B136","doi-asserted-by":"publisher","first-page":"116733","DOI":"10.1016\/j.lfs.2019.116733","article-title":"Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment","volume":"233","author":"Yaghoubi","year":"2019","journal-title":"Life Sci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/odi.12141","article-title":"Genome-wide association study of degenerative bony changes of the temporomandibular joint","volume":"20","author":"Yamaguchi","year":"2014","journal-title":"Oral Dis."},{"key":"B138","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.archoralbio.2014.05.024","article-title":"Decreased bone marrow stromal cells activity involves in unilateral anterior crossbite-induced early subchondral bone loss of temporomandibular joints","volume":"59","author":"Yang","year":"2014","journal-title":"Archives Oral Biol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41551-019-0485-1","article-title":"Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation","volume":"4","author":"Yang","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/jcb.25394","article-title":"Macrophage-associated osteoactivin\/GPNMB mediates mesenchymal stem cell survival, proliferation, and migration via a CD44-dependent mechanism","volume":"17","author":"Yu","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"B141","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3390\/membranes12020225","article-title":"Hypoxia-preconditioned extracellular vesicles from mesenchymal stem cells improve cartilage repair in osteoarthritis","volume":"12","author":"Zhang","year":"","journal-title":"Membranes"},{"key":"B142","doi-asserted-by":"publisher","first-page":"121169","DOI":"10.1016\/j.biomaterials.2021.121169","article-title":"Injectable Mussel-Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration","volume":"278","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/j.joca.2017.05.007","article-title":"Matrix replenishing by BMSCs is beneficial for osteoarthritic temporomandibular joint cartilage","volume":"25","author":"Zhang","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"B144","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.biomaterials.2017.11.028","article-title":"MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity","volume":"156","author":"Zhang","year":"2018","journal-title":"Biomaterials"},{"key":"B145","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.biomaterials.2019.02.006","article-title":"MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis","volume":"200","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"B146","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12951-022-01245-8","article-title":"Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis","volume":"20","author":"Zhang","year":"","journal-title":"J. Nanobiotechnology"},{"key":"B147","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41413-018-0027-6","article-title":"Aberrant activation of latent transforming growth factor-\u03b2 initiates the onset of temporomandibular joint osteoarthritis","volume":"6","author":"Zheng","year":"2018","journal-title":"Bone Res."},{"key":"B148","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.2217\/nnm-2018-0498","article-title":"Primary chondrocyte exosomes mediate osteoarthritis progression by regulating mitochondrion and immune reactivity","volume":"14","author":"Zheng","year":"2019","journal-title":"Nanomedicine Lond. Engl."},{"key":"B149","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.actbio.2020.01.040","article-title":"The dual character of exosomes in osteoarthritis: Antagonists and therapeutic agents","volume":"105","author":"Zhou","year":"","journal-title":"Acta Biomater."},{"key":"B150","doi-asserted-by":"publisher","first-page":"8197","DOI":"10.7150\/thno.43968","article-title":"Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice","volume":"10","author":"Zhou","year":"","journal-title":"Theranostics"},{"key":"B151","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41420-021-00418-y","article-title":"Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis","volume":"7","author":"Zhou","year":"2021","journal-title":"Cell Death Discov."},{"key":"B152","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13287-017-0510-9","article-title":"Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis","volume":"8","author":"Zhu","year":"2017","journal-title":"Stem Cell Res. Ther."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.1074536\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T04:33:32Z","timestamp":1669350812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.1074536\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":157,"alternative-id":["10.3389\/fbioe.2022.1074536"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2022.1074536","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,25]]},"article-number":"1074536"}}