{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:55:12Z","timestamp":1791910512872,"version":"4.3.4"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Hippocampal injury is common in traumatic brain injury (TBI) patients, but the underlying pathogenesis remains elusive. In this study, we hypothesize that the presence of the adjacent fluid-containing temporal horn exacerbates the biomechanical vulnerability of the hippocampus. Two finite element models of the human head were used to investigate this hypothesis, one with and one without the temporal horn, and both including a detailed hippocampal subfield delineation. A fluid-structure interaction coupling approach was used to simulate the brain-ventricle interface, in which the intraventricular cerebrospinal fluid was represented by an arbitrary Lagrangian-Eulerian multi-material formation to account for its fluid behavior. By comparing the response of these two models under identical loadings, the model that included the temporal horn predicted increased magnitudes of strain and strain rate in the hippocampus with respect to its counterpart without the temporal horn. This specifically affected cornu ammonis (CA) 1 (CA1), CA2\/3, hippocampal tail, subiculum, and the adjacent amygdala and ventral diencephalon. These computational results suggest that the presence of the temporal horn exacerbate the vulnerability of the hippocampus, highlighting the mechanobiological dependency of the hippocampus on the temporal horn.<\/jats:p>","DOI":"10.3389\/fbioe.2022.754344","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T17:31:23Z","timestamp":1648402283000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["The Presence of the Temporal Horn Exacerbates the Vulnerability of Hippocampus During Head Impacts"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhou","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August G.","family":"Domel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Georgiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svein","family":"Kleiven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Camarillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zeineh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3171\/jns.2004.100.1.0111","article-title":"Tensile Strength of Cranial Pia Mater: Preliminary Results","volume":"100","author":"Aimedieu","year":"2004","journal-title":"J. Neurosurg."},{"key":"B2","volume-title":"The hippocampus Book","author":"Amaral","year":"2007"},{"key":"B3","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1089\/089771503770195812","article-title":"Impact Mechanics and Axonal Injury in a Sheep Model","volume":"20","author":"Anderson","year":"2003","journal-title":"J. Neurotrauma"},{"key":"B4","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1007\/s10439-018-1988-8","article-title":"Human Brain Modeling with its Anatomical Structure and Realistic Material Properties for Brain Injury Prediction","volume":"46","author":"Atsumi","year":"2018","journal-title":"Ann. Biomed. Eng."},{"key":"B5","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1089\/neu.1997.14.385","article-title":"Neuronal Cell Loss in the CA3 Subfield of the hippocampus Following Cortical Contusion Utilizing the Optical Disector Method for Cell Counting","volume":"14","author":"Baldwin","year":"1997","journal-title":"J. Neurotrauma"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1177\/0954411911420002","article-title":"Computational Model of an Infant Brain Subjected to Periodic Motion Simplified Modelling and Bayesian Sensitivity Analysis","volume":"225","author":"Batterbee","year":"2011","journal-title":"Proc. Inst. Mech. Eng. H"},{"key":"B7","first-page":"255","article-title":"Temporal Lobe Morphology in normal Aging and Traumatic Brain Injury","volume":"23","author":"Bigler","year":"2002","journal-title":"AJNR Am. J. Neuroradiol"},{"key":"B8","first-page":"11","article-title":"Hippocampal Volume in normal Aging and Traumatic Brain Injury","volume":"18","author":"Bigler","year":"1997","journal-title":"AJNR Am. J. Neuroradiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1097\/00004424-200109000-00006","article-title":"Brain Volume, Intracranial Volume, and Dementia","volume":"36","author":"Bigler","year":"2001","journal-title":"Invest. Radiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nrn2335","article-title":"The hippocampus and Memory: Insights from Spatial Processing","volume":"9","author":"Bird","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B11","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/978-3-7091-9115-6_93","article-title":"Changes in Extracellular Glutamate Concentration after Acute Subdural Haematoma in the Rat - Evidence for an \u201cExcitotoxic\u201d Mechanism","volume-title":"Brain Edema VIII","author":"Bullock","year":"1990"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1007\/s10439-013-0801-y","article-title":"An Instrumented Mouthguard for Measuring Linear and Angular Head Impact Kinematics in American Football","volume":"41","author":"Camarillo","year":"2013","journal-title":"Ann. Biomed. Eng."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1089\/neu.2011.2168","article-title":"Trends in the Incidence of Physician-Diagnosed Mild Traumatic Brain Injury Among Active Duty U.S. Military Personnel between 1997 and 2007","volume":"29","author":"Cameron","year":"2012","journal-title":"J. Neurotrauma"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1016\/j.jbiomech.2005.09.023","article-title":"Temporal Development of Hippocampal Cell Death Is Dependent on Tissue Strain but Not Strain Rate","volume":"39","author":"Cater","year":"2006","journal-title":"J. Biomech."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1007\/s10439-021-02853-5","article-title":"Identifying Factors Associated with Head Impact Kinematics and Brain Strain in High School American Football via Instrumented Mouthguards","volume":"49","author":"Cecchi","year":"2021","journal-title":"Ann. Biomed. Eng."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/2017.10.JNS17352","article-title":"Estimating the Global Incidence of Traumatic Brain Injury","volume":"130","author":"Dewan","year":"2018","journal-title":"J. Neurosurg."},{"key":"B17","doi-asserted-by":"publisher","first-page":"7501","DOI":"10.1038\/s41598-021-87085-2","article-title":"A New Open-Access Platform for Measuring and Sharing mTBI Data","volume":"11","author":"Domel","year":"2021","journal-title":"Scientific Reports"},{"key":"B18","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1126\/science.2567056","article-title":"The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury","volume":"244","author":"Faden","year":"1989","journal-title":"Science"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0361-9230(99)00012-x","article-title":"Stereotaxic Atlas of the Pig Brain","volume":"49","author":"F\u00e9lix","year":"1999","journal-title":"Brain Res. Bull."},{"key":"B20","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fnagi.2015.00044","article-title":"Age-specific MRI Brain and Head Templates for Healthy Adults from 20 through 89 Years of Age","volume":"7","author":"Fillmore","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"NeuroImage"},{"key":"B22","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1007\/s10439-018-2015-9","article-title":"Development of a Metric for Predicting Brain Strain Responses Using Head Kinematics","volume":"46","author":"Gabler","year":"2018","journal-title":"Ann. Biomed. Eng."},{"key":"B23","first-page":"160","article-title":"Traumatic Brain Injury and Temporal Horn Enlargement: Correlates with Tests of Intelligence and Memory","volume":"7","author":"Gale","year":"1994","journal-title":"Neuropsychiatry, Neuropsychol. Behav. Neurol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/ana.410120611","article-title":"Diffuse Axonal Injury and Traumatic Coma in the Primate","volume":"12","author":"Gennarelli","year":"1982","journal-title":"Ann. Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0022-510x(78)90124-7","article-title":"Ischaemic Brain Damage in Fatal Non-missile Head Injuries","volume":"39","author":"Graham","year":"1978","journal-title":"J. Neurol. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1136\/jnnp.52.3.346","article-title":"Ischaemic Brain Damage Is Still Common in Fatal Non-missile Head Injury","volume":"52","author":"Graham","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s10237-019-01273-8","article-title":"Embedded Axonal Fiber Tracts Improve Finite Element Model Predictions of Traumatic Brain Injury","volume":"19","author":"Hajiaghamemar","year":"2020","journal-title":"Biomech. Model. Mechanobiol"},{"key":"B28","volume-title":"LS-DYNA Keyword User\u2019s Manual","author":"Hallquist","year":"2007"},{"key":"B29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4271\/2007-22-0002","article-title":"A Study of the Response of the Human Cadaver Head to Impact","volume":"51","author":"Hardy","year":"2007","journal-title":"Stapp Car Crash J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1007\/s10439-014-1212-4","article-title":"Six Degree-Of-freedom Measurements of Human Mild Traumatic Brain Injury","volume":"43","author":"Hernandez","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"B31","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s004010050421","article-title":"Temporal and Spatial Characterization of Neuronal Injury Following Lateral Fluid-Percussion Brain Injury in the Rat","volume":"91","author":"Hicks","year":"1996","journal-title":"Acta Neuropathologica"},{"key":"B32","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jbiomech.2017.06.023","article-title":"The peculiar Properties of the Falx and Tentorium in Brain Injury Biomechanics","volume":"60","author":"Ho","year":"2017","journal-title":"J. Biomech."},{"key":"B33","volume-title":"Nonlinear Solid Mechanics II","author":"Holzapfel","year":"2000"},{"key":"B34","first-page":"871","article-title":"Hippocampal Formation","volume-title":"The Human Nervous System","author":"Insausti","year":"2003"},{"key":"B35","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1089\/neu.2013.3268","article-title":"Group-wise Evaluation and Comparison of white Matter Fiber Strain and Maximum Principal Strain in Sports-Related Concussion","volume":"32","author":"Ji","year":"2015","journal-title":"J. Neurotrauma"},{"key":"B36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-1-4939-3816-2_12","article-title":"Weight Drop Models in Traumatic Brain Injury","volume-title":"Injury Models of the central Nervous System","author":"Kalish","year":"2016"},{"key":"B37","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s10237-014-0622-4","article-title":"Functional Tolerance to Mechanical Deformation Developed from Organotypic Hippocampal Slice Cultures","volume":"14","author":"Kang","year":"2015","journal-title":"Biomech. Model. Mechanobiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"509","DOI":"10.4271\/2006-22-0019","article-title":"Investigation of Anteroposterior Head-Neck Responses during Severe Frontal Impacts Using a Brain-Spinal Cord Complex FE Model","volume":"50","author":"Kimpara","year":"2006","journal-title":"Stapp Car Crash J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"123","DOI":"10.4271\/2002-22-0007","article-title":"Correlation of an FE Model of the Human Head with Local Brain Motion--Consequences for Injury Prediction","volume":"46","author":"Kleiven","year":"2002","journal-title":"Stapp Car Crash J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"81","DOI":"10.4271\/2007-22-0003","article-title":"Predictors for Traumatic Brain Injuries Evaluated through Accident Reconstructions","volume":"51","author":"Kleiven","year":"2007","journal-title":"Stapp Car Crash J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1089\/neu.1991.8.247","article-title":"Selective Vulnerability of Hippocampal Neurons in Acceleration-Induced Experimental Head Injury","volume":"8","author":"Kotapka","year":"1991","journal-title":"J. Neurotrauma"},{"key":"B42","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/j.1365-2990.1993.tb00417.x","article-title":"Hippocampal Damage in Fatal Paediatric Head Injury","volume":"19","author":"Kotapka","year":"1993","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1089\/neu.1994.11.317","article-title":"Hippocampal Pathology in Fatal Human Head Injury without High Intracranial Pressure","volume":"11","author":"Kotapka","year":"1994","journal-title":"J. Neurotrauma"},{"key":"B44","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1007\/bf00310031","article-title":"Hippocampal Pathology in Fatal Non-missile Human Head Injury","volume":"83","author":"Kotapka","year":"1992","journal-title":"Acta Neuropathol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.euromechflu.2021.01.010","article-title":"Modelling of the Transient Cerebrospinal Fluid Flow under External Impacts","volume":"87","author":"Lang","year":"2021","journal-title":"Eur. J. Mechanics-B\/Fluids"},{"key":"B46","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/00001199-200505000-00001","article-title":"Preface","volume":"20","author":"Langlois","year":"2005","journal-title":"J. Head Trauma Rehabil."},{"key":"B47","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/s0306-4522(96)83003-x","article-title":"AMPA Receptors in the Rat and Primate hippocampus: a Possible Absence of GluR2\/3 Subunits in Most Interneurons","volume":"70","author":"Leranth","year":"1996","journal-title":"Neuroscience"},{"key":"B48","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s10237-020-01391-8","article-title":"An Anatomically Detailed and Personalizable Head Injury Model: Significance of Brain and white Matter Tract Morphological Variability on Strain","volume":"20","author":"Li","year":"2020","journal-title":"Biomech. Model. Mechanobiology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1007\/s10439-020-02629-3","article-title":"Validation and Comparison of Instrumented Mouthguards for Measuring Head Kinematics and Assessing Brain Deformation in Football Impacts","volume":"48","author":"Liu","year":"2020","journal-title":"Ann. Biomed. Eng."},{"key":"B50","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","article-title":"Traumatic Brain Injury: Integrated Approaches to Improve Prevention, Clinical Care, and Research","volume":"16","author":"Maas","year":"2017","journal-title":"Lancet Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"111002","DOI":"10.1115\/1.4025101","article-title":"Development of a Finite Element Human Head Model Partially Validated with Thirty Five Experimental Cases","volume":"135","author":"Mao","year":"2013","journal-title":"J. Biomech. Eng."},{"key":"B52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-642-04319-2_5","article-title":"Advances in Octree-Based All-Hexahedral Mesh Generation: Handling Sharp Features","volume-title":"Proceedings of the 18th International Meshing Roundtable","author":"Mar\u00e9chal","year":"2009"},{"key":"B53","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1093\/jnen\/62.3.272","article-title":"There Is Differential Loss of Pyramidal Cells from the Human hippocampus with Survival after blunt Head Injury","volume":"62","author":"Maxwell","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s10439-011-0402-6","article-title":"Maximum Principal Strain and Strain Rate Associated with Concussion Diagnosis Correlates with Changes in Corpus Callosum white Matter Indices","volume":"40","author":"Mcallister","year":"2012","journal-title":"Ann. Biomed. Eng."},{"key":"B55","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/bpa.12248","article-title":"The Neuropathology of Chronic Traumatic Encephalopathy","volume":"25","author":"Mckee","year":"2015","journal-title":"Brain Pathol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.jsams.2014.07.008","article-title":"The Underreporting of Self-Reported Symptoms Following Sports-Related Concussion","volume":"18","author":"Meier","year":"2015","journal-title":"J. Sci. Med. Sport"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s10237-015-0754-1","article-title":"Development and Validation of an Atlas-Based Finite Element Brain Model","volume":"15","author":"Miller","year":"2016","journal-title":"Biomech. Model. Mechanobiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"116864","DOI":"10.1016\/j.neuroimage.2020.116864","article-title":"Longitudinal Alteration of Cortical Thickness and Volume in High-Impact Sports","volume":"217","author":"Mills","year":"2020","journal-title":"NeuroImage"},{"key":"B59","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/bf00688181","article-title":"Changes in the hippocampus and the Cerebellum Resulting from Hypoxic Insults: Frequency and Distribution","volume":"78","author":"Ng","year":"1989","journal-title":"Acta Neuropathol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1007\/s10439-012-0519-2","article-title":"Development of a Finite Element Model for Blast Brain Injury and the Effects of CSF Cavitation","volume":"40","author":"Panzer","year":"2012","journal-title":"Ann. Biomed. Eng."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1089\/neu.2018.6357","article-title":"Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football","volume":"36","author":"Parivash","year":"2019","journal-title":"J. Neurotrauma"},{"key":"B62","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/s0028-3908(99)00019-2","article-title":"Memantine Is a Clinically Well Tolerated N-Methyl-D-Aspartate (NMDA) Receptor Antagonist-A Review of Preclinical Data","volume":"38","author":"Parsons","year":"1999","journal-title":"Neuropharmacology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1093\/neurosurgery\/53.3.799","article-title":"Concussion in Professional Football: Reconstruction of Game Impacts and Injuries","volume":"53","author":"Pellman","year":"2003","journal-title":"Neurosurgery"},{"key":"B64","first-page":"632","article-title":"3D Slicer","author":"Pieper","year":""},{"key":"B65","first-page":"29","article-title":"Selective Neuronal Vulnerability: Morphological and Molecular Characteristics","volume-title":"Progress in Brain Research","author":"Pulsinelli","year":"1985"},{"key":"B66","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nrneurol.2013.22","article-title":"Changing Patterns in the Epidemiology of Traumatic Brain Injury","volume":"9","author":"Roozenbeek","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1177\/0363546514530091","article-title":"National High School Athlete Concussion Rates from 2005-2006 to 2011-2012","volume":"42","author":"Rosenthal","year":"2014","journal-title":"Am. J. Sports Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1089\/08977150151070892","article-title":"A New Model for Diffuse Brain Injury by Rotational Acceleration: II. Effects on Extracellular Glutamate, Intracranial Pressure, and Neuronal Apoptosis","volume":"18","author":"Runnerstam","year":"2001","journal-title":"J. Neurotrauma"},{"key":"B69","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.clinbiomech.2018.02.019","article-title":"A Reanalysis of Football Impact Reconstructions for Head Kinematics and Finite Element Modeling","volume":"64","author":"Sanchez","year":"2019","journal-title":"Clin. Biomech."},{"key":"B70","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1073\/pnas.1222878110","article-title":"Genomic Responses in Mouse Models Poorly Mimic Human Inflammatory Diseases","volume":"110","author":"Seok","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1001\/jama.2014.3313","article-title":"Relationship of Collegiate Football Experience and Concussion with Hippocampal Volume and Cognitive Outcomes","volume":"311","author":"Singh","year":"2014","journal-title":"Jama"},{"key":"B72","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1097\/00005072-199756070-00009","article-title":"Characterization of Diffuse Axonal Pathology and Selective Hippocampal Damage Following Inertial Brain Trauma in the Pig","volume":"56","author":"Smith","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/s0045-7825(99)00432-6","article-title":"ALE Formulation for Fluid-Structure Interaction Problems","volume":"190","author":"Souli","year":"2000","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4271\/2008-22-0001","article-title":"Investigation of Traumatic Brain Injuries Using the Next Generation of Simulated Injury Monitor (SIMon) Finite Element Head Model","volume":"52","author":"Takhounts","year":"2008","journal-title":"Stapp Car Crash J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"105448","DOI":"10.1016\/j.ijmecsci.2020.105448","article-title":"Biofidelic Finite Element Modelling of Brain Trauma: Importance of the Scalp in Simulating Head Impact","volume":"173","author":"Trotta","year":"2020","journal-title":"Int. J. Mech. Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/0021-9991(79)90145-1","article-title":"Towards the Ultimate Conservative Difference Scheme. V. A Second-Order Sequel to Godunov's Method","volume":"32","author":"Van Leer","year":"1979","journal-title":"J. Comput. Phys."},{"key":"B77","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0142-9612(81)90086-7","article-title":"A Study of the Uniaxial Mechanical Properties of Human Dura Mater Preserved in Glycerol","volume":"2","author":"Van Noort","year":"1981","journal-title":"Biomaterials"},{"key":"B78","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1227\/01.neu.0000186950.54075.3b","article-title":"Concussion in Professional Football: Brain Responses by Finite Element Analysis: Part 9","volume":"57","author":"Viano","year":"2005","journal-title":"Neurosurgery"},{"key":"B79","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fnagi.2014.00261","article-title":"A Critical Appraisal of the Hippocampal Subfield Segmentation Package in FreeSurfer","volume":"6","author":"Wisse","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/hbm.25234","article-title":"Hippocampal Subfield Volumetry from Structural Isotropic 1 Mm 3 MRI Scans: A Note of Caution","volume":"42","author":"Wisse","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1089\/neu.2016.4848","article-title":"Concussion Induces Hippocampal Circuitry Disruption in Swine","volume":"34","author":"Wolf","year":"2017","journal-title":"J. Neurotrauma"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1089\/neu.2020.7445","article-title":"Evaluation of Tissue-Level Brain Injury Metrics Using Species-specific Simulations","volume":"38","author":"Wu","year":"2021","journal-title":"J. Neurotrauma"},{"key":"B83","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.neuroimage.2015.01.004","article-title":"Quantitative Comparison of 21 Protocols for Labeling Hippocampal Subfields and Parahippocampal Subregions in In Vivo MRI: towards a Harmonized Segmentation Protocol","volume":"111","author":"Yushkevich","year":"2015","journal-title":"Neuroimage"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s10237-017-0915-5","article-title":"Injury Prediction and Vulnerability Assessment Using Strain and Susceptibility Measures of the Deep white Matter","volume":"16","author":"Zhao","year":"2017","journal-title":"Biomech. Model. Mechanobiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s10439-018-02159-z","article-title":"Mesh Convergence Behavior and the Effect of Element Integration of a Human Head Injury Model","volume":"47","author":"Zhao","year":"2019","journal-title":"Ann. Biomed. Eng."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4271\/2019-22-0001","article-title":"Brain Strain from Motion of Sparse Markers","volume":"63","author":"Zhou","year":"","journal-title":"Stapp Car Crash J."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1089\/neu.2020.7412","article-title":"White Matter Tract-Oriented Deformation Is Dependent on Real-Time Axonal Fiber Orientation","volume":"38","author":"Zhou","year":"","journal-title":"J. Neurotrauma"},{"key":"B88","volume-title":"Evaluation of Fluid-Structure Interaction and Biofidelity of Finite Element Head Models","author":"Zhou","year":"2019"},{"key":"B89","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cmpb.2016.04.013","article-title":"Numerical Simulations of the 10-Year-Old Head Response in Drop Impacts and Compression Tests","volume":"131","author":"Zhou","year":"2016","journal-title":"Comput. Methods Programs Biomed."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1089\/neu.2018.6143","article-title":"Biomechanics of Acute Subdural Hematoma in the Elderly: A Fluid-Structure Interaction Study","volume":"36","author":"Zhou","year":"","journal-title":"J. Neurotrauma"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1089\/neu.2019.6634","article-title":"Biomechanics of Periventricular Injury","volume":"37","author":"Zhou","year":"","journal-title":"J. Neurotrauma"},{"key":"B92","doi-asserted-by":"publisher","first-page":"109787","DOI":"10.1016\/j.jbiomech.2020.109787","article-title":"Evaluation of Brain-Skull Interface Modelling Approaches on the Prediction of Acute Subdural Hematoma in the Elderly","volume":"105","author":"Zhou","year":"","journal-title":"J. Biomech."},{"key":"B93","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s10237-018-1074-z","article-title":"Fluid-structure Interaction Simulation of the Brain-Skull Interface for Acute Subdural Haematoma Prediction","volume":"18","author":"Zhou","year":"","journal-title":"Biomech. Model. Mechanobiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1089\/neu.2021.0195","article-title":"Toward a Comprehensive Delineation of White Matter Tract-Related Deformation","volume":"38","author":"Zhou","year":"","journal-title":"J. Neurotrauma"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.754344\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T17:31:32Z","timestamp":1648402292000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.754344\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":94,"alternative-id":["10.3389\/fbioe.2022.754344"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2022.754344","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.07.471634","asserted-by":"object"}]},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,22]]},"article-number":"754344"}}