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Bioeng. Biotechnol."],"abstract":"<jats:p>Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP) produced by senescent cells is found to remodel extracellular matrix (ECM) metabolism and destruct homeostasis. Elimination of senescent cells by senolytics and suppression of SASP production by senomorphics\/senostatics are effective strategies to alleviate degenerative diseases including IVDD. Here, we review the involvement of senescence in the process of IVDD; we also discuss the potential of senolytics on eliminating senescent disc cells and alleviating IVDD; finally, we provide a table listing senolytic drugs and small molecules, aiming to propose potential drugs for IVDD therapy in the future.<\/jats:p>","DOI":"10.3389\/fbioe.2022.823945","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T05:24:16Z","timestamp":1646198656000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration"],"prefix":"10.3389","volume":"10","author":[{"given":"Yuhao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naifeng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The Bcl-2 Protein Family: Arbiters of Cell Survival","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1097\/01.brs.0000231761.73859.2c","article-title":"What is Intervertebral Disc Degeneration, and what Causes it?","volume":"31","author":"Adams","year":"2006","journal-title":"Spine"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e13468","DOI":"10.1111\/acel.13468","article-title":"Inhibition of the cGAS\u2010STING Pathway Ameliorates the Premature Senescence Hallmarks of Ataxia\u2010Telangiectasia Brain Organoids","volume":"20","author":"Aguado","year":"2021","journal-title":"Aging Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1002\/jor.23583","article-title":"Age-related Reduction in the Expression of FOXO Transcription Factors and Correlations with Intervertebral Disc Degeneration","volume":"35","author":"Alvarez-Garcia","year":"2017","journal-title":"J. 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