{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:50:14Z","timestamp":1762660214948,"version":"3.41.2"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0105201 2021YFA1101300 2020YFA0112503"],"award-info":[{"award-number":["2017YFA0105201 2021YFA1101300 2020YFA0112503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030029 81970882 81800913 81974142"],"award-info":[{"award-number":["82030029 81970882 81800913 81974142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2021YFS0371"],"award-info":[{"award-number":["2021YFS0371"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017607","name":"Shenzhen Fundamental Research Program","doi-asserted-by":"publisher","award":["JCYJ20190814093401920 JCYJ20210324125608022"],"award-info":[{"award-number":["JCYJ20190814093401920 JCYJ20210324125608022"]}],"id":[{"id":"10.13039\/501100017607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Neural stem cell therapy has become a promising cure in the treatment of neurodegenerative disorders. Owing to the anisotropy of the nervous system, the newly derived neurons need not only the functional integrity but also the oriented growth to contact with the partner cells to establish functional connections. So the oriented growth of the newly derived neurons is a key factor in neural stem cell\u2013based nerve regeneration. Nowadays, various biomaterials have been applied to assist in the oriented growth of neural stem cell\u2013derived neurons. However, among these biomaterials, the magnetic materials applied in guiding the neuronal growth are still fewer than the other materials, such as the fibers. So in this work, we developed the magnetic nanochains to guide the oriented growth of neural stem cell\u2013derived neurons. With the guidance of the magnetic nanochains, the seeded neural stem cells exhibited a good arrangement, and the neural stem cell\u2013derived neurons showed well-oriented growth with the orientation of the nanochains. We anticipated that the magnetic nanochains would have huge potential in stem cell\u2013based nerve regeneration.<\/jats:p>","DOI":"10.3389\/fbioe.2022.895107","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T05:30:15Z","timestamp":1653283815000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Oriented Growth of Neural Stem Cell\u2013Derived Neurons Regulated by Magnetic Nanochains"],"prefix":"10.3389","volume":"10","author":[{"given":"Lin","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiming","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renjie","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/35094583","article-title":"Cytokines and Acute Neurodegeneration","volume":"2","author":"Allan","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2105239","DOI":"10.1002\/advs.202105239","article-title":"Glucose\u2010Sensing Photonic Nanochain Probes with Color Change in Seconds","volume":"9","author":"Cai","year":"2022","journal-title":"Adv. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2109145","DOI":"10.1002\/adma.202109145","article-title":"2D FeP Nanoframe Superlattices via Space\u2010Confined Topochemical Transformation","volume":"34","author":"Deng","year":"2022","journal-title":"Adv. Mater."},{"key":"B4","doi-asserted-by":"publisher","first-page":"64434","DOI":"10.1039\/c6ra10355c","article-title":"Autoclave-free Facile Approach to the Synthesis of Highly Tunable Nanocrystal Clusters for Magnetic Responsive Photonic Crystals","volume":"6","author":"Dong","year":"2016","journal-title":"RSC Adv."},{"key":"B5","doi-asserted-by":"publisher","first-page":"4316","DOI":"10.3390\/polym13244316","article-title":"Composite Materials Based on Iron Oxide Nanoparticles and Polyurethane for Improving the Quality of MRI","volume":"13","author":"Gradinaru","year":"2021","journal-title":"Polymers"},{"key":"B6","doi-asserted-by":"publisher","first-page":"339208","DOI":"10.1016\/j.aca.2021.339208","article-title":"Noble-metal-free Fe3O4\/Co3S4 Nanosheets with Oxygen Vacancies as an Efficient Electrocatalyst for Highly Sensitive Electrochemical Detection of As(III)","volume":"1189","author":"Huang","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03486-9","article-title":"Fe3O4@Au Core-Shell Hybrid Nanocomposite for MRI-Guided Magnetic Targeted Photo-Chemotherapy","author":"Khani","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1021\/acs.nanolett.7b04218","article-title":"Responsive Hydrogel-Based Photonic Nanochains for Microenvironment Sensing and Imaging in Real Time and High Resolution","volume":"20","author":"Luo","year":"2020","journal-title":"Nano Lett."},{"key":"B9","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.bioactmat.2021.05.039","article-title":"An Injectable, Self-Healing, Electroconductive Extracellular Matrix-Based Hydrogel for Enhancing Tissue Repair after Traumatic Spinal Cord Injury","volume":"7","author":"Luo","year":"2022","journal-title":"Bioact. Mater."},{"key":"B10","doi-asserted-by":"publisher","first-page":"16511","DOI":"10.1039\/d1nj02582a","article-title":"Robust Synthesis of Highly Charged Superparamagnetic Fe3O4 Colloidal Nanocrystal Clusters for Magnetically Responsive Photonic Crystals","volume":"45","author":"Pan","year":"2021","journal-title":"New J. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"20143","DOI":"10.1021\/acs.jpcc.1c05115","article-title":"Self-Assemblies of Nanocrystals in Tumor Cells: Controlling the Intracellular Fate, Manipulation, and Photothermal Effects","volume":"125","author":"Pileni","year":"2021","journal-title":"J. Phys. Chem. C"},{"key":"B12","doi-asserted-by":"publisher","first-page":"130906","DOI":"10.1016\/j.cej.2021.130906","article-title":"A Dual-Drug Enhanced Injectable Hydrogel Incorporated with Neural Stem Cells for Combination Therapy in Spinal Cord Injury","volume":"427","author":"Qi","year":"2022","journal-title":"Chem. Eng. J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.jcis.2021.12.012","article-title":"Core-shell Fe3O4@SnO2 Nanochains toward the Application of Radar-Infrared-Visible Compatible Stealth","volume":"609","author":"Qiao","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.1021\/acsanm.0c03328","article-title":"MoS2 Nanoflowers Decorated with Fe3O4\/Graphite Nanosheets for Controllable Electromagnetic Wave Absorption","volume":"4","author":"Qin","year":"2021","journal-title":"ACS Appl. Nano Mat."},{"key":"B15","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.lfs.2019.03.057","article-title":"Parkinson's Disease: Mechanisms, Translational Models and Management Strategies","volume":"226","author":"Raza","year":"2019","journal-title":"Life Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"151097","DOI":"10.1016\/j.ejcb.2020.151097","article-title":"Mesenchymal Stromal Cells (MSCs) for Neurodegenerative Disease: A Promising Frontier","volume":"99","author":"Shariati","year":"2020","journal-title":"Eur. J. Cell Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"121279","DOI":"10.1016\/j.biomaterials.2021.121279","article-title":"A DAMP-Scavenging, IL-10-releasing Hydrogel Promotes Neural Regeneration and Motor Function Recovery after Spinal Cord Injury","volume":"280","author":"Shen","year":"2022","journal-title":"Biomaterials"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1007\/s12035-016-9729-1","article-title":"Ghrelin and Neurodegenerative Disorders-A Review","volume":"54","author":"Shi","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"18021","DOI":"10.1021\/acs.jpcc.8b05967","article-title":"Instantaneous Magnetically Assembled and Hydrophilic Photonic Crystals with Controlled Diffraction Colors","volume":"122","author":"Tang","year":"2018","journal-title":"J. Phys. Chem. C"},{"key":"B20","doi-asserted-by":"publisher","first-page":"139060","DOI":"10.1016\/j.cplett.2021.139060","article-title":"Preparation Fe3O4@chitosan-Graphene Quantum Dots Nanocomposites for Fluorescence and Magnetic Resonance Imaging","volume":"783","author":"Wang","year":"2021","journal-title":"Chem. Phys. Lett."},{"key":"B21","doi-asserted-by":"publisher","first-page":"095601","DOI":"10.1088\/1361-6528\/ac3b0e","article-title":"Magnetically Induced Self-Assembly DNAzyme Electrochemical Biosensor Based on Gold-Modified \u03b1-Fe2O3\/Fe3O4 Heterogeneous Nanoparticles for Sensitive Detection of Ni2+","volume":"33","author":"Yu","year":"2022","journal-title":"Nanotechnology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1902198","DOI":"10.1002\/smll.201902198","article-title":"Super\u2010Elastic Magnetic Structural Color Hydrogels","volume":"15","author":"Zhang","year":"2019","journal-title":"Small"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.895107\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T05:30:19Z","timestamp":1653283819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.895107\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,23]]},"references-count":22,"alternative-id":["10.3389\/fbioe.2022.895107"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2022.895107","relation":{},"ISSN":["2296-4185"],"issn-type":[{"type":"electronic","value":"2296-4185"}],"subject":[],"published":{"date-parts":[[2022,5,23]]},"article-number":"895107"}}