{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:11:19Z","timestamp":1787497879769,"version":"build-2736575974"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    This study aimed to investigate the correlation of axial length\/corneal radius of curvature ratio with stress\u2013strain index (SSI).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Retrospective analysis was conducted to compare the right eyes of those with high myopia (HM, n = 132; age and 10\u201348\u00a0years) with those without high myopia (NHM, n = 135; age and 7\u201348 years), where the baseline axial length, corneal radius of curvature ratio, and central corneal thickness were analyzed; the differences in two groups were compared; and the relationship of axial length and axial length\/corneal radius of curvature ratio with SSI were explored.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Compared with AL &amp;lt; 26mm, SSI significantly decreased when AL \u2265 26\u00a0mm (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001), while there was no correlation with AL in the NHM group (\n                    <jats:italic>r<\/jats:italic>\n                    = -0.14,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.12) or HM group (\n                    <jats:italic>r<\/jats:italic>\n                    = -0.09,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.32). AL\/CR was significantly associated with SSI in both the NHM (\n                    <jats:italic>r<\/jats:italic>\n                    = -0.4,\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001) and HM (\n                    <jats:italic>r<\/jats:italic>\n                    = -0.18,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04) groups. In the NHM group, AL\/CR was significantly associated with SSI (unstandardized beta = -0.514, se = 0.109,\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001) with the adjustment of age and gender. Additionally, a significant association of SSI with AL\/CR was also found after adjusting for age and gender (unstandardized beta = -0.258, se = 0.096, and\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0082) in the HM group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    SSI showed a significant negative correlation with AL\/CR in patients without high myopia and in patients with high myopia. However, SSI exhibited no decrease with the worsening of myopia, but it gradually remained stable at a low level. The findings of this study validate, to some extent, the possibility of analyzing the dynamic changes in ocular wall stiffness during the development of myopia by measuring\n                    <jats:italic>in vivo<\/jats:italic>\n                    corneal biomechanical parameters.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2022.939129","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:46:09Z","timestamp":1660524369000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["The relationship between axial length\/corneal radius of curvature ratio and stress\u2013strain index in myopic eyeballs: Using Corvis ST tonometry"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhe","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjiao","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.1167\/iovs.04-0292","article-title":"Eye shape in emmetropia and myopia","volume":"45","author":"Atchison","year":"2004","journal-title":"Invest. 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