{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:41:16Z","timestamp":1791646876583,"version":"4.3.4"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    Melanoma is an aggressive type of skin cancer that accounts for over 75% of skin cancer deaths despite comprising less than 5% of all skin cancers. Despite promising improvements in surgical approaches for melanoma resection, the survival of undetectable microtumor residues has remained a concern. As a result, hyperthermia- and drug-based therapies have grown as attractive techniques to target and treat cancer. In this work, we aim to develop a stimuli-responsive hydrogel based on chitosan methacrylate (ChiMA), porcine small intestine submucosa methacrylate (SISMA), and doxorubicin-functionalized reduced graphene oxide (rGO-DOX) that eliminates microtumor residues from surgically resected melanoma through the coupled effect of NIR light-induced photothermal therapy and heat-induced doxorubicin release. Furthermore, we developed an\n                    <jats:italic>in silico<\/jats:italic>\n                    model to optimize heat and mass transport and evaluate the proposed chemo\/photothermal therapy\n                    <jats:italic>in vitro<\/jats:italic>\n                    over melanoma cell cultures.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2022.947616","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T12:12:13Z","timestamp":1657109533000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS\/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Daniela N.","family":"C\u00e9spedes-Valenzuela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"S\u00e1nchez-Renter\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cifuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul C.","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian A.","family":"Serna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rueda-Gensini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ostos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Mu\u00f1oz-Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1463814","DOI":"10.1080\/23311916.2018.1463814","article-title":"Computational Modeling of Drug Diffusion and Inductive Heating in an Implantable Biomedical Device for Localized Thermo-Chemotherapy of Cancer Cells\/tissue","volume":"5","author":"Ani","year":"2018","journal-title":"Cogent Eng."},{"key":"B2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/gels6020014","article-title":"Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery","volume":"6","author":"Askari","year":"2020","journal-title":"Gels"},{"key":"B3","doi-asserted-by":"publisher","first-page":"254","DOI":"10.3390\/polym10030254","article-title":"Assessing Mucoadhesion in Polymer Gels: The Effect of Method Type and Instrument Variables","volume":"10","author":"da Silva","year":"2018","journal-title":"Polymers"},{"key":"B4","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nrm2636","article-title":"Epidermal Homeostasis: a Balancing Act of Stem Cells in the Skin","volume":"10","author":"Blanpain","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.thromres.2004.05.010","article-title":"Methyl-methacrylate Bone Cement Surface Does Not Promote Platelet Aggregation or Plasma Coagulation in Vitro","volume":"114","author":"Blinc","year":"2004","journal-title":"Thrombosis Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s41598-018-36617-4","article-title":"Graphene Oxide as a Multifunctional Platform for Intracellular Delivery, Imaging, and Cancer Sensing","volume":"9","author":"Campbell","year":"2019","journal-title":"Sci. Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.21533\/pen.v5i2.139","article-title":"Raman and FT-IR Spectra, DFT and SQMFF Calculations for N,N-Dimethylaniline","volume":"5","author":"\u00c7at\u0131kka\u015f","year":"2017","journal-title":"Periodicals Eng. Nat. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3390\/polym14010126","article-title":"Preparation and Characterization of an Injectable and Photo-Responsive Chitosan Methacrylate\/Graphene Oxide Hydrogel: Potential Applications in Bone Tissue Adhesion and Repair","volume":"14","author":"C\u00e9spedes-Valenzuela","year":"","journal-title":"Polymers"},{"key":"B9","doi-asserted-by":"crossref","DOI":"10.1109\/CI-IBBI54220.2021.9626101","article-title":"Chitosan Methacrylate-Based Bioadhesive: towards a Photoresponsive and Extrudable Material for Bone Fracture Repair","author":"C\u00e9spedes-Valenzuela","year":""},{"key":"B10","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1021\/acsami.9b19518","article-title":"Multifunctional Graphene-Oxide-Reinforced Dissolvable Polymeric Microneedles for Transdermal Drug Delivery","volume":"12","author":"Chen","year":"2019","journal-title":"ACS Appl. Mat. Interfaces"},{"key":"B11","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/s0006-291x(03)00173-6","article-title":"Chitosan Enhances Platelet Adhesion and Aggregation","volume":"302","author":"Chou","year":"2003","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"367","DOI":"10.6004\/jnccn.2019.0018","article-title":"Cutaneous Melanoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology","volume":"17","author":"Coit","year":"2019","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"B13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1201\/9780203746349-2","article-title":"Introduction to Rheology and Fluid Mechanics","volume-title":"Mudflow Rheology and Dynamics","author":"Coussot","year":"2017"},{"key":"B14","doi-asserted-by":"publisher","first-page":"500","DOI":"10.4065\/81.4.500","article-title":"Cutaneous Malignant Melanoma","volume":"81","author":"Cummins","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"B15","doi-asserted-by":"publisher","first-page":"8051","DOI":"10.1016\/j.biomaterials.2010.06.054","article-title":"A Stimuli-Responsive Hydrogel for Doxorubicin Delivery","volume":"31","author":"Dadsetan","year":"2010","journal-title":"Biomaterials"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.3390\/ijms22062989","article-title":"Functionalized Reduced Graphene Oxide as a Versatile Tool for Cancer Therapy","volume":"22","author":"Dash","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1089\/cbr.2008.0591","article-title":"Update: Turning the Heat on Cancer","volume":"23","author":"DeNardo","year":"2008","journal-title":"Cancer Biotherapy Radiopharm."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1002\/adma.200903689","article-title":"Chemically Derived Graphene Oxide: Towards Large-Area Thin-Film Electronics and Optoelectronics","volume":"22","author":"Eda","year":"2010","journal-title":"Adv. Mat."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4212","DOI":"10.1039\/c5an00256g","article-title":"Raman Micro Spectroscopy for in Vitro Drug Screening: Subcellular Localisation and Interactions of Doxorubicin","volume":"140","author":"Farhane","year":"2015","journal-title":"Analyst"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1038\/ncomms2555","article-title":"A Low-Temperature Method to Produce Highly Reduced Graphene Oxide","volume":"4","author":"Feng","year":"2013","journal-title":"Nat. Commun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1900215","DOI":"10.1002\/adom.201900215","article-title":"The Role of Photochemical Reactions in the Development of Advanced Soft Materials for Biomedical Applications","volume":"7","author":"Fernandez\u2010Villamarin","year":"2019","journal-title":"Adv. Opt. Mat."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.2147\/ijn.s240305","article-title":"Design and Characterization of Chitosan-Graphene Oxide Nanocomposites for the Delivery of Proanthocyanidins","volume":"15","author":"Figueroa","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"B23","doi-asserted-by":"publisher","first-page":"33200","DOI":"10.1038\/srep33200","article-title":"Vitamin B2 as a Virulence Factor in Pseudogymnoascus Destructans Skin Infection","volume":"6","author":"Flieger","year":"2016","journal-title":"Sci. Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.compbiomed.2005.08.004","article-title":"A Numerical Coupling Model to Analyze the Blood Flow, Temperature, and Oxygen Transport in Human Breast Tumor under Laser Irradiation","volume":"36","author":"He","year":"2006","journal-title":"Comput. Biol. Med."},{"key":"B25","first-page":"530","article-title":"Studies of Thermal Injury: I. The Conduction of Heat to and through Skin and the Temperatures Attained Therein. A Theoretical and an Experimental Investigation","volume":"23","author":"Henriques","year":"1947","journal-title":"Am. J. Pathol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.ejso.2014.03.002","article-title":"Residual Melanoma after an Excisional Biopsy Is an Independent Prognostic Factor for Local Recurrence and Overall Survival","volume":"40","author":"Hocevar","year":"2014","journal-title":"Eur. J. Surg. Oncol. (EJSO)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.3892\/or.2019.7329","article-title":"Core-shell T-ype T-hermo-nanoparticles L-oaded with T-emozolomide C-ombined with P-hotothermal T-herapy in M-elanoma C-ells","volume":"42","author":"Hou","year":"2019","journal-title":"Oncol. Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"22657","DOI":"10.1039\/c8nr07627h","article-title":"Recent Advances in Nanomaterials for Enhanced Photothermal Therapy of Tumors","volume":"10","author":"Hu","year":"2018","journal-title":"Nanoscale"},{"key":"B29","doi-asserted-by":"publisher","first-page":"116650","DOI":"10.1016\/j.carbpol.2020.116650","article-title":"Dextran Methacrylate Hydrogel Microneedles Loaded with Doxorubicin and Trametinib for Continuous Transdermal Administration of Melanoma","volume":"246","author":"Huang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"B30","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.cherd.2020.07.020","article-title":"Preparation and Assessment of Electro-Conductive Poly(acrylamide-Co-Acrylic Acid) Carboxymethyl Cellulose\/reduced Graphene Oxide Hydrogel with High Viscoelasticity","volume":"162","author":"Jafarigol","year":"2020","journal-title":"Chem. Eng. Res. Des."},{"key":"B31","volume-title":"Doxorubicin","author":"Johnson-Arbor","year":"2021"},{"key":"B32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.suc.2019.09.001","article-title":"Surgical Management of Primary Cutaneous Melanoma","volume":"100","author":"Joyce","year":"2020","journal-title":"Surg. Clin. N. Am."},{"key":"B33","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.msec.2016.04.067","article-title":"Fabrication of Keratin-Silica Hydrogel for Biomedical Applications","volume":"66","author":"Kakkar","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"B34","doi-asserted-by":"publisher","first-page":"123138","DOI":"10.1016\/j.cej.2019.123138","article-title":"Ultrasmall Platinum Nanoparticles Enable Deep Tumor Penetration and Synergistic Therapeutic Abilities through Free Radical Species-Assisted Catalysis to Combat Cancer Multidrug Resistance","volume":"383","author":"Kankala","year":"2020","journal-title":"Chem. Eng. J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"8116","DOI":"10.1039\/d0tb01149e","article-title":"Functionalized Graphene Oxide as a Vehicle for Targeted Drug Delivery and Bioimaging Applications","volume":"8","author":"Karki","year":"2020","journal-title":"J. Mat. Chem. B"},{"key":"B36","doi-asserted-by":"publisher","first-page":"6331","DOI":"10.2147\/ijn.s86467","article-title":"Combination of Glycosphingosomes and Liposomal Doxorubicin Shows Increased Activity against Dimethyl-&alpha;-Benzanthracene-Induced Fibrosarcoma in Mice","volume":"10","author":"Khan","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"B37","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.ijbiomac.2020.03.134","article-title":"Dual Crosslinked Alginate Hydrogels by Riboflavin as Photoinitiator","volume":"154","author":"Kim","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"6735","DOI":"10.1021\/nn403096s","article-title":"Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide","volume":"7","author":"Kim","year":"2013","journal-title":"ACS Nano"},{"key":"B39","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00339-011-6720-6","article-title":"Investigation of Raman and Photoluminescence Studies of Reduced Graphene Oxide Sheets","volume":"106","author":"Krishnamoorthy","year":"2011","journal-title":"Appl. Phys. A"},{"key":"B40","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.carbon.2012.10.013","article-title":"The Chemical and Structural Analysis of Graphene Oxide with Different Degrees of Oxidation","volume":"53","author":"Krishnamoorthy","year":"2013","journal-title":"Carbon"},{"key":"B41","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.apsusc.2018.11.121","article-title":"The Structure of PA-Se-S-Cd Composite Materials Probed with FTIR Spectroscopy","volume":"470","author":"Krylova","year":"2019","journal-title":"Appl. Surf. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"16071","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing Hydrogels for Controlled Drug Delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater"},{"key":"B43","doi-asserted-by":"publisher","first-page":"111294","DOI":"10.1016\/j.msec.2020.111294","article-title":"Injectable In Situ Forming Thermo-Responsive Graphene Based Hydrogels for Cancer Chemo-Photothermal Therapy and NIR Light-Enhanced Antibacterial Applications","volume":"117","author":"Lima-Sousa","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"B44","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1021\/acsbiomaterials.9b01214","article-title":"Magnetite-OmpA Nanobioconjugates as Cell-Penetrating Vehicles with Endosomal Escape Abilities","volume":"6","author":"Lopez-Barbosa","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B45","doi-asserted-by":"publisher","first-page":"4806","DOI":"10.1021\/nn1006368","article-title":"Improved Synthesis of Graphene Oxide","volume":"4","author":"Marcano","year":"2010","journal-title":"ACS Nano"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.3390\/ma11071050","article-title":"Characterization of Graphite Oxide and Reduced Graphene Oxide Obtained from Different Graphite Precursors and Oxidized by Different Methods Using Raman Spectroscopy","volume":"11","author":"Muzyka","year":"2018","journal-title":"Materials"},{"key":"B47","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1001\/jamadermatol.2016.6138","article-title":"Outcomes of Melanoma In Situ Treated with Mohs Micrographic Surgery Compared with Wide Local Excision","volume":"153","author":"Nosrati","year":"2017","journal-title":"JAMA Dermatol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.2741\/2947","article-title":"Platelets and Wound Healing","volume":"13","author":"Nurden","year":"2008","journal-title":"Front. Biosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3390\/biom11070922","article-title":"Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces Lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings","volume":"11","author":"Patarroyo","year":"2021","journal-title":"Biomolecules"},{"key":"B50","doi-asserted-by":"publisher","first-page":"044107","DOI":"10.1088\/1758-5090\/aa8dd8","article-title":"Proposal to Assess Printability of Bioinks for Extrusion-Based Bioprinting and Evaluation of Rheological Properties Governing Bioprintability","volume":"9","author":"Paxton","year":"2017","journal-title":"Biofabrication"},{"key":"B51","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1152\/jappl.1948.1.2.93","article-title":"Analysis of Tissue and Arterial Blood Temperatures in the Resting Human Forearm","volume":"1","author":"Pennes","year":"1948","journal-title":"J. Appl. Physiology"},{"key":"B52","volume-title":"Mohs Micrographic Surgery","author":"Prickett","year":"2022"},{"key":"B53","doi-asserted-by":"publisher","first-page":"119226","DOI":"10.1016\/j.ijpharm.2020.119226","article-title":"Graphene Oxide and Reduced Graphene Oxide-Based Scaffolds in Regenerative Medicine","volume":"580","author":"Raslan","year":"2020","journal-title":"Int. J. Pharm."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1038\/s41467-020-15546-9","article-title":"Pre-clinical Modeling of Cutaneous Melanoma","volume":"11","author":"Rebecca","year":"2020","journal-title":"Nat. Commun."},{"key":"B55","doi-asserted-by":"publisher","first-page":"353","DOI":"10.18063\/ijb.v7i3.353","article-title":"Graphene Oxide-Embedded Extracellular Matrix- Derived Hydrogel as a Multiresponsive Platform for 3D Bioprinting Applications","volume":"7","author":"Rueda-Gensini","year":"2021","journal-title":"Int. J. Bioprint"},{"key":"B56","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.carbpol.2016.10.059","article-title":"Synthesis of Modified Gum Tragacanth\/graphene Oxide Composite Hydrogel for Heavy Metal Ions Removal and Preparation of Silver Nanocomposite for Antibacterial Activity","volume":"157","author":"Sahraei","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1016\/j.jbiomech.2014.04.048","article-title":"Effects of Fabrication on the Mechanics, Microstructure and Micromechanical Environment of Small Intestinal Submucosa Scaffolds for Vascular Tissue Engineering","volume":"47","author":"S\u00e1nchez-Palencia","year":"2014","journal-title":"J. Biomechanics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.foodhyd.2008.01.001","article-title":"Effect of Temperature and Cross-Linking Density on Rheology of Chemical Cross-Linked Guar Gum at the Gel Point","volume":"23","author":"Sandolo","year":"2009","journal-title":"Food Hydrocoll."},{"key":"B59","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3892\/etm.2020.8675","article-title":"Regressive Melanoma in a Female Patient: A Case Report","volume":"20","author":"Sandru","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.ijheatmasstransfer.2015.07.089","article-title":"Temperature Distribution in Multi-Layer Skin Tissue in Presence of a Tumor","volume":"91","author":"Sarkar","year":"2015","journal-title":"Int. J. Heat Mass Transf."},{"key":"B61","doi-asserted-by":"publisher","first-page":"569","DOI":"10.3390\/polym11030569","article-title":"Formulation and Characterization of a SIS-Based Photocrosslinkable Bioink","volume":"11","author":"Serna","year":"2019","journal-title":"Polymers"},{"key":"B62","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1248\/bpb.31.2326","article-title":"Preparation of Fucoidan-Chitosan Hydrogel and its Application as Burn Healing Accelerator on Rabbits","volume":"31","author":"Sezer","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1700848","DOI":"10.1002\/advs.201700848","article-title":"Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer","volume":"5","author":"Shao","year":"2018","journal-title":"Adv. Sci. (Weinh)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.radphyschem.2014.02.022","article-title":"Corrigendum to: \"A Comparative Study of the Effect of Ni9+ and Au8+ Ion Beams on the Properties of Poly(methacrylic Acid) Grafted Gum Ghatti Films [Radiat. Phys. Chem. 97 (2014) 253-261]\"","volume":"99","author":"Sharma","year":"2014","journal-title":"Radiat. Phys. Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"115970","DOI":"10.1016\/j.carbpol.2020.115970","article-title":"DLP Printing Photocurable Chitosan to Build Bio-Constructs for Tissue Engineering","volume":"235","author":"Shen","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"B66","first-page":"161","article-title":"Cutaneous Malignant Melanoma: A Primary Care Perspective","volume":"85","author":"Shenenberger","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"B67","doi-asserted-by":"publisher","first-page":"011915","DOI":"10.1103\/physreve.74.011915","article-title":"Cellular Tolerance to Pulsed Hyperthermia","volume":"74","author":"Simanovskii","year":"2006","journal-title":"Phys. Rev. E"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/135138","article-title":"Simple Synthesis and Enhanced Performance of Graphene Oxide-Gold Composites","volume":"2012","author":"Song","year":"2012","journal-title":"J. Nanomater."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.carbon.2007.02.034","article-title":"Synthesis of Graphene-Based Nanosheets via Chemical Reduction of Exfoliated Graphite Oxide","volume":"45","author":"Stankovich","year":"2007","journal-title":"Carbon"},{"key":"B70","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.elspec.2014.07.003","article-title":"Graphene Oxide and Reduced Graphene Oxide Studied by the XRD, TEM and Electron Spectroscopy Methods","volume":"195","author":"Stobinski","year":"2014","journal-title":"J. Electron Spectrosc. Relat. Phenom."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/7520741","article-title":"Polyurethane Nanocomposites Containing Reduced Graphene Oxide, FTIR, Raman, and XRD Studies","volume":"2016","author":"Strankowski","year":"2016","journal-title":"J. Spectrosc."},{"key":"B72","doi-asserted-by":"publisher","first-page":"13672","DOI":"10.1038\/s41598-018-31939-9","article-title":"Doxorubicin Induces an Extensive Transcriptional and Metabolic Rewiring in Yeast Cells","volume":"8","author":"Taymaz-Nikerel","year":"2018","journal-title":"Sci. Rep."},{"key":"B73","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1097\/01.prs.0000067479.77859.31","article-title":"Excision Margins for Nonmelanotic Skin Cancer","volume":"112","author":"Thomas","year":"2003","journal-title":"Plastic Reconstr. Surg."},{"key":"B74","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s10924-020-01920-7","article-title":"Carboxymethyl Cellulose-Grafted Graphene Oxide\/Polyethylene Glycol for Efficient Ni(II) Adsorption","volume":"29","author":"Tohamy","year":"2020","journal-title":"J. Polym. Environ."},{"key":"B75","doi-asserted-by":"publisher","first-page":"762","DOI":"10.12991\/mpj.2017.3","article-title":"Development of iitu Poloxamer-Chitosan Hydrogels for Vaginal Drug Delivery of Benzydamine Hydrochloride: Textural, Mucoadhesive and in Vitro Release Properties","volume":"21","author":"Tu\u011fcu-demi\u0307r\u00f6z","year":"2017","journal-title":"Marmara Pharm. J."},{"key":"B76","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/026567399285765","article-title":"Invited Review: For the Clinical Application of Thermochemotherapy Given at Mild Temperatures","volume":"15","author":"Urano","year":"1999","journal-title":"Int. J. Hyperth."},{"key":"B77","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1166\/jbn.2011.1224","article-title":"Toxicity of Graphene in Normal Human Lung Cells (BEAS-2B)","volume":"7","author":"Vallabani","year":"2011","journal-title":"J. Biomed. Nanotechnol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fchem.2019.00167","article-title":"Gold Nanoparticles for Photothermal Cancer Therapy","volume":"7","author":"Vines","year":"2019","journal-title":"Front. Chem."},{"key":"B79","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/s1470-2045(02)00818-5","article-title":"Hyperthermia in Combined Treatment of Cancer","volume":"3","author":"Wust","year":"2002","journal-title":"Lancet Oncol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12976-019-0107-3","article-title":"Mathematical Simulation of Temperature Distribution in Tumor Tissue and Surrounding Healthy Tissue Treated by Laser Combined with Indocyanine Green","volume":"16","author":"Xu","year":"2019","journal-title":"Theor. Biol. Med. Model"},{"key":"B81","doi-asserted-by":"publisher","first-page":"7079","DOI":"10.2147\/ijn.s207419","article-title":"A New Strategy for Accurate Targeted Diagnosis and Treatment of Cutaneous Malignant Melanoma: Dual-Mode Phase-Change Lipid Nanodroplets as Ultrasound Contrast Agents","volume":"14","author":"Yang","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"B82","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3109\/10837450902882351","article-title":"Benzydamine Hydrochloride Buccal Bioadhesive Gels Designed for Oral Ulcers: Preparation, Rheological, Textural, Mucoadhesive and Release Properties","volume":"14","author":"Yaprak Karavana","year":"2009","journal-title":"Pharm. Dev. Technol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"10408","DOI":"10.1021\/jp500709m","article-title":"High-Speed Actuation and Mechanical Properties of Graphene-Incorporated Shape Memory Polyurethane Nanofibers","volume":"118","author":"Yoo","year":"2014","journal-title":"J. Phys. Chem. C"},{"key":"B84","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jconrel.2019.05.036","article-title":"Photothermal Therapy Mediated by Phase-Transformation Nanoparticles Facilitates Delivery of Anti-PD1 Antibody and Synergizes with Antitumor Immunotherapy for Melanoma","volume":"306","author":"Zhang","year":"2019","journal-title":"J. Control. Release"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1002\/jbm.a.34525","article-title":"Stimuli Responsive Deswelling of Radiation Synthesized Collagen Hydrogel in Simulated Physiological Environment","author":"Zhang","year":"2012","journal-title":"J. Biomed. Mat. Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/198145","article-title":"Study of Tumor Growth under Hyperthermia Condition","volume":"2012","author":"Zhu","year":"2012","journal-title":"Comput. Math. Methods Med."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.947616\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T12:12:20Z","timestamp":1657109540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.947616\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":86,"alternative-id":["10.3389\/fbioe.2022.947616"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2022.947616","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]},"article-number":"947616"}}