{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:42:04Z","timestamp":1780555324255,"version":"3.54.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>To assess the diagnostic value of <jats:sup>18<\/jats:sup>F-NaF PET\/CT in diagnosing bone metastases in patients with nasopharyngeal carcinoma (NPC) using visual and quantitative analyses. 164 patients with NPC who underwent <jats:sup>18<\/jats:sup>F-NaF PET\/CT between 2017 and 2021 were included. The sensitivity, specificity, and accuracy were calculated. All bone lesions were divided into metastatic bone lesion group and benign lesion group; the benign lesion group was further subdivided into benign lesion without osteophyte and fracture group (CT images showing no osteophyte, no fracture), and benign lesion with osteophyte and fracture group (CT images showing typical osteophytes and fractures), the differences in maximum standardized uptake value (SUVmax) were compared between every two groups, and the diagnostic cut-off values were derived from receiver operating characteristic curves (ROC). Quantitative data were expressed as mean \u00b1 SD, multiple continuous variables were compared using one-way analysis of variance (ANOVA), and multiple comparisons among more than two groups were made using the Bonferroni method. The sensitivity, specificity, and overall accuracy of <jats:sup>18<\/jats:sup>F-NaF PET\/CT for the diagnosis of bone metastases in NPC were 97.1%, 94.6%, and 95.1% based on the patient level and 99.5%, 91.5%, and 96.4% based on the lesion level, respectively. The SUVmax was significantly different between the metastatic bone lesion group and the benign lesion without osteophyte and fracture group (<jats:italic>p<\/jats:italic> &amp;lt; 0.05); the area under the curve was 0.865, the threshold was 12.5, the sensitivity was 0.912, and the specificity was 0.656. Visual analysis of <jats:sup>18<\/jats:sup>F-NaF PET\/CT has high sensitivity and specificity for diagnosing bone metastases in NPC. After excluding osteophytes and fracture lesions based on CT findings, using SUVmax \u226512.5 as the threshold can be an important reference for the differential diagnosis of bone metastases and benign bone lesions in patients with NPC.<\/jats:p>","DOI":"10.3389\/fbioe.2022.949480","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T06:57:11Z","timestamp":1661324231000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The value of 18F-NaF PET\/CT in the diagnosis of bone metastases in patients with nasopharyngeal carcinoma using visual and quantitative analyses"],"prefix":"10.3389","volume":"10","author":[{"given":"Dong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiWen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChengMao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shisang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XuFeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingXing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13550-019-0475-z","article-title":"Comparison of standardized uptake values between (99m)Tc-HDP SPECT\/CT and (18)F-NaF PET\/CT in bone metastases of breast and prostate cancer","volume":"9","author":"Arvola","year":"2019","journal-title":"EJNMMI Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s00259-020-04967-9","article-title":"The value of (18)F-FDG PET\/CT for predicting or monitoring immunotherapy response in patients with metastatic melanoma: a systematic review and meta-analysis","volume":"48","author":"Ayati","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1007\/s00259-015-3138-y","article-title":"18F-NaF PET\/CT: EANM procedure guidelines for bone imaging","volume":"42","author":"Beheshti","year":"2015","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"B4","doi-asserted-by":"publisher","first-page":"11s","DOI":"10.2967\/jnumed.108.057182","article-title":"Standards for PET image acquisition and quantitative data analysis","volume":"50","author":"Boellaard","year":"2009","journal-title":"J. Nucl. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"8714","DOI":"10.1007\/s00330-021-07956-0","article-title":"Prospective comparison of the diagnostic accuracy of 18F-FDG PET\/MRI, MRI, CT, and bone scintigraphy for the detection of bone metastases in the initial staging of primary breast cancer patients","volume":"31","author":"Bruckmann","year":"2021","journal-title":"Eur. Radiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/s0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"key":"B7","first-page":"272","article-title":"Assessment of malignant skeletal disease: initial experience with 18F-fluoride PET\/CT and comparison between 18F-fluoride PET and 18F-fluoride PET\/CT","volume":"45","author":"Even-Sapir","year":"2004","journal-title":"J. Nucl. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.2967\/jnumed.106.037200","article-title":"Skeletal PET with 18F-fluoride: applying new technology to an old tracer","volume":"49","author":"Grant","year":"2008","journal-title":"J. Nucl. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/rlu.0000000000003502","article-title":"Impact of 18F-FDG PET, PET\/CT, and PET\/MRI on staging and management as an initial staging modality in breast cancer: A systematic review and meta-analysis","volume":"46","author":"Han","year":"2021","journal-title":"Clin. Nucl. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1200\/jco.2017.72.2348","article-title":"Quantitative assessment of early [(18)F]sodium fluoride positron emission tomography\/computed tomography response to treatment in men with metastatic prostate cancer to bone","volume":"35","author":"Harmon","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"B11","first-page":"633","article-title":"Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET","volume":"33","author":"Hawkins","year":"1992","journal-title":"J. Nucl. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e290","DOI":"10.1097\/RLU.0b013e3182815f64","article-title":"Pilot prospective evaluation of 99mTc-MDP scintigraphy, 18F NaF PET\/CT, 18F FDG PET\/CT and whole-body MRI for detection of skeletal metastases","volume":"38","author":"Iagaru","year":"2013","journal-title":"Clin. Nucl. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1097\/RLU.0b013e318252d829","article-title":"Prospective evaluation of 18F-NaF and 18F-FDG PET\/CT in detection of occult metastatic disease in biochemical recurrence of prostate cancer","volume":"37","author":"Jadvar","year":"2012","journal-title":"Clin. Nucl. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1053\/j.semnuclmed.2016.07.003","article-title":"(18)F-NaF-PET\/CT and (99m)Tc-MDP bone scintigraphy in the detection of bone metastases in prostate cancer","volume":"46","author":"Langsteger","year":"2016","journal-title":"Semin. Nucl. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.2967\/jnumed.116.177295","article-title":"Repeatability of quantitative 18F-NaF PET: A multicenter study","volume":"57","author":"Lin","year":"2016","journal-title":"J. Nucl. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.crad.2018.12.011","article-title":"The diagnostic performance of 18F-fluoride PET\/CT in bone metastases detection: a meta-analysis","volume":"74","author":"Liu","year":"2019","journal-title":"Clin. Radiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3390\/tomography7020013","article-title":"Whole-body [(18)F]-Fluoride PET SUV imaging to monitor response to dasatinib therapy in castration-resistant prostate cancer bone metastases: Secondary results from ACRIN 6687","volume":"7","author":"Muzi","year":"2021","journal-title":"Tomography"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e3490","DOI":"10.1097\/md.0000000000003490","article-title":"18F-Labeled NaF PET-CT in detection of bone metastases in patients with preoperative lung cancer","volume":"95","author":"Rao","year":"2016","journal-title":"Med. Baltim."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e228","DOI":"10.1097\/rlu.0000000000000633","article-title":"18F-sodium fluoride PET\/CT in oncology: an atlas of SUVs","volume":"40","author":"Sabbah","year":"2015","journal-title":"Clin. Nucl. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.2967\/jnumed.110.082263","article-title":"SNM practice guideline for sodium 18F-fluoride PET\/CT bone scans 1.0","volume":"51","author":"Segall","year":"2010","journal-title":"J. Nucl. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/rlu.0000000000000592","article-title":"Performance of 18F-fluoride PET or PET\/CT for the detection of bone metastases: a meta-analysis","volume":"40","author":"Shen","year":"2015","journal-title":"Clin. Nucl. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s40880-015-0031-9","article-title":"Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system","volume":"34","author":"Shen","year":"2015","journal-title":"Chin. J. Cancer"},{"key":"B23","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1097\/mnm.0000000000001243","article-title":"Observer agreement and accuracy of 18F-sodium fluoride PET\/computed tomography in the diagnosis of skull-base bone invasion and osseous metastases in newly diagnosed nasopharyngeal carcinoma","volume":"41","author":"Xiao","year":"2020","journal-title":"Nucl. Med. Commun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"4871","DOI":"10.1210\/jc.2016-2815","article-title":"Bone metastases and skeletal-related events in medullary thyroid carcinoma","volume":"101","author":"Xu","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B25","first-page":"211","article-title":"Skeletal-related adverse events during bone metastasis of breast cancer: current status","volume":"27","author":"Yang","year":"2019","journal-title":"Discov. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"8271313","DOI":"10.1155\/2018\/8271313","article-title":"Comparison of (18)F-NaF PET\/CT and (18)F-FDG PET\/CT for detection of skull-base invasion and osseous metastases in nasopharyngeal carcinoma","volume":"2018","author":"Zhang","year":"2018","journal-title":"Contrast Media Mol. Imaging"},{"key":"B27","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/mnm.0000000000001311","article-title":"The value of skeletal standardized uptake values obtained by quantitative single-photon emission computed tomography-computed tomography in differential diagnosis of bone metastases","volume":"42","author":"Zhang","year":"2021","journal-title":"Nucl. Med. Commun."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.949480\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T06:57:16Z","timestamp":1661324236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.949480\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":27,"alternative-id":["10.3389\/fbioe.2022.949480"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2022.949480","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"article-number":"949480"}}