{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:28:21Z","timestamp":1762072101467,"version":"build-2065373602"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Due to the increasing need for suitable alternatives to bone grafts, artificial bones made of biphasic calcium phosphate (BCP) are currently being extensively researched. These porous bone substitutes have also demonstrated considerable incorporation with the host bone, and new bone is able to grow within the porous structure. They therefore offer a potential therapeutic approach for bone defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Vancomycin-loaded Bicera\u2122, a BCP bone substitute, was investigated in order to prevent implant-associated osteomyelitis and postoperative infection after orthopedic surgery. The loading capacity of Bicera\u2122 was measured to understand its potential antibiotic adsorption volume. An antibiotic susceptibility test was also carried out to analyze the effect of Bicera\u2122 loaded with different concentrations of vancomycin on the growth inhibition of methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA). Vancomycin-loaded Bicera\u2122 was implanted into rabbits with bone defects, and general gross, radiographic, and histological evaluation was undertaken at 4, 12, and 24\u00a0weeks after implantation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The maximum loading capacity of vancomycin-loaded Bicera\u2122 was 0.9\u00a0ml of liquid regardless of the vancomycin concentration. Antibiotic susceptibility tests showed that vancomycin-loaded Bicera\u2122 inhibited the growth of MRSA for 6\u00a0weeks. In addition, animal studies revealed that new bone grew into the vancomycin-loaded Bicera\u2122. The percentage of new bone formation from 4 to 24\u00a0weeks after implantation increased from 17% to 36%.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Vancomycin-loaded Bicera\u2122 could effectively inhibit the growth of MRSA <jats:italic>in vitro<\/jats:italic>. It was found to incorporate into the host bone well, and new bone was able to grow within the bone substitute. The results of this study indicate that vancomycin-loaded Bicera\u2122 is a potential bone substitute that can prevent implant-associated osteomyelitis and postoperative infection.<\/jats:p>","DOI":"10.3389\/fbioe.2022.988436","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T05:04:35Z","timestamp":1667279075000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The efficacy of vancomycin-loaded biphasic calcium phosphate bone substitute in the promotion of new bone growth and the prevention of postoperative infection"],"prefix":"10.3389","volume":"10","author":[{"given":"Shi-Yong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-Bin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Shun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang-Chien","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Ying","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsu-Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sher-Wei","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.7150\/ijms.6.274","article-title":"Mechanical complications and reconstruction strategies at the site of hip spacer implantation","volume":"6","author":"Anagnostakos","year":"2009","journal-title":"Int. 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