{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:33:31Z","timestamp":1788413611602,"version":"build-2803163510"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Posterior capsule opacification (PCO) is one of the most frequent late-onset complications after cataract surgery. Several kinds of drug-eluting intraocular lenses (IOL) were designed for sustainable drug release to suppress ocular inflammation, the proliferation of lens epithelial cells (LECs) and the development of PCO after cataract surgery. Despite previous advances in this field, the drug-loaded IOLs were limited in ocular toxicity, insufficient drug-loading capacity, and short release time. To prevent PCO and to address these drawbacks, a novel drug-loaded IOL (Rapa@Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub>-IOL), prepared from two-dimensional ultrathin Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub> MXene nanosheets and rapamycin (Rapa), was fabricated with a two-step spin coating method in this study. Rapa@Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub> was prepared via electrostatic self-assembly of Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub> and Rapa, with a loading capacity of Rapa at 92%. Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub> was used as a drug delivery reservoir of Rapa. Rapa@Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub>-IOL was designed to have the synergistic photothermal and near infrared (NIR)-controllable drug release property. As a result, Rapa@Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub>-IOL exhibited the advantages of simple preparation, high light transmittance, excellent photothermal conversion capacity, and NIR-controllable drug release behavior. The Rapa@Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub> coating effectively eliminated the LECs around Rapa@Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub>-IOL under a mild 808-nm NIR laser irradiation (1.0\u00a0W\/cm<jats:sup>\u22122<\/jats:sup>). Moreover, NIR-controllable Rapa release inhibited the migration of LECs and suppressed the inflammatory response after photothermal therapy <jats:italic>in vitro.<\/jats:italic> Then, Rapa@Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub>-IOL was implanted into chinchilla rabbit eyes, and the effectiveness and biocompatibility to prevent PCO were evaluated for 4 weeks. The Rapa@Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub>-IOL implant exhibited excellent PCO prevention ability with the assistance of NIR irradiation and no obvious pathological damage was observed in surrounding healthy tissues. In summary, the present study offers a promising strategy for preventing PCO <jats:italic>via<\/jats:italic> ultrathin Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub> MXene nanosheet-based IOLs with synergistic photothermal and NIR-controllable Rapa release properties.<\/jats:p>","DOI":"10.3389\/fbioe.2022.989099","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T05:44:20Z","timestamp":1661838260000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Two-dimensional ultrathin Ti3C2 MXene nanosheets coated intraocular lens for synergistic photothermal and NIR-controllable rapamycin releasing therapy against posterior capsule opacification"],"prefix":"10.3389","volume":"10","author":[{"given":"Zi","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianju","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S280","DOI":"10.1016\/j.ihj.2018.05.014","article-title":"Seven-year clinical outcomes in patients undergoing percutaneous coronary intervention with biodegradable polymer coated sirolimus-eluting stent: Results from a single-center real-world experience","volume":"70","author":"Abhyankar","year":"2018","journal-title":"Indian Heart J. Teach. Ser."},{"key":"B2","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.survophthal.2017.03.005","article-title":"Multifocal intraocular lenses: An overview","volume":"62","author":"Alio","year":"2017","journal-title":"Surv. Ophthalmol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"113943","DOI":"10.1016\/j.bios.2021.113943","article-title":"2D metal carbides and nitrides (MXenes) for sensors and biosensors","volume":"205","author":"Alwarappan","year":"2022","journal-title":"Biosens. Bioelectron. X."},{"key":"B4","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1001\/archophthalmol.2009.3","article-title":"Posterior capsular opacification: A problem reduced but not yet eradicated","volume":"127","author":"Awasthi","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e2100067","DOI":"10.1002\/advs.202100067","article-title":"Targeted drug delivery for sustainable crop protection: Transport and stability of polymeric nanocarriers in plants","volume":"8","author":"Beckers","year":"2021","journal-title":"Adv. Sci. (Weinh)."},{"key":"B6","first-page":"550","article-title":"Frequency of retinal detachment and other complications after neodymium:Yag laser capsulotomy","volume":"58","author":"Burq","year":"2008","journal-title":"J. Pak. Med. Assoc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3390\/pharmaceutics13060860","article-title":"Factors affecting posterior capsule opacification in the development of intraocular lens materials","volume":"13","author":"Cooksley","year":"2021","journal-title":"Pharmaceutics"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ajo.2022.01.013","article-title":"Lens epithelial cell removal in routine phacoemulsification: Is it worth the bother?","volume":"239","author":"Darian-Smith","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"60478","DOI":"10.1021\/acsami.1c19890","article-title":"MXene-coated wrinkled fabrics for stretchable and multifunctional electromagnetic interference shielding and electro\/photo-thermal conversion applications","volume":"13","author":"Dong","year":"2021","journal-title":"ACS Appl. Mat. Interfaces"},{"key":"B10","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.ijbiomac.2022.06.144","article-title":"Photothermal nanofibrillar membrane based on hyaluronic acid and graphene oxide to treat Staphylococcus aureus and Pseudomonas aeruginosa infected wounds","volume":"214","author":"Federico","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"12613","DOI":"10.1021\/acsnano.9b03889","article-title":"Flexible two-dimensional Ti3C2 MXene films as thermoacoustic devices","volume":"13","author":"Gou","year":"2019","journal-title":"ACS Nano"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e1701394","DOI":"10.1002\/adhm.201701394","article-title":"2D ultrathin MXene-based drug-delivery nanoplatform for synergistic photothermal ablation and chemotherapy of cancer","volume":"7","author":"Han","year":"2018","journal-title":"Adv. Healthc. Mat."},{"key":"B13","doi-asserted-by":"publisher","first-page":"9047","DOI":"10.2147\/IJN.S215802","article-title":"Anti-Adhesive and antiproliferative synergistic surface modification of intraocular lens for reduced posterior capsular opacification","volume":"14","author":"Han","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"B14","doi-asserted-by":"publisher","first-page":"114178","DOI":"10.1016\/j.addr.2022.114178","article-title":"Biomedical engineering of two-dimensional MXenes","volume":"184","author":"Huang","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jhazmat.2017.06.004","article-title":"In vitro studies on cytotoxicity of delaminated Ti3C2 MXene","volume":"339","author":"Jastrzebska","year":"2017","journal-title":"J. Hazard. Mat."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.3390\/jcm10132847","article-title":"Posterior capsule opacification: A review of experimental studies","volume":"10","author":"Konopinska","year":"2021","journal-title":"J. Clin. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3390\/pharmaceutics14020304","article-title":"Engineering the surface of Ti3C2 MXene nanosheets for high stability and multimodal anticancer therapy","volume":"14","author":"Korupalli","year":"2022","journal-title":"Pharmaceutics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.ajo.2020.04.011","article-title":"Posterior capsule opacification with two hydrophobic acrylic intraocular lenses: 3-Year results of a randomized trial","volume":"217","author":"Leydolt","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1039\/d1tb02456f","article-title":"Poly-l-lysine derivative-coated black phosphorus as a nanoplatform for photothermal chemotherapy to enhance anti-tumor efficiency","volume":"10","author":"Li","year":"2022","journal-title":"J. Mat. Chem. B"},{"key":"B20","doi-asserted-by":"publisher","first-page":"16235","DOI":"10.1021\/jacs.7b07818","article-title":"A two-dimensional biodegradable niobium carbide (MXene) for photothermal tumor eradication in NIR-I and NIR-II biowindows","volume":"139","author":"Lin","year":"","journal-title":"J. Am. Chem. Soc."},{"key":"B21","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1021\/acs.nanolett.6b04339","article-title":"Two-dimensional ultrathin MXene ceramic nanosheets for photothermal conversion","volume":"17","author":"Lin","year":"","journal-title":"Nano Lett."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1701617","DOI":"10.1002\/adma.201701617","article-title":"Photothermal ring integrated intraocular lens for high-efficient eye disease treatment","volume":"29","author":"Lin","year":"","journal-title":"Adv. Mat."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1021\/acs.biomac.1c01388","article-title":"Foldable bulk anti-adhesive polyacrylic intraocular lens material design and fabrication for posterior capsule opacification prevention","volume":"23","author":"Liu","year":"","journal-title":"Biomacromolecules"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e2201098","DOI":"10.1002\/smll.202201098","article-title":"Nanoporous gold ring-integrated photothermal intraocular lens for active prevention of posterior capsular opacification","volume":"2022","author":"Liu","year":"","journal-title":"Small"},{"key":"B25","first-page":"1646","article-title":"The effects of rapamycin on lens epithelial cell proliferation, migration, and matrix formation: An in vitro study","volume":"16","author":"Liu","year":"2010","journal-title":"Mol. Vis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s00417-008-1007-0","article-title":"Polylactide-glycoli acid and rapamycin coating intraocular lens prevent posterior capsular opacification in rabbit eyes","volume":"247","author":"Liu","year":"2009","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e2100946","DOI":"10.1002\/smll.202100946","article-title":"2D MXene nanomaterials for versatile biomedical applications: Current trends and future prospects","volume":"17","author":"Lu","year":"2021","journal-title":"Small"},{"key":"B28","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.actbio.2021.11.018","article-title":"Centrifugally concentric ring-patterned drug-loaded polymeric coating as an intraocular lens surface modification for efficient prevention of posterior capsular opacification","volume":"138","author":"Lu","year":"2022","journal-title":"Acta Biomater."},{"key":"B29","doi-asserted-by":"publisher","first-page":"CD012516","DOI":"10.1002\/14651858.CD012516.pub2","article-title":"Intraocular lens optic edge design for the prevention of posterior capsule opacification after cataract surgery","volume":"8","author":"Maedel","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"108282","DOI":"10.1016\/j.exer.2020.108282","article-title":"CuInS\/ZnS quantum dots modified intraocular lens for photothermal therapy of posterior capsule opacification","volume":"202","author":"Mao","year":"2021","journal-title":"Exp. Eye Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1007\/s00417-013-2435-z","article-title":"mTOR regulates TGF-\u03b22-induced epithelial\u2013mesenchymal transition in cultured human lens epithelial cells","volume":"251","author":"Meng","year":"2013","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3390\/ph13120448","article-title":"A critical appraisal of New developments in intraocular lens modifications and drug delivery systems for the prevention of cataract surgery complications","volume":"13","author":"Mylona","year":"2020","journal-title":"Pharm. (Basel)"},{"key":"B33","doi-asserted-by":"publisher","first-page":"364","DOI":"10.14744\/AnatolJCardiol.2020.98452","article-title":"Twelve-month clinical outcomes of sirolimus-eluting stent in coronary artery disease: An experience in real-world Indian patients","volume":"24","author":"Nathani","year":"2020","journal-title":"Anatol. J. Cardiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"529","DOI":"10.23736\/S0026-4806.20.06333-8","article-title":"Impact of ultra-long sirolimus-eluting stents on coronary artery lesions: One-year results of real-world FLEX-LONG study","volume":"111","author":"Pamidimukkala","year":"2020","journal-title":"Minerva Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000452174","article-title":"The protective effect of Brown-Gray-and blue-tinted lenses against blue LED light-induced cell death in A2E-laden human retinal pigment epithelial cells","volume":"57","author":"Park","year":"2017","journal-title":"Ophthalmic Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.3390\/polym14071464","article-title":"New polymeric composites based on two-dimensional nanomaterials for biomedical applications","volume":"14","author":"Pires","year":"2022","journal-title":"Polym. (Basel)"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1021\/acsnano.6b00181","article-title":"Antibacterial Activity of Ti3C2T<i>x<\/i> MXene","volume":"10","author":"Rasool","year":"2016","journal-title":"ACS Nano"},{"key":"B38","doi-asserted-by":"publisher","first-page":"110790","DOI":"10.1016\/j.msec.2020.110790","article-title":"A simple, low-cost and green method for controlling the cytotoxicity of MXenes","volume":"111","author":"Rozmyslowska-Wojciechowska","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"B39","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/s41433-019-0569-x","article-title":"Posterior capsule opacification and Nd:YAG laser rates with two hydrophobic acrylic single-piece IOLs","volume":"34","author":"Schartmuller","year":"2020","journal-title":"Eye (Lond)"},{"key":"B40","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/s0161-6420(00)00020-8","article-title":"Ultrasonographic measurement of induced myopia associated with capsular bag distention syndrome","volume":"107","author":"Sorenson","year":"2000","journal-title":"Ophthalmology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.trsl.2021.05.005","article-title":"Immune responses to injury and their links to eye disease","volume":"236","author":"Stepp","year":"2021","journal-title":"Transl. Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"114099","DOI":"10.1016\/j.addr.2021.114099","article-title":"The 10th anniversary of MXenes: Challenges and prospects for their surface modification toward future biotechnological applications","volume":"182","author":"Szuplewska","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1039\/d0tb02802a","article-title":"Surface modification of intraocular lenses via photodynamic coating for safe and effective PCO prevention","volume":"9","author":"Tang","year":"2021","journal-title":"J. Mat. Chem. B"},{"key":"B44","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/j.1463-5224.2010.00831.x","article-title":"Rabbits' eye globe sonographic biometry","volume":"13","author":"Toni","year":"2010","journal-title":"Vet. Ophthalmol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"120613","DOI":"10.1016\/j.ijpharm.2021.120613","article-title":"Intraocular lenses as drug delivery devices","volume":"602","author":"Topete","year":"2021","journal-title":"Int. J. Pharm. X."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1038\/s41433-018-0131-2","article-title":"Three-year incidence of Nd:YAG capsulotomy and posterior capsule opacification and its relationship to monofocal acrylic IOL biomaterial: A UK real world evidence study","volume":"32","author":"Ursell","year":"2018","journal-title":"Eye (Lond)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"eabf1581","DOI":"10.1126\/science.abf1581","article-title":"The world of two-dimensional carbides and nitrides (MXenes)","volume":"2021","author":"VahidMohammadi","year":"2021","journal-title":"Science"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1016\/s0886-3350(03)00215-3","article-title":"Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification","volume":"29","author":"Vargas","year":"2003","journal-title":"J. Cataract. Refract. Surg."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/s0886-3350(02)01216-6","article-title":"Evaluation of 3 modern single-piece foldable intraocular lenses: Clinicopathological study of posterior capsule opacification in a rabbit model","volume":"28","author":"Vargas","year":"2002","journal-title":"J. Cataract. Refract. Surg."},{"key":"B50","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.actbio.2021.05.027","article-title":"Near-infrared light-controllable MXene hydrogel for tunable on-demand release of therapeutic proteins","volume":"130","author":"Wang","year":"2021","journal-title":"Acta Biomater."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e2108560","DOI":"10.1002\/adma.202108560","article-title":"MXenes for energy harvesting","volume":"34","author":"Wang","year":"2022","journal-title":"Adv. Mat."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2000841","DOI":"10.1002\/adfm.202000841","article-title":"2D titanium carbide (Ti 3 C 2 Tx) in accommodating intraocular lens design","volume":"30","author":"Ward","year":"2020","journal-title":"Adv. Funct. Mat."},{"key":"B53","doi-asserted-by":"publisher","first-page":"100905","DOI":"10.1016\/j.preteyeres.2020.100905","article-title":"Posterior capsule opacification: What's in the bag?","volume":"82","author":"Wormstone","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1021\/acs.chemrestox.0c00232","article-title":"Evaluating the cytotoxicity of Ti3C2 MXene to neural stem cells","volume":"33","author":"Wu","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.1021\/acs.biomac.1c00582","article-title":"Foldable glistening-free acrylic intraocular lens biomaterials with dual-side heterogeneous surface modification for postoperative endophthalmitis and posterior capsule opacification prophylaxis","volume":"22","author":"Xiang","year":"2021","journal-title":"Biomacromolecules"},{"key":"B56","doi-asserted-by":"publisher","first-page":"405101","DOI":"10.1088\/1361-6528\/aad358","article-title":"Doxorubicin\/gold nanoparticles coated with liposomes for chemo-photothermal synergetic antitumor therapy","volume":"29","author":"Xing","year":"2018","journal-title":"Nanotechnology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"5362","DOI":"10.7150\/thno.27631","article-title":"A biomimetic gold nanocages-based nanoplatform for efficient tumor ablation and reduced inflammation","volume":"8","author":"Xu","year":"2018","journal-title":"Theranostics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3390\/pharmaceutics14030492","article-title":"Sirolimus release from biodegradable polymers for coronary stent application: A review","volume":"14","author":"Xu","year":"2022","journal-title":"Pharmaceutics"},{"key":"B59","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jconrel.2021.09.030","article-title":"NIR-triggered drug delivery system for chemo-photothermal therapy of posterior capsule opacification","volume":"339","author":"Ying-Yan","year":"2021","journal-title":"J. Control. Release"},{"key":"B60","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jcis.2022.03.132","article-title":"Thin film nanoarchitectonics of layer-by-layer assembly with reduced graphene oxide on intraocular lens for photothermal therapy of posterior capsular opacification","volume":"619","author":"Zhang","year":"","journal-title":"J. Colloid Interface Sci"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1702678","DOI":"10.1002\/adma.201702678","article-title":"Transparent, flexible, and conductive 2D titanium carbide (MXene) films with high volumetric capacitance","volume":"29","author":"Zhang","year":"2017","journal-title":"Adv. Mat."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/2181685","article-title":"Research progress of drug prophylaxis for lens capsule opacification after cataract surgery","volume":"2020","author":"Zhang","year":"2020","journal-title":"J. Ophthalmol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.bioactmat.2021.07.015","article-title":"Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification","volume":"9","author":"Zhang","year":"","journal-title":"Bioact. Mat."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2015.10.006","article-title":"Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention","volume":"498","author":"Zhang","year":"2016","journal-title":"Int. J. Pharm. X."},{"key":"B65","doi-asserted-by":"publisher","first-page":"12405","DOI":"10.1021\/acsnano.1c04526","article-title":"Facile fabrication of densely packed Ti3C2 MXene\/nanocellulose composite films for enhancing electromagnetic interference shielding and electro-\/photothermal performance","volume":"15","author":"Zhou","year":"2021","journal-title":"ACS Nano"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.989099\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T05:44:23Z","timestamp":1661838263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.989099\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,30]]},"references-count":65,"alternative-id":["10.3389\/fbioe.2022.989099"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2022.989099","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,30]]},"article-number":"989099"}}