{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:37:07Z","timestamp":1764571027211,"version":"3.41.2"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Nasopharyngeal carcinoma occurs in many parts of the pars nasalis pharyngis, and the pathological type is mainly squamous cell carcinoma. Because of the special position of nasopharynx, breathing, pronunciation and daily life will be seriously affected. At present, the research direction of nasopharyngeal carcinoma is mainly to explore the law of tumor cell proliferation and migration, study the molecular mechanism, master its biological behavior and clinical significance, try to find therapeutic targets, and further improve the level of tumor treatment. However, the pathologic structure and molecular mechanism of nasopharyngeal carcinoma have not been fully elucidated. In this study, the Lentivirus-mediated EIF3C shRNA vector (L.V-shEIF3C) was constructed to down-regulate the expression of EIF3C in human pharyngeal squamous carcinoma cell FaDu and the human nasopharyngeal carcinoma cell 5-8F, it was found that down-regulation of EIF3C could significantly inhibit the cell proliferation, promote cell apoptosis, induce cell cycle arrest, and inhibit the formation and growth of tumors in mouse models. This study provides strong evidence that EIF3C is a key gene driving the development and progression of head and neck cancer, which is of great significance for the diagnosis, prognosis or treatment of tumors, suggesting that EIF3C may become a valuable therapeutic development and intervention target.<\/jats:p>","DOI":"10.3389\/fbioe.2022.994628","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T08:56:34Z","timestamp":1662454594000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting EIF3C to suppress the development and progression of nasopharyngeal carcinoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Qian","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxia","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suxia","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1097\/cco.0000000000000629","article-title":"Epidemiology of head and neck cancers: An update","volume":"32","author":"Aup\u00e9rin","year":"2020","journal-title":"Curr. Opin. Oncol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3390\/nu7010265","article-title":"Nutritional interventions in head and neck cancer patients undergoing chemoradiotherapy: A narrative review","volume":"7","author":"Bossola","year":"2015","journal-title":"Nutrients"},{"key":"B3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/s0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s10565-008-9092-8","article-title":"Role of parp-1 and parp-2 in the expression of apoptosis-regulating genes in hela cells","volume":"25","author":"Cohausz","year":"2009","journal-title":"Cell Biol. Toxicol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.canlet.2013.04.026","article-title":"Eif3c: A potential therapeutic target for cancer","volume":"336","author":"Emmanuel","year":"2013","journal-title":"Cancer Lett."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1039\/c5mb00101c","article-title":"The pi3k\/akt\/mtor interactive pathway","volume":"11","author":"Ersahin","year":"2015","journal-title":"Mol. Biosyst."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.2147\/ott.S187209","article-title":"Knockdown of Eif3c promotes human U-2os cells apoptosis through increased casp3\/7 and Chk1\/2 by upregulating sapk\/jnk","volume":"12","author":"Gao","year":"2019","journal-title":"Onco. Targets. Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"101977","DOI":"10.1016\/j.ctrv.2020.101977","article-title":"Biomarkers for immunotherapy response in head and neck cancer","volume":"84","author":"Gavrielatou","year":"2020","journal-title":"Cancer Treat. Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.trecan.2019.02.007","article-title":"Immune evasion by head and neck cancer: Foundations for combination therapy","volume":"5","author":"Horton","year":"2019","journal-title":"Trends Cancer"},{"key":"B10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/hed.25932","article-title":"Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy","volume":"41","author":"Hsieh","year":"2019","journal-title":"Head Neck"},{"key":"B11","doi-asserted-by":"publisher","first-page":"9225","DOI":"10.1002\/jcp.27601","article-title":"Overexpressed Circ_0067934 acts as an oncogene to facilitate cervical cancer progression via the mir-545\/eif3c Axis","volume":"234","author":"Hu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ijrobp.2020.08.054","article-title":"Radiation therapy-induced changes of the nasopharyngeal commensal microbiome in nasopharyngeal carcinoma patients","volume":"109","author":"Huang","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"B13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nrm2838","article-title":"The mechanism of eukaryotic translation initiation and principles of its regulation","volume":"11","author":"Jackson","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.drup.2018.09.001","article-title":"Precision medicine in head and neck cancer","volume":"40","author":"Kaidar-Person","year":"2018","journal-title":"Drug resist. updat."},{"key":"B16","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s10555-017-9690-0","article-title":"Alcohol and head and neck cancer","volume":"36","author":"Kawakita","year":"2017","journal-title":"Cancer Metastasis Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.3389\/fonc.2020.01020","article-title":"A literature review of the potential diagnostic biomarkers of head and neck neoplasms","volume":"10","author":"Konings","year":"2020","journal-title":"Front. Oncol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.3390\/cancers13215471","article-title":"Current and emerging molecular therapies for head and neck squamous cell carcinoma","volume":"13","author":"Kordbacheh","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"110548","DOI":"10.1016\/j.nut.2019.06.028","article-title":"Nutrition and swallowing therapy strategies for patients with head and neck cancer","volume":"69","author":"Kristensen","year":"2020","journal-title":"Nutrition"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.12688\/f1000research.15066.1","article-title":"Recent advances in the management of nasopharyngeal carcinoma","volume":"7","author":"Lam","year":"2018","journal-title":"F1000Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nature14267","article-title":"Eif3 targets cell-proliferation messenger rnas for translational activation or repression","volume":"522","author":"Lee","year":"2015","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/cas.13209","article-title":"Transcriptomic analyses of rna-binding proteins reveal Eif3c promotes cell proliferation in hepatocellular carcinoma","volume":"108","author":"Li","year":"2017","journal-title":"Cancer Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00432-019-03067-y","article-title":"Superiority of intensity-modulated radiation therapy in nasopharyngeal carcinoma with skull-base invasion","volume":"146","author":"Liao","year":"2020","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12943-018-0763-7","article-title":"Long non-coding rna implicated in the invasion and metastasis of head and neck cancer: Possible function and mechanisms","volume":"17","author":"Luo","year":"2018","journal-title":"Mol. Cancer"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1016\/j.bbamcr.2010.12.012","article-title":"The mapk cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation","volume":"1813","author":"Plotnikov","year":"2011","journal-title":"Biochimica Biophysica Acta - Mol. Cell Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fonc.2014.00064","article-title":"Targeting pi3k\/akt\/mtor signaling in cancer","volume":"4","author":"Porta","year":"2014","journal-title":"Front. Oncol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"a032896","DOI":"10.1101\/cshperspect.a032896","article-title":"Translational control in cancer","volume":"11","author":"Robichaud","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e2030672","DOI":"10.1001\/jamanetworkopen.2020.30672","article-title":"Multimodality therapy for locoregional nasopharyngeal carcinoma-a decision tool for treatment optimization","volume":"3","author":"Rosenberg","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"B29","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.smim.2014.02.009","article-title":"Tnf and map kinase signalling pathways","volume":"26","author":"Sabio","year":"2014","journal-title":"Semin. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.soc.2012.12.001","article-title":"Multidisciplinary care of the patient with head and neck cancer","volume":"22","author":"Saloura","year":"2013","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"B31","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/s1097-2765(02)00482-3","article-title":"Mechanisms of caspase activation and inhibition during apoptosis","volume":"9","author":"Shi","year":"2002","journal-title":"Mol. Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"Ca. A Cancer J. Clin."},{"key":"B33","doi-asserted-by":"publisher","first-page":"BSR20180992","DOI":"10.1042\/bsr20180992","article-title":"Apoptosis and apoptotic body: Disease message and therapeutic target potentials","volume":"39","author":"Xu","year":"2019","journal-title":"Biosci. Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"8277","DOI":"10.7150\/thno.35686","article-title":"Conditional knockout of tgf-\u00dfrii\/Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation","volume":"9","author":"Yang","year":"2019","journal-title":"Theranostics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1080\/15384047.2015.1046022","article-title":"The interplay between DNA repair and autophagy in cancer therapy","volume":"16","author":"Zhang","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"B36","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.12659\/msm.906389","article-title":"Decreasing eukaryotic initiation factor 3c (Eif3c) suppresses proliferation and stimulates apoptosis in breast cancer cell lines through mammalian target of rapamycin (mtor) pathway","volume":"23","author":"Zhao","year":"2017","journal-title":"Med. Sci. Monit."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.994628\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T08:56:37Z","timestamp":1662454597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.994628\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":36,"alternative-id":["10.3389\/fbioe.2022.994628"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2022.994628","relation":{},"ISSN":["2296-4185"],"issn-type":[{"type":"electronic","value":"2296-4185"}],"subject":[],"published":{"date-parts":[[2022,9,6]]},"article-number":"994628"}}