{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:51:01Z","timestamp":1783572661386,"version":"3.55.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Tricuspid regurgitation (TR) is a relatively common valvular disease, which can result from structural abnormalities of any anatomic part of the tricuspid valve. Severe TR is linked to congestive heart failure and hemodynamic impairment, resulting in high mortality when repaired by elective surgery. This study was undertaken to quantify the structural and hemodynamic performance of the novel Transcatheter Bicaval Valves System (TricValve) percutaneously implanted in the superior vena cava (SVC) and inferior vena cava (IVC) of two patients with severe TR and venous congestion.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> After developing the SVC and IVC device models, the contact pressure exerted on the vena cava wall was obtained by computational analysis. Both smoothed-particle hydrodynamics (SPH) and computational fluid dynamics were carried out to quantify caval reflux in the right atrium and the pressure field of pre- and post-TricValve scenarios, respectively.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Analysis of contact pressure highlighted the main anchoring area of the SVC device occurring near the SVC device belly, while the IVC device exerted pronounced forces in the device\u2019s proximal and distal parts. SPH-related flow velocities revealed the absence of caval reflux, and a decrease in time-averaged pressure was observed near the SVC and IVC after TricValve implantation.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> Findings demonstrated the potential of computational tools for enhancing our understanding of the biomechanical performance of structural tricuspid valve interventions and improving the way we design next-generation transcatheter therapies to treat the tricuspid valve with heterotopic caval valve implantation.<\/jats:p>","DOI":"10.3389\/fbioe.2023.1179774","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T07:43:25Z","timestamp":1684395805000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Biomechanical performance of the Bicaval Transcatheter System for the treatment of severe tricuspid regurgitation"],"prefix":"10.3389","volume":"11","author":[{"given":"Fabrizio","family":"Crasc\u00ec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cannata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Gandolfo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Pasta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.3390\/jcm10194601","article-title":"Caval valve implantation (CAVI): An emerging therapy for treating severe tricuspid regurgitation","volume":"10","author":"Altisent","year":"2021","journal-title":"J. Clin. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1080\/10255842.2012.746676","article-title":"Simulation of transcatheter aortic valve implantation: A patient-specific finite element approach","volume":"17","author":"Auricchio","year":"2014","journal-title":"Comput. methods biomechanics Biomed. Eng."},{"key":"B3","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1080\/10255842.2015.1058928","article-title":"Assessing the impact of including leaflets in the simulation of TAVI deployment into a patient-specific aortic root","volume":"19","author":"Bailey","year":"2016","journal-title":"Comput. methods biomechanics Biomed. Eng."},{"key":"B4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.compbiomed.2019.04.022","article-title":"On the role of material properties in ascending thoracic aortic aneurysms","volume":"109","author":"Cosentino","year":"2019","journal-title":"Comput. Biol. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.15420\/icr.2019.5.1","article-title":"Update on the current landscape of transcatheter options for tricuspid regurgitation treatment","volume":"14","author":"Curio","year":"2019","journal-title":"Interv. Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.jcmg.2018.07.032","article-title":"Anatomy and physiology of the tricuspid valve","volume":"12","author":"Dahou","year":"2019","journal-title":"Jacc-Cardiovasc Imag."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e0247438","DOI":"10.1371\/journal.pone.0247438","article-title":"Computational fluid dynamics of the right atrium: Assessment of modelling criteria for the evaluation of dialysis catheters","volume":"16","author":"de Oliveira","year":"2021","journal-title":"Plos One"},{"key":"B8","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.yjmcc.2019.04.010","article-title":"Identification of circumferential regional heterogeneity of ascending thoracic aneurysmal aorta by biaxial mechanical testing","volume":"130","author":"Di Giuseppe","year":"2019","journal-title":"J. Mol. Cell Cardiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/j.jcin.2022.05.022","article-title":"6-Month outcomes of the TricValve system in patients with tricuspid regurgitation: The TRICUS EURO study","volume":"15","author":"Estevez-Loureiro","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.1016\/j.jcin.2020.01.194","article-title":"Transfemoral transcatheter tricuspid valve replacement","volume":"13","author":"Fam","year":"2020","journal-title":"Jacc-Cardiovasc Inte."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1016\/j.mayocp.2019.04.036","article-title":"Prognostic importance and predictors of survival in isolated tricuspid regurgitation: A growing problem","volume":"94","author":"Fender","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"B12","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/heartjnl-2017-311586","article-title":"Isolated tricuspid regurgitation: Outcomes and therapeutic interventions","volume":"104","author":"Fender","year":"2018","journal-title":"Heart"},{"key":"B13","doi-asserted-by":"publisher","first-page":"Y116","DOI":"10.4244\/Eijv12sya32","article-title":"Transcatheter interventions for tricuspid regurgitation - heterotopic technology: TricValve","volume":"12","author":"Figulla","year":"2016","journal-title":"EuroIntervention J. Eur. Collab. Work. Group Interventional Cardiol. Eur. Soc. Cardiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.medengphy.2017.06.045","article-title":"Finite element analysis of TAVI: Impact of native aortic root computational modeling strategies on simulation outcomes","volume":"47","author":"Finotello","year":"2017","journal-title":"Med. Eng. Phys."},{"key":"B15","doi-asserted-by":"publisher","first-page":"138","DOI":"10.4244\/AIJ-D-21-00037","article-title":"Novel treatment of atrial functional tricuspid regurgitation using transcatheter bicaval valve implantation (TricValve)","volume":"8","author":"Jin","year":"2022","journal-title":"AsiaIntervention"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1136\/heartjnl-2019-315004","article-title":"Outcomes of patients with severe tricuspid regurgitation and congestive heart failure","volume":"105","author":"Kadri","year":"2019","journal-title":"Heart"},{"key":"B17","doi-asserted-by":"publisher","first-page":"414","DOI":"10.5152\/AnatolJCardiol.2021.1247","article-title":"TricValve pop-out: Management of transcatheter caval valve migration","volume":"26","author":"Kultursay","year":"2022","journal-title":"Anatol. J. Cardiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"E2046","DOI":"10.1016\/S0735-1097(12)62047-6","article-title":"INTERVENTIONAL perspective of tricuspid regurgitation &ndash; caval valve implantation from preclinical trials to first human application","volume":"59","author":"Lauten","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1093\/eurheartj\/ehr028","article-title":"Heterotopic transcatheter tricuspid valve implantation: First-in-man application of a novel approach to tricuspid regurgitation","volume":"32","author":"Lauten","year":"2011","journal-title":"Eur. Heart J."},{"key":"B20","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s13239-019-00427-0","article-title":"On the modeling of patient-specific transcatheter aortic valve replacement: A fluid\u2013structure interaction approach","volume":"10","author":"Luraghi","year":"2019","journal-title":"Cardiovasc. Eng. Technol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s13239-016-0285-7","article-title":"Fluid-structure interaction study of transcatheter aortic valve dynamics using smoothed particle hydrodynamics","volume":"7","author":"Mao","year":"2016","journal-title":"Cardiovasc Eng. Technol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1016\/j.jbiomech.2014.06.007","article-title":"Simulation of transcatheter aortic valve implantation through patient-specific finite element analysis: Two clinical cases","volume":"47","author":"Morganti","year":"2014","journal-title":"J. Biomechanics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/bioengineering8050052","article-title":"CoreValve vs. Sapien 3 transcatheter aortic valve replacement: A finite element analysis study","volume":"8","author":"Nappi","year":"2021","journal-title":"Bioengineering"},{"key":"B24","doi-asserted-by":"crossref","first-page":"031108","DOI":"10.1115\/1.4054526","article-title":"Computational fluid dynamics of the right atrium: A comparison of modeling approaches in a range of flow conditions","volume":"5","author":"Parker","year":"2022","journal-title":"J. Eng. Sci. Med. Diagnostics Ther."},{"key":"B25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.medengphy.2020.05.018","article-title":"Simulation of left ventricular outflow tract (LVOT) obstruction in transcatheter mitral valve-in-ring replacement","volume":"82","author":"Pasta","year":"2020","journal-title":"Med. Eng. Phys."},{"key":"B26","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s11517-020-02138-4","article-title":"Simulation study of transcatheter heart valve implantation in patients with stenotic bicuspid aortic valve","volume":"58","author":"Pasta","year":"2020","journal-title":"Med. Biol. Eng. Comput."},{"key":"B27","doi-asserted-by":"publisher","first-page":"111337","DOI":"10.1016\/j.jbiomech.2022.111337","article-title":"Numerical simulation of transcatheter mitral valve replacement: The dynamic implication of LVOT obstruction in the valve-in-ring case","volume":"144","author":"Pasta","year":"2022","journal-title":"J. Biomechanics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1177\/1526602815611888","article-title":"An in vitro phantom study on the role of the bird-beak configuration in endograft infolding in the aortic arch","volume":"23","author":"Pasta","year":"2016","journal-title":"J. Endovascular Ther."},{"key":"B29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.17925\/Hi.2022.16.1.49","article-title":"Current status of transcatheter tricuspid valve therapies","volume":"16","author":"Romeo","year":"2022","journal-title":"Heart Int."},{"key":"B30","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.healun.2017.03.016","article-title":"Shear stress alterations in the celiac trunk of patients with a continuous-flow left ventricular assist device as shown by in-silico and in-vitro flow analyses","volume":"36","author":"Scardulla","year":"2017","journal-title":"J. Heart Lung Transpl."},{"key":"B31","doi-asserted-by":"publisher","first-page":"758","DOI":"10.4244\/Eij-D-18-00440","article-title":"First-in-man implantation of the Tricento transcatheter heart valve for the treatment of severe tricuspid regurgitation","volume":"14","author":"Toggweiler","year":"2018","journal-title":"EuroIntervention J. Eur. Collab. Work. Group Interventional Cardiol. Eur. Soc. Cardiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jcmg.2018.06.014","article-title":"Burden of tricuspid regurgitation in patients diagnosed in the community setting","volume":"12","author":"Topilsky","year":"2019","journal-title":"JACC Cardiovasc. imaging"},{"key":"B33","doi-asserted-by":"publisher","first-page":"E219","DOI":"10.1161\/Circulationaha.110.972836","article-title":"Percutaneous transcatheter valve-in-valve implantation in stenosed tricuspid valve bioprosthesis","volume":"123","author":"Van Garsse","year":"2011","journal-title":"Circulation"},{"key":"B34","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10237-014-0583-7","article-title":"Simulations of transcatheter aortic valve implantation: Implications for aortic root rupture","volume":"14","author":"Wang","year":"2015","journal-title":"Biomechanics Model. Mechanobiol."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2023.1179774\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T07:43:33Z","timestamp":1684395813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2023.1179774\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,18]]},"references-count":34,"alternative-id":["10.3389\/fbioe.2023.1179774"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2023.1179774","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,18]]},"article-number":"1179774"}}