{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:21:33Z","timestamp":1778170893758,"version":"3.51.4"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> To investigate the correlation between corneal biomechanical characteristics (<jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>) and corneal densitometry in myopia.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The Pentacam (Oculus, Wetzlar, Germany) corneal densitometry (CD) and Corvis ST (Oculus, Wetzlar, Germany) exams were conducted prior to surgery for myopic patients who were intended to undergo small-incision lenticule extraction (SMILE). CD values (grayscale units, GSUs), and <jats:italic>in vivo<\/jats:italic> biomechanical parameters were obtained. The stromal lenticule was subjected to a uniaxial tensile test to obtain the elastic modulus E <jats:italic>in vitro<\/jats:italic>. We exam the correlations among <jats:italic>in vivo<\/jats:italic>, <jats:italic>in vitro<\/jats:italic> biomechanical characteristics and CD values.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In this study, 37 myopic patients (63 eyes) were included. The mean age of participants was 25.14 \u00b1 6.74\u00a0years (range:16\u201339\u00a0years). The mean CD values of the total cornea, anterior layer, intermediate layer, posterior layer, 0\u20132\u00a0mm region and 2\u20136\u00a0mm region were 15.03 \u00b1 1.23 GSU, 20.35 \u00b1 1.98 GSU, 11.76 \u00b1 1.01 GSU, 10.95 \u00b1 0.83 GSU, 15.57 \u00b1 1.12 GSU and 11.94 \u00b1 1.77 GSU, respectively. Elastic modulus E (<jats:italic>in vitro<\/jats:italic> biomechanical indicator) was negatively correlated with intermediate layer CD (r = \u22120.35, <jats:italic>p<\/jats:italic> = 0.01) and 2\u20136\u00a0mm region CD (r = \u22120.39, <jats:italic>p<\/jats:italic> = 0.00). A negative correlation was also found between 0-2\u00a0mm central region CD and <jats:italic>in vivo<\/jats:italic> biomechanical indicator SP-HC (r = \u22120.29, <jats:italic>p<\/jats:italic> = 0.02).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In myopic patients, densitometry is negatively correlated with biomechanical properties both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. With an increase in CD, the cornea deformed more easily.<\/jats:p>","DOI":"10.3389\/fbioe.2023.1182372","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T05:57:31Z","timestamp":1682488651000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Analysis of the correlation between biomechanical properties and corneal densitometry in myopic eyes"],"prefix":"10.3389","volume":"11","author":[{"given":"Yuwei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"251584142110127","DOI":"10.1177\/25158414211012796","article-title":"Advances in the diagnosis and treatment of keratoconus","volume":"13","author":"Atalay","year":"2021","journal-title":"Ther. 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