{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:02:25Z","timestamp":1793131345072,"version":"4.5.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Healing of severe fractures and bone defects involves many complex biological processes, including angiogenesis and osteogenesis, presenting significant clinical challenges. Biomaterials used for bone tissue engineering often possess multiple functions to meet these challenges, including proangiogenic, proosteogenic, and antibacterial properties. We fabricated lithium and cobalt co-doped mesoporous bioactive glass nanoparticles (Li-Co-MBGNs) using a modified sol-gel method. Physicochemical analysis revealed that the nanoparticles had high specific surface areas (&amp;gt;600\u00a0m<jats:sup>2<\/jats:sup>\/g) and a mesoporous structure suitable for hydroxyapatite (HA) formation and sustained release of therapeutic ions. <jats:italic>In vitro<\/jats:italic> experiments with Li-Co-MBGNs showed that these promoted angiogenic properties in HUVECs and pro-osteogenesis abilities in BMSCs by releasing Co<jats:sup>2+<\/jats:sup> and Li<jats:sup>+<\/jats:sup> ions. We observed their antibacterial activity against <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic>, indicating their potential applications in bone tissue engineering. Overall, our findings indicate the feasibility of its application in bone tissue engineering.<\/jats:p>","DOI":"10.3389\/fbioe.2023.1288393","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T04:44:02Z","timestamp":1704343442000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Lithium and cobalt co-doped mesoporous bioactive glass nanoparticles promote osteogenesis and angiogenesis in bone regeneration"],"prefix":"10.3389","volume":"11","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuankai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglong","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.colsurfb.2016.09.047","article-title":"Cobalt iron oxide nanoparticles induce cytotoxicity and regulate the apoptotic genes through ROS in human liver cells (HepG2)","volume":"148","author":"Ahamed","year":"2016","journal-title":"Colloids surfaces, B, Biointerfaces"},{"key":"B2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2147\/IJN.S37924C","article-title":"Oxidative stress contributes to cobalt oxide nanoparticles-induced cytotoxicity and DNA damage in human hepatocarcinoma cells","volume":"8","author":"Alarifi","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"B3","doi-asserted-by":"publisher","first-page":"8854","DOI":"10.1039\/c0jm01111h","article-title":"Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration","volume":"20","author":"Azevedo","year":"2010","journal-title":"J. Mater. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1039\/c1mt00099c","article-title":"Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance","volume":"3","author":"Barras","year":"2011","journal-title":"Metallomics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s10971-018-4823-7","article-title":"The influence of cobalt incorporation and cobalt precursor selection on the structure and bioactivity of sol\u2013gel-derived bioactive glass","volume":"88","author":"Barrioni","year":"2018","journal-title":"J. Sol-Gel Sci. Technol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"025001","DOI":"10.1088\/1748-6041\/10\/2\/025001","article-title":"Sol\u2013gel synthesis andin vitro bioactivity of copper and zinc-doped silicate bioactive glasses and glass-ceramics","volume":"10","author":"Bejarano","year":"2015","journal-title":"Biomed. Mat."},{"key":"B7","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ceramint.2019.08.291","article-title":"Antibacterial and magnetic response of site-specific cobalt incorporated hydroxyapatite","volume":"46","author":"Bhattacharjee","year":"2020","journal-title":"Ceram. Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.actbio.2018.11.025","article-title":"Dual-ion delivery for synergistic angiogenesis and bactericidal capacity with silica-based microsphere","volume":"83","author":"Boldbaatar","year":"2019","journal-title":"Acta Biomater."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1002\/anie.201405310","article-title":"Bioactive glasses-structure and properties","volume":"54","author":"Brauer","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1021\/ja01864a025","article-title":"On a theory of the van der Waals adsorption of gases","volume":"62","author":"Brunauer","year":"1940","journal-title":"J. Am. Chem. Soc."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.7150\/ijbs.32358","article-title":"Hypoxia-Mimicking cobalt-doped borosilicate bioactive glass scaffolds with enhanced angiogenic and osteogenic capacity for bone regeneration","volume":"15","author":"Deng","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"34836","DOI":"10.1016\/j.ceramint.2021.09.024","article-title":"Facile fabrication of hollow mesoporous bioactive glass spheres: from structural behaviour to in vitro biology evaluation","volume":"47","author":"Ding","year":"2021","journal-title":"Ceram. Int."},{"key":"B13","doi-asserted-by":"publisher","first-page":"100887","DOI":"10.1016\/j.pmatsci.2021.100887","article-title":"Multifunctional antimicrobial materials: from rational design to biomedical applications","volume":"125","author":"Duan","year":"2022","journal-title":"Prog. Mat. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s10971-018-4795-7","article-title":"Structural characterization of bioactive glasses by solid state NMR","volume":"88","author":"Eckert","year":"2018","journal-title":"J. Sol-Gel Sci. Technol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"120999","DOI":"10.1016\/j.jnoncrysol.2021.120999","article-title":"Sol-gel synthesis and characterization of novel cobalt ions-containing mesoporous bioactive glass nanospheres as hypoxia and ferroptosis-inducing nanotherapeutics","volume":"569","author":"El-Fiqi","year":"2021","journal-title":"J. Non-Cryst. Solids"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2017.08.030","article-title":"Regenerating bone with bioactive glass scaffolds: a review of in vivo studies in bone defect models","volume":"62","author":"El-Rashidy","year":"2017","journal-title":"Acta Biomater."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1016\/j.biomaterials.2006.01.035","article-title":"Effect of cobalt and chromium ions on human MG-63 osteoblasts in vitro: morphology, cytotoxicity, and oxidative stress","volume":"27","author":"Fleury","year":"2006","journal-title":"Biomaterials"},{"key":"B18","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.1016\/j.biomaterials.2012.05.061","article-title":"The cementogenic differentiation of periodontal ligament cells via the activation of Wnt\/\u03b2-catenin signalling pathway by Li+ ions released from bioactive scaffolds","volume":"33","author":"Han","year":"2012","journal-title":"Biomaterials"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1039\/c4bm00111g","article-title":"Lithium release from \u03b2-tricalcium phosphate inducing cementogenic and osteogenic differentiation of both hPDLCs and hBMSCs","volume":"2","author":"Han","year":"2014","journal-title":"Biomater. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"740","DOI":"10.3390\/ma10070740","article-title":"Vitro human umbilical vein endothelial cells response to ionic dissolution products from lithium-containing 45S5 bioactive glass","volume":"10","author":"Haro Durand","year":"2017","journal-title":"Materials"},{"key":"B21","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1006\/dbio.1997.8552","article-title":"Activation of the wnt signaling pathway: a molecular mechanism for lithium action","volume":"185","author":"Hedgepeth","year":"1997","journal-title":"Dev. Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.biomaterials.2018.07.017","article-title":"Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives","volume":"180","author":"Ho-Shui-Ling","year":"2018","journal-title":"Biomaterials"},{"key":"B23","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.matlet.2014.07.041","article-title":"Facile synthesis of hollow mesoporous bioactive glass sub-micron spheres with a tunable cavity size","volume":"134","author":"Hu","year":"2014","journal-title":"Mat. Lett."},{"key":"B24","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jnoncrysol.2016.07.025","article-title":"Synthesis, physico-chemical and biological characterization of strontium and cobalt substituted bioactive glasses for bone tissue engineering","volume":"449","author":"Kargozar","year":"2016","journal-title":"J. Non-Cryst. Solids"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.msec.2011.07.011","article-title":"In vitro bioactivity and biocompatibility of lithium substituted 45S5 bioglass","volume":"31","author":"Khorami","year":"2011","journal-title":"Mater. Sci. Eng. C"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1016\/j.biomaterials.2006.01.017","article-title":"How useful is SBF in predicting in vivo bone bioactivity?","volume":"27","author":"KokuboT","year":"2006","journal-title":"Biomaterials"},{"key":"B27","doi-asserted-by":"publisher","first-page":"100150","DOI":"10.1016\/j.mtbio.2021.100150","article-title":"Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications","volume":"12","author":"Kurtuldu","year":"","journal-title":"Mat. Today Bio"},{"key":"B28","doi-asserted-by":"publisher","first-page":"112050","DOI":"10.1016\/j.msec.2021.112050","article-title":"Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: bioactivity, biocompatibility and antibacterial activity","volume":"124","author":"Kurtuldu","year":"","journal-title":"Mater. Sci. Eng. C"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/jbm.a.37095","article-title":"Cobalt\u2010containing bioactive glass mimics vascular endothelial growth factor A and hypoxia inducible factor 1 function","volume":"109","author":"Laia","year":"2021","journal-title":"J. Biomed. Mat. Res. Part A"},{"key":"B30","doi-asserted-by":"publisher","first-page":"5552","DOI":"10.1021\/jp7107973","article-title":"Multinuclear solid-state NMR studies of ordered mesoporous bioactive glasses","volume":"112","author":"Leonova","year":"2008","journal-title":"J. Phys. Chem. C"},{"key":"B31","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.biomaterials.2018.11.007","article-title":"Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis","volume":"192","author":"Liu","year":"2019","journal-title":"Biomaterials"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-013-1457-0","article-title":"Nanoengineering of bioactive glasses: hollow and dense nanospheres","volume":"15","author":"Luz","year":"2013","journal-title":"J. Nanopart. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jnoncrysol.2015.03.027","article-title":"Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair","volume":"432","author":"Miguez-Pacheco","year":"2016","journal-title":"J. Non-Cryst. Solids"},{"key":"B34","doi-asserted-by":"publisher","first-page":"12835","DOI":"10.1016\/j.ceramint.2017.06.174","article-title":"Synthesis and in vitro studies of sol-gel derived lithium substituted 58S bioactive glass","volume":"43","author":"Moghanian","year":"2017","journal-title":"Ceram. Int."},{"key":"B35","doi-asserted-by":"publisher","first-page":"120740","DOI":"10.1016\/j.jnoncrysol.2021.120740","article-title":"Synthesis, characterization and in vitro biological properties of simultaneous co-substituted Ti+4\/Li+1 58s bioactive glass","volume":"561","author":"Moghanian","year":"2021","journal-title":"J. Non-Cryst. Solids"},{"key":"B36","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.bioactmat.2019.10.002","article-title":"Multifunctional zinc ion doped sol \u2013 gel derived mesoporous bioactive glass nanoparticles for biomedical applications","volume":"4","author":"Ne\u0161\u010d\u00e1kov\u00e1","year":"2019","journal-title":"Bioact. Mat."},{"key":"B37","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1089\/ten.teb.2011.0475","article-title":"Bone tissue engineering and regeneration: from discovery to the clinic\u2014an overview","volume":"17","author":"O'Keefe","year":"2011","journal-title":"Tissue Eng. Part B Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"8115","DOI":"10.1039\/c8tb02678e","article-title":"Lithium-containing biomaterials inhibit osteoclastogenesis of macrophages in vitro and osteolysis in vivo","volume":"6","author":"Pan","year":"2018","journal-title":"J. Mat. Chem. B"},{"key":"B39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fbioe.2018.00105","article-title":"Tissue engineering and cell-based therapies for fractures and bone defects","volume":"6","author":"Perez","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cej.2018.01.073","article-title":"Hybrid injectable platforms for the in situ delivery of therapeutic ions from mesoporous glasses","volume":"340","author":"Pontremoli","year":"2018","journal-title":"Chem. Eng. J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"121015","DOI":"10.1016\/j.jnoncrysol.2021.121015","article-title":"Synthesis and characterization of in vitro properties and biological behavior of Ag\/Li co-doped 68S bioactive glass with and without phosphate","volume":"570","author":"Rahmani","year":"2021","journal-title":"J. Non-Cryst. Solids"},{"key":"B42","doi-asserted-by":"publisher","first-page":"045003","DOI":"10.1088\/1748-605X\/acd03f","article-title":"The antimicrobial efficacy of copper, cobalt, zinc and silver nanoparticles: alone and in combination","volume":"18","author":"Raja","year":"2023","journal-title":"Biomed. Mat."},{"key":"B43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.actbio.2015.04.019","article-title":"Stimulation of osteogenesis and angiogenesis of hBMSCs by delivering Si ions and functional drug from mesoporous silica nanospheres","volume":"21","author":"Shi","year":"2015","journal-title":"Acta Biomater."},{"key":"B44","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.actbio.2018.12.048","article-title":"Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing","volume":"86","author":"Shi","year":"2019","journal-title":"Acta Biomater."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1065597","DOI":"10.3389\/fbioe.2023.1065597","article-title":"Sol-gel synthesis of lithium doped mesoporous bioactive glass nanoparticles and tricalcium silicate for restorative dentistry: comparative investigation of physico-chemical structure, antibacterial susceptibility and biocompatibility","volume":"11","author":"Simila","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40824-020-00202-6","article-title":"Bioactive glasses and electrospun composites that release cobalt to stimulate the HIF pathway for wound healing applications","volume":"25","author":"Solanki","year":"2021","journal-title":"Biomater. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1365-2184.2012.00810.x","article-title":"Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells throughHIF-1\u03b1 pathway","volume":"45","author":"Song","year":"2012","journal-title":"Cell Prolif."},{"key":"B48","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ceramint.2013.05.135","article-title":"Structure and antibacterial property of nano-SiO2 supported oxide ceramic","volume":"40","author":"Talebian","year":"2014","journal-title":"Ceram. Int."},{"key":"B49","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.msec.2018.09.027","article-title":"Optimization of silver-containing bioglass nanoparticles envisaging biomedical applications","volume":"94","author":"Vale","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"B50","doi-asserted-by":"publisher","first-page":"100121","DOI":"10.1016\/j.mtbio.2021.100121","article-title":"Mesoporous bioactive glasses for regenerative medicine","volume":"11","author":"Vallet-Regi","year":"2021","journal-title":"Mat. Today Bio"},{"key":"B51","doi-asserted-by":"publisher","first-page":"225102","DOI":"10.1088\/0957-4484\/27\/22\/225102","article-title":"Biodegradable mesoporous bioactive glass nanospheres for drug delivery and bone tissue regeneration","volume":"27","author":"Wang","year":"2016","journal-title":"Nanotechnology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.3390\/ma14081864","article-title":"Impact of zinc- or copper-doped mesoporous bioactive glass nanoparticles on the osteogenic differentiation and matrix formation of mesenchymal stromal cells","volume":"14","author":"Westhauser","year":"","journal-title":"Materials"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1002\/jbm.a.37136","article-title":"Effect of manganese, zinc, and copper on the biological and osteogenic properties of mesoporous bioactive glass nanoparticles","volume":"109","author":"Westhauser","year":"","journal-title":"J. Biomed. Mat. Res. Part A"},{"key":"B54","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.jconrel.2014.04.026","article-title":"Multifunctional mesoporous bioactive glasses for effective delivery of therapeutic ions and drug\/growth factors","volume":"193","author":"Wu","year":"2014","journal-title":"J. Control. Release"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1016\/j.biomaterials.2011.11.042","article-title":"Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering","volume":"33","author":"Wu","year":"2012","journal-title":"Biomaterials"},{"key":"B56","doi-asserted-by":"publisher","first-page":"4473","DOI":"10.1002\/adfm.201304304","article-title":"A Bi-lineage conducive scaffold for osteochondral defect regeneration","volume":"24","author":"Wu","year":"2014","journal-title":"Adv. Funct. Mat."},{"key":"B57","doi-asserted-by":"publisher","first-page":"41168","DOI":"10.1021\/acsami.7b13167","article-title":"Inorganic strengthened hydrogel membrane as regenerative periosteum","volume":"9","author":"Xin","year":"2017","journal-title":"ACS Appl. Mat. Interfaces"},{"key":"B58","doi-asserted-by":"publisher","first-page":"6840","DOI":"10.1021\/acsami.9b18496","article-title":"Programmed sustained release of recombinant human bone morphogenetic protein-2 and inorganic ion composite hydrogel as artificial periosteum","volume":"12","author":"Xin","year":"2020","journal-title":"ACS Appl. Mat. Interfaces"},{"key":"B59","doi-asserted-by":"publisher","first-page":"3705","DOI":"10.1039\/d2tb00032f","article-title":"Co-exchanged montmorillonite: a potential antibacterial agent with good antibacterial activity and cytocompatibility","volume":"10","author":"Yang","year":"","journal-title":"J. Mat. Chem. B"},{"key":"B60","doi-asserted-by":"publisher","first-page":"112677","DOI":"10.1016\/j.msec.2022.112677","article-title":"Development of PVA-based microsphere as a potential embolization agent","volume":"135","author":"Yang","year":"","journal-title":"Biomater. Adv."},{"key":"B61","doi-asserted-by":"publisher","first-page":"15911","DOI":"10.1074\/jbc.M300463200","article-title":"Cobalt inhibits the interaction between hypoxia-inducible factor-\u03b1 and von Hippel-lindau protein by direct binding to hypoxia-inducible factor-\u03b1","volume":"278","author":"Yuan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"5872","DOI":"10.1021\/acsbiomaterials.9b00950","article-title":"Enhanced osteoconductivity and osseointegration in calcium polyphosphate bioceramic scaffold via lithium doping for bone regeneration","volume":"5","author":"Yuan","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B63","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bone.2008.10.001","article-title":"Lithium's effect on bone mineral density","volume":"44","author":"Zamani","year":"2009","journal-title":"Bone"},{"key":"B64","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.colsurfb.2018.06.038","article-title":"Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs","volume":"170","author":"Zhang","year":"2018","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3729","DOI":"10.1016\/j.ceramint.2021.10.155","article-title":"Homology of selenium (Se) and tellurium (Te) endow the functional similarity of Se-doped and Te-doped mesoporous bioactive glass nanoparticles in bone tissue engineering","volume":"48","author":"Zhang","year":"","journal-title":"Ceram. Int."},{"key":"B66","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jcis.2021.11.122","article-title":"Construction of tellurium-doped mesoporous bioactive glass nanoparticles for bone cancer therapy by promoting ROS-mediated apoptosis and antibacterial activity","volume":"610","author":"Zhang","year":"","journal-title":"J. Colloid. Interface. Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/jace.13258","article-title":"Aging time and temperature effects on the structure and bioactivity of gel-derived 45S5 glass-ceramics","volume":"98","author":"Zheng","year":"2015","journal-title":"J. Am. Ceram. Soc."},{"key":"B68","doi-asserted-by":"publisher","first-page":"100041","DOI":"10.1016\/j.mtbio.2020.100041","article-title":"Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities","volume":"5","author":"Zheng","year":"2020","journal-title":"Mat. Today Bio"},{"key":"B69","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.msec.2019.02.020","article-title":"Dual therapeutic cobalt-incorporated bioceramics accelerate bone tissue regeneration","volume":"99","author":"Zheng","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"B70","doi-asserted-by":"publisher","first-page":"127077","DOI":"10.1016\/j.cej.2020.127077","article-title":"Lanthanum-doped mesoporous bioglasses\/chitosan composite scaffolds enhance synchronous osteogenesis and angiogenesis for augmented osseous regeneration","volume":"405","author":"Zhu","year":"","journal-title":"Chem. Eng. J."},{"key":"B71","doi-asserted-by":"publisher","first-page":"4110","DOI":"10.1016\/j.bioactmat.2021.03.043","article-title":"Bone physiological microenvironment and healing mechanism: basis for future bone-tissue engineering scaffolds","volume":"6","author":"Zhu","year":"","journal-title":"Bioact. Mat."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2023.1288393\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T04:44:05Z","timestamp":1704343445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2023.1288393\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,4]]},"references-count":71,"alternative-id":["10.3389\/fbioe.2023.1288393"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2023.1288393","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,4]]},"article-number":"1288393"}}