{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:16:45Z","timestamp":1788585405461,"version":"build-2803163510"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009609","name":"Hospital Infantil de M\u00e9xico Federico G\u00f3mez","doi-asserted-by":"publisher","award":["HIM\/2020\/059"],"award-info":[{"award-number":["HIM\/2020\/059"]}],"id":[{"id":"10.13039\/501100009609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> There is a strong interest in designing new scaffolds for their potential application in tissue engineering and regenerative medicine. The incorporation of functionalization molecules can lead to the enhancement of scaffold properties, resulting in variations in scaffold compatibility. Therefore, the efficacy of the therapy could be compromised by the foreign body reaction triggered after implantation.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: In this study, the biocompatibilities of three scaffolds made from an alginate\u2013chitosan combination and functionalized with gold nanoparticles (AuNp) and alginate-coated gold nanoparticles (AuNp + Alg) were evaluated in a subcutaneous implantation model in Wistar rats. Scaffolds and surrounding tissue were collected at 4-, 7- and 25-day postimplantation and processed for histological analysis and quantification of the expression of genes involved in angiogenesis, macrophage profile, and proinflammatory (IL-1\u03b2 and TNF\u03b1) and anti-inflammatory (IL-4 and IL-10) cytokines.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: Histological analysis showed a characteristic foreign body response that resolved 25\u00a0days postimplantation. The intensity of the reaction assessed through capsule thickness was similar among groups. Functionalizing the device with AuNp and AuNp + Alg decreased the expression of markers associated with cell death by apoptosis and polymorphonuclear leukocyte recruitment, suggesting increased compatibility with the host tissue. Similarly, the formation of many foreign body giant cells was prevented. Finally, an increased detection of alpha smooth muscle actin was observed, showing the angiogenic properties of the elaborated scaffolds.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>: Our results show that the proposed scaffolds have improved biocompatibility and exhibit promising potential as biomaterials for elaborating tissue engineering constructs.<\/jats:p>","DOI":"10.3389\/fbioe.2023.1295626","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:30:38Z","timestamp":1700757038000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["In vivo biocompatibility testing of nanoparticle-functionalized alginate\u2013chitosan scaffolds for tissue engineering applications"],"prefix":"10.3389","volume":"11","author":[{"given":"Nancy G.","family":"Viveros-Moreno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Garcia-Lorenzana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Pe\u00f1a-Mercado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josune","family":"Garc\u00eda-Sanmart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Narro-\u00cd\u00f1iguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Salazar-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Huerta-Yepez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Sanchez-Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nohra E.","family":"Beltran-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.actbio.2021.04.021","article-title":"Control of innate immune response by biomaterial surface topography, energy, and stiffness","volume":"133","author":"Abaricia","year":"2021","journal-title":"Acta Biomater."},{"key":"B2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1021\/acs.nanolett.5b04033","article-title":"Gold nanoparticle-decorated scaffolds promote neuronal differentiation and maturation","volume":"16","author":"Baranes","year":"2016","journal-title":"Nano Lett."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e2115857119","DOI":"10.1073\/pnas.2115857119","article-title":"Prevention of the foreign body response to implantable medical devices by inflammasome inhibition","volume":"119","author":"Barone","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.3390\/polym14163233","article-title":"Sodium alginate\/chitosan scaffolds for cardiac tissue engineering: the influence of its three-dimensional material preparation and the use of gold nanoparticles","volume":"14","author":"Beltran-Vargas","year":"2022","journal-title":"Polym. (Basel)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1021\/acs.chemrev.2c00179","article-title":"Self-healing injectable hydrogels for tissue regeneration","volume":"123","author":"Bertsch","year":"2023","journal-title":"Chem. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4874","DOI":"10.1016\/j.biomaterials.2004.11.059","article-title":"The modulation of angiogenesis in the foreign body response by the poxviral protein M-T7","volume":"26","author":"Boomker","year":"2005","journal-title":"Biomaterials"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e8621","DOI":"10.1590\/1414-431X20198621","article-title":"Enhancement of cellular activity in hyperglycemic mice dermal wounds dressed with chitosan-alginate membranes","volume":"53","author":"Breder","year":"2020","journal-title":"Braz J. Med. Biol. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"118692","DOI":"10.1016\/j.ijpharm.2019.118692","article-title":"Alginate-chitosan PEC scaffolds: a useful tool for soft tissues cell therapy","volume":"571","author":"Bushkalova","year":"2019","journal-title":"Int. J. Pharm."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1002\/jbm.b.33277","article-title":"Chitosan-alginate membranes accelerate wound healing","volume":"103","author":"Caetano","year":"2015","journal-title":"J. Biomed. Mater Res. B Appl. Biomater."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e2101415","DOI":"10.1002\/adhm.202101415","article-title":"3D printed dual-porosity scaffolds: the combined effect of stiffness and porosity in the modulation of macrophage polarization","volume":"11","author":"Camarero-Espinosa","year":"2022","journal-title":"Adv. Healthc. Mater"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e10300","DOI":"10.1002\/btm2.10300","article-title":"Advanced strategies to thwart foreign body response to implantable devices","volume":"7","author":"Capuani","year":"2022","journal-title":"Bioeng. Transl. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"622524","DOI":"10.3389\/fbioe.2021.622524","article-title":"Foreign body reaction to implanted biomaterials and its impact in nerve neuroprosthetics","volume":"9","author":"Carnicer-Lombarte","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"820940","DOI":"10.3389\/fbioe.2022.820940","article-title":"Interactions between immunomodulatory biomaterials and immune microenvironment: cues for immunomodulation strategies in tissue repair","volume":"10","author":"Chen","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.3390\/pharmaceutics15051385","article-title":"Therapeutic applications of mesenchymal stem cell loaded with gold nanoparticles for regenerative medicine","volume":"15","author":"Cheng","year":"2023","journal-title":"Pharmaceutics"},{"key":"B16","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.addr.2017.07.006","article-title":"Key players in the immune response to biomaterial scaffolds for regenerative medicine","volume":"114","author":"Chung","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e3465","DOI":"10.21769\/BioProtoc.3465","article-title":"Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an integrated protocol","volume":"9","author":"Crowe","year":"2019","journal-title":"Bio Protoc."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1007\/s10856-007-3014-9","article-title":"Immune evaluation of biomaterials in TNF-\u03b1 and IL-1\u03b2 at mRNA level","volume":"18","author":"Ding","year":"2007","journal-title":"J. Mater Sci. Mater Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"055003","DOI":"10.1088\/1748-605X\/ab316a","article-title":"Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds","volume":"15","author":"Divakar","year":"2020","journal-title":"Biomed. Mater"},{"key":"B20","doi-asserted-by":"publisher","first-page":"135976","DOI":"10.1016\/j.scitotenv.2019.135976","article-title":"Engineered bioactive nanoparticles incorporated biofunctionalized ECM\/silk proteins based cardiac patches combined with MSCs for the repair of myocardial infarction: in vitro and in vivo evaluations","volume":"707","author":"Dong","year":"2020","journal-title":"Sci. Total Environ."},{"key":"B21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/jbm.a.36816","article-title":"In vitro and in vivo biocompatibility assessment of free radical scavenging nanocomposite scaffolds for bone tissue regeneration","volume":"108","author":"Dulany","year":"2020","journal-title":"J. Biomed. Mater Res. A"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/2495848","article-title":"Advances in regenerative medicine and tissue engineering: innovation and transformation of medicine","volume":"2018","author":"Dzobo","year":"2018","journal-title":"Stem Cells Int."},{"key":"B23","doi-asserted-by":"publisher","first-page":"045013","DOI":"10.1088\/1758-5090\/ac88a1","article-title":"Scaffold microarchitecture regulates angiogenesis and the regeneration of large bone defects","volume":"14","author":"Eichholz","year":"2022","journal-title":"Biofabrication"},{"key":"B24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3390\/md21030189","article-title":"Alginate-Based biomaterials in tissue engineering and regenerative medicine","volume":"21","author":"Farshidfar","year":"2023","journal-title":"Mar. Drugs"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1021\/acsbiomaterials.0c00243","article-title":"Design of functional electrospun scaffolds based on poly(glycerol sebacate) elastomer and poly(lactic acid) for cardiac tissue engineering","volume":"6","author":"Flaig","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B26","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3390\/biology11030358","article-title":"Endoglin and activin receptor-like kinase 1 (Alk1) modify adrenomedullin expression in an organ-specific manner in mice","volume":"11","author":"Garc\u00eda-Sanmart\u00edn","year":"2022","journal-title":"Biol. (Basel)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"105271","DOI":"10.1016\/j.jmbbm.2022.105271","article-title":"Electro-conductive 3D printed polycaprolactone\/gold nanoparticles nanocomposite scaffolds for myocardial tissue engineering","volume":"132","author":"Ghaziof","year":"2022","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"B28","doi-asserted-by":"publisher","first-page":"731031","DOI":"10.3389\/fsurg.2021.731031","article-title":"Regenerative engineering: current applications and future perspectives","volume":"8","author":"Goldenberg","year":"2021","journal-title":"Front. Surg."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1205792","DOI":"10.3389\/fbioe.2023.1205792","article-title":"Engineered biomimetic micro\/nano-materials for tissue regeneration","volume":"11","author":"Han","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1016\/j.ijbiomac.2021.05.190","article-title":"Marine polysaccharide-based composite hydrogels containing fucoidan: preparation, physicochemical characterization, and biocompatible evaluation","volume":"183","author":"Hao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e2102087","DOI":"10.1002\/adhm.202102087","article-title":"Medical applications of porous biomaterials: features of porosity and tissue-specific implications for biocompatibility","volume":"11","author":"Hernandez","year":"2022","journal-title":"Adv. Healthc. Mater"},{"key":"B32","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00238-017-1308-9","article-title":"Characterization of the foreign body response to common surgical biomaterials in a murine model","volume":"40","author":"Ibrahim","year":"2017","journal-title":"Eur. J. Plast. Surg."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/jbm.a.35993","article-title":"In vivo study on the biocompatibility of chitosan-hydroxyapatite film depending on degree of deacetylation","volume":"105","author":"Jeong","year":"2017","journal-title":"J. Biomed. Mater Res. A"},{"key":"B35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41392-021-00593-5","article-title":"Correction to: bioactive potential of natural biomaterials: identification, retention and assessment of biological properties","volume":"6","author":"Joyce","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"B36","doi-asserted-by":"publisher","first-page":"730938","DOI":"10.3389\/fbioe.2021.730938","article-title":"Mobilizing endogenous repair through understanding immune reaction with biomaterials","volume":"9","author":"Karkanitsa","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3390\/pharmaceutics15030807","article-title":"Chitosan-Based biomaterials for tissue regeneration","volume":"15","author":"Kim","year":"2023","journal-title":"Pharm."},{"key":"B38","doi-asserted-by":"publisher","first-page":"022007","DOI":"10.1088\/1748-605X\/ac5574","article-title":"Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity","volume":"17","author":"Kyriakides","year":"2022","journal-title":"Biomed. Mater"},{"key":"B39","doi-asserted-by":"publisher","first-page":"20693","DOI":"10.1021\/acsami.2c02001","article-title":"Pore size of 3D-printed polycaprolactone\/polyethylene glycol\/hydroxyapatite scaffolds affects bone regeneration by modulating macrophage polarization and the foreign body response","volume":"14","author":"Li","year":"2022","journal-title":"ACS Appl. Mater Interfaces"},{"key":"B40","doi-asserted-by":"publisher","first-page":"107415","DOI":"10.1016\/j.compositesb.2019.107415","article-title":"Synthesis and characterization of gold\/silica hybrid nanoparticles incorporated gelatin methacrylate conductive hydrogels for H9C2 cardiac cell compatibility study","volume":"177","author":"Maharjan","year":"2019","journal-title":"Compos. Part B Eng."},{"key":"B41","doi-asserted-by":"publisher","first-page":"325","DOI":"10.22038\/ajp.2022.19574","article-title":"Enhancing the efficacy of Hypericum perforatum in the treatment of an experimental model of multiple sclerosis using gold nanoparticles: an in vivo study","volume":"12","author":"Mahmoudi","year":"2022","journal-title":"Avicenna J. Phytomed"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1097\/PRS.0000000000001193","article-title":"The foreign body response: at the interface of surgery and bioengineering","volume":"135","author":"Major","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"B43","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.actbio.2021.03.038","article-title":"Macrophage phenotypes in tissue repair and the foreign body response: implications for biomaterial-based regenerative medicine strategies","volume":"133","author":"Martin","year":"2021","journal-title":"Acta Biomater."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1002\/jbm.a.35280","article-title":"Phenotypic expression in human monocyte-derived interleukin-4-induced foreign body giant cells and macrophages in vitro: dependence on material surface properties","volume":"103","author":"McNally","year":"2015","journal-title":"J. Biomed. Mater Res. A"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e0157894","DOI":"10.1371\/journal.pone.0157894","article-title":"Biocompatibility of subcutaneously implanted plant-derived cellulose biomaterials","volume":"11","author":"Modulevsky","year":"2016","journal-title":"PLoS One"},{"key":"B46","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/s0142-9612(97)00017-3","article-title":"Effects of chitin and its derivatives on the proliferation and cytokine production of fibroblasts in vitro","volume":"18","author":"Mori","year":"1997","journal-title":"Biomaterials"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.ijbiomac.2017.07.087","article-title":"Chitosan as a bioactive polymer: processing, properties and applications","volume":"105","author":"Muxika","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.carbpol.2008.11.002","article-title":"Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone","volume":"76","author":"Muzzarelli","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.2147\/ijn.S195218","article-title":"<p>Anti-neuroinflammatory effects of <em>Ephedra sinica Stapf<\/em> extract-capped gold nanoparticles in microglia<\/p>","volume":"14","author":"Park","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"B50","doi-asserted-by":"publisher","first-page":"eadd0014","DOI":"10.1126\/sciadv.add0014","article-title":"Dissecting the recruitment and self-organization of \u03b1SMA-positive fibroblasts in the foreign body response","volume":"8","author":"Parlani","year":"2022","journal-title":"Sci. Adv."},{"key":"B51","doi-asserted-by":"publisher","first-page":"eabm6586","DOI":"10.1126\/scitranslmed.abm6586","article-title":"Reactive oxygen species-degradable polythioketal urethane foam dressings to promote porcine skin wound repair","volume":"14","author":"Patil","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e2000160","DOI":"10.1002\/biot.202000160","article-title":"Biocompatibility of biomaterials for tissue regeneration or replacement","volume":"15","author":"Raut","year":"2020","journal-title":"Biotechnol. J."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1002\/jbm.a.37250","article-title":"The effects of the molecular weight of chitosan on the tissue inflammatory response","volume":"109","author":"Ribeiro","year":"2021","journal-title":"J. Biomed. Mater Res. A"},{"key":"B55","doi-asserted-by":"publisher","first-page":"13877","DOI":"10.1038\/s41598-021-93367-6","article-title":"Bioengineered 3D nanocomposite based on gold nanoparticles and gelatin nanofibers for bone regeneration: in vitro and in vivo study","volume":"11","author":"Samadian","year":"2021","journal-title":"Sci. Rep."},{"key":"B56","doi-asserted-by":"publisher","first-page":"18118","DOI":"10.1021\/acsomega.9b02009","article-title":"Self-assembled polysaccharide-diphenylalanine\/Au nanospheres for photothermal therapy and photoacoustic imaging","volume":"4","author":"Shen","year":"2019","journal-title":"ACS Omega"},{"key":"B57","doi-asserted-by":"publisher","first-page":"5792","DOI":"10.1021\/nl502673m","article-title":"Gold nanoparticle-decellularized matrix hybrids for cardiac tissue engineering","volume":"14","author":"Shevach","year":"2014","journal-title":"Nano Lett."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1177\/08853282211051586","article-title":"Investigation of an injectable gold nanoparticle extracellular matrix","volume":"36","author":"Snider","year":"2022","journal-title":"J. Biomaterials Appl."},{"key":"B59","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.biomaterials.2015.12.022","article-title":"Knockdown of TNF-\u03b1 by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction","volume":"83","author":"Somasuntharam","year":"2016","journal-title":"Biomaterials"},{"key":"B60","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1089\/ten.TEA.2017.0221","article-title":"RGDfK-peptide modified alginate scaffold for cell transplantation and cardiac neovascularization","volume":"24","author":"Sondermeijer","year":"2018","journal-title":"Tissue Eng. Part A"},{"key":"B61","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.msec.2017.05.079","article-title":"Multifunctional gold coated iron oxide core-shell nanoparticles stabilized using thiolated sodium alginate for biomedical applications","volume":"80","author":"Sood","year":"2017","journal-title":"Mater Sci. Eng. C Mater Biol. Appl."},{"key":"B62","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/jbm.a.37283","article-title":"Chitosan\/hydroxyapatite nanocomposite scaffolds to modulate osteogenic and inflammatory response","volume":"110","author":"Soriente","year":"2022","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"B63","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.colsurfb.2015.07.019","article-title":"Cardiogenic differentiation of mesenchymal stem cells with gold nanoparticle loaded functionalized nanofibers","volume":"134","author":"Sridhar","year":"2015","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.3390\/ma6041285","article-title":"Alginate-Based biomaterials for regenerative medicine applications","volume":"6","author":"Sun","year":"2013","journal-title":"Mater. (Basel)"},{"key":"B65","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.biomaterials.2014.10.035","article-title":"Modulation of the inflammatory response to chitosan through M2 macrophage polarization using pro-resolution mediators","volume":"37","author":"Vasconcelos","year":"2015","journal-title":"Biomaterials"},{"key":"B66","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nmat4290","article-title":"Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates","volume":"14","author":"Veiseh","year":"2015","journal-title":"Nat. Mater"},{"key":"B67","doi-asserted-by":"publisher","first-page":"5129","DOI":"10.1016\/j.biomaterials.2014.03.025","article-title":"The effect of scaffold macroporosity on angiogenesis and cell survival in tissue-engineered smooth muscle","volume":"35","author":"Walthers","year":"2014","journal-title":"Biomaterials"},{"key":"B68","doi-asserted-by":"publisher","first-page":"664592","DOI":"10.3389\/fbioe.2021.664592","article-title":"Host response to biomaterials for cartilage tissue engineering: key to remodeling","volume":"9","author":"Wei","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"11305","DOI":"10.1021\/acs.chemrev.0c00895","article-title":"Immunomodulatory biomaterials for tissue repair","volume":"121","author":"Whitaker","year":"2021","journal-title":"Chem. Rev."},{"key":"B70","doi-asserted-by":"publisher","first-page":"e1801451","DOI":"10.1002\/adhm.201801451","article-title":"Macrophage and fibroblast interactions in biomaterial-mediated fibrosis","volume":"8","author":"Witherel","year":"2019","journal-title":"Adv. Healthc. Mater"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1021\/acs.nanolett.9b00472","article-title":"Gold nanoparticle-integrated scaffolds for tissue engineering and regenerative medicine","volume":"19","author":"Yadid","year":"2019","journal-title":"Nano Lett."},{"key":"B72","doi-asserted-by":"publisher","first-page":"120216","DOI":"10.1016\/j.biomaterials.2020.120216","article-title":"Modulation of macrophages by bioactive glass\/sodium alginate hydrogel is crucial in skin regeneration enhancement","volume":"256","author":"Zhu","year":"2020","journal-title":"Biomaterials"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2023.1295626\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:30:44Z","timestamp":1700757044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2023.1295626\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":70,"alternative-id":["10.3389\/fbioe.2023.1295626"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2023.1295626","relation":{},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]},"article-number":"1295626"}}