{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:55:29Z","timestamp":1793307329858,"version":"4.5.0"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Clinical grade magnetic bead implants have important applications in interfacing with the human body, providing contactless mechanical attachment or wireless communication through human tissue. We recently developed a new strategy, magnetomicrometry, that uses magnetic bead implants as passive communication devices to wirelessly sense muscle tissue lengths. We manufactured clinical-grade magnetic bead implants and verified their biocompatibility via intramuscular implantation, cytotoxicity, sensitization, and intracutaneous irritation testing. In this work, we test the pyrogenicity of the magnetic bead implants via a lagomorph model, and we test the biocompatibility of the magnetic bead implants via a full chemical characterization and toxicological risk assessment. Further, we test the cleaning, sterilization, and dry time of the devices that are used to deploy these magnetic bead implants. We find that the magnetic bead implants are non-pyrogenic and biocompatible, with the insertion device determined to be safe to clean, sterilize, and dry in a healthcare setting. These results provide confidence for the safe use of these magnetic bead implants in humans.<\/jats:p>","DOI":"10.3389\/fbioe.2024.1290453","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:57:30Z","timestamp":1708390650000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Non-pyrogenicity and biocompatibility of parylene-coated magnetic bead implants"],"prefix":"10.3389","volume":"12","author":[{"given":"Cameron R.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua K.","family":"Nott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilmini H.","family":"Ratnasena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh M.","family":"Herr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/jez.2031","article-title":"Fluoromicrometry: a method for measuring muscle length dynamics with biplanar videofluoroscopy","volume":"325","author":"Camp","year":"2016","journal-title":"J. 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Methods"},{"key":"B3","doi-asserted-by":"publisher","first-page":"6766","DOI":"10.1039\/d0ra07989h","article-title":"Stability and in vivo safety of gold, titanium nitride and Parylene C coatings on NdFeB magnets implanted in muscles towards a new generation of myokinetic prosthetic limbs","volume":"11","author":"Iacovacci","year":"2021","journal-title":"RSC Adv."},{"key":"B4","doi-asserted-by":"publisher","first-page":"113334","DOI":"10.1016\/j.jpba.2020.113334","article-title":"Reducing relative response factor variation using a multidetector approach for extractables and leachables (E&L) analysis to mitigate the need for uncertainty factors","volume":"186","author":"Jordi","year":"2020","journal-title":"J. Pharm. Biomed. Analysis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1010276","DOI":"10.3389\/fbioe.2022.1010276","article-title":"Clinical viability of magnetic bead implants in muscle","volume":"10","author":"Taylor","year":"","journal-title":"Front. Bioeng. 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Biotechnol."}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2024.1290453\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:57:33Z","timestamp":1708390653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2024.1290453\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":7,"alternative-id":["10.3389\/fbioe.2024.1290453"],"URL":"https:\/\/doi.org\/10.3389\/fbioe.2024.1290453","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.09.01.555995","asserted-by":"object"}]},"ISSN":["2296-4185"],"issn-type":[{"value":"2296-4185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]},"article-number":"1290453"}}