{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:50:27Z","timestamp":1789415427487,"version":"build-2803163510"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>\n                    The current literature studied the median nerve (MN) at specific locations during joint motions. As only a few particular parts of the nerve are depicted, the relevant information available is limited. This experiment investigated the morphological and biomechanical properties of the MN. The effects of the shoulder and wrist motions on MN were explored as well. Eight young healthy female individuals were tested with two-dimensional ultrasound and shear wave elastography (SWE). The morphological and biomechanical properties were examined in limb position 1, with the wrist at the neutral position, the elbow extended at 180\u00b0, and the shoulder abducted at 60\u00b0. In addition, the experiment assessed the differences among the wrist, forearm, elbow, and upper arm with Friedman\u2019s test and Bonferroni\n                    <jats:italic>post hoc<\/jats:italic>\n                    analysis. Two groups of limb positions were designed to explore the effects of shoulder movements (shoulder abducted at 90\u00b0 and 120\u00b0) and wrist movements (wrist extended at 45\u00b0 and flexed at 45\u00b0) on the thickness and Young\u2019s modulus. Differences among the distributions of five limb positions were tested as well. The ICC\n                    <jats:sub>3, 1<\/jats:sub>\n                    values for thickness and Young\u2019s modulus were 0.976 and 0.996, respectively. There were differences among the MN thicknesses of four arm locations in limb position 1, while Young\u2019s modulus was higher at the elbow and wrist than at the forearm and upper arm. Compared to limb position 1, only limb position 4 had an effect on MN thickness at the wrist. Both shoulder and wrist motions affected MN Young\u2019s modulus, and the stiffness variations at typical locations all showed a downward trend proximally in all. The distributions of MN thickness and Young\u2019s modulus showed fold line patterns but differed at the wrist and the pronator teres. The MN in the wrist is more susceptible to limb positions, and Young\u2019s modulus is sensitive to nerve changes and is more promising for the early diagnosis of neuropathy.\n                  <\/jats:p>","DOI":"10.3389\/fbioe.2024.1329960","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:27:20Z","timestamp":1712795240000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Non-invasive in vivo study of morphology and mechanical properties of the median nerve"],"prefix":"10.3389","volume":"12","author":[{"given":"Ruixia","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luquan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"648779","DOI":"10.3389\/fsurg.2021.648779","article-title":"The myth of median nerve in forearm and its role in double crush syndrome: a cadaveric study","volume":"8","author":"Abdalbary","year":"2021","journal-title":"Front. 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