{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:48:05Z","timestamp":1753890485795,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:p>Lips form a structure that are difficult to reconstruct after a traumatic avulsion injury or cancer ablative surgery secondary to loss of volumetric muscle mass. Traditional tissue engineering approaches of <jats:italic>in vitro<\/jats:italic> fabrication of mature tissue constructs can supply an alternative to the current surgical standard of care for functional lip reconstruction. We demonstrate a hybrid approach that combines the advantages of <jats:italic>in situ<\/jats:italic> muscle flap prefabrication with <jats:italic>in vitro<\/jats:italic> fabrication of an autogenous mucocutaneous construct as the laminate for prelamination to form a designer microvascular muscle free flap for lip reconstruction.<\/jats:p>","DOI":"10.3389\/fbioe.2024.1364705","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T05:07:01Z","timestamp":1723439221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Reconstruction of functional human lips utilizing a prelaminated flap"],"prefix":"10.3389","volume":"12","author":[{"given":"Stephen E.","family":"Feinberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia L.","family":"Marcelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.archoralbio.2004.09.012","article-title":"The differentiation profile of the epithelium of the human lip","volume":"50","author":"Barrett","year":"2005","journal-title":"Arch. 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