{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:32:37Z","timestamp":1759091557257,"version":"3.41.2"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aims to investigate the differences in binocular corneal parameters and their interrelation with binocular biometric parameters asymmetry in patients with simple myopic anisometropia, thereby elucidating the influence of myopia process on various corneal parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross-sectional study, 65 patients with anisometropia in monocular myopia were included. They were divided into low anisometropia group: 3.00D&amp;lt;\u0394 spherical equivalent (SE)\u2264\u22121.00D (\u0394 represents the difference between the two eyes, i.e., myopic data minus emmetropic data) and high anisometropia group: \u0394SE \u2264 \u22123.00D. Corneal and ocular biometric parameters were measured using Pentacam, Corvis ST, and IOL Master 700. Statistical analyses focused on the binocular corneal parameters asymmetry, using the contralateral emmetropia as a control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of participants was 18.5 \u00b1 1.3 years, with the average SE for myopia and emmetropia being \u22122.93 \u00b1 1.09D and \u22120.16 \u00b1 0.41D, respectively. The central corneal thickness (CCT), flat keratometry (Kf), keratometry astigmatism (Ka), total corneal aberration (6\u00a0mm) (TOA), surface variance index (ISV), vertical asymmetry index (IVA), stress-strain index (SSI), and first applanation stiffness parameter (SPA1) and ambrosia relational thickness-horizontal (ARTh) showed significant differences between anisometropic fellow eyes (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). There were significant differences in \u0394IVA, \u0394 the difference between the mean refractive power of the inferior and superior corneas (I-S), \u0394 deviation value of Belin\/Ambr\u00f3sio enhanced ectasia display (BAD-D), \u0394 deformation amplitude ratio max (2\u00a0mm) (DAR)and \u0394 tomographic biomechanical index (TBI) (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) in two groups. Asymmetry of corneal parameters was correlated with asymmetry of ocular biometric parameters. Anisometropia (\u0394SE) was positively correlated with \u0394IVA (r = 0.255, <jats:italic>p<\/jats:italic> = 0.040), \u0394BAD-D (r = 0.360, <jats:italic>p<\/jats:italic> = 0.006), and \u0394SSI (r = 0.276, <jats:italic>p<\/jats:italic> = 0.039) and negatively correlated with \u0394DAR (r = \u22120.329, <jats:italic>p<\/jats:italic> = 0.013) in multiple regression analysis. \u0394 mean keratometry (Km), \u0394 anterior chamber depth (ACD), and \u0394 biomechanically corrected intraocular pressure (bIOP) were also associated with binocular corneal differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to contralateral emmetropia, myopic eyes have thinner corneas and smaller corneal astigmatism. Myopic corneas exhibit relatively more regular surface morphology but are more susceptible to deformation and possess marginally inferior biomechanical properties. In addition, there is a certain correlation between anisometropia and corneal parameter asymmetry, which would be instrumental in predicting the development of myopia.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fbioe.2024.1366408","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T04:45:45Z","timestamp":1716353145000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative analysis of corneal parameters in simple myopic anisometropia using Scheimpflug technology"],"prefix":"10.3389","volume":"12","author":[{"given":"Di","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijin","family":"Nan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"542","DOI":"10.3390\/diagnostics11030542","article-title":"Relationship between axial length and corneo-scleral topography: a preliminary study","volume":"11","author":"Bataille","year":"2021","journal-title":"Diagn. 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